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  1. Diabetic foot ulcer (DFU) is a serious chronic complication of diabetes. This study aimed to establish weighted risk models for determining DFU occurrence and severity in diabetic patients.

    Authors: Lu Shi, Huiyi Wei, Tianxiao Zhang, Zhiying Li, Xiaoxian Chi, Dandan Liu, Dandan Chang, Yueying Zhang, Xiaodan Wang and Qingbin Zhao
    Citation: Diabetology & Metabolic Syndrome 2021 13:92
    Content type: Research Published on:

  3. Diabetic nephropathy (DN) is a common complication of diabetes. Long non-coding RNA (lncRNA) cancer susceptibility candidate 2 (CASC2) is reported to exert a protective role in DN by a previous study. The work...

    Authors: Dongju Zhu, Xiang Wu and Qian Xue
    Citation: Diabetology & Metabolic Syndrome 2021 13:89
    Content type: Research Published on:

  4. Dipeptidyl peptidase-4 inhibitors (DPP-4i) provide a unique antihyperglycemic effect by regulating incretin peptides in type 2 diabetes mellitus (T2DM) patients who are inadequately controlled with insulin the...

    Authors: Xin Wei, Yu Bai, Zhuo Wang, Xiaohong Zheng, Zening Jin and Xin Liu
    Citation: Diabetology & Metabolic Syndrome 2021 13:88
    Content type: Research Published on:

  5. The world guidance on the measures of social distancing for prevention of COVID-19 has changed the daily habits of great part of the population, and this could influence the care and resilience with diabetes d...

    Authors: Bárbara Aparecida Binhardi, Carla Regina de Souza Teixeira, Bianca de Almeida-Pititto, Francisco Barbosa-Junior, Laercio Joel Franco, Karla Fabiana Santana de Melo, Domingos Augusto Cherino Malerbi and Rinaldo Eduardo Machado de Oliveira
    Citation: Diabetology & Metabolic Syndrome 2021 13:87
    Content type: Research Published on:

  6. Diabetes mellitus is a serious metabolic disorder which becomes common in middle and low incomes countries since few decades. Microvascular complications include retinopathy, neuropathy and nephropathy all of ...

    Authors: Mohammed Abdu Seid, Yonas Akalu, Yibeltal Yismaw Gela, Yitayeh Belsti, Mengistie Diress, Sofonias Addis Fekadu, Baye Dagnew and Mihret Getnet
    Citation: Diabetology & Metabolic Syndrome 2021 13:86
    Content type: Research Published on:

  7. 1,5-anhydroglucitol is a reduction product of 1,5-anhydrofructose. Circulating 1,5-anhydroglucitol is usually excreted by the kidneys and is reabsorbed via sodium-glucose co-transporter 4 in the renal tubules....

    Authors: Kenji Tanaka, Akiko Sakasai-Sakai, Yasuki Motomiya, Tatsuo Yoneda and Masayoshi Takeuchi
    Citation: Diabetology & Metabolic Syndrome 2021 13:85
    Content type: Research Published on:

  8. Diabetes mellitus (DM) causes excess risk of fracture at varied sites. Whereas, the difference between the roles of types 1 DM (T1DM) and 2 DM (T2DM) diabetes in the risk of fractures remains limited and incon...

    Authors: Jiaqing Dou, Jing Wang and Qiu Zhang
    Citation: Diabetology & Metabolic Syndrome 2021 13:84
    Content type: Research Published on:

  9. Although the well-established role of the HLA genes on the predisposition of type 1 diabetes (T1D), its contribution to the development and progression of diabetic retinopathy is still unclear, especially in a...

    Authors: Deborah Conte Santos, Luís Cristóvão Porto, Marcela Haas Pizarro, Laura Gomes Nunes de Melo, Dayse A. Silva, Romulo Vianna Oliveira, Anna Paula Villela, Luiza Harcar Muniz, Camila Soares, Lucianne Righeti Monteiro Tannus, Karla Rezende Guerra Drummond, André Araújo Pinheiro, Felipe Mallmann, Franz Schubert Lopes Leal, Fernando Korn Malerbi, Paulo Henrique Morales…
    Citation: Diabetology & Metabolic Syndrome 2021 13:83
    Content type: Research Published on:

  10. We investigated the association of anthropometric indices including body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), and hip circumference (HC) with the ...

