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  1. The aim of this randomized, double-blinded, controlled trial was to investigate the effect of daily consumption of a synbiotic bread containing lactic acid on glycemic status, antioxidant biomarkers and inflam...

    Authors: Atie Ghafouri, Mitra Zarrati, Farzad Shidfar, Iraj Heydari, Raheleh Shokouhi Shoormasti and Omid Eslami

    Citation: Diabetology & Metabolic Syndrome 2019 11:103

    Content type: Research

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  2. Prediabetes has been proposed as a risk factor for the development of type 2 diabetes mellitus (DM2) and cardiovascular disease (CVD). Despite the clinical importance of prediabetes, little is known about the ...

    Authors: Jennifer Garay, Paul A. Camacho, Jose Lopez-Lopez, Juliana Alvernia, Marcela Garcia, Daniel D. Cohen, Carlos Calderon and Patricio Lopez-Jaramillo

    Citation: Diabetology & Metabolic Syndrome 2019 11:102

    Content type: Research

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  3. The present study was designed to determine whether zinc supplementation would increase the effects of restricted calorie diet (RCD) on obesity.

    Authors: Hoda Khorsandi, Omid Nikpayam, Reyhaneh Yousefi, Maryam Parandoosh, Nima Hosseinzadeh, Atoosa Saidpour and Arman Ghorbani

    Citation: Diabetology & Metabolic Syndrome 2019 11:101

    Content type: Research

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  4. Although bilirubin has been generally regarded as a waste with potential neurotoxicity at high levels, a few clinical studies suggest a potential protective role of physiological serum total bilirubin (TBIL) c...

    Authors: Pijun Yan, Zhihong Zhang, Ying Miao, Yong Xu, Jianhua Zhu and Qin Wan

    Citation: Diabetology & Metabolic Syndrome 2019 11:100

    Content type: Research

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  5. Alpha-synuclein (SNCA) as the presynaptic protein is expressed in different tissues and prevents insulin-resistance (IR) through increasing glucose-uptake by adipocytes and muscles. However, the effect of insu...

    Authors: Amirhosein Khoshi, Golnaz Goodarzi, Rezvan Mohammadi, Roghaye Arezumand, Meysam Moghbeli and Mahnaz Najariyan

    Citation: Diabetology & Metabolic Syndrome 2019 11:99

    Content type: Research

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  6. Epigenetic changes in visceral adipose tissue (VAT) with obesity and their effects on gene expression are poorly understood, especially during emergent obesity in youth. The current study tested the hypothesis...

    Authors: Matthew D. Barberio, Evan P. Nadler, Samantha Sevilla, Rosemary Lu, Brennan Harmon and Monica J. Hubal

    Citation: Diabetology & Metabolic Syndrome 2019 11:98

    Content type: Research

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  7. The association of diabetic nephropathy (DN) risk with single nucleotide polymorphisms (SNPs) within Engulfment and Cell Motility 1 (ELMO1) gene and gene–environment synergistic effect have not been extensively e...

    Authors: Yi Hou, Yong Gao, Yan Zhang, Si-Tong Lin, Yue Yu and Liu Yang

    Citation: Diabetology & Metabolic Syndrome 2019 11:97

    Content type: Research

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  8. To investigate effects of metformin on the regulation of proteins of white adipose tissue (WAT) and brown adipose tissue (BAT) in obesity and explore the underlying mechanisms on energy metabolism.

    Authors: Tao Yuan, Juan Li, Wei-Gang Zhao, Wei Sun, Shuai-Nan Liu, Quan Liu, Yong Fu and Zhu-Fang Shen

    Citation: Diabetology & Metabolic Syndrome 2019 11:96

    Content type: Research

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  9. Insulin resistance (IR) is frequently observed in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). In clinical practice, IR assessment is limited to a low proportion of patients d...

