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  1. Content type: Research

    Previous studies comparing insulin degludec/insulin aspart (IDegAsp) with premixed insulin twice daily among insulin users with type 2 diabetes have not thoroughly investigated differences in the glucose varia...

    Authors: Kanta Fujimoto, Toshio Iwakura, Megumi Aburaya and Naoki Matsuoka

    Citation: Diabetology & Metabolic Syndrome 2018 10:64

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  2. Content type: Research

    Flash glucose monitoring (FGM) is a factory-calibrated, blood glucose measuring sensor system for patients with diabetes. We aimed to investigate the correlation between the sensor glucose (SG) value obtained ...

    Authors: Keiko Koide, Koichiro Azuma, Jun Nojima, Kenichiro Kodama and Yoshihito Atsumi

    Citation: Diabetology & Metabolic Syndrome 2018 10:63

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  3. Content type: Research

    Several studies have linked vascular endothelial growth factors (VEGFs) with metabolic syndrome or its components. However, there has been no systematic appraisal of the findings of these studies to date. The ...

    Authors: Mohammad Ishraq Zafar, Kerry Mills, Xiaofeng Ye, Brette Blakely, Jie Min, Wen Kong, Nan Zhang, Luoning Gou, Anita Regmi, Sheng Qing Hu, Juan Zheng and Lu-Lu Chen

    Citation: Diabetology & Metabolic Syndrome 2018 10:62

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  4. Content type: Review

    Previous studies have demonstrated that elevated homocysteine (Hcy) level represents an independent risk factor for macrovascular disease. However, the relationship between hyperhomocysteinemia and the progres...

    Authors: Xunwen Lei, Guifeng Zeng, Yuemei Zhang, Qiang Li, Jinzhi Zhang, Zhenggang Bai and Kehu Yang

    Citation: Diabetology & Metabolic Syndrome 2018 10:61

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  5. Content type: Research

    We described, in a large sample of patients with type 1 diabetes mellitus (T1DM) and GFR ≤ 60 mL/min/1.73 m2 (with or without albuminuria), the differences in the clinical features associated with the two differe...

    Authors: Olga Lamacchia, Francesca Viazzi, Paola Fioretto, Antonio Mirijello, Carlo Giorda, Antonio Ceriello, Giuseppina Russo, Pietro Guida, Roberto Pontremoli and Salvatore De Cosmo

    Citation: Diabetology & Metabolic Syndrome 2018 10:60

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  6. Content type: Research

    Mesenchymal stem cells (MSCs) perform paracrine functions by releasing extracellular vesicles (EVs) containing microRNA, mRNA, and proteins. We investigated the mRNA content of EVs in metabolic syndrome (MetS)...

    Authors: Yu Meng, Alfonso Eirin, Xiang-Yang Zhu, Daniel R. O’Brien, Amir Lerman, Andre J. van Wijnen and Lilach O. Lerman

    Citation: Diabetology & Metabolic Syndrome 2018 10:58

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  7. Content type: Research

    Metabolic syndrome (MetS) is a cluster of conditions that conjoined represents a 1.5–2.5 fold increased risk of developing cardiovascular disease (CVD). Recent studies have reported that gut dysbiosis and leak...

    Authors: Ayodeji Awoyemi, Marius Trøseid, Harald Arnesen, Svein Solheim and Ingebjørg Seljeflot

    Citation: Diabetology & Metabolic Syndrome 2018 10:59

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  8. Content type: Research

    Acute hyperglycemia is associated with worse outcomes in diabetic patients admitted with ST-elevation myocardial infarction (STEMI). However, the impact of full-scale decompensated diabetes on STEMI outcomes h...

    Authors: Mayada Issa, Fahad Alqahtani, Chalak Berzingi, Mohammad Al-Hajji, Tatiana Busu and Mohamad Alkhouli

    Citation: Diabetology & Metabolic Syndrome 2018 10:57

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  9. Content type: Research

    The reported outcomes of the metabolic syndrome (MetS), containing atherosclerotic cardiovascular disease and diabetes, vary according to the definitions used. This study was designed to compare the performanc...

    Authors: Sung-Sheng Tsai, Yun-Yi Chu, Szu-Tah Chen and Pao-Hsien Chu

    Citation: Diabetology & Metabolic Syndrome 2018 10:56

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  10. Content type: Research

    Elevated serum uric acid (SUA) levels are associated with glucose control. However, whether baseline and changes in SUA predict long-term follow-up glucose control [e.g., glycated hemoglobin (HbA1c)] remains u...