    Authors: Seyyed Saeed Moazzeni, Seyed Saeed Tamehri Zadeh, Samaneh Asgari, Fereidoun Azizi and Farzad Hadaegh
    Citation: Diabetology & Metabolic Syndrome 2021 13:82
    Content type: Research Published on:

  11. Atherosclerotic cardiovascular diseases are the leading cause of adverse outcomes in patients with type 2 diabetes, and all new anti-diabetic agents are mandated to undergo cardiovascular outcome trials (CVOTs...

    Authors: Miguel Melo, Cristina Gavina, José Silva-Nunes, Luís Andrade and Davide Carvalho
    Citation: Diabetology & Metabolic Syndrome 2021 13:81
    Content type: Review Published on:

  12. The aim of this study was to compare individuals with type 1 diabetes with continuous subcutaneous insulin infusion (CSII) and intensified insulin therapy (ICT) in routine care regarding metabolic control and ...

    Authors: Guido Kramer, Christof Kloos, Ulrich A. Müller, Gunter Wolf and Nadine Kuniss
    Citation: Diabetology & Metabolic Syndrome 2021 13:80
    Content type: Research Published on:

  13. Several studies have demonstrated suppressed levels of acylated (AG) and unacylated ghrelin (UAG) in patients with type 2 diabetes. However, the role of these hormones in type 1 diabetes has not been extensive...

    Authors: Behiye Özcan, Patric J. D. Delhanty, Martin Huisman, Jenny A. Visser, Sebastian J. Neggers and Aart Jan van der Lely
    Citation: Diabetology & Metabolic Syndrome 2021 13:79
    Content type: Research Published on:

  14. Authors: Samereh Abdoli, Monica S. V. M. Silveira, Mehri Doosti-Irani, Paulo Fanti, Katherine Miller-Bains, Elizabeth João Pavin, Edimariz Buin Cardoso, Leila Rafee Vardanjani, Kobra Noorian and Danielle Hessler
    Citation: Diabetology & Metabolic Syndrome 2021 13:78
    Content type: Correction Published on:

    The original article was published in Diabetology & Metabolic Syndrome 2021 13:63

  15. To investigate the impact of microecological preparation combined with modified low-carbon diet on the glucolipid metabolism and cardiovascular complication in obese patients.

    Authors: Jianguo Liu, Liehui Xiao, Hezhongrong Nie, Yong Pan, Yan Liu, Zhentian Zhang, Xiuping Lin, Yuan Zhang, Jinchuang Cai, Muxiu Yang, Yajing Liu, Leijun Zhang, Aimin Xu and Cuifeng Zhu
    Citation: Diabetology & Metabolic Syndrome 2021 13:77
    Content type: Research Published on:

  16. COVID-19 has stroke Brazil harshly, deaths by COVID-19 in Brazil represent almost 13% of the total deaths by COVID-19 in the world, even though Brazilian population represents only 2.6% of the world population...

    Authors: Rodrigo Esaki Tamura, Said Muhammad Said, Leticia Mussin de Freitas and Ileana Gabriela Sanchez Rubio
    Citation: Diabetology & Metabolic Syndrome 2021 13:76
    Content type: Research Published on:

  17. Previous studies have analyzed the potential effect of KCNQ1 rs2237892 polymorphism on the predisposition to type 2 diabetes mellitus, but the findings are inconclusive and the subject of debate. The purpose of o...

    Authors: Hong-Liang Jiang, Han Du, Ying-Jun Deng and Xue Liang
    Citation: Diabetology & Metabolic Syndrome 2021 13:75
    Content type: Research Published on:

  18. We investigate the effect of aerobic physical training (APT) on muscle morphofunctional markers and Angiotensin Converting Enzyme 2/Angiotensin 1-7/Mas receptor (ACE2/Ang 1-7/Mas) axis in an obesity-linked ins...