    Authors: Betsabe Contreras-Haro, Sandra Ofelia Hernandez-Gonzalez, Laura Gonzalez-Lopez, Maria Claudia Espinel-Bermudez, Leonel Garcia-Benavides, Edsaul Perez-Guerrero, Maria Luisa Vazquez-Villegas, Jose Antonio Robles-Cervantes, Mario Salazar-Paramo, Diana Mercedes Hernandez-Corona, Arnulfo Hernan Nava-Zavala and Jorge I. Gamez-Nava

    Citation: Diabetology & Metabolic Syndrome 2019 11:95

    Content type: Research

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  10. Treatment with metformin, the biguanide of hepatic insulin sensitizer, in patients with non-alcoholic fatty liver disease (NAFLD) has been reported with contradictory findings regarding the effectiveness on bl...

    Authors: Yi Sui, Xianhe Kong, Rongrong Fan, Yanbin Ye, Haiyan Mai, Shuyu Zhuo, Wei Lu, Peishan Ruan, Shi Fang and Tao Yang

    Citation: Diabetology & Metabolic Syndrome 2019 11:94

    Content type: Research

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  11. A number of studies have shown central adiposity, in particular visceral adipose tissue (VAT) accumulation to be a hallmark of metabolic syndrome (MetS). In clinical practice, waist circumference (WC) is used ...

    Authors: Florence E. Davidson, Tandi E. Matsha, Rajiv T. Erasmus, Andre Pascal Kengne and Julia H. Goedecke

    Citation: Diabetology & Metabolic Syndrome 2019 11:93

    Content type: Research

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  12. Evidence from observational studies have found a relationship between serum cholesterol and diabetic retinopathy (DR). Apart of the assumption that cholesterolemic control has benefits for patients with diabet...

    Authors: Vânia Mozetic, Rafael Leite Pacheco, Carolina de Oliveira Cruz Latorraca and Rachel Riera

    Citation: Diabetology & Metabolic Syndrome 2019 11:92

    Content type: Review

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  13. Many studies have investigated the relationship between coffee and diabetes. Evaluation of the current evidence on the effect of coffee intake on diabetes is critical. Therefore, we aimed to investigate the po...

    Authors: Omid Nikpayam, Marziyeh Najafi, Samad Ghaffari, Mohammad Asghari Jafarabadi, Golbon Sohrab and Neda Roshanravan

    Citation: Diabetology & Metabolic Syndrome 2019 11:91

    Content type: Review

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  14. Guidelines for Type 2 diabetes mellitus (T2DM) management in Japan provide physicians the discretion to select treatment options based on patient pathophysiology of the disease. There exists a wide variation o...

    Authors: Yohei Morita, Hiroki Murayama, Masato Odawara and Melissa Bauer

    Citation: Diabetology & Metabolic Syndrome 2019 11:90

    Content type: Research

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  15. The stratification system from the International Working Group on the Diabetic Foot (IWGDF) was used to classify the participants as to the ulcer risk. However, it is not yet known what the classification grou...

    Authors: Jane S. S. P. Ferreira, João P. Panighel, Érica Q. Silva, Renan L. Monteiro, Ronaldo H. Cruvinel Júnior and Isabel C. N. Sacco

    Citation: Diabetology & Metabolic Syndrome 2019 11:89

    Content type: Research

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  16. Abdominal obesity is a risk factor for cardiovascular disease. The aim was to explore the influence of midnight salivary cortisol (MSC), antidepressants and sex on abdominal obesity in type 1 diabetes (T1D). W...

    Authors: Eva Olga Melin, Magnus Hillman, Maria Thunander and Mona Landin-Olsson

    Citation: Diabetology & Metabolic Syndrome 2019 11:88

    Content type: Research

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  17. Metabolic syndrome (MetS) is a clinical condition potentially promoting the development of atherosclerotic disease. To date, the clinical impact of elevated serum homocysteine (Hcy) levels in MetS is still und...

