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  1. With the increasing prevalence of metabolic syndrome (MS), there is a need to track and predict the development of MS. In this study, we established a Markov model to explore the natural history and predict th...

    Authors: Xiaoxian Jia, Qicai Chen, Peipei Wu, Meng Liu, Xiaoxiao Chen, Juan Xiao, Lili Chen, Pengpeng Zhang and Shumei Wang

    Citation: Diabetology & Metabolic Syndrome 2018 10:24

    Content type: Research

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  2. The aim of this study was to explore the predictors of QOL and health state and examine the relationship with glycemic control among type 2 diabetes mellitus (T2DM) patients.

    Authors: Syed Wasif Gillani, Irfan Altaf Ansari, Hisham A. Zaghloul, Mohi Iqbal Mohammad Abdul, Syed Azhar Syed Sulaiman and Mirza R. Baig

    Citation: Diabetology & Metabolic Syndrome 2018 10:23

    Content type: Research

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  3. Diabetes nephropathy is a microvascular complication associated with high morbidity and mortality in patients with type 1 diabetes, and its pathogenesis is not fully understood. Our aim was to evaluate the ass...

    Authors: Marcela Haas Pizarro, Deborah Conte Santos, Bianca Senger Vasconcelos Barros, Laura Gomes Nunes de Melo and Marilia Brito Gomes

    Citation: Diabetology & Metabolic Syndrome 2018 10:22

    Content type: Research

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  4. Obesity is known to be related to the development of type 2 diabetes mellitus (T2D). The most commonly used anthropometric indicator (body mass index [BMI]) presents several limitations such as the lack of pos...

    Authors: Fernando Gomez-Peralta, Cristina Abreu, Margarita Cruz-Bravo, Elvira Alcarria, Gala Gutierrez-Buey, Nir Y. Krakauer and Jesse C. Krakauer

    Citation: Diabetology & Metabolic Syndrome 2018 10:21

    Content type: Research

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  5. Obesity is associated with significant physical, psychosocial and economic burden globally. In Brazil, almost 50% of the population is either overweight or obese. The prevalence of morbid obesity increased by ...

    Authors: Ian Kudel, Jefferson S. Alves, Thiago de Menezes Goncalves, Kristjan Kull and Emil Nørtoft

    Citation: Diabetology & Metabolic Syndrome 2018 10:20

    Content type: Research

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  6. Patients with ischemic cardiomyopathy and severe left ventricular dysfunction have a worse survival prognosis than patients with preserved ventricular function. The role of diabetes in the long-term prognosis ...

    Authors: Thiago Hueb, Mauricio S. Rocha, Sergio F. Siqueira, Silvana Angelina D´Orio Nishioka, Giselle L. Peixoto, Marcos M. Saccab, Eduardo Gomes Lima, Rosa Maria Rahmi Garcia, José Antonio F. Ramires, Roberto Kalil Filho and Martino Martinelli Filho

    Citation: Diabetology & Metabolic Syndrome 2018 10:19

    Content type: Letter to the Editor

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  7. Vitamins are essential micronutrients with antioxidant potential that may provide a complementary treatment for patients with chronic diseases. Our aim was to assess the effect of vitamin supplementation on th...

    Authors: Maria E. Balbi, Fernanda S. Tonin, Antonio M. Mendes, Helena H. Borba, Astrid Wiens, Fernando Fernandez-Llimos and Roberto Pontarolo

    Citation: Diabetology & Metabolic Syndrome 2018 10:18

    Content type: Research

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  8. Diabetic retinopathy has a significant impact in every healthcare system. Despite that fact, there are few accurate estimates in the prevalence of DR in Brazil’s different geographic regions, particularly prol...

    Authors: Karla Rezende Guerra Drummond, Fernando Korn Malerbi, Paulo Henrique Morales, Tessa Cerqueira Lemos Mattos, André Araújo Pinheiro, Felipe Mallmann, Ricardo Vessoni Perez, Franz Schubert Lopes Leal, Laura Gomes Nunes de Melo and Marília Brito Gomes

    Citation: Diabetology & Metabolic Syndrome 2018 10:17

    Content type: Research

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  9. This observational study aimed to assess the effectiveness of lixisenatide as add on therapy to basal insulin in diabetic type 2 patients previously treated with different insulin regimes.