    Authors: Ryuichi Kawamoto, Daisuke Ninomiya, Asuka Kikuchi, Taichi Akase and Teru Kumagi

    Citation: Diabetology & Metabolic Syndrome 2018 10:55

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  11. Content type: Research

    Adiponectin is an insulin-sensitizer adipocytokine endowed with neuroprotective actions. Whether adiponectin regulates neuronal functioning toward delaying cognitive decline independently of the glucose metabo...

    Authors: Adriana Cezaretto, Claudia Kimie Suemoto, Isabela Bensenor, Paulo A. Lotufo, Bianca de Almeida-Pititto and Sandra R. G. Ferreira

    Citation: Diabetology & Metabolic Syndrome 2018 10:54

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  12. Content type: Research

    To evaluate the relationship between smoking and metabolic parameters in patients affected by type 1 diabetes (T1D).

    Authors: Valeria Calcaterra, Jonathan P. Winickoff, Catherine Klersy, Luca Maria Schiano, Rossella Bazzano, Chiara Montalbano, Valeria Musella, Corrado Regalbuto, Daniela Larizza and Hellas Cena

    Citation: Diabetology & Metabolic Syndrome 2018 10:53

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  13. Content type: Research

    This study aims to determine the association of dietary patterns with metabolic syndrome (MetS) and its components in children and adolescents.

    Authors: Roya Kelishadi, Ramin Heshmat, Marjan Mansourian, Mohammad Esmaeil Motlagh, Hasan Ziaodini, Majzoubeh Taheri, Zeinab Ahadi, Tahereh Aminaee, Azam Goodarzi, Morteza Mansourian, Mostafa Qorbani and Nafiseh Mozafarian

    Citation: Diabetology & Metabolic Syndrome 2018 10:52

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  14. Content type: Research

    This study was conducted to evaluate the effects of probiotic supplementation on metabolic profiles in diabetic patients with coronary heart disease (CHD).

    Authors: Fariba Raygan, Zohreh Rezavandi, Fereshteh Bahmani, Vahidreza Ostadmohammadi, Mohammad Ali Mansournia, Maryam Tajabadi-Ebrahimi, Shokoofeh Borzabadi and Zatollah Asemi

    Citation: Diabetology & Metabolic Syndrome 2018 10:51

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  15. Content type: Research

    Previous evidence regarding the associations between serum calcium concentrations, dietary calcium intake, and type 2 diabetes (T2D) is limited. We investigated the longitudinal associations of serum calcium l...

    Authors: Kyoung-Nam Kim, Se-Young Oh and Yun-Chul Hong

    Citation: Diabetology & Metabolic Syndrome 2018 10:50

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  16. Content type: Research

    Waist circumference (WC) has been incorporated in the definition of the metabolic syndrome (MetS) but the exact WC cut-off points across populations are not clear. The Joint Interim Statement (JIS) suggested p...

    Authors: Thiane Ristow Cardinal, Alvaro Vigo, Bruce Bartholow Duncan, Sheila Maria Alvim Matos, Maria de Jesus Mendes da Fonseca, Sandhi Maria Barreto and Maria Inês Schmidt

    Citation: Diabetology & Metabolic Syndrome 2018 10:49

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  17. Content type: Research

    In mitochondrial diabetes, apoptosis of β-cells caused by mitochondrial stress plays an important role in impaired insulin secretion. Several studies have reported that coenzyme Q10 (CoQ10) has therapeutic eff...

    Authors: Keisuke Sumi, Tsuyoshi Okura, Youhei Fujioka, Masahiko Kato, Takeshi Imamura, Shin-ichi Taniguchi and Kazuhiro Yamamoto

    Citation: Diabetology & Metabolic Syndrome 2018 10:47

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  18. Content type: Research

    To describe the frequency of diabetic retinopathy (DR) and its associated variables in Brazilian Xavante Indians.

    Authors: Carlos Gustavo M. G. Lima, Laercio Joel Franco, Amaury L. Dal Fabbro, Edson Z. Martinez, João Paulo Botelho Veira-Filho, Alexandre A. C. M. Ventura, Leonardo Prevelato and Antonio Augusto V. Cruz

    Citation: Diabetology & Metabolic Syndrome 2018 10:46

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  19. Content type: Research

    The risk of metabolic syndrome can be influenced by inadequate vitamin D levels, and exposure to sunlight is the main external source of vitamin D. The present study assessed the influence of environmental, bi...

