Articles

Zinc supplementation improves body weight management, inflammatory biomarkers and insulin resistance in individuals with obesity: a randomized, placebo-controlled, double-blind trial

The present study was designed to determine whether zinc supplementation would increase the effects of restricted calorie diet (RCD) on obesity.

Authors: Hoda Khorsandi, Omid Nikpayam, Reyhaneh Yousefi, Maryam Parandoosh, Nima Hosseinzadeh, Atoosa Saidpour and Arman Ghorbani

Physiological serum total bilirubin concentrations were inversely associated with diabetic peripheral neuropathy in Chinese patients with type 2 diabetes: a cross-sectional study

Although bilirubin has been generally regarded as a waste with potential neurotoxicity at high levels, a few clinical studies suggest a potential protective role of physiological serum total bilirubin (TBIL) c...

Authors: Pijun Yan, Zhihong Zhang, Ying Miao, Yong Xu, Jianhua Zhu and Qin Wan

Reducing effect of insulin resistance on alpha-synuclein gene expression in skeletal muscle

Alpha-synuclein (SNCA) as the presynaptic protein is expressed in different tissues and prevents insulin-resistance (IR) through increasing glucose-uptake by adipocytes and muscles. However, the effect of insu...

Authors: Amirhosein Khoshi, Golnaz Goodarzi, Rezvan Mohammadi, Roghaye Arezumand, Meysam Moghbeli and Mahnaz Najariyan

Comparison of visceral adipose tissue DNA methylation and gene expression profiles in female adolescents with obesity

Epigenetic changes in visceral adipose tissue (VAT) with obesity and their effects on gene expression are poorly understood, especially during emergent obesity in youth. The current study tested the hypothesis...

Authors: Matthew D. Barberio, Evan P. Nadler, Samantha Sevilla, Rosemary Lu, Brennan Harmon and Monica J. Hubal

Interaction between ELMO1 gene polymorphisms and environment factors on susceptibility to diabetic nephropathy in Chinese Han population

The association of diabetic nephropathy (DN) risk with single nucleotide polymorphisms (SNPs) within Engulfment and Cell Motility 1 (ELMO1) gene and gene–environment synergistic effect have not been extensively e...

Authors: Yi Hou, Yong Gao, Yan Zhang, Si-Tong Lin, Yue Yu and Liu Yang

Effects of metformin on metabolism of white and brown adipose tissue in obese C57BL/6J mice

To investigate effects of metformin on the regulation of proteins of white adipose tissue (WAT) and brown adipose tissue (BAT) in obesity and explore the underlying mechanisms on energy metabolism.

Authors: Tao Yuan, Juan Li, Wei-Gang Zhao, Wei Sun, Shuai-Nan Liu, Quan Liu, Yong Fu and Zhu-Fang Shen

Fasting triglycerides and glucose index: a useful screening test for assessing insulin resistance in patients diagnosed with rheumatoid arthritis and systemic lupus erythematosus

Insulin resistance (IR) is frequently observed in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). In clinical practice, IR assessment is limited to a low proportion of patients d...

Authors: Betsabe Contreras-Haro, Sandra Ofelia Hernandez-Gonzalez, Laura Gonzalez-Lopez, Maria Claudia Espinel-Bermudez, Leonel Garcia-Benavides, Edsaul Perez-Guerrero, Maria Luisa Vazquez-Villegas, Jose Antonio Robles-Cervantes, Mario Salazar-Paramo, Diana Mercedes Hernandez-Corona, Arnulfo Hernan Nava-Zavala and Jorge I. Gamez-Nava

Long-term treatment with metformin in the prevention of fatty liver in Zucker diabetic fatty rats

Treatment with metformin, the biguanide of hepatic insulin sensitizer, in patients with non-alcoholic fatty liver disease (NAFLD) has been reported with contradictory findings regarding the effectiveness on bl...

