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  1. Long non-coding RNAs (lncRNAs) have been reported to play vital roles in diabetic nephropathy (DN). The aim of this study was to explore the function of mechanism of lncRNA KCNQ1 opposite strand/antisense tran...

    Authors: Li Zhao, Huaqian Chen, Lin Wu, Zhengdong Li, Ren Zhang, Yan Zeng, Tao Yang and Hualing Ruan
    Citation: Diabetology & Metabolic Syndrome 2021 13:108
    Content type: Research Published on:

  2. Diabetic nephropathy (DN) is the most common causes of end-stage renal disease. Long non-coding RNA cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) is connected with the development of DN, bu...

    Authors: Min Xiao, Shoujun Bai, Jing Chen, Yaxi Li, Shu Zhang and Zhao Hu
    Citation: Diabetology & Metabolic Syndrome 2021 13:107
    Content type: Research Published on:

  3. Evidence suggests gut microbiome is associated with diabetes. However, it’s unclear whether the association remains in non-diabetic participants. A Chinese monozygotic twin study, in which the participants are...

    Authors: Ke Yu, Cai-Guo Yu, Xing-Qi Yin, Zong-Wei Wang, Xiao-Bo Wang, Li-Li Wang, Shuang Guo, Ya-Xin An and Dong Zhao
    Citation: Diabetology & Metabolic Syndrome 2021 13:106
    Content type: Research Published on:

  4. Hyperglycemia is associated with albuminuria and renal glomerular endothelial dysfunction in patients with diabetic nephropathy. The mTOR and RhoA/ROCK signaling pathways are involved in glomerular filtration ...

    Authors: Xiaolin Chen, Jianhui Chen, Xianfan Li and Zengpu Yu
    Citation: Diabetology & Metabolic Syndrome 2021 13:105
    Content type: Research Published on:

  5. Studies highlight the inaccuracy of glycated hemoglobin (HbA1c) for the assessment of glycemic control in dialysis diabetics and suggest the use of continuous glucose monitoring (CGM) as an alternative. Of the...

    Authors: Marcelo Rocha Nasser Hissa, Priscilla Nogueira Gomes Hissa, Sérgio Botelho Guimarães and Miguel Nasser Hissa
    Citation: Diabetology & Metabolic Syndrome 2021 13:104
    Content type: Research Published on:

  6. Abnormal glucose metabolism including diabetes (DM) and prediabetes (pre-DM) have been reported as predictors of poorer outcomes after acute myocardial infarction (AMI). However, the prognostic value of pre-DM...

    Authors: Side Gao, Wenjian Ma, Sizhuang Huang, Xuze Lin and Mengyue Yu
    Citation: Diabetology & Metabolic Syndrome 2021 13:103
    Content type: Research Published on:

  7. Deterioration of sleep quality has been reported to contribute to the incidence of diabetes and may be responsible for glycemic status in diabetes. The present study explored the relationship between sleep qua...

    Authors: Yang Yang, Li-hua Zhao, Dan-dan Li, Feng Xu, Xiao-hua Wang, Chun-feng Lu, Chun-hua Wang, Chao Yu, Xiu-lin Zhang, Li-yan Ning, Xue-qin Wang, Jian-bin Su and Li-hua Wang
    Citation: Diabetology & Metabolic Syndrome 2021 13:102
    Content type: Research Published on:

  9. Previous studies that explored the relationship of serum albumin with diabetic peripheral neuropathy (DPN) have indicated inconsistent results. Thus, the present study aimed to evaluated the association betwee...

    Authors: Pijun Yan, Qian Tang, Yuru Wu, Qin Wan, Zhihong Zhang, Yong Xu, Jianhua Zhu and Ying Miao
    Citation: Diabetology & Metabolic Syndrome 2021 13:100
    Content type: Research Published on:

  10. There is currently a large arsenal of antidiabetic drugs available to treat type 2 diabetes (T2D). However, this is a serious chronic disease that affects millions of adults worldwide and is responsible for se...