    Authors: Giuseppina Piazzolla, Mafalda Candigliota, Margherita Fanelli, Anna Castrovilli, Elsa Berardi, Gianfranco Antonica, Stefano Battaglia, Vincenzo Solfrizzi, Carlo Sabbà and Cosimo Tortorella

    Citation: Diabetology & Metabolic Syndrome 2019 11:87

    Content type: Research

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  18. Several researches have recommended vitamin D possible health benefits on diabetic complications development, but a few number of studies have been accomplished on the molecular and cellular mechanisms. Certai...

    Authors: Mahsa Omidian, Mahmoud Djalali, Mohammad Hassan Javanbakht, Mohammad Reza Eshraghian, Maryam Abshirini, Parisa Omidian, Ehsan Alvandi and Maryam Mahmoudi

    Citation: Diabetology & Metabolic Syndrome 2019 11:86

    Content type: Research

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  19. The combined harmful effects of cigarette smoking and hyperglycemia can accelerate vascular damage in patients with diabetes who smoke, as is well known. Can smoking cause diabetes? What are the effects of smo...

    Authors: D. Campagna, A. Alamo, A. Di Pino, C. Russo, A. E. Calogero, F. Purrello and R. Polosa

    Citation: Diabetology & Metabolic Syndrome 2019 11:85

    Content type: Review

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  20. Mobile phone applications (apps) have been shown to successfully facilitate the self-management of chronic disease. This study aims to evaluate firstly the experiences, barriers and facilitators to app usage a...

    Authors: Bronte Jeffrey, Melina Bagala, Ashley Creighton, Tayla Leavey, Sarah Nicholls, Crystal Wood, Jo Longman, Jane Barker and Sabrina Pit

    Citation: Diabetology & Metabolic Syndrome 2019 11:84

    Content type: Research

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  21. Previous studies investigating the association between metabolic syndrome (MetS) and incidence of gastric cancer (GC) showed inconsistent results. The aim of the study was to evaluate the influence of MetS on ...

    Authors: Zhibin Li, Hongfeng Han and Yuan Chang

    Citation: Diabetology & Metabolic Syndrome 2019 11:83

    Content type: Research

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  22. SHORT syndrome is an autosomal dominant condition associated severe insulin resistance (IR) and lipoatrophy due to post-receptor defect in insulin signaling involving phosphoinositide-3-kinase regulatory subun...

    Authors: Krzysztof C. Lewandowski, Katarzyna Dąbrowska, Maria Brzozowska, Joanna Kawalec and Andrzej Lewiński

    Citation: Diabetology & Metabolic Syndrome 2019 11:81

    Content type: Short report

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  23. The recent American Diabetes Association and the European Association for the Study of Diabetes guideline mentioned glycaemia management in type 2 diabetes mellitus (T2DM) patients with cardiovascular diseases...

    Authors: Alaaeldin Bashier, Azza Bin Hussain, Elamin Abdelgadir, Fatheya Alawadi, Hani Sabbour and Robert Chilton

    Citation: Diabetology & Metabolic Syndrome 2019 11:80

    Content type: Review

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  24. Fibroblast growth factor 19 (FGF19) takes part in maintaining the balance of glycolipids and may be involved in regulating the secretory activity of islet beta cells in patients with type 2 diabetes. This stud...

    Authors: Meng-jie Tang, Jian‑bin Su, Tian-li Xu, Xue‑qin Wang, Dong-mei Zhang and Xiao-hua Wang

    Citation: Diabetology & Metabolic Syndrome 2019 11:79

    Content type: Research

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  25. The enzyme 11-beta hydroxysteroid dehydrogenase type 1 (HSD11B1) converts inactive cortisone to active cortisol in a process mediated by the enzyme hexose-6-phosphate dehydrogenase (H6PD). The generation of co...

    Authors: Marcio F. Chedid, Filipe V. do Nascimento, Fernanda S. de Oliveira, Bianca M. de Souza, Cleber R. P. Kruel, Richard R. Gurski, Luis H. Canani, Daisy Crispim and Fernando Gerchman

    Citation: Diabetology & Metabolic Syndrome 2019 11:78

    Content type: Research

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  26. Since there is no evidence demonstrating the relationship between dietary patterns and subclinical atherosclerosis in children and adolescents, we aimed to examine the association between dietary patterns and ...