Authors: Yi Sui, Xianhe Kong, Rongrong Fan, Yanbin Ye, Haiyan Mai, Shuyu Zhuo, Wei Lu, Peishan Ruan, Shi Fang and Tao Yang

The discriminatory power of visceral adipose tissue area vs anthropometric measures as a diagnostic marker for metabolic syndrome in South African women

A number of studies have shown central adiposity, in particular visceral adipose tissue (VAT) accumulation to be a hallmark of metabolic syndrome (MetS). In clinical practice, waist circumference (WC) is used ...

Authors: Florence E. Davidson, Tandi E. Matsha, Rajiv T. Erasmus, Andre Pascal Kengne and Julia H. Goedecke

Statins and/or fibrates for diabetic retinopathy: a systematic review and meta-analysis

Evidence from observational studies have found a relationship between serum cholesterol and diabetic retinopathy (DR). Apart of the assumption that cholesterolemic control has benefits for patients with diabet...

Authors: Vânia Mozetic, Rafael Leite Pacheco, Carolina de Oliveira Cruz Latorraca and Rachel Riera

Effects of green coffee extract on fasting blood glucose, insulin concentration and homeostatic model assessment of insulin resistance (HOMA-IR): a systematic review and meta-analysis of interventional studies

Many studies have investigated the relationship between coffee and diabetes. Evaluation of the current evidence on the effect of coffee intake on diabetes is critical. Therefore, we aimed to investigate the po...

Authors: Omid Nikpayam, Marziyeh Najafi, Samad Ghaffari, Mohammad Asghari Jafarabadi, Golbon Sohrab and Neda Roshanravan

Treatment patterns of drug-naive patients with type 2 diabetes mellitus: a retrospective cohort study using a Japanese hospital database

Guidelines for Type 2 diabetes mellitus (T2DM) management in Japan provide physicians the discretion to select treatment options based on patient pathophysiology of the disease. There exists a wide variation o...

Authors: Yohei Morita, Hiroki Murayama, Masato Odawara and Melissa Bauer

Foot function and strength of patients with diabetes grouped by ulcer risk classification (IWGDF)

The stratification system from the International Working Group on the Diabetic Foot (IWGDF) was used to classify the participants as to the ulcer risk. However, it is not yet known what the classification grou...

Authors: Jane S. S. P. Ferreira, João P. Panighel, Érica Q. Silva, Renan L. Monteiro, Ronaldo H. Cruvinel Júnior and Isabel C. N. Sacco

Midnight salivary cortisol secretion and the use of antidepressants were associated with abdominal obesity in women with type 1 diabetes: a cross sectional study

Abdominal obesity is a risk factor for cardiovascular disease. The aim was to explore the influence of midnight salivary cortisol (MSC), antidepressants and sex on abdominal obesity in type 1 diabetes (T1D). W...

Authors: Eva Olga Melin, Magnus Hillman, Maria Thunander and Mona Landin-Olsson

Hyperhomocysteinemia is an independent risk factor of atherosclerosis in patients with metabolic syndrome

Metabolic syndrome (MetS) is a clinical condition potentially promoting the development of atherosclerotic disease. To date, the clinical impact of elevated serum homocysteine (Hcy) levels in MetS is still und...

Authors: Giuseppina Piazzolla, Mafalda Candigliota, Margherita Fanelli, Anna Castrovilli, Elsa Berardi, Gianfranco Antonica, Stefano Battaglia, Vincenzo Solfrizzi, Carlo Sabbà and Cosimo Tortorella

Effects of vitamin D supplementation on advanced glycation end products signaling pathway in T2DM patients: a randomized, placebo-controlled, double blind clinical trial

Several researches have recommended vitamin D possible health benefits on diabetic complications development, but a few number of studies have been accomplished on the molecular and cellular mechanisms. Certai...

Authors: Mahsa Omidian, Mahmoud Djalali, Mohammad Hassan Javanbakht, Mohammad Reza Eshraghian, Maryam Abshirini, Parisa Omidian, Ehsan Alvandi and Maryam Mahmoudi

Smoking and diabetes: dangerous liaisons and confusing relationships

The combined harmful effects of cigarette smoking and hyperglycemia can accelerate vascular damage in patients with diabetes who smoke, as is well known. Can smoking cause diabetes? What are the effects of smo...