    Authors: Séphora Louyse Silva Aquino, Aline Tuane Oliveira da Cunha, Hermilla Torres Pereira, Erika Paula Silva Freitas, Ana Paula Trussardi Fayh, Josivan Gomes Lima, Severina Carla Vieira Cunha Lima, Karine Cavalcanti Maurício Sena-Evangelista and Lucia Fátima Campos Pedrosa

    Citation: Diabetology & Metabolic Syndrome 2018 10:45

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  20. Content type: Research

    Low adiponectin levels are associated with increased insulin resistance (IR) and arterial stiffness in hypertensive patients, but higher adiponectin levels are also found in heart failure patients. This discre...

    Authors: Juhyun Song, So Ra Yoon and Oh Yoen Kim

    Citation: Diabetology & Metabolic Syndrome 2018 10:44

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  21. Content type: Correction

    It has been highlighted that the original article [1], published 21 February 2018, contained some errors in Table 3. This correction article shows the correct version of Table 3 and the changes that were made.

    Authors: Nahla Khawaja, Jawad Abu-Shennar, Mohammed Saleh, Said S. Dahbour, Yousef S. Khader and Kamel M. Ajlouni

    Citation: Diabetology & Metabolic Syndrome 2018 10:43

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    The original article was published in Diabetology & Metabolic Syndrome 2018 10:8

  22. Content type: Research

    The severity of the metabolic syndrome (MetS) predicts future coronary heart disease (CHD) and diabetes independent of the individual MetS components. Our aim was to evaluate whether MetS severity conferred ad...

    Authors: Yi Guo, Solomon K. Musani, Mario Sims, Thomas A. Pearson, Mark D. DeBoer and Matthew J. Gurka

    Citation: Diabetology & Metabolic Syndrome 2018 10:42

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  23. Content type: Research

    Adipokines are involved in the pathogenesis of metabolic disorders including obesity and type 2 diabetes mellitus (T2DM). This study investigates the levels of leptin, resistin, visfatin, secreted frizzled-rel...

    Authors: Nguyen Linh Toan, Nguyen Van Hoan, Doan Viet Cuong, Nguyen Viet Dung, Phan The Dung, Ngo Thu Hang, Do Thi Huyen Dieu, Dang Thanh Chung, Ho Anh Son, Pham Xuan Phong, George Binh Lenon, Doan Van De and Hoang Van Tong

    Citation: Diabetology & Metabolic Syndrome 2018 10:41

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  24. Content type: Research

    Idiopathic type 1 diabetes mellitus (IDM) is characterized by an onset with insulinopenia and ketoacidosis with negative β-cell autoimmunity markers and lack of association with HLA. The aim of the study is to...

    Authors: Valentina Guarnotta, Enrica Vigneri, Giuseppe Pillitteri, Alessandro Ciresi, Giuseppe Pizzolanti and Carla Giordano

    Citation: Diabetology & Metabolic Syndrome 2018 10:40

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  25. Content type: Research

    Type 2 diabetes is a chronic disease that is expanding at an alarming rate in the world. Research on individuals with type 2 diabetes showed that stressful life events cause problems in the effective managemen...

    Authors: Fereshteh Zamani-Alavijeh, Marzieh Araban, Hamid Reza Koohestani and Mahmood Karimy

    Citation: Diabetology & Metabolic Syndrome 2018 10:39

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  26. Content type: Research

    The aim of this study was to compare acute effects of turnip rapeseed oil rich with mono- and polyunsaturated fatty acids and cream on postprandial triglyceride levels and post-glucose load measures of insulin...

    Authors: Harri Juhani Saarinen, Sari Husgafvel, Hanna Pohjantähti-Maaroos, Marja Wallenius and Ari Palomäki

    Citation: Diabetology & Metabolic Syndrome 2018 10:38

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  27. Content type: Research

    The TCF7L2 rs7903146 variant is strongly associated with type 2 diabetes mellitus (T2DM). However, the mechanisms involved in this association remain unknown and may include extrapancreatic effects. The aim of th...

    Authors: Mari Cassol Ferreira, Maria Elizabeth Rossi da Silva, Rosa Tsuneshiro Fukui, Maria do Carmo Arruda-Marques and Rosa Ferreira dos Santos

    Citation: Diabetology & Metabolic Syndrome 2018 10:37

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  28. Content type: Research

    Individuals who suffer from mental illness are more prone to obesity and related co-morbidities, including the metabolic syndrome. Autopsies provide an outstanding platform for the macroscopic, microscopic and...

    Authors: Martin Roest Christensen, Anne Bugge, Mariam Elmegaard Malik, Jørgen Lange Thomsen, Niels Lynnerup, Jørgen Rungby and Jytte Banner

    Citation: Diabetology & Metabolic Syndrome 2018 10:36

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  29. Content type: Research

    Metabolic syndrome (MetS) is one of the main reasons for elevated cardiovascular morbidity and mortality worldwide. Obese and overweight individuals are at high risk of developing these chronic diseases. The a...