    Authors: Bruno Vecchiatto, Rafael C. da Silva, Talita S. Higa, Cynthia R. Muller, Anna Laura V. Américo, Vanessa C. Fortunato-Lima, Marília M. Ferreira, Luiz Felipe Martucci, Miriam H. Fonseca-Alaniz and Fabiana S. Evangelista
    Citation: Diabetology & Metabolic Syndrome 2021 13:74
    Content type: Research Published on:

  19. Pregnant women with a history of gestational diabetes mellitus (GDM) are at high risk of GDM. It is unclear whether this population has pregnancy characteristics different from the general population. Whether ...

    Authors: Xin Liang, Wei Zheng, Cheng Liu, Lirui Zhang, Li Zhang, Zhihong Tian and Guanghui Li
    Citation: Diabetology & Metabolic Syndrome 2021 13:73
    Content type: Research Published on:

  20. Circular RNAs (circRNAs) have been considered as pivotal biomarkers in Diabetic nephropathy (DN). CircRNA ARP2 actin-related protein 2 homolog (circ-ACTR2) could promote the HG-induced cell injury in DN. Howev...

    Authors: Jie Yun, Jinyu Ren, Yufei Liu, Lijuan Dai, Liqun Song, Xiaopeng Ma, Shan Luo and Yexu Song
    Citation: Diabetology & Metabolic Syndrome 2021 13:72
    Content type: Research Published on:

  21. Stroke is a serious complication in patients with type 2 diabetes (T2DM). Arterial stiffness may improve stroke prediction. We investigated the association between carotid-femoral pulse wave velocity [PWV] and...

    Authors: Kristian L. Funck, Esben Laugesen, Pernille Høyem, Brian Stausbøl-Grøn, Won Y. Kim, Leif Østergaard, Dora Grauballe, Troels K. Hansen, Christian S. Buhl and Per L. Poulsen
    Citation: Diabetology & Metabolic Syndrome 2021 13:71
    Content type: Research Published on:

  22. Serum fatty acid-binding protein 4 (FABP4), as an intracellular lipid chaperone and adipokine, was reported to be related to the incidence of type 2 diabetes (T2D) and diabetic complications, but its associati...

    Authors: Hong Wang, Jie Cao, Jian-bin Su, Xue-qin Wang, Xing Wang, Dong-mei Zhang and Xiao-hua Wang
    Citation: Diabetology & Metabolic Syndrome 2021 13:70
    Content type: Research Published on:

  23. Diabetes mellitus (DM) is a major risk factor for contrast-induced acute kidney injury (CI-AKI). DM and CI-AKI result in oxidative damage and inflammation that can be reduced when treated with the coenzyme Q-1...

    Authors: Sheila Marques Fernandes Couto, Cassiane Dezoti da Fonseca, Mirian Watanabe and Maria de Fátima Fernandes Vattimo
    Citation: Diabetology & Metabolic Syndrome 2021 13:69
    Content type: Research Published on:

  24. Patients with type 2 diabetes mellitus (T2DM) from Latin American countries face challenges in access to healthcare, leading to under-diagnosis, under-achievement of glycemic target, and long-term complication...

    Authors: Sérgio Vencio, Juan P. Manosalva, Chantal Mathieu, Pieter Proot, Hernan Yupanqui Lozno and Päivi M. Paldánius
    Citation: Diabetology & Metabolic Syndrome 2021 13:68
    Content type: Research Published on:

  25. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Himani Thakkar, Vinnyfred Vincent, Sakshi Shukla, Manraj Sra, Uma Kanga, Sandeep Aggarwal and Archna Singh
    Citation: Diabetology & Metabolic Syndrome 2021 13:67
    Content type: Correction Published on:

    The original article was published in Diabetology & Metabolic Syndrome 2021 13:46

  26. To provide the latest evidence of performance and robustness of waist-to-height ratio (WHtR) in discriminating clusters of cardiometabolic risk factors (CMRs) and promote WHtR in routine primary health care pr...