    Authors: Freddy G. Eliaschewitz and Luis Henrique Canani
    Citation: Diabetology & Metabolic Syndrome 2021 13:99
    Content type: Review Published on:

  11. Obesity-associated coronary heart disease (CHD) risk is higher in women than in men with type 2 diabetes (T2DM). Resistin, an adipokine secreted by adispose tissue, may contribute to this higher risk.

    Authors: A. Giandalia, A. Alibrandi, L. Giorgianni, F. Lo Piano, F. Consolo, G. Longo Elia, B. Asztalos, D. Cucinotta, G. Squadrito and G. T. Russo
    Citation: Diabetology & Metabolic Syndrome 2021 13:98
    Content type: Research Published on:

  12. Type 2 diabetes mellitus (T2DM) affects the social economy and quality of life, and has become a major threat to human health. This observation aimed to study the possibility of serum HOTAIR as a diagnostic in...

    Authors: Huiyun Wang, Yu Xia and Yanxia Zhang
    Citation: Diabetology & Metabolic Syndrome 2021 13:97
    Content type: Research Published on:

  13. A retrospective observational study was conducted to assess the prevalence of maturity onset diabetes of the young (MODY) in a large paediatric population of Southern Italy newly diagnosed with diabetes. Clini...

    Authors: Stefano Passanisi, Giuseppina Salzano, Bruno Bombaci and Fortunato Lombardo
    Citation: Diabetology & Metabolic Syndrome 2021 13:96
    Content type: Research Published on:

  14. In 2019, a new virus known as severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has emerged. Coronavirus disease 2019 (COVID-19) was classified as a pandemic in a short period of time. In order...

    Authors: Claudia Eberle and Stefanie Stichling
    Citation: Diabetology & Metabolic Syndrome 2021 13:95
    Content type: Review Published on:

  15. Glucose monitoring is vital for glycemic control in patients with diabetes mellitus (DM). Continuous glucose monitoring (CGM) measures whole-day glucose levels. Hemoglobin A1c (HbA1c) is a vital outcome predic...

    Authors: Jen-Hung Huang, Yung-Kuo Lin, Ting-Wei Lee, Han-Wen Liu, Yu-Mei Chien, Yu-Chun Hsueh, Ting-I Lee and Yi-Jen Chen
    Citation: Diabetology & Metabolic Syndrome 2021 13:94
    Content type: Research Published on:

  16. Sarcopenia was a frequent chronic complication in patients with type 2 diabetes mellitus (T2DM), and previous evidence showed conflicting results regarding the prevalence and risk factors of sarcopenia in T2DM...

    Authors: Yaqin Ai, Ruoxin Xu and Lingping Liu
    Citation: Diabetology & Metabolic Syndrome 2021 13:93
    Content type: Research Published on:

  17. Diabetic foot ulcer (DFU) is a serious chronic complication of diabetes. This study aimed to establish weighted risk models for determining DFU occurrence and severity in diabetic patients.

    Authors: Lu Shi, Huiyi Wei, Tianxiao Zhang, Zhiying Li, Xiaoxian Chi, Dandan Liu, Dandan Chang, Yueying Zhang, Xiaodan Wang and Qingbin Zhao
    Citation: Diabetology & Metabolic Syndrome 2021 13:92
    Content type: Research Published on:

  18. A young female patient, diagnosed with diabetes mellitus at the age of 28 years old in 2009, carries KCNJ11 R136C by whole exome sequencing and her daughter doesn’t carry this mutation. Bioinformatics software pr...

    Authors: Yaning Chen, Xiaodong Hu, Jia Cui, Mingwei Zhao and Hebin Yao
    Citation: Diabetology & Metabolic Syndrome 2021 13:91
    Content type: Short report Published on:

  20. Diabetic nephropathy (DN) is a common complication of diabetes. Long non-coding RNA (lncRNA) cancer susceptibility candidate 2 (CASC2) is reported to exert a protective role in DN by a previous study. The work...

