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  1. Research

    Association of body mass index and visceral fat with aortic valve calcification and mortality after transcatheter aortic valve replacement: the obesity paradox in severe aortic stenosis

    Previous studies showed that metabolic syndrome is associated with aortic valve calcification (AVC) and poor outcomes in aortic stenosis (AS). However, if these associations change and how body fat impacts the...

    Jennifer Mancio, Paulo Fonseca, Bruno Figueiredo, Wilson Ferreira, Monica Carvalho, Nuno Ferreira, Pedro Braga, Alberto Rodrigues, Antonio Barros, Ines Falcao-Pires, Adelino Leite-Moreira, Vasco Gama Ribeiro and Nuno Bettencourt

    Diabetology & Metabolic Syndrome 2017 9:86

    Published on: 19 October 2017

  2. Review

    The impact of type 2 diabetes on bone metabolism

    Diabetes complications and osteoporotic fractures are two of the most important causes of morbidity and mortality in older patients and share many features including genetic susceptibility, molecular mechanism...

    Claudia Pinheiro Sanches, Andre Gustavo Daher Vianna and Fellype de Carvalho Barreto

    Diabetology & Metabolic Syndrome 2017 9:85

    Published on: 19 October 2017

  3. Research

    Hypermethylation in the promoter of the MTHFR gene is associated with diabetic complications and biochemical indicators

    DNA methylation is an epigenetic mechanism for regulating the transcription of many genes and has been linked to the development of various diseases. A promising gene to investigate is methylenetetrahydrofolat...

    Mayara Karla dos Santos Nunes, Alexandre Sérgio Silva, Isabella Wanderley de Queiroga Evangelista, João Modesto Filho, Cecília Neta Alves Pegado Gomes, Rayner Anderson Ferreira do Nascimento, Rafaella Cristhine Pordeus Luna, Maria José de Carvalho Costa, Naila Francis Paulo de Oliveira and Darlene Camati Persuhn

    Diabetology & Metabolic Syndrome 2017 9:84

    Published on: 18 October 2017

  4. Research

    Shift work is associated with metabolic syndrome in male steel workers-the role of resistin and WBC count-related metabolic derangements

    There is increasing evidence linking a shift work schedule with various adverse health effects. The present study aimed to examine the relationship between shift work and the metabolic syndrome (MetS) in male ...

    Yung-Chuan Lu, Chao-Ping Wang, Teng-Hung Yu, I-Ting Tsai, Wei-Chin Hung, I-Cheng Lu, Chia-Chang Hsu, Wei-Hua Tang, Jer-Yiing Houng, Fu-Mei Chung and Mei-Chu Yen Jean

    Diabetology & Metabolic Syndrome 2017 9:83

    Published on: 16 October 2017

  5. Research

    Aliskiren effect on non-alcoholic steatohepatitis in metabolic syndrome

    Non-alcoholic steatohepatitis (NASH) is highly associated with metabolic syndrome, a major cause of morbidity in the globalized society. The renin–angiotensin system (RAS) influences hepatic fatty acid metabol...

    F. N. Ramalho, S. C. Sanches, M. C. Foss, M. J. Augusto, D. M. Silva, A. M. Oliveira and L. N. Ramalho

    Diabetology & Metabolic Syndrome 2017 9:82

    Published on: 13 October 2017

  6. Research

    Long-term feeding of high-fat plus high-fructose diet induces isolated impaired glucose tolerance and skeletal muscle insulin resistance in miniature pigs

    During the prediabetic development, the changes in β-cell function and tissue-specific insulin resistance have been described. However, there are conflicting views in insulin secretory capacity between early c...

    Meng-Chieh Hsu, Mu-En Wang, Yi-Fan Jiang, Hung-Chang Liu, Yi-Chen Chen and Chih-Hsien Chiu

    Diabetology & Metabolic Syndrome 2017 9:81

    Published on: 13 October 2017

  7. Research

    High prevalence of Berardinelli-Seip Congenital Lipodystrophy in Rio Grande do Norte State, Northeast Brazil

    Berardinelli-Seip Congenital Lipodystrophy (BSCL) is a rare disease characterized by the almost complete absence of adipose tissue. Although a large number of BSCL cases was previously identified in Rio Grande...