Authors: D. Campagna, A. Alamo, A. Di Pino, C. Russo, A. E. Calogero, F. Purrello and R. Polosa

Mobile phone applications and their use in the self-management of Type 2 Diabetes Mellitus: a qualitative study among app users and non-app users

Mobile phone applications (apps) have been shown to successfully facilitate the self-management of chronic disease. This study aims to evaluate firstly the experiences, barriers and facilitators to app usage a...

Authors: Bronte Jeffrey, Melina Bagala, Ashley Creighton, Tayla Leavey, Sarah Nicholls, Crystal Wood, Jo Longman, Jane Barker and Sabrina Pit

22nd Brazilian Diabetes Society Congress

Authors:

Association between metabolic syndrome and the incidence of gastric cancer: a meta-analysis of cohort studies

Previous studies investigating the association between metabolic syndrome (MetS) and incidence of gastric cancer (GC) showed inconsistent results. The aim of the study was to evaluate the influence of MetS on ...

Authors: Zhibin Li, Hongfeng Han and Yuan Chang

Metformin paradoxically worsens insulin resistance in SHORT syndrome

SHORT syndrome is an autosomal dominant condition associated severe insulin resistance (IR) and lipoatrophy due to post-receptor defect in insulin signaling involving phosphoinositide-3-kinase regulatory subun...

Authors: Krzysztof C. Lewandowski, Katarzyna Dąbrowska, Maria Brzozowska, Joanna Kawalec and Andrzej Lewiński

Consensus recommendations for management of patients with type 2 diabetes mellitus and cardiovascular diseases

The recent American Diabetes Association and the European Association for the Study of Diabetes guideline mentioned glycaemia management in type 2 diabetes mellitus (T2DM) patients with cardiovascular diseases...

Authors: Alaaeldin Bashier, Azza Bin Hussain, Elamin Abdelgadir, Fatheya Alawadi, Hani Sabbour and Robert Chilton

Serum fibroblast growth factor 19 and endogenous islet beta cell function in type 2 diabetic patients

Fibroblast growth factor 19 (FGF19) takes part in maintaining the balance of glycolipids and may be involved in regulating the secretory activity of islet beta cells in patients with type 2 diabetes. This stud...

Authors: Meng-jie Tang, Jian‑bin Su, Tian-li Xu, Xue‑qin Wang, Dong-mei Zhang and Xiao-hua Wang

Interaction of HSD11B1 and H6PD polymorphisms in subjects with type 2 diabetes are protective factors against obesity: a cross-sectional study

The enzyme 11-beta hydroxysteroid dehydrogenase type 1 (HSD11B1) converts inactive cortisone to active cortisol in a process mediated by the enzyme hexose-6-phosphate dehydrogenase (H6PD). The generation of co...

Authors: Marcio F. Chedid, Filipe V. do Nascimento, Fernanda S. de Oliveira, Bianca M. de Souza, Cleber R. P. Kruel, Richard R. Gurski, Luis H. Canani, Daisy Crispim and Fernando Gerchman

Association of dietary pattern with carotid intima media thickness among children with overweight or obesity

Since there is no evidence demonstrating the relationship between dietary patterns and subclinical atherosclerosis in children and adolescents, we aimed to examine the association between dietary patterns and ...

Authors: Assa Akbari-Sedigh, Golaleh Asghari, Emad Yuzbashian, Pooneh Dehghan, Hossein Imani and Parvin Mirmiran

Body adiposity index in assessing the risk of type 2 diabetes mellitus development: the Baependi Heart Study

The association between diabetes and obesity is very well established. Faced with this, several anthropometric indices of adiposity are often involved in studies on diabetes. Our main goal in this paper is to ...

Authors: Camila Maciel de Oliveira, Jessica Pavani, José Eduardo Krieger, Rafael de Oliveira Alvim, Carlos Alberto Mourão-Junior and Alexandre da Costa Pereira

Effect of L. acidophilus and B. lactis on blood glucose in women with gestational diabetes mellitus: a randomized placebo-controlled trial

Gestational diabetes mellitus (GDM) is a complication of pregnancy that can be associated with neonatal complications and adverse pregnancy outcomes. Recently, probiotic use has been proposed for better contro...