    Authors: Yuan Jiang, Yalan Dou, Hongyan Chen, Yi Zhang, Xiaotian Chen, Yin Wang, Myanca Rodrigues and Weili Yan
    Citation: Diabetology & Metabolic Syndrome 2021 13:66
    Content type: Research Published on:

  27. A new strain of human coronavirus (HCoV) spread rapidly around the world. Diabetes and obesity are associated with a worse prognosis in these patients. Congenital Generalized Lipodystrophy (CGL) patients gener...

    Authors: Mayara Ponte Madeira, Erika Bastos Lima Freire, Virginia Oliveira Fernandes, Grayce Ellen da Cruz Paiva Lima, Ivana da Ponte Melo, Ana Paula Dias Rangel Montenegro, José Ednésio da Cruz Freire, Caroline de Fátima Aquino Moreira-Nunes, Raquel Carvalho Montenegro, Jeová Keny Baima Colares and Renan Magalhães Montenegro Junior
    Citation: Diabetology & Metabolic Syndrome 2021 13:65
    Content type: Research Published on:

  28. Diabetes mellitus (DM) is a prevalent disease among elderly population. As the disease progresses, insulin may become necessary. The use of pens application seems to be more practical. However, the influence o...

    Authors: Rafael Vaz Machry, Gustavo Fonseca Cipriani, Henrique Umpierre Pedroso, Rafaela Ramos Nunes, Thayme Luisa Souza Pires, Raquel Ferreira, Betina Vescovi, Gabriela Pereira de Moura and Ticiana Costa Rodrigues
    Citation: Diabetology & Metabolic Syndrome 2021 13:64
    Content type: Research Published on:

  29. The COVID-19 pandemic is a global public health emergency, which presents wide-ranging negative impacts on individuals with diabetes. To examine psychosocial well-being and diabetes outcomes in individuals wit...

    Authors: Samereh Abdoli, Monica S. V. M. Silveira, Mehri Doosti-Irani, Paulo Fanti, Katherine Miller-Bains, Elizabeth João Pavin, Edimariz Buin Cardoso, Leila Rafiee Vardanjani, Kobra Noorian and Danielle Hessler
    Citation: Diabetology & Metabolic Syndrome 2021 13:63
    Content type: Research Published on:

    The Correction to this article has been published in Diabetology & Metabolic Syndrome 2021 13:78

  30. Research elucidating the metabolic mechanisms that differentiate subtypes of obesity has been increasing. We aimed to investigate the effects of a 12-week dietary intervention on the metabolomic profiles of ob...

    Authors: Hye Yoon Jang, Youngmin Han, Hye Jin Yoo, Jong Ho Lee and Minjoo Kim
    Citation: Diabetology & Metabolic Syndrome 2021 13:62
    Content type: Research Published on:

  31. Prediabetes is characterized by a hemoglobin A1c of 5.7–6.4% and fasting blood glucose of 100–125 mg/dl. A high percentage of prediabetes subjects develop type 2 diabetes mellitus in the next years. The effect...

    Authors: Shatha Rouf Moustafa
    Citation: Diabetology & Metabolic Syndrome 2021 13:61
    Content type: Research Published on:

  32. Laminin, one of the largest glycoproteins of the basement membrane, is an important component of the extracellular matrix. Functions of the basement membrane include regulation of cell signaling behaviors and ...

    Authors: Özgür Altun, Yücel Arman, Şengül Aydın Yoldemir, Ayşe Selcen Pala, Perihan Özkan Gümüşkaya, Mustafa Özcan, Mustafa Karataş, Okan Dikker and Tufan Tükek
    Citation: Diabetology & Metabolic Syndrome 2021 13:60
    Content type: Research Published on:

  33. To identify genetic associations of quantitative metabolic syndrome (MetS) traits and characterize heterogeneity across ethnic groups.

    Authors: Jia Y. Wan, Deborah L. Goodman, Emileigh L. Willems, Alexis R. Freedland, Trina M. Norden-Krichmar, Stephanie A. Santorico and Karen L. Edwards
    Citation: Diabetology & Metabolic Syndrome 2021 13:59
    Content type: Research Published on:

  34. Gestational diabetes mellitus (GDM) is the most common medical complication of pregnancy. CircRNA polyribonucleotide nucleotidyltransferase 1 (circ-PNPT1) has been found to be abnormally expressed in GDM patie...