    Authors: Dongju Zhu, Xiang Wu and Qian Xue
    Citation: Diabetology & Metabolic Syndrome 2021 13:89
    Content type: Research Published on:

  21. Dipeptidyl peptidase-4 inhibitors (DPP-4i) provide a unique antihyperglycemic effect by regulating incretin peptides in type 2 diabetes mellitus (T2DM) patients who are inadequately controlled with insulin the...

    Authors: Xin Wei, Yu Bai, Zhuo Wang, Xiaohong Zheng, Zening Jin and Xin Liu
    Citation: Diabetology & Metabolic Syndrome 2021 13:88
    Content type: Research Published on:

  22. The world guidance on the measures of social distancing for prevention of COVID-19 has changed the daily habits of great part of the population, and this could influence the care and resilience with diabetes d...

    Authors: Bárbara Aparecida Binhardi, Carla Regina de Souza Teixeira, Bianca de Almeida-Pititto, Francisco Barbosa-Junior, Laercio Joel Franco, Karla Fabiana Santana de Melo, Domingos Augusto Cherino Malerbi and Rinaldo Eduardo Machado de Oliveira
    Citation: Diabetology & Metabolic Syndrome 2021 13:87
    Content type: Research Published on:

  23. Diabetes mellitus is a serious metabolic disorder which becomes common in middle and low incomes countries since few decades. Microvascular complications include retinopathy, neuropathy and nephropathy all of ...

    Authors: Mohammed Abdu Seid, Yonas Akalu, Yibeltal Yismaw Gela, Yitayeh Belsti, Mengistie Diress, Sofonias Addis Fekadu, Baye Dagnew and Mihret Getnet
    Citation: Diabetology & Metabolic Syndrome 2021 13:86
    Content type: Research Published on:

  24. 1,5-anhydroglucitol is a reduction product of 1,5-anhydrofructose. Circulating 1,5-anhydroglucitol is usually excreted by the kidneys and is reabsorbed via sodium-glucose co-transporter 4 in the renal tubules....

    Authors: Kenji Tanaka, Akiko Sakasai-Sakai, Yasuki Motomiya, Tatsuo Yoneda and Masayoshi Takeuchi
    Citation: Diabetology & Metabolic Syndrome 2021 13:85
    Content type: Research Published on:

  25. Diabetes mellitus (DM) causes excess risk of fracture at varied sites. Whereas, the difference between the roles of types 1 DM (T1DM) and 2 DM (T2DM) diabetes in the risk of fractures remains limited and incon...

    Authors: Jiaqing Dou, Jing Wang and Qiu Zhang
    Citation: Diabetology & Metabolic Syndrome 2021 13:84
    Content type: Research Published on:

  26. Although the well-established role of the HLA genes on the predisposition of type 1 diabetes (T1D), its contribution to the development and progression of diabetic retinopathy is still unclear, especially in a...

    Authors: Deborah Conte Santos, Luís Cristóvão Porto, Marcela Haas Pizarro, Laura Gomes Nunes de Melo, Dayse A. Silva, Romulo Vianna Oliveira, Anna Paula Villela, Luiza Harcar Muniz, Camila Soares, Lucianne Righeti Monteiro Tannus, Karla Rezende Guerra Drummond, André Araújo Pinheiro, Felipe Mallmann, Franz Schubert Lopes Leal, Fernando Korn Malerbi, Paulo Henrique Morales…
    Citation: Diabetology & Metabolic Syndrome 2021 13:83
    Content type: Research Published on:

  27. We investigated the association of anthropometric indices including body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), and hip circumference (HC) with the ...