    Authors: Assa Akbari-Sedigh, Golaleh Asghari, Emad Yuzbashian, Pooneh Dehghan, Hossein Imani and Parvin Mirmiran

    Citation: Diabetology & Metabolic Syndrome 2019 11:77

    Content type: Research

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  27. The association between diabetes and obesity is very well established. Faced with this, several anthropometric indices of adiposity are often involved in studies on diabetes. Our main goal in this paper is to ...

    Authors: Camila Maciel de Oliveira, Jessica Pavani, José Eduardo Krieger, Rafael de Oliveira Alvim, Carlos Alberto Mourão-Junior and Alexandre da Costa Pereira

    Citation: Diabetology & Metabolic Syndrome 2019 11:76

    Content type: Letter to the Editor

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  28. Gestational diabetes mellitus (GDM) is a complication of pregnancy that can be associated with neonatal complications and adverse pregnancy outcomes. Recently, probiotic use has been proposed for better contro...

    Authors: Farnaz Sahhaf Ebrahimi, Aziz Homayouni Rad, Metanat Mosen, Fatemeh Abbasalizadeh, Aydin Tabrizi and Leila Khalili

    Citation: Diabetology & Metabolic Syndrome 2019 11:75

    Content type: Research

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  29. This is an overview of the mechanisms of obesity and its relation to cardiovascular risks, describing the available treatment options to manage this condition.

    Authors: C. Cercato and F. A. Fonseca

    Citation: Diabetology & Metabolic Syndrome 2019 11:74

    Content type: Review

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  30. Type 2 diabetes is one of the most common chronic diseases worldwide, and one of the long-term complications of this disease is sexual dysfunction in women with type 2 diabetes, which has been studied in fewer...

    Authors: Elham Rahmanian, Nader Salari, Masoud Mohammadi and Rostam Jalali

    Citation: Diabetology & Metabolic Syndrome 2019 11:73

    Content type: Review

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  31. Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and its prevalence worldwide is increasing along with enhancing type two of diabetes. Contrary results have been found i...

    Authors: Fatemeh Nasiri-Amiri, Mahdi Sepidarkish, Marjan Ahmad Shirvani, Payam Habibipour and Narges Sadat Motahari Tabari

    Citation: Diabetology & Metabolic Syndrome 2019 11:72

    Content type: Review

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  32. Polycystic ovary syndrome (PCOS) has been consistently associated with subsequent gestational diabetes mellitus (GDM). Women with PCOS showed a high prevalence of obesity, which raises the question regarding t...

    Authors: Wei Zheng, Wenyu Huang, Li Zhang, Zhihong Tian, Qi Yan, Teng Wang, Lirui Zhang and Guanghui Li

    Citation: Diabetology & Metabolic Syndrome 2019 11:71

    Content type: Research

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  33. Obesity is the main risk factor for diabetes and excessive visceral fat triggers low-grade inflammatory process, mediated by activation and release of cytokines and high flow of free fatty acids that contribut...

    Authors: Alessandra Schiapaccassa, Priscila A. Maranhão, Maria das Graças Coelho de Souza, Diogo G. Panazzolo, José Firmino Nogueira Neto, Eliete Bouskela and Luiz Guilherme Kraemer-Aguiar

    Citation: Diabetology & Metabolic Syndrome 2019 11:70

    Content type: Research

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  34. Hypertension and diabetes mellitus are often jointly present, especially in early onset cases of either disease. We investigated clinical characteristics of hypertensive patients with newly diagnosed diabetes ...

    Authors: Chang-Yuan Liu, Wei Zhang, Li-Nong Ji and Ji-Guang Wang

    Citation: Diabetology & Metabolic Syndrome 2019 11:69

    Content type: Research

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  35. Both obesity and gestational diabetes (GDM) are associated with adverse outcomes. Diet during pregnancy impacts weight gain and fetal growth. Therefore, we aimed to explore non-pharmacological treatment succes...