    Authors: Tomislav Božek, Ines Bilić-Ćurčić, Maja Cigrovski Berković, Marina Gradišer, Tina Tićinović Kurir, Sanja Klobučar Majanović and Srećko Marušić

    Citation: Diabetology & Metabolic Syndrome 2018 10:16

    Content type: Short report

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  10. Vascular endothelial dysfunction induced by hyperglycemia and elevated insulin resistance is a potent risk factor for cardiovascular disease and likely contributes to multiple chronic disease complications ass...

    Authors: Jung-Hoon Lee, Ruda Lee, Moon-Hyon Hwang, Marc T. Hamilton and Yoonjung Park

    Citation: Diabetology & Metabolic Syndrome 2018 10:15

    Content type: Review

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  11. To evaluate the utility of glycated haemoglobin A1c (HbA1c) alone and in combination with haematocrit (HCT) for screening gestational diabetes mellitus (GDM) between 12–16 gestational weeks.

    Authors: Kui Wu, Yan Cheng, Tingting Li, Ziwen Ma, Junxiu Liu, Qingying Zhang and Haidong Cheng

    Citation: Diabetology & Metabolic Syndrome 2018 10:14

    Content type: Research

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  12. Wistar Ottawa Karlsburg W (RT1u) rats (WOKW) are a model of the metabolic syndrome (MetS). Adipose tissue (AT) and peripheral nerves of WOKW rats exhibit up-regulated autophagy and inflammation corresponding w...

    Authors: J. Kosacka, M. Nowicki, S. Paeschke, P. Baum, M. Blüher and N. Klöting

    Citation: Diabetology & Metabolic Syndrome 2018 10:13

    Content type: Research

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  13. The aim of this study to compare the diagnostic accuracy of the metabolic syndrome (MetS) with the FINDRISC score to screen for type 2 diabetes mellitus T2DM in an overweight/obese population.

    Authors: Abraham S. Meijnikman, Christophe E. M. De Block, An Verrijken, Ilse Mertens and Luc F. Van Gaal

    Citation: Diabetology & Metabolic Syndrome 2018 10:12

    Content type: Research

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  14. The benefits of sodium glucose cotransporters 2 (SGLT2) inhibitors in patients with type 2 diabetes mellitus include plasma glucose control, reduction in body weight and blood pressure, and low risk of hypogly...

    Authors: Hiroki Nakajima, Sadanori Okada, Takako Mohri, Eiichiro Kanda, Naoyuki Inaba, Yoko Hirasawa, Hiroaki Seino, Hisamoto Kuroda, Toru Hiyoshi, Tetsuji Niiya and Hitoshi Ishii

    Citation: Diabetology & Metabolic Syndrome 2018 10:11

    Content type: Research

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  15. Use of combination antiretroviral therapy (cART) has led to significant reductions in morbidity and mortality. However, there is a growing concern about metabolic syndromes (MS), among patients receiving cART....

    Authors: Dula Dessalegn Bosho, Lemessa Dube, Teshale Ayele Mega, Dawit Abera Adare, Mikyas Gashaw Tesfaye and Tesfahun Chanie Eshetie

    Citation: Diabetology & Metabolic Syndrome 2018 10:10

    Content type: Research

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  16. There is ongoing scientific interest regarding comorbidities associated with the metabolic syndrome (MeTS). MeTS comprises a combination of parameters that predispose individuals to the development of type 2 d...

    Authors: Ellie C. Stefanadi, Georgios Dimitrakakis, Christos-Konstantinos Antoniou, Dimitrios Challoumas, Nikita Punjabi, Inetzi Aggeliki Dimitrakaki, Sangeeta Punjabi and Christodoulos I. Stefanadis

    Citation: Diabetology & Metabolic Syndrome 2018 10:9

    Content type: Review

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  17. Peripheral neuropathy is one of the most common microvascular complication of diabetes mellitus. This study is conducted to determine the prevalence of diabetic peripheral neuropathy (DPN) and its associated f...

    Authors: Nahla Khawaja, Jawad Abu-Shennar, Mohammed Saleh, Said S. Dahbour, Yousef S. Khader and Kamel M. Ajlouni

    Citation: Diabetology & Metabolic Syndrome 2018 10:8

    Content type: Research

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    The Correction to this article has been published in Diabetology & Metabolic Syndrome 2018 10:43

  18. People with type 2 diabetes (T2D) have impaired exercise capacity, even in the absence of complications, which is predictive of their increased cardiovascular mortality. Cardiovascular dysfunction is one poten...