    Authors: Seyyed Saeed Moazzeni, Seyed Saeed Tamehri Zadeh, Samaneh Asgari, Fereidoun Azizi and Farzad Hadaegh
    Citation: Diabetology & Metabolic Syndrome 2021 13:82
    Content type: Research Published on:

  28. Atherosclerotic cardiovascular diseases are the leading cause of adverse outcomes in patients with type 2 diabetes, and all new anti-diabetic agents are mandated to undergo cardiovascular outcome trials (CVOTs...

    Authors: Miguel Melo, Cristina Gavina, José Silva-Nunes, Luís Andrade and Davide Carvalho
    Citation: Diabetology & Metabolic Syndrome 2021 13:81
    Content type: Review Published on:

  29. The aim of this study was to compare individuals with type 1 diabetes with continuous subcutaneous insulin infusion (CSII) and intensified insulin therapy (ICT) in routine care regarding metabolic control and ...

    Authors: Guido Kramer, Christof Kloos, Ulrich A. Müller, Gunter Wolf and Nadine Kuniss
    Citation: Diabetology & Metabolic Syndrome 2021 13:80
    Content type: Research Published on:

  30. Several studies have demonstrated suppressed levels of acylated (AG) and unacylated ghrelin (UAG) in patients with type 2 diabetes. However, the role of these hormones in type 1 diabetes has not been extensive...

    Authors: Behiye Özcan, Patric J. D. Delhanty, Martin Huisman, Jenny A. Visser, Sebastian J. Neggers and Aart Jan van der Lely
    Citation: Diabetology & Metabolic Syndrome 2021 13:79
    Content type: Research Published on:

  31. Authors: Samereh Abdoli, Monica S. V. M. Silveira, Mehri Doosti-Irani, Paulo Fanti, Katherine Miller-Bains, Elizabeth João Pavin, Edimariz Buin Cardoso, Leila Rafee Vardanjani, Kobra Noorian and Danielle Hessler
    Citation: Diabetology & Metabolic Syndrome 2021 13:78
    Content type: Correction Published on:

    The original article was published in Diabetology & Metabolic Syndrome 2021 13:63

  32. To investigate the impact of microecological preparation combined with modified low-carbon diet on the glucolipid metabolism and cardiovascular complication in obese patients.

    Authors: Jianguo Liu, Liehui Xiao, Hezhongrong Nie, Yong Pan, Yan Liu, Zhentian Zhang, Xiuping Lin, Yuan Zhang, Jinchuang Cai, Muxiu Yang, Yajing Liu, Leijun Zhang, Aimin Xu and Cuifeng Zhu
    Citation: Diabetology & Metabolic Syndrome 2021 13:77
    Content type: Research Published on:

  33. COVID-19 has stroke Brazil harshly, deaths by COVID-19 in Brazil represent almost 13% of the total deaths by COVID-19 in the world, even though Brazilian population represents only 2.6% of the world population...

    Authors: Rodrigo Esaki Tamura, Said Muhammad Said, Leticia Mussin de Freitas and Ileana Gabriela Sanchez Rubio
    Citation: Diabetology & Metabolic Syndrome 2021 13:76
    Content type: Research Published on:

  34. Previous studies have analyzed the potential effect of KCNQ1 rs2237892 polymorphism on the predisposition to type 2 diabetes mellitus, but the findings are inconclusive and the subject of debate. The purpose of o...

    Authors: Hong-Liang Jiang, Han Du, Ying-Jun Deng and Xue Liang
    Citation: Diabetology & Metabolic Syndrome 2021 13:75
    Content type: Research Published on:

  35. We investigate the effect of aerobic physical training (APT) on muscle morphofunctional markers and Angiotensin Converting Enzyme 2/Angiotensin 1-7/Mas receptor (ACE2/Ang 1-7/Mas) axis in an obesity-linked ins...