    Authors: Basma Damiri, Mohammed S. Abualsoud, Amjad M. Samara and Sakhaa K. Salameh

    Citation: Diabetology & Metabolic Syndrome 2018 10:34

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  30. Content type: Research

    A significant association is known between increased glycaemic variability and mortality in critical patients. To ascertain whether glycaemic profiles during the first week after liver transplantation might be...

    Authors: Elena Giráldez, Evaristo Varo, Ipek Guler, Carmen Cadarso-Suarez, Santiago Tomé, Patricia Barral, Antonio Garrote and Francisco Gude

    Citation: Diabetology & Metabolic Syndrome 2018 10:35

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  31. Content type: Research

    The adverse effects of cigarette smoking have been widely studied before, whilst the effects of hookah smoking has received less attention, although it is a common habit in the Middle East. Here we have invest...

    Authors: Sara Saffar Soflaei, Susan Darroudi, Maryam Tayefi, Abolfazl Nosrati Tirkani, Mohsen Moohebati, Mahmoud Ebrahimi, Habibollah Esmaily, Seyed Mohammad Reza Parizadeh, Ali Reza Heidari-Bakavoli, Gordon A. Ferns and Majid Ghayour-Mobarhan

    Citation: Diabetology & Metabolic Syndrome 2018 10:33

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  32. Content type: Review

    Chikungunya (CHIK) is a viral disease transmitted by mosquitoes. The first cases in Brazil were confirmed in 2014. Between 2016 and 2017, over 300,000 cases were identified during this period, with nearly 300 ...

    Authors: Francisca Kalline de Almeida Barreto, Renan Magalhães Montenegro Jr., Virginia Oliveira Fernandes, Rhaquel Oliveira, Lívia Aline de Araújo Batista, Akhtar Hussain and Luciano Pamplona de Góes Cavalcanti

    Citation: Diabetology & Metabolic Syndrome 2018 10:32

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  33. Content type: Research

    Purinergic receptors are expressed in different tissues including the retina. These receptors are involved in processes like cell growth, proliferation, activation and survival. ATP is the major activator of P...

    Authors: Jorge E. Mancini, Gustavo Ortiz, Constanza Potilinstki, Juan P. Salica, Emiliano S. Lopez, J. Oscar Croxatto and Juan E. Gallo

    Citation: Diabetology & Metabolic Syndrome 2018 10:31

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  34. Content type: Research

    Type 2 diabetes is a chronic disease associated with poorer health outcomes and decreased health related quality of life (HRQoL). The aim of this analysis was to explore the impact of a disease management prog...

    Authors: Sigrid Panisch, Tim Johansson, Maria Flamm, Henrike Winkler, Raimund Weitgasser and Andreas C. Sönnichsen

    Citation: Diabetology & Metabolic Syndrome 2018 10:28

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  35. Content type: Research

    Although the number of antihyperglycemic agents has expanded significantly, sulfonylureas (in particular gliclazide) remain an important option because of a variety of patient and health system factors. The la...

    Authors: Lawrence A. Leiter, Marina V. Shestakova and Ilhan Satman

    Citation: Diabetology & Metabolic Syndrome 2018 10:30

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  36. Content type: Research

    Most of prior studies to demonstrate the association between mean platelet volume (MPV) and type 2 diabetes mellitus (T2DM) risk were cross-sectional design with inconsistent results. In the present prospectiv...

    Authors: Zhaoyang Li, Jing Wang, Xu Han, Jing Yuan, Huan Guo, Xiaomin Zhang, Dan Zheng, Yuhan Tang, Handong Yang and Meian He

    Citation: Diabetology & Metabolic Syndrome 2018 10:29

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  37. Content type: Review

    Glycemic control has been considered a major therapeutic goal within the scope of diabetes management, as supported by robust observational and experimental evidence. However, the coexistence of micro and macr...

    Authors: Rodrigo Oliveira Moreira, Roberta Cobas and Raquel C. Lopes Assis Coelho

    Citation: Diabetology & Metabolic Syndrome 2018 10:26

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  38. Content type: Research

    Diabetics are at increased risk for impaired mobility and strength, frequently related to the disease control. Sarcopenia is the reduction of muscle mass associated with the decrease in muscle strength and/or ...

    Authors: Heloísa Trierweiler, Gabrielle Kisielewicz, Thaísa Hoffmann Jonasson, Ricardo Rasmussen Petterle, Carolina Aguiar Moreira and Victória Zeghbi Cochenski Borba

    Citation: Diabetology & Metabolic Syndrome 2018 10:25

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  39. Content type: Research

    With the increasing prevalence of metabolic syndrome (MS), there is a need to track and predict the development of MS. In this study, we established a Markov model to explore the natural history and predict th...