    Authors: Rebecca L. Scalzo, Timothy A. Bauer, Kylie Harrall, Kerrie Moreau, Cemal Ozemek, Leah Herlache, Shawna McMillin, Amy G. Huebschmann, Jennifer Dorosz, Jane E. B. Reusch and Judith G. Regensteiner

    Citation: Diabetology & Metabolic Syndrome 2018 10:7

    Content type: Research

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  19. Familial partial lipodystrophy of the Dunnigan type is one of the most common inherited lipodystrophies variables. These individuals have important metabolic disorders that cause predisposition to various dise...

    Authors: Maria C. Foss-Freitas, Rafael C. Ferraz, Luciana Z. Monteiro, Patricia M. Gomes, Ricardo Iwakura, Luiz Carlos C. de Freitas and Milton C. Foss

    Citation: Diabetology & Metabolic Syndrome 2018 10:6

    Content type: Research

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  20. In HIV patients using HAART insulin resistance is a central pathophysiological condition that can contribute to the development of diabetes and cardiovascular complications. To examine the role of adipocyte ho...

    Authors: Marcelo Nardi Pedro, Daniela Oliveira Magro, Elizabete Urbano Pinaço Pinto da Silva, Dioze Guadagnini, Andrey Santos, Rogerio de Jesus Pedro and Mario José Abdalla Saad

    Citation: Diabetology & Metabolic Syndrome 2018 10:5

    Content type: Research

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  21. In humans and animal models, excessive intake of dietary fat, fructose and cholesterol has been linked to the development of non-alcoholic fatty liver disease (NAFLD). However, the individual roles of the diet...

    Authors: Victoria Svop Jensen, Henning Hvid, Jesper Damgaard, Helle Nygaard, Camilla Ingvorsen, Erik Max Wulff, Jens Lykkesfeldt and Christian Fledelius

    Citation: Diabetology & Metabolic Syndrome 2018 10:4

    Content type: Research

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  22. Although multidisciplinary treatment is recommended for type 2 diabetes mellitus and hypertension (HTN), there is a lack of scientific literature supporting the hypothesis of extending this treatment strategy ...

    Authors: Thiago Veiga Jardim, Sayuri Inuzuka, Luan Galvão, Leandra Anália Freitas Negretto, Rogério Orlow de Oliveira, Wanessa Faria Sá, Haroldo Silva de Souza, Andrea Crisitina Sousa, Patricia Silva Carneiro, Weimar Kunz Sebba Barroso, Ana Luiza Lima Sousa and Paulo César Veiga Jardim

    Citation: Diabetology & Metabolic Syndrome 2018 10:3

    Content type: Research

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  23. Gestational diabetes is a risk factor for future development of type 2 diabetes. The primary aim of this study was to estimate the prevalence of postpartum glucose tolerance status evaluation in pregnancies co...

    Authors: C. A. Cabizuca, P. S. Rocha, J. V. Marques, T. F. L. R. Costa, A. S. N. Santos, A. L. Schröder, C. A. G. Mello, H. D. Sousa, E. S. G. Silva, F. O. Braga, R. C. Abi-Abib and M. B. Gomes

    Citation: Diabetology & Metabolic Syndrome 2018 10:2

    Content type: Research

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  24. No proper data on prognosis and management of type-2 diabetic ST elevation myocardial infarction (STEMI) patients with culprit obstructive lesion and multivessel non obstructive coronary stenosis (Mv-NOCS) exi...

    Authors: Raffaele Marfella, Celestino Sardu, Maria Luisa Balestrieri, Mario Siniscalchi, Fabio Minicucci, Giuseppe Signoriello, Paolo Calabrò, Ciro Mauro, Gorizio Pieretti, Antonino Coppola, Gianfranco Nicoletti, Maria Rosaria Rizzo, Giuseppe Paolisso and Michelangela Barbieri

    Citation: Diabetology & Metabolic Syndrome 2018 10:1

    Content type: Research

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  26. Exercise stimulates the production of fibronectin type III domain-containing protein 5 (FNDC5), which is cleaved to release a protein called irisin. This protein induces browning of white adipose tissue result...