    Lázaro Batista de Azevedo Medeiros, Verônica Kristina Cândido Dantas, Aquiles Sales Craveiro Sarmento, Lucymara Fassarella Agnez-Lima, Adriana Lúcia Meireles, Thaiza Teixeira Xavier Nobre, Josivan Gomes de Lima and Julliane Tamara Araújo de Melo Campos

    Diabetology & Metabolic Syndrome 2017 9:80

    Published on: 13 October 2017

  8. Research

    Elevated circulating fasting glucagon-like peptide-1 in surgical patients with aortic valve disease and diabetes

    Diabetes is a risk factor for peripheral, coronary, and cerebrovascular disease. In contrast, results also indicate that patients with diabetes have reduced prevalence of aortic aneurysms, although the mechani...

    Camilla Krizhanovskii, Stelia Ntika, Christian Olsson, Per Eriksson and Anders Franco-Cereceda

    Diabetology & Metabolic Syndrome 2017 9:79

    Published on: 10 October 2017

  9. Research

    Canagliflozin reduces epicardial fat in patients with type 2 diabetes mellitus

    It is unknown whether canagliflozin, a selective sodium glucose co-transporter 2 inhibitor, reduces epicardial adipose tissue (EAT) thickness, which is associated with insulin resistance and is a risk factor f...

    Shusuke Yagi, Yukina Hirata, Takayuki Ise, Kenya Kusunose, Hirotsugu Yamada, Daiju Fukuda, Hotimah Masdan Salim, Gulinu Maimaituxun, Susumu Nishio, Yuriko Takagawa, Saori Hama, Tomomi Matsuura, Koji Yamaguchi, Takeshi Tobiume, Takeshi Soeki, Tetsuzo Wakatsuki…

    Diabetology & Metabolic Syndrome 2017 9:78

    Published on: 4 October 2017

  10. Research

    Association of meal frequency with metabolic syndrome in Korean adults: from the Korea National Health and Nutrition Examination Survey (KNHANES)

    Although previous studies have established a close relationship between caloric intake and metabolic syndrome, there is limited research exploring the impact of meal frequency adjusted by caloric intake on met...

    Chan-Hee Jung, Ji Sung Lee, Hee Jung Ahn, Jin-Sun Choi, Min Young Noh, Ji Jeung Lee, Eun Young Lee, Jeong Hyun Lim, Young Ran Lee, So Yoon Yoon, Chong Hwa Kim, Dong-Hyeok Cho, Young Sik Choi and Kyung Mook Choi

    Diabetology & Metabolic Syndrome 2017 9:77

    Published on: 3 October 2017

  11. Research

    Neutrophil killing of Staphylococcus aureus in diabetes, obesity and metabolic syndrome: a prospective cellular surveillance study

    Obesity, metabolic syndrome (MetS), and diabetes are frequent in surgical populations and can enhance susceptibility to postoperative surgical site infections. Reduced neutrophil function has been linked with ...

    Ingrid Lea Scully, Lisa Kristin McNeil, Sudam Pathirana, Christine Lee Singer, Yongdong Liu, Stanley Mullen, Douglas Girgenti, Alejandra Gurtman, Michael W. Pride, Kathrin Ute Jansen, Paul L. Huang and Annaliesa S. Anderson

    Diabetology & Metabolic Syndrome 2017 9:76

    Published on: 3 October 2017

  12. Review

    Review article: effects of type 2 diabetes therapies on bone metabolism

    Diabetes complications and osteoporotic fractures are two of the most important causes of morbidity and mortality in older patients, and they share many features, including genetic susceptibility, molecular me...