    Authors: Xiaoxian Jia, Qicai Chen, Peipei Wu, Meng Liu, Xiaoxiao Chen, Juan Xiao, Lili Chen, Pengpeng Zhang and Shumei Wang

    Citation: Diabetology & Metabolic Syndrome 2018 10:24

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  40. Content type: Research

    The aim of this study was to explore the predictors of QOL and health state and examine the relationship with glycemic control among type 2 diabetes mellitus (T2DM) patients.

    Authors: Syed Wasif Gillani, Irfan Altaf Ansari, Hisham A. Zaghloul, Mohi Iqbal Mohammad Abdul, Syed Azhar Syed Sulaiman and Mirza R. Baig

    Citation: Diabetology & Metabolic Syndrome 2018 10:23

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  41. Content type: Research

    Diabetes nephropathy is a microvascular complication associated with high morbidity and mortality in patients with type 1 diabetes, and its pathogenesis is not fully understood. Our aim was to evaluate the ass...

    Authors: Marcela Haas Pizarro, Deborah Conte Santos, Bianca Senger Vasconcelos Barros, Laura Gomes Nunes de Melo and Marilia Brito Gomes

    Citation: Diabetology & Metabolic Syndrome 2018 10:22

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  42. Content type: Research

    Obesity is known to be related to the development of type 2 diabetes mellitus (T2D). The most commonly used anthropometric indicator (body mass index [BMI]) presents several limitations such as the lack of pos...

    Authors: Fernando Gomez-Peralta, Cristina Abreu, Margarita Cruz-Bravo, Elvira Alcarria, Gala Gutierrez-Buey, Nir Y. Krakauer and Jesse C. Krakauer

    Citation: Diabetology & Metabolic Syndrome 2018 10:21

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  43. Content type: Research

    Obesity is associated with significant physical, psychosocial and economic burden globally. In Brazil, almost 50% of the population is either overweight or obese. The prevalence of morbid obesity increased by ...

    Authors: Ian Kudel, Jefferson S. Alves, Thiago de Menezes Goncalves, Kristjan Kull and Emil Nørtoft

    Citation: Diabetology & Metabolic Syndrome 2018 10:20

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  44. Content type: Letter to the Editor

    Patients with ischemic cardiomyopathy and severe left ventricular dysfunction have a worse survival prognosis than patients with preserved ventricular function. The role of diabetes in the long-term prognosis ...

    Authors: Thiago Hueb, Mauricio S. Rocha, Sergio F. Siqueira, Silvana Angelina D´Orio Nishioka, Giselle L. Peixoto, Marcos M. Saccab, Eduardo Gomes Lima, Rosa Maria Rahmi Garcia, José Antonio F. Ramires, Roberto Kalil Filho and Martino Martinelli Filho

    Citation: Diabetology & Metabolic Syndrome 2018 10:19

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  45. Content type: Research

    Vitamins are essential micronutrients with antioxidant potential that may provide a complementary treatment for patients with chronic diseases. Our aim was to assess the effect of vitamin supplementation on th...

    Authors: Maria E. Balbi, Fernanda S. Tonin, Antonio M. Mendes, Helena H. Borba, Astrid Wiens, Fernando Fernandez-Llimos and Roberto Pontarolo

    Citation: Diabetology & Metabolic Syndrome 2018 10:18

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  46. Content type: Research

    Diabetic retinopathy has a significant impact in every healthcare system. Despite that fact, there are few accurate estimates in the prevalence of DR in Brazil’s different geographic regions, particularly prol...

    Authors: Karla Rezende Guerra Drummond, Fernando Korn Malerbi, Paulo Henrique Morales, Tessa Cerqueira Lemos Mattos, André Araújo Pinheiro, Felipe Mallmann, Ricardo Vessoni Perez, Franz Schubert Lopes Leal, Laura Gomes Nunes de Melo and Marília Brito Gomes

    Citation: Diabetology & Metabolic Syndrome 2018 10:17

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  47. Content type: Short report

    This observational study aimed to assess the effectiveness of lixisenatide as add on therapy to basal insulin in diabetic type 2 patients previously treated with different insulin regimes.

    Authors: Tomislav Božek, Ines Bilić-Ćurčić, Maja Cigrovski Berković, Marina Gradišer, Tina Tićinović Kurir, Sanja Klobučar Majanović and Srećko Marušić

    Citation: Diabetology & Metabolic Syndrome 2018 10:16

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