    Authors: Carolina Archundia-Herrera, Maciste Macias-Cervantes, Bernardo Ruiz-Muñoz, Katya Vargas-Ortiz, Carlos Kornhauser and Victoriano Perez-Vazquez

    Citation: Diabetology & Metabolic Syndrome 2017 9:101

    Content type: Research

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  27. Diabetics have increased risks for cardiovascular disease (CVD) and mortality, reducing their life expectancy by up to 15 years. Type 2 diabetes mellitus specifically increases the risk for cardiovascular mort...

    Authors: Andréa Cristina Sousa, Thiago Veiga Jardim, Thiago Olivera Costa, Fabrício Galdino Magalhães, Marcos Paulo Marinho Montelo, Weimar K. Barroso Souza, Paulo César Brandão Veiga Jardim and Ana Luiza Lima Sousa

    Citation: Diabetology & Metabolic Syndrome 2017 9:98

    Content type: Research

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  28. Type 1 diabetes patients have a higher risk of developing hypoglycemia or hyperglycemia during physical activity, which may compromise their safety during exercise but results regarding the exercise capacity o...

    Authors: Milena S. Nascimento, Carolina F. Espindola, Cristiane do Prado, Melina Blanco Amarins, Ana Lucia Potenza, Luciana Pacheco, Erica Santos and Teresa Cristina A. Vieira

    Citation: Diabetology & Metabolic Syndrome 2017 9:100

    Content type: Research

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  29. Obesity-mediated oxidative stress results in mitochondrial dysfunction, which has been implicated in the pathogenesis of metabolic syndrome and T2DM. Recently, mitophagy, a cell-reparative process has emerged ...

    Authors: Shipra Bhansali, Anil Bhansali and Veena Dhawan

    Citation: Diabetology & Metabolic Syndrome 2017 9:99

    Content type: Short report

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  30. Type II diabetes is an important health problem with a complex connection to obesity, leading to a broad range of cardiovascular complications. Insulin therapy often results in weight gain and does not always ...

    Authors: Tomislav Bozek, Antonela Blazekovic, Matea Nikolac Perkovic, Kristina Gotovac Jercic, Aleksandra Sustar, Lea Smircic-Duvnjak, Tiago F. Outeiro, Nela Pivac and Fran Borovecki

    Citation: Diabetology & Metabolic Syndrome 2017 9:97

    Content type: Research

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  31. Diabetes is a progressive disease needing multiple drugs for achieving and maintaining good glycemic control. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) is a novel class of anti-diabetic agent which o...

    Authors: Yotsapon Thewjitcharoen, Nalin Yenseung, Areeya Malidaeng, Soontaree Nakasatien, Phawinpon Chotwanvirat, Sirinate Krittiyawong, Ekgaluck Wanothayaroj and Thep Himathongkam

    Citation: Diabetology & Metabolic Syndrome 2017 9:96

    Content type: Research

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  32. The interplay between adiponectin and resistin, the two adipokines of opposite effects, may determine the metabolic profile of obese individuals and development of obesity-related complications. The current st...

    Authors: Marta Izabela Jonas, Alina Kurylowicz, Zbigniew Bartoszewicz, Wojciech Lisik, Maurycy Jonas, Justyna Domienik-Karlowicz and Monika Puzianowska-Kuznicka

    Citation: Diabetology & Metabolic Syndrome 2017 9:95

    Content type: Research

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  34. To explore the impact of glycaemic control (HbA1c) on functional capacity during cardio-pulmonary exercise testing in people with type 1 diabetes.

    Authors: Othmar Moser, Max L. Eckstein, Olivia McCarthy, Rachel Deere, Stephen C. Bain, Hanne L. Haahr, Eric Zijlstra and Richard M. Bracken

    Citation: Diabetology & Metabolic Syndrome 2017 9:93

    Content type: Short report

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  35. Diabetic patients may be more susceptible to myocardial injury after coronary interventions. Thus, the aim of this study was to assess the release of cardiac biomarkers, CK-MB and troponin, and the findings of...