Authors: Farnaz Sahhaf Ebrahimi, Aziz Homayouni Rad, Metanat Mosen, Fatemeh Abbasalizadeh, Aydin Tabrizi and Leila Khalili

Cardiovascular risk and obesity

This is an overview of the mechanisms of obesity and its relation to cardiovascular risks, describing the available treatment options to manage this condition.

Authors: C. Cercato and F. A. Fonseca

Evaluation of sexual dysfunction and female sexual dysfunction indicators in women with type 2 diabetes: a systematic review and meta-analysis

Type 2 diabetes is one of the most common chronic diseases worldwide, and one of the long-term complications of this disease is sexual dysfunction in women with type 2 diabetes, which has been studied in fewer...

Authors: Elham Rahmanian, Nader Salari, Masoud Mohammadi and Rostam Jalali

The effect of exercise on the prevention of gestational diabetes in obese and overweight pregnant women: a systematic review and meta-analysis

Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and its prevalence worldwide is increasing along with enhancing type two of diabetes. Contrary results have been found i...

Authors: Fatemeh Nasiri-Amiri, Mahdi Sepidarkish, Marjan Ahmad Shirvani, Payam Habibipour and Narges Sadat Motahari Tabari

Early pregnancy metabolic factors associated with gestational diabetes mellitus in normal-weight women with polycystic ovary syndrome: a two-phase cohort study

Polycystic ovary syndrome (PCOS) has been consistently associated with subsequent gestational diabetes mellitus (GDM). Women with PCOS showed a high prevalence of obesity, which raises the question regarding t...

Authors: Wei Zheng, Wenyu Huang, Li Zhang, Zhihong Tian, Qi Yan, Teng Wang, Lirui Zhang and Guanghui Li

30-days effects of vildagliptin on vascular function, plasma viscosity, inflammation, oxidative stress, and intestinal peptides on drug-naïve women with diabetes and obesity: a randomized head-to-head metformin-controlled study

Obesity is the main risk factor for diabetes and excessive visceral fat triggers low-grade inflammatory process, mediated by activation and release of cytokines and high flow of free fatty acids that contribut...

Authors: Alessandra Schiapaccassa, Priscila A. Maranhão, Maria das Graças Coelho de Souza, Diogo G. Panazzolo, José Firmino Nogueira Neto, Eliete Bouskela and Luiz Guilherme Kraemer-Aguiar

Comparison between newly diagnosed hypertension in diabetes and newly diagnosed diabetes in hypertension

Hypertension and diabetes mellitus are often jointly present, especially in early onset cases of either disease. We investigated clinical characteristics of hypertensive patients with newly diagnosed diabetes ...

Authors: Chang-Yuan Liu, Wei Zhang, Li-Nong Ji and Ji-Guang Wang

Association between pre-pregnancy body weight and dietary pattern with large-for-gestational-age infants in gestational diabetes

Both obesity and gestational diabetes (GDM) are associated with adverse outcomes. Diet during pregnancy impacts weight gain and fetal growth. Therefore, we aimed to explore non-pharmacological treatment succes...

Authors: Ana Munda, Marjanca Starčič Erjavec, Katja Molan, Jerneja Ambrožič Avguštin, Darja Žgur-Bertok and Draženka Pongrac Barlovič

Glycemic variability is associated with vascular calcification by the markers of endoplasmic reticulum stress-related apoptosis, Wnt1, galectin-3 and BMP-2

The present study identified whether glycemic variability (GV) was associated with vascular calcification and explored the underlying mechanisms.

Authors: Li Zhang, Haichen Sun, Shuang Liu, Jinhuan Gao and Jinggang Xia

Incidence and risk factors for metabolic syndrome among urban, adult Sri Lankans: a prospective, 7-year community cohort, follow-up study

The metabolic syndrome (MetS) is a clustering of abdominal obesity, diabetes and prediabetes, high cholesterol and high blood pressure, that confers an increased risk of cardiovascular disease. There is limite...