    Authors: Ana Munda, Marjanca Starčič Erjavec, Katja Molan, Jerneja Ambrožič Avguštin, Darja Žgur-Bertok and Draženka Pongrac Barlovič

    Citation: Diabetology & Metabolic Syndrome 2019 11:68

    Content type: Research

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  36. The present study identified whether glycemic variability (GV) was associated with vascular calcification and explored the underlying mechanisms.

    Authors: Li Zhang, Haichen Sun, Shuang Liu, Jinhuan Gao and Jinggang Xia

    Citation: Diabetology & Metabolic Syndrome 2019 11:67

    Content type: Research

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  37. The metabolic syndrome (MetS) is a clustering of abdominal obesity, diabetes and prediabetes, high cholesterol and high blood pressure, that confers an increased risk of cardiovascular disease. There is limite...

    Authors: Shamila T. De Silva, Madunil A. Niriella, Dileepa S. Ediriweera, Dulani Kottahachchi, Anuradhani Kasturiratne, Arjuna P. de Silva, Anuradha S. Dassanayaka, Arunasalam Pathmeswaran, Rajitha Wickramasinghe, N. Kato and H. Janaka de Silva

    Citation: Diabetology & Metabolic Syndrome 2019 11:66

    Content type: Research

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  38. Omentin, releasing by adipose-tissue may be related to glucose metabolism. The omentin circulating levels and the related mRNA expression in visceral adipose-tissue are different in types of diabetes and the e...

    Authors: Golnaz Goodarzi, Amirreza Shirgir, Sadegh Alavi and Amirhosein Khoshi

    Citation: Diabetology & Metabolic Syndrome 2019 11:65

    Content type: Research

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  39. Diabetes mellitus is a multifactorial disorder characterized by a high level of glucose in the blood. Both genetic and environmental factors interact to cause diabetes. Insulin receptor substrate (IRS) proteins h...

    Authors: Anam Ijaz, Sana Babar, Sumbal Sarwar, Saleem Ullah Shahid and Shabana

    Citation: Diabetology & Metabolic Syndrome 2019 11:64

    Content type: Research

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  40. Adipokines and the myokine irisin, involved in mechanisms associated with obesity and metabolic syndrome (MS), are understudied in the pediatric population.

    Authors: Adrian M. Gonzalez-Gil, Mariana Peschard-Franco, Elena C. Castillo, Gustavo Gutierrez-DelBosque, Victor Treviño, Christian Silva-Platas, Luisa Perez-Villarreal, Gerardo Garcia-Rivas and Leticia Elizondo-Montemayor

    Citation: Diabetology & Metabolic Syndrome 2019 11:63

    Content type: Research

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  41. Endothelial dysfunction (ED) is a hallmark in type 2 diabetes mellitus (T2DM) that favor both atherogenesis and ischemia and reperfusion injury (IRI). Sodium-glucose-2 co-transporter inhibitors (SGLT2i) may hy...

    Authors: Riobaldo M. R. Cintra, Alexandre A. S. Soares, Ikaro Breder, Daniel B. Munhoz, Joaquim Barreto, Sheila T. Kimura-Medorima, Pamela Cavalcante, Renata Zanchetta, Jessica Cunha Breder, Camila Moreira, Vitor W. Virginio, Isabella Bonilha, Jose Carlos Lima-Junior, Otavio R. Coelho-Filho, Vaneza L. W. Wolf, Gil Guerra-Junior…

    Citation: Diabetology & Metabolic Syndrome 2019 11:62

    Content type: Study Protocol

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  42. Metabolic syndrome, an obesity-related condition associated with insulin resistance and low-grade inflammation, leads to diabetes, cardiovascular diseases, cancer, osteoarthritis, and other disorders. Optimal ...