    Authors: Bruno Vecchiatto, Rafael C. da Silva, Talita S. Higa, Cynthia R. Muller, Anna Laura V. Américo, Vanessa C. Fortunato-Lima, Marília M. Ferreira, Luiz Felipe Martucci, Miriam H. Fonseca-Alaniz and Fabiana S. Evangelista
    Citation: Diabetology & Metabolic Syndrome 2021 13:74
    Content type: Research Published on:

  36. Pregnant women with a history of gestational diabetes mellitus (GDM) are at high risk of GDM. It is unclear whether this population has pregnancy characteristics different from the general population. Whether ...

    Authors: Xin Liang, Wei Zheng, Cheng Liu, Lirui Zhang, Li Zhang, Zhihong Tian and Guanghui Li
    Citation: Diabetology & Metabolic Syndrome 2021 13:73
    Content type: Research Published on:

  37. Circular RNAs (circRNAs) have been considered as pivotal biomarkers in Diabetic nephropathy (DN). CircRNA ARP2 actin-related protein 2 homolog (circ-ACTR2) could promote the HG-induced cell injury in DN. Howev...

    Authors: Jie Yun, Jinyu Ren, Yufei Liu, Lijuan Dai, Liqun Song, Xiaopeng Ma, Shan Luo and Yexu Song
    Citation: Diabetology & Metabolic Syndrome 2021 13:72
    Content type: Research Published on:

  38. Stroke is a serious complication in patients with type 2 diabetes (T2DM). Arterial stiffness may improve stroke prediction. We investigated the association between carotid-femoral pulse wave velocity [PWV] and...

    Authors: Kristian L. Funck, Esben Laugesen, Pernille Høyem, Brian Stausbøl-Grøn, Won Y. Kim, Leif Østergaard, Dora Grauballe, Troels K. Hansen, Christian S. Buhl and Per L. Poulsen
    Citation: Diabetology & Metabolic Syndrome 2021 13:71
    Content type: Research Published on:

  39. Serum fatty acid-binding protein 4 (FABP4), as an intracellular lipid chaperone and adipokine, was reported to be related to the incidence of type 2 diabetes (T2D) and diabetic complications, but its associati...

    Authors: Hong Wang, Jie Cao, Jian-bin Su, Xue-qin Wang, Xing Wang, Dong-mei Zhang and Xiao-hua Wang
    Citation: Diabetology & Metabolic Syndrome 2021 13:70
    Content type: Research Published on:

  40. Diabetes mellitus (DM) is a major risk factor for contrast-induced acute kidney injury (CI-AKI). DM and CI-AKI result in oxidative damage and inflammation that can be reduced when treated with the coenzyme Q-1...

    Authors: Sheila Marques Fernandes Couto, Cassiane Dezoti da Fonseca, Mirian Watanabe and Maria de Fátima Fernandes Vattimo
    Citation: Diabetology & Metabolic Syndrome 2021 13:69
    Content type: Research Published on:

  41. Patients with type 2 diabetes mellitus (T2DM) from Latin American countries face challenges in access to healthcare, leading to under-diagnosis, under-achievement of glycemic target, and long-term complication...

    Authors: Sérgio Vencio, Juan P. Manosalva, Chantal Mathieu, Pieter Proot, Hernan Yupanqui Lozno and Päivi M. Paldánius
    Citation: Diabetology & Metabolic Syndrome 2021 13:68
    Content type: Research Published on:

  42. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Himani Thakkar, Vinnyfred Vincent, Sakshi Shukla, Manraj Sra, Uma Kanga, Sandeep Aggarwal and Archna Singh
    Citation: Diabetology & Metabolic Syndrome 2021 13:67
    Content type: Correction Published on:

    The original article was published in Diabetology & Metabolic Syndrome 2021 13:46

  43. To provide the latest evidence of performance and robustness of waist-to-height ratio (WHtR) in discriminating clusters of cardiometabolic risk factors (CMRs) and promote WHtR in routine primary health care pr...