    Authors: Paulo Cury Rezende, Whady Hueb, Rosa Maria Rahmi, Thiago Luis Scudeler, Diogo Freitas Cardoso de Azevedo, Cibele Larrosa Garzillo, Carlos Alexandre Wainrober Segre, Jose Antonio Franchini Ramires and Roberto Kalil Filho

    Citation: Diabetology & Metabolic Syndrome 2017 9:92

    Content type: Research

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  36. Here, we studied the beneficial effects of aerobic exercise on metabolic syndrome components, cognitive performance, brain derived neurotrophic factor (BDNF) and irisin in ovariectomized rats with different se...

    Authors: Parvin Babaei, Samaneh Ghorbani Shirkouhi, Rastegar Hosseini and Bahram Soltani Tehrani

    Citation: Diabetology & Metabolic Syndrome 2017 9:91

    Content type: Research

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  37. Type 2 diabetes mellitus (T2DM) is one of the most common diseases worldwide and insulin insufficiency and insulin resistance are two main metabolic issues connected with it. The dyslipidemia associated with i...

    Authors: Elena Filipova, Katya Uzunova, Krassimir Kalinov and Toni Vekov

    Citation: Diabetology & Metabolic Syndrome 2017 9:90

    Content type: Review

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  38. The purpose of the present study was to assess the validity of continuous metabolic syndrome score (cMetS) for predicting metabolic syndrome (MetS) and to determine the cutoff values in a representative sample...

    Authors: Ramin Heshmat, Motahar Heidari, Hanieh-Sadat Ejtahed, Mohammad Esmaeil Motlagh, Armita Mahdavi-Gorab, Hasan Ziaodini, Majzoubeh Taheri, Gita Shafiee, Shaghayegh Beshtar, Mostafa Qorbani and Roya Kelishadi

    Citation: Diabetology & Metabolic Syndrome 2017 9:89

    Content type: Research

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  39. To describe current prevalence of obesity and related non-communicable diseases (NCDs) in expatriates living in the United Arab Emirates (UAE).

    Authors: Nabil Sulaiman, Salah Elbadawi, Amal Hussein, Salah Abusnana, Abdulrazzag Madani, Maisoon Mairghani, Fatheya Alawadi, Ahmad Sulaiman, Paul Zimmet, Oliver Huse, Jonathan Shaw and Anna Peeters

    Citation: Diabetology & Metabolic Syndrome 2017 9:88

    Content type: Research

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  40. Metabolic syndrome (MetS) is associated with structural and functional vascular abnormalities, which may lead to increased arterial stiffness, more frequent cardiovascular events and higher mortality. However,...

    Authors: Wanda R. P. Lopes-Vicente, Sara Rodrigues, Felipe X. Cepeda, Camila Paixão Jordão, Valéria Costa-Hong, Akothirene C. B. Dutra-Marques, Jefferson C. Carvalho, Maria Janieire N. N. Alves, Luiz A. Bortolotto and Ivani C. Trombetta

    Citation: Diabetology & Metabolic Syndrome 2017 9:87

    Content type: Research

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  41. Previous studies showed that metabolic syndrome is associated with aortic valve calcification (AVC) and poor outcomes in aortic stenosis (AS). However, if these associations change and how body fat impacts the...

    Authors: Jennifer Mancio, Paulo Fonseca, Bruno Figueiredo, Wilson Ferreira, Monica Carvalho, Nuno Ferreira, Pedro Braga, Alberto Rodrigues, Antonio Barros, Ines Falcao-Pires, Adelino Leite-Moreira, Vasco Gama Ribeiro and Nuno Bettencourt

    Citation: Diabetology & Metabolic Syndrome 2017 9:86

    Content type: Research

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  42. Diabetes complications and osteoporotic fractures are two of the most important causes of morbidity and mortality in older patients and share many features including genetic susceptibility, molecular mechanism...

    Authors: Claudia Pinheiro Sanches, Andre Gustavo Daher Vianna and Fellype de Carvalho Barreto

    Citation: Diabetology & Metabolic Syndrome 2017 9:85

    Content type: Review

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  43. DNA methylation is an epigenetic mechanism for regulating the transcription of many genes and has been linked to the development of various diseases. A promising gene to investigate is methylenetetrahydrofolat...