    Authors: Janet B. McGill, Mariko Johnson, Stacy Hurst, William T. Cade, Kevin E. Yarasheski, Richard E. Ostlund, Kenneth B. Schechtman, Babak Razani, Michael B. Kastan, Donald A. McClain, Lisa de las Fuentes, Victor G. Davila-Roman, Daniel S. Ory, Samuel A. Wickline and Clay F. Semenkovich

    Citation: Diabetology & Metabolic Syndrome 2019 11:61

    Content type: Research

    Published on:

  43. Visfatin is a multifaceted protein that plays an important role in regulating a variety of physiological and pathological processes, including obesity, diabetes and cardiovascular disease. However, circulating...

    Authors: Long-Yi Zheng, Xia Xu, Ren-Hui Wan, Sheng Xia, Jin Lu and Qin Huang

    Citation: Diabetology & Metabolic Syndrome 2019 11:60

    Content type: Research

    Published on:

  44. To study the prevalence of postprandial hyperglycaemia (PPH) in type 2 diabetes mellitus (T2DM) patients treated with basal insulin, having fasting glucose < 130 mg/dL but HbA1c > 7.0% (53 mmol/mol).

    Authors: Francisco J. Tinahones, María Molina-Vega, Juan Parra-Barona, Juana Flores-Le Roux and Ricardo Gómez-Huelgas

    Citation: Diabetology & Metabolic Syndrome 2019 11:59

    Content type: Research

    Published on:

  45. The results of studies that assessed the impact of metformin treatments on gestational diabetes mellitus (GDM) in patients with polycystic ovary syndrome (PCOS) are inconclusive. In addition, the impact of tim...

    Authors: Razieh Bidhendi Yarandi, Samira Behboudi-Gandevani, Mina Amiri and Fahimeh Ramezani Tehrani

    Citation: Diabetology & Metabolic Syndrome 2019 11:58

    Content type: Review

    Published on:

  46. Recently, clinical studies have shown the protective effects of sodium glucose co-transporter2 (SGLT2) inhibitors against progression of diabetic nephropathy, but the underlying molecular mechanisms remain unc...

    Authors: Masa-Ki Inoue, Yasuka Matsunaga, Yusuke Nakatsu, Takeshi Yamamotoya, Koji Ueda, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Hiraku Ono, Misaki Iwashita, Tomomi Sano, Fusanori Nishimura, Kenichi Morii, Kensuke Sasaki, Takao Masaki and Tomoichiro Asano

    Citation: Diabetology & Metabolic Syndrome 2019 11:57

    Content type: Research

    Published on:

  47. Some genetic association studies tried to investigate potential associations of Transcription Factor 7 Like 2 (TCF7L2) rs7903146 polymorphism with type 2 diabetes mellitus (T2DM). However, the results of these st...

    Authors: Liying Lou, Jingjing Wang and Jing Wang

    Citation: Diabetology & Metabolic Syndrome 2019 11:56

    Content type: Research

    Published on:

  48. Transcription factor 7-like 2 (TCF7L2), which previously known as TCF-4, is a major form of transcription factor involved in the downstream WNT signaling and exhibits the strongest association to diabetes susc...

    Authors: Hui-Hui Wu, Yan-Liang Li, Nai-Jia Liu, Zhen Yang, Xiao-Ming Tao, Yan-Ping Du, Xuan-Chun Wang, Bin Lu, Zhao-Yun Zhang, Ren-Ming Hu and Jie Wen

    Citation: Diabetology & Metabolic Syndrome 2019 11:55

    Content type: Research

    Published on:

  49. Diabetes and its complications produce significant clinical, economic and social impact. The knowledge of the costs of diabetes generates subsidies to maintain the financial sustainability of public health and...

    Authors: Luciana Ribeiro Bahia, Michelle Quarti Machado da Rosa, Denizar Vianna Araujo, Marcelo Goulart Correia, Roger dos Santos dos Rosa, Bruce Bartholow Duncan and Cristiana Maria Toscano

    Citation: Diabetology & Metabolic Syndrome 2019 11:54

    Content type: Research

    Published on:


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