    Authors: Yuan Jiang, Yalan Dou, Hongyan Chen, Yi Zhang, Xiaotian Chen, Yin Wang, Myanca Rodrigues and Weili Yan
    Citation: Diabetology & Metabolic Syndrome 2021 13:66
    Content type: Research Published on:

  44. A new strain of human coronavirus (HCoV) spread rapidly around the world. Diabetes and obesity are associated with a worse prognosis in these patients. Congenital Generalized Lipodystrophy (CGL) patients gener...

    Authors: Mayara Ponte Madeira, Erika Bastos Lima Freire, Virginia Oliveira Fernandes, Grayce Ellen da Cruz Paiva Lima, Ivana da Ponte Melo, Ana Paula Dias Rangel Montenegro, José Ednésio da Cruz Freire, Caroline de Fátima Aquino Moreira-Nunes, Raquel Carvalho Montenegro, Jeová Keny Baima Colares and Renan Magalhães Montenegro Junior
    Citation: Diabetology & Metabolic Syndrome 2021 13:65
    Content type: Research Published on:

  45. Diabetes mellitus (DM) is a prevalent disease among elderly population. As the disease progresses, insulin may become necessary. The use of pens application seems to be more practical. However, the influence o...

    Authors: Rafael Vaz Machry, Gustavo Fonseca Cipriani, Henrique Umpierre Pedroso, Rafaela Ramos Nunes, Thayme Luisa Souza Pires, Raquel Ferreira, Betina Vescovi, Gabriela Pereira de Moura and Ticiana Costa Rodrigues
    Citation: Diabetology & Metabolic Syndrome 2021 13:64
    Content type: Research Published on:

  46. The COVID-19 pandemic is a global public health emergency, which presents wide-ranging negative impacts on individuals with diabetes. To examine psychosocial well-being and diabetes outcomes in individuals wit...

    Authors: Samereh Abdoli, Monica S. V. M. Silveira, Mehri Doosti-Irani, Paulo Fanti, Katherine Miller-Bains, Elizabeth João Pavin, Edimariz Buin Cardoso, Leila Rafiee Vardanjani, Kobra Noorian and Danielle Hessler
    Citation: Diabetology & Metabolic Syndrome 2021 13:63
    Content type: Research Published on:

    The Correction to this article has been published in Diabetology & Metabolic Syndrome 2021 13:78

  47. Research elucidating the metabolic mechanisms that differentiate subtypes of obesity has been increasing. We aimed to investigate the effects of a 12-week dietary intervention on the metabolomic profiles of ob...

    Authors: Hye Yoon Jang, Youngmin Han, Hye Jin Yoo, Jong Ho Lee and Minjoo Kim
    Citation: Diabetology & Metabolic Syndrome 2021 13:62
    Content type: Research Published on:

  48. Prediabetes is characterized by a hemoglobin A1c of 5.7–6.4% and fasting blood glucose of 100–125 mg/dl. A high percentage of prediabetes subjects develop type 2 diabetes mellitus in the next years. The effect...

    Authors: Shatha Rouf Moustafa
    Citation: Diabetology & Metabolic Syndrome 2021 13:61
    Content type: Research Published on:

  49. Laminin, one of the largest glycoproteins of the basement membrane, is an important component of the extracellular matrix. Functions of the basement membrane include regulation of cell signaling behaviors and ...

    Authors: Özgür Altun, Yücel Arman, Şengül Aydın Yoldemir, Ayşe Selcen Pala, Perihan Özkan Gümüşkaya, Mustafa Özcan, Mustafa Karataş, Okan Dikker and Tufan Tükek
    Citation: Diabetology & Metabolic Syndrome 2021 13:60
    Content type: Research Published on:

  50. To identify genetic associations of quantitative metabolic syndrome (MetS) traits and characterize heterogeneity across ethnic groups.

    Authors: Jia Y. Wan, Deborah L. Goodman, Emileigh L. Willems, Alexis R. Freedland, Trina M. Norden-Krichmar, Stephanie A. Santorico and Karen L. Edwards
    Citation: Diabetology & Metabolic Syndrome 2021 13:59
    Content type: Research Published on:

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