    Authors: Mayara Karla dos Santos Nunes, Alexandre Sérgio Silva, Isabella Wanderley de Queiroga Evangelista, João Modesto Filho, Cecília Neta Alves Pegado Gomes, Rayner Anderson Ferreira do Nascimento, Rafaella Cristhine Pordeus Luna, Maria José de Carvalho Costa, Naila Francis Paulo de Oliveira and Darlene Camati Persuhn

    Citation: Diabetology & Metabolic Syndrome 2017 9:84

    Content type: Research

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  44. There is increasing evidence linking a shift work schedule with various adverse health effects. The present study aimed to examine the relationship between shift work and the metabolic syndrome (MetS) in male ...

    Authors: Yung-Chuan Lu, Chao-Ping Wang, Teng-Hung Yu, I-Ting Tsai, Wei-Chin Hung, I-Cheng Lu, Chia-Chang Hsu, Wei-Hua Tang, Jer-Yiing Houng, Fu-Mei Chung and Mei-Chu Yen Jean

    Citation: Diabetology & Metabolic Syndrome 2017 9:83

    Content type: Research

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  45. Non-alcoholic steatohepatitis (NASH) is highly associated with metabolic syndrome, a major cause of morbidity in the globalized society. The renin–angiotensin system (RAS) influences hepatic fatty acid metabol...

    Authors: F. N. Ramalho, S. C. Sanches, M. C. Foss, M. J. Augusto, D. M. Silva, A. M. Oliveira and L. N. Ramalho

    Citation: Diabetology & Metabolic Syndrome 2017 9:82

    Content type: Research

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  46. During the prediabetic development, the changes in β-cell function and tissue-specific insulin resistance have been described. However, there are conflicting views in insulin secretory capacity between early c...

    Authors: Meng-Chieh Hsu, Mu-En Wang, Yi-Fan Jiang, Hung-Chang Liu, Yi-Chen Chen and Chih-Hsien Chiu

    Citation: Diabetology & Metabolic Syndrome 2017 9:81

    Content type: Research

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  47. Berardinelli-Seip Congenital Lipodystrophy (BSCL) is a rare disease characterized by the almost complete absence of adipose tissue. Although a large number of BSCL cases was previously identified in Rio Grande...

    Authors: Lázaro Batista de Azevedo Medeiros, Verônica Kristina Cândido Dantas, Aquiles Sales Craveiro Sarmento, Lucymara Fassarella Agnez-Lima, Adriana Lúcia Meireles, Thaiza Teixeira Xavier Nobre, Josivan Gomes de Lima and Julliane Tamara Araújo de Melo Campos

    Citation: Diabetology & Metabolic Syndrome 2017 9:80

    Content type: Research

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  48. Diabetes is a risk factor for peripheral, coronary, and cerebrovascular disease. In contrast, results also indicate that patients with diabetes have reduced prevalence of aortic aneurysms, although the mechani...

    Authors: Camilla Krizhanovskii, Stelia Ntika, Christian Olsson, Per Eriksson and Anders Franco-Cereceda

    Citation: Diabetology & Metabolic Syndrome 2017 9:79

    Content type: Research

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  49. It is unknown whether canagliflozin, a selective sodium glucose co-transporter 2 inhibitor, reduces epicardial adipose tissue (EAT) thickness, which is associated with insulin resistance and is a risk factor f...

    Authors: Shusuke Yagi, Yukina Hirata, Takayuki Ise, Kenya Kusunose, Hirotsugu Yamada, Daiju Fukuda, Hotimah Masdan Salim, Gulinu Maimaituxun, Susumu Nishio, Yuriko Takagawa, Saori Hama, Tomomi Matsuura, Koji Yamaguchi, Takeshi Tobiume, Takeshi Soeki, Tetsuzo Wakatsuki…

    Citation: Diabetology & Metabolic Syndrome 2017 9:78

    Content type: Research

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  50. Obesity, metabolic syndrome (MetS), and diabetes are frequent in surgical populations and can enhance susceptibility to postoperative surgical site infections. Reduced neutrophil function has been linked with ...

    Authors: Ingrid Lea Scully, Lisa Kristin McNeil, Sudam Pathirana, Christine Lee Singer, Yongdong Liu, Stanley Mullen, Douglas Girgenti, Alejandra Gurtman, Michael W. Pride, Kathrin Ute Jansen, Paul L. Huang and Annaliesa S. Anderson

    Citation: Diabetology & Metabolic Syndrome 2017 9:76

    Content type: Research

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