Authors: Shamila T. De Silva, Madunil A. Niriella, Dileepa S. Ediriweera, Dulani Kottahachchi, Anuradhani Kasturiratne, Arjuna P. de Silva, Anuradha S. Dassanayaka, Arunasalam Pathmeswaran, Rajitha Wickramasinghe, N. Kato and H. Janaka de Silva

Effect of insulin–glucose metabolism compared with obesity on adipose omentin gene expression in different models of diabetic C57BL/6 mice

Omentin, releasing by adipose-tissue may be related to glucose metabolism. The omentin circulating levels and the related mRNA expression in visceral adipose-tissue are different in types of diabetes and the e...

Authors: Golnaz Goodarzi, Amirreza Shirgir, Sadegh Alavi and Amirhosein Khoshi

The combined role of allelic variants of IRS-1 and IRS-2 genes in susceptibility to type2 diabetes in the Punjabi Pakistani subjects

Diabetes mellitus is a multifactorial disorder characterized by a high level of glucose in the blood. Both genetic and environmental factors interact to cause diabetes. Insulin receptor substrate (IRS) proteins h...

Authors: Anam Ijaz, Sana Babar, Sumbal Sarwar, Saleem Ullah Shahid and Shabana

Myokine–adipokine cross-talk: potential mechanisms for the association between plasma irisin and adipokines and cardiometabolic risk factors in Mexican children with obesity and the metabolic syndrome

Adipokines and the myokine irisin, involved in mechanisms associated with obesity and metabolic syndrome (MS), are understudied in the pediatric population.

Authors: Adrian M. Gonzalez-Gil, Mariana Peschard-Franco, Elena C. Castillo, Gustavo Gutierrez-DelBosque, Victor Treviño, Christian Silva-Platas, Luisa Perez-Villarreal, Gerardo Garcia-Rivas and Leticia Elizondo-Montemayor

Assessment of dapagliflozin effect on diabetic endothelial dysfunction of brachial artery (ADDENDA-BHS2 trial): rationale, design, and baseline characteristics of a randomized controlled trial

Endothelial dysfunction (ED) is a hallmark in type 2 diabetes mellitus (T2DM) that favor both atherogenesis and ischemia and reperfusion injury (IRI). Sodium-glucose-2 co-transporter inhibitors (SGLT2i) may hy...

Authors: Riobaldo M. R. Cintra, Alexandre A. S. Soares, Ikaro Breder, Daniel B. Munhoz, Joaquim Barreto, Sheila T. Kimura-Medorima, Pamela Cavalcante, Renata Zanchetta, Jessica Cunha Breder, Camila Moreira, Vitor W. Virginio, Isabella Bonilha, Jose Carlos Lima-Junior, Otavio R. Coelho-Filho, Vaneza L. W. Wolf, Gil Guerra-Junior…

Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness

Metabolic syndrome, an obesity-related condition associated with insulin resistance and low-grade inflammation, leads to diabetes, cardiovascular diseases, cancer, osteoarthritis, and other disorders. Optimal ...

Authors: Janet B. McGill, Mariko Johnson, Stacy Hurst, William T. Cade, Kevin E. Yarasheski, Richard E. Ostlund, Kenneth B. Schechtman, Babak Razani, Michael B. Kastan, Donald A. McClain, Lisa de las Fuentes, Victor G. Davila-Roman, Daniel S. Ory, Samuel A. Wickline and Clay F. Semenkovich

Association between serum visfatin levels and atherosclerotic plaque in patients with type 2 diabetes

Visfatin is a multifaceted protein that plays an important role in regulating a variety of physiological and pathological processes, including obesity, diabetes and cardiovascular disease. However, circulating...

Authors: Long-Yi Zheng, Xia Xu, Ren-Hui Wan, Sheng Xia, Jin Lu and Qin Huang

Prevalence of postprandial hyperglycaemia in basal insulin-treated patients with type 2 diabetes mellitus with controlled fasting glycaemia and elevated glycosylated haemoglobin

To study the prevalence of postprandial hyperglycaemia (PPH) in type 2 diabetes mellitus (T2DM) patients treated with basal insulin, having fasting glucose < 130 mg/dL but HbA1c > 7.0% (53 mmol/mol).