    Authors: Li Zhang, Ming Zeng, Fei Tang, Jun Chen, Dongmei Cao and Ze-nan Tang
    Citation: Diabetology & Metabolic Syndrome 2021 13:58
    Content type: Research Published on:

  35. Adipocytokines, which are secreted by the adipose tissue, contribute to the pathogenesis of obesity-related complications. To evaluate this assumption, we investigated the effects of aerobic exercise training ...

    Authors: Hamideh Dinari Ghozhdi, Ali Heidarianpour, Maryam Keshvari and Hassan Tavassoli
    Citation: Diabetology & Metabolic Syndrome 2021 13:57
    Content type: Research Published on:

  36. Roux-en-Y gastric bypass (RYGB) surgery is one of the most efficient procedures for the treatment of obesity, also improving metabolic and inflammatory status, in patients with mild obesity. The underlying mec...

    Authors: Eva Lau, Eugeni Belda, Paul Picq, Davide Carvalho, Manuel Ferreira-Magalhães, Maria Manuel Silva, Isaac Barroso, Flora Correia, Cidália Pina Vaz, Isabel Miranda, Adelino Barbosa, Karine Clément, Joel Doré, Paula Freitas and Edi Prifti
    Citation: Diabetology & Metabolic Syndrome 2021 13:56
    Content type: Research Published on:

  37. This study aims to analyze the patient-reported outcome (PRO) of treatment satisfaction in a sample of children, adolescents and young adults with long-duration type 1 diabetes and to determine potential risk ...

    Authors: Anna Stahl-Pehe, Silvia Selinski, Christina Bächle and Joachim Rosenbauer
    Citation: Diabetology & Metabolic Syndrome 2021 13:55
    Content type: Short report Published on:

  38. Type 2 diabetes (T2D) is a chronic low-grade inflammatory disease, which characterized by islet beta cell dysfunction. Serum adenosine deaminase (ADA) is an important enzyme that regulates the biological activ...

    Authors: Jie Cao, Hong Wang, Jian-bin Su, Xue-qin Wang, Dong-mei Zhang, Xiao-hua Wang, Wang-shu Liu and Xiao-qin Ge
    Citation: Diabetology & Metabolic Syndrome 2021 13:54
    Content type: Research Published on:

  39. We aim to assess the association of empirical dietary (EDIH) and lifestyle (ELIH) index for hyperinsulinemia with the risk of insulin resistance, hyperinsulinemia, insulin sensitivity, and β-cell dysfunction i...

    Authors: Ebrahim Mokhtari, Hossein Farhadnejad, Farshad Teymoori, Parvin Mirmiran and Fereidoun Azizi
    Citation: Diabetology & Metabolic Syndrome 2021 13:53
    Content type: Research Published on:

  40. This study aimed to examine the effects of l-citrulline (l-CIT) on low-grade inflammation (meta-inflammation) and insulin sensitivity in type 2 diabetes (T2D) patients since it has exhibited hypoglycemic and anti...

    Authors: Fatemeh Abbaszadeh, Samaneh Azizi, Majid Mobasseri and Mehrangiz Ebrahimi-Mameghani
    Citation: Diabetology & Metabolic Syndrome 2021 13:52
    Content type: Research Published on:

  41. The adipokine asprosin, which was recently discovered, facilitates hepatic glucose production. The aim of this study is to see whether serum asprosin concentrations are linked to diabetic nephropathy (DN).

    Authors: Rui Wang, Peng Lin, Huibo Sun and Wenchao Hu
    Citation: Diabetology & Metabolic Syndrome 2021 13:51
    Content type: Research Published on:

  42. Hesperidin, a natural flavanone, has been proven to have multiple protective effects in diabetic rats, such as antioxidant, anti-inflammatory and anti-apoptotic effects. However, the molecular mechanisms under...