    A. G. D. Vianna, C. P. Sanches and F. C. Barreto

    Diabetology & Metabolic Syndrome 2017 9:75

    Published on: 25 September 2017

  13. Research

    Endurance exercise training decreased serum levels of surfactant protein D and improved aerobic fitness of obese women with type-2 diabetes

    Surfactant protein D (SP-D) is a member of the collectin family and is an important component of the pulmonary innate host defense. To find the relationship between exercise training and SP-D in diabetes, we e...

    Sajjad Rezaei, Mahdieh Molanouri Shamsi, Mehdi Mahdavi, Azadeh Jamali, Jonato Prestes, Ramires Alsamir Tibana, James Wilfred Navalta and Fabrício Azevedo Voltarelli

    Diabetology & Metabolic Syndrome 2017 9:74

    Published on: 25 September 2017

  14. Research

    The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors

    Recently, we reported that toll-like receptor (TLR)2 and TLR4 localized on the glomerular endothelium in the glomeruli of streptozotocin (STZ)-induced type 1 diabetic mice and high fat diet feed-induced type 2...

    Koichiro Kajiwara, Shunsuke Takata, Thao T. To, Kenyo Takara, Yuji Hatakeyama, Sachio Tamaoki, Richard Peters Darveau, Hiroyuki Ishikawa and Yoshihiko Sawa

    Diabetology & Metabolic Syndrome 2017 9:73

    Published on: 22 September 2017

  15. Research

    Prevalence and severity of syndrome Z in women with metabolic syndrome on waiting list for bariatric surgery: a cross-sectional study

    In recent years, obesity has become one of the most important public health problems in the world, with a growing prevalence in both developed and developing countries. Recent studies show that sleep disturban...

    Eduardo Araujo Perez, Luis Vicente Franco Oliveira, Wilson Rodrigues Freitas Jr., Carlos Alberto Malheiros, Elias Jirjoss Ilias, Anderson Soares Silva, Jessica Julioti Urbano, Patricia Clemente Oliveira, Felipe X. Cepeda, Luciana M. M. Sampaio, Ivani C. Trombetta, Humberto Delle, Daniel Gianella Neto, Sergio Roberto Nacif and Roberto Stirbulov

    Diabetology & Metabolic Syndrome 2017 9:72

    Published on: 20 September 2017

  16. Research

    Moderate- to high-intensity statins for secondary prevention in patients with type 2 diabetes mellitus on dialysis after acute myocardial infarction

    Evidences support the benefits of moderate- to high-intensity statins for patients with acute myocardial infarction (AMI) except for those with type 2 diabetes mellitus (T2DM) on dialysis after AMI. This study...

    Yan-Rong Li, Sung-Sheng Tsai, Yu-Sheng Lin, Chang-Min Chung, Szu-Tah Chen, Jui-Hung Sun, Miaw-Jene Liou and Tien-Hsing Chen

    Diabetology & Metabolic Syndrome 2017 9:71

    Published on: 19 September 2017

  17. Erratum

    Erratum to: Cardiovascular risk assessment in patients with diabetes

    Upon publication of the original article [1], it was noticed that the Ref. [32] was incorrectly given as [32]: Allan GM, Nouri F, Korownyk C, Kolber MR, Vandermeer B, McCormack J. Agreement among cardiovascular d...

    Marcello Casaccia Bertoluci and Viviane Zorzanelli Rocha

    Diabetology & Metabolic Syndrome 2017 9:70

    Published on: 19 September 2017

    The original article was published in Diabetology & Metabolic Syndrome 2017 9:25

  18. Research

    The relationship between insulin sensitivity and heart rate-corrected QT interval in patients with type 2 diabetes

    Reduced insulin sensitivity not only contributes to the pathogenesis of type 2 diabetes but is also linked to multiple metabolic risk factors and cardiovascular diseases (CVD). A prolonged heart rate-corrected...