Authors: Francisco J. Tinahones, María Molina-Vega, Juan Parra-Barona, Juana Flores-Le Roux and Ricardo Gómez-Huelgas

Metformin therapy before conception versus throughout the pregnancy and risk of gestational diabetes mellitus in women with polycystic ovary syndrome: a systemic review, meta-analysis and meta-regression

The results of studies that assessed the impact of metformin treatments on gestational diabetes mellitus (GDM) in patients with polycystic ovary syndrome (PCOS) are inconclusive. In addition, the impact of tim...

Authors: Razieh Bidhendi Yarandi, Samira Behboudi-Gandevani, Mina Amiri and Fahimeh Ramezani Tehrani

Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice

Recently, clinical studies have shown the protective effects of sodium glucose co-transporter2 (SGLT2) inhibitors against progression of diabetic nephropathy, but the underlying molecular mechanisms remain unc...

Authors: Masa-Ki Inoue, Yasuka Matsunaga, Yusuke Nakatsu, Takeshi Yamamotoya, Koji Ueda, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Hiraku Ono, Misaki Iwashita, Tomomi Sano, Fusanori Nishimura, Kenichi Morii, Kensuke Sasaki, Takao Masaki and Tomoichiro Asano

Genetic associations between Transcription Factor 7 Like 2 rs7903146 polymorphism and type 2 diabetes mellitus: a meta-analysis of 115,809 subjects

Some genetic association studies tried to investigate potential associations of Transcription Factor 7 Like 2 (TCF7L2) rs7903146 polymorphism with type 2 diabetes mellitus (T2DM). However, the results of these st...

Authors: Liying Lou, Jingjing Wang and Jing Wang

TCF7L2 regulates pancreatic β-cell function through PI3K/AKT signal pathway

Transcription factor 7-like 2 (TCF7L2), which previously known as TCF-4, is a major form of transcription factor involved in the downstream WNT signaling and exhibits the strongest association to diabetes susc...

Authors: Hui-Hui Wu, Yan-Liang Li, Nai-Jia Liu, Zhen Yang, Xiao-Ming Tao, Yan-Ping Du, Xuan-Chun Wang, Bin Lu, Zhao-Yun Zhang, Ren-Ming Hu and Jie Wen

Economic burden of diabetes in Brazil in 2014

Diabetes and its complications produce significant clinical, economic and social impact. The knowledge of the costs of diabetes generates subsidies to maintain the financial sustainability of public health and...

Authors: Luciana Ribeiro Bahia, Michelle Quarti Machado da Rosa, Denizar Vianna Araujo, Marcelo Goulart Correia, Roger dos Santos dos Rosa, Bruce Bartholow Duncan and Cristiana Maria Toscano

Association between cardiovascular autonomic neuropathy and left ventricular hypertrophy in young patients with congenital generalized lipodystrophy

Congenital generalized lipodystrophy (CGL) is a rare disorder characterized by the absence of subcutaneous adipose tissue, severe insulin resistance, diabetes mellitus, and cardiovascular complications, includ...

Authors: Clarisse Mourão Melo Ponte, Virgínia Oliveira Fernandes, Christiane Bezerra Rocha Liberato, Ana Paula Dias Rangel Montenegro, Lívia Aline Batista, Maria Helane Costa Gurgel, Lia Beatriz de Azevedo Karbage, Izabella Tamira Galdino Farias Vasconcelos, Catarina Brasil d’Alva and Renan Magalhães Montenegro Júnior

The dietary acid load is higher in subjects with prediabetes who are at greater risk of diabetes: a case–control study

We aimed to examine the association of dietary acid load and prediabetes in a case–control study.

Authors: Maryam Abshirini, Fariba Bagheri, Behzad Mahaki, Fereydoun Siassi, Fariba Koohdani, Maryam Safabakhsh and Gity Sotoudeh