    Authors: Miao Tian, Yu-Bo Han, Cheng-Cheng Zhao, Li Liu and Fu-Li Zhang
    Citation: Diabetology & Metabolic Syndrome 2021 13:50
    Content type: Research Published on:

  43. As a subcomponent of low-density lipoprotein cholesterol (LDL-C), small dense LDL-C (sdLDL-C) has been suggested to be a better predictor of cardiovascular diseases (CVD). The aim of this research was to evalu...

    Authors: Li Xu, Xu Chen, Jingfen Lu, Yan Xu, Honglin Yang, Xuewen Zhou, Jun Zhou, Jianhong Xu and Hao Shen
    Citation: Diabetology & Metabolic Syndrome 2021 13:49
    Content type: Research Published on:

  44. Atherosclerosis cardiovascular disease (ASCVD) is the main cause of morbidity and mortality in type 2 diabetes mellitus (T2DM). As most diabetic patients with ASCVD are asymptomatic, it is most neglected in cl...

    Authors: Lu Gao, Wei Zhao, Jin-Kui Yang and Ming-Zhao Qin
    Citation: Diabetology & Metabolic Syndrome 2021 13:48
    Content type: Research Published on:

  45. This claims-based retrospective cohort study examined the prevalence and incremental impact of non-alcoholic steatohepatitis among children with type 2 diabetes mellitus in the United States. Although diagnose...

    Authors: Lauren Parlett, Qinli Ma, Qian Shi, Geoffrey Crawford, Laura Herrera Scott, Vincent Willey and Abiy Agiro
    Citation: Diabetology & Metabolic Syndrome 2021 13:47
    Content type: Letter to the Editor Published on:

  46. Bariatric surgery can alleviate cardiovascular risk via effects on cardiovascular disease (CVD) risk factors such as diabetes mellitus, hypertension, and dyslipidemia. Our study aimed to assess the cholesterol...

    Authors: Himani Thakkar, Vinnyfred Vincent, Sakshi Shukla, Manraj Sra, Uma Kanga, Sandeep Aggarwal and Archna Singh
    Citation: Diabetology & Metabolic Syndrome 2021 13:46
    Content type: Research Published on:

    The Correction to this article has been published in Diabetology & Metabolic Syndrome 2021 13:67

  47. HbA1c variability is independent of mean HbA1c, and associated with mortality due to vascular complications. However, the significance of HbA1c variability is unknown at present. In this study, we used flash g...

    Authors: Akemi Tokutsu, Yosuke Okada, Keiichi Torimoto and Yoshiya Tanaka
    Citation: Diabetology & Metabolic Syndrome 2021 13:45
    Content type: Research Published on:

  48. The impact of subcutaneous fat accumulation remains controversial. This study assessed the association between visceral or subcutaneous fat area (VFA and SFA, respectively) and diabetes mellitus (DM) among Jap...

    Authors: Hirohide Yokokawa, Hiroshi Fukuda, Mizue Saita, Kento Goto, Tengen Kaku, Taiju Miyagami, Yuichi Takahashi, Chieko Hamada, Teruhiko Hisaoka and Toshio Naito
    Citation: Diabetology & Metabolic Syndrome 2021 13:44
    Content type: Research Published on:

  49. Metformin plays a consolidated role in the management of polycystic ovary syndrome (PCOS). However, there is no clear answer on how long we should treat and on how long its beneficial impact sustain after we s...

    Authors: Nika Aleksandra Kravos, Andrej Janež, Katja Goričar, Vita Dolžan and Mojca Jensterle
    Citation: Diabetology & Metabolic Syndrome 2021 13:43
    Content type: Research Published on:

  50. Obesity is considered a major health concern and mounting evidence suggests that the exposure to environmental endocrine disruptors, including Bisphenol-A (BPA), may enhance the risk to develop the disease. Mo...

    Authors: Amin Salehpour, Farzad Shidfar, Mehdi Hedayati, Ali Asghar Farshad, Asal Neshatbini Tehrani and Saeed Mohammadi
    Citation: Diabetology & Metabolic Syndrome 2021 13:41
    Content type: Research Published on:


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