    Xiao-hua Yang, Jian-bin Su, Xiu-lin Zhang, Li-hua Zhao, Feng Xu, Xue-qin Wang and Xing-bo Cheng

    Diabetology & Metabolic Syndrome 2017 9:69

    Published on: 11 September 2017

  19. Research

    Addition of nonalbumin proteinuria to albuminuria improves prediction of type 2 diabetic nephropathy progression

    Albuminuria is generally accepted as a sensitive marker of diabetic nephropathy but has limitations in predicting its progression. The aim of this study was to evaluate the use of nonalbumin proteinuria in add...

    Jong Ho Kim, Seo Young Oh, Eun Heui Kim, Min Jin Lee, Yun Kyung Jeon, Bo Hyun Kim, Jin Mi Kim, Yong Ki Kim, Sang Soo Kim and In Joo Kim

    Diabetology & Metabolic Syndrome 2017 9:68

    Published on: 6 September 2017

  20. Research

    Elevated serum interleukin-6 is predictive of coronary artery disease in intermediate risk overweight patients referred for coronary angiography

    Interleukin-6 (IL-6) plays a central role in atherosclerosis and inflammation. It may improve risk prediction in patients at intermediate cardiovascular risk.

    Marco V. Wainstein, Márcio Mossmann, Gustavo N. Araujo, Sandro C. Gonçalves, Gabriela L. Gravina, Marlei Sangalli, Francine Veadrigo, Roselene Matte, Rejane Reich, Fernanda G. Costa, Michael Andrades, Antônio Marcos V. da Silva and Marcello C. Bertoluci

    Diabetology & Metabolic Syndrome 2017 9:67

    Published on: 6 September 2017

  21. Research

    Analysis of factors influencing glucose tolerance in Japanese patients with non-alcoholic fatty liver disease

    While the association of the prevalence of non-alcoholic fatty liver disease (NAFLD) with impaired glucose metabolism has been reported, the factors influencing glucose tolerance in NAFLD remain to be clarified.

    Satoko Ohmi, Masafumi Ono, Hiroshi Takata, Seiki Hirano, Shogo Funakoshi, Yuichi Nishi, Kumiko Yoshimura, Eri Amano, Yoshio Terada, Toshiji Saibara and Shimpei Fujimoto

    Diabetology & Metabolic Syndrome 2017 9:65

    Published on: 5 September 2017

  22. Research

    Association of the leptin-to-adiponectin ratio with metabolic syndrome in a sub-Saharan African population

    Worldwide there is an increased prevalence of metabolic syndrome mainly due to life-style modifications, and Africans are not saved of this situation. Many markers have been studied to predict the risk of this...

    Clarisse Noël A. Ayina, Francky Teddy A. Endomba, Samuel Honoré Mandengue, Jean Jacques N. Noubiap, Laurent Serge Etoundi Ngoa, Philippe Boudou, Jean-François Gautier, Jean Claude Mbanya and Eugene Sobngwi

    Diabetology & Metabolic Syndrome 2017 9:66

    Published on: 5 September 2017

  23. Research

    Association between aerobic capacity and the improvement in glycemic control after the exercise training in type 2 diabetes

    We investigated the influence of aerobic capacity on the improvement in glycemic control achieved by long-term aerobic exercise in type 2 diabetes.

    Hideki Nojima, Masayasu Yoneda, Hiroshi Watanabe, Kiminori Yamane, Yoshihiro Kitahara, Kiyokazu Sekikawa, Hideya Yamamoto, Akihito Yokoyama, Noboru Hattori and Nobuoki Kohno

    Diabetology & Metabolic Syndrome 2017 9:63

    Published on: 18 August 2017

  24. Research

    Worse inflammatory profile in omnivores than in vegetarians associates with the gut microbiota composition

    To describe the abundance of major phyla and some genera in the gut microbiota of individuals according to dietary habits and examine their associations with inflammatory markers, insulin resistance, and cardi...

    Ana Carolina Franco-de-Moraes, Bianca de Almeida-Pititto, Gabriel da Rocha Fernandes, Everton Padilha Gomes, Alexandre da Costa Pereira and Sandra Roberta G. Ferreira

    Diabetology & Metabolic Syndrome 2017 9:62

    Published on: 15 August 2017

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