Articles

Molecular basis of the anti-hyperglycemic activity of RA-3 in hyperlipidemic and streptozotocin-induced type 2 diabetes in rats

Insulin resistance is a hallmark of type 2 diabetes mellitus (T2DM) and the underlying cause of various metabolic changes observed in type 2 diabetic patients. This study investigated the molecular basis of th...

Authors: Sihle Ephraim Mabhida, Rabia Johnson, Musawenkosi Ndlovu, Johan Louw, Andrew Opoku and Rebamang Anthony Mosa

Prevalence of metabolic syndrome and the comparison of fasting plasma glucose and HbA1c as the glycemic criterion for MetS definition in non-diabetic population in Ghana

Glycated hemoglobin (HbA1c), owing to its ability to reflect glycemia over a relatively longer time span, is still been investigated as an adjunct test for fasting plasma glucose (FPG) to identify subjects at ...

Authors: Max Efui Annani-Akollor, Edwin Ferguson Laing, Henry Osei, Evans Mensah, Eddie-Williams Owiredu, Bright Oppong Afranie and Enoch Odame Anto

The relationship between mean platelet volume and diabetic retinopathy: a systematic review and meta-analysis

Diabetic retinopathy (DR) is one of the most common diseases causing blindness in the world, and most patients are already in advanced stage. Recent years, many studies reported mean platelet volume (MPV) may ...

Authors: ShuaiFei Ji, Jie Zhang, XiuDe Fan, XiQiang Wang, XiaoNa Ning, BaBo Zhang, Heng Shi and Hong Yan

Differential role of insulin resistance and β-cell function in the development of prediabetes and diabetes in middle-aged and elderly Chinese population

The prevalence of diabetes and prediabetes were estimated to be 10.9% and 35.7% in the Chinese adult population, respectively, and the middle-aged and elderly Chinese are at even higher risk of diabetes and pr...

Authors: Xueli Cai, Lili Xia, Yuesong Pan, Dian He, Huiping Zhu, Tiemin Wei and Yan He

Physical inactivity as risk factor for mortality by diabetes mellitus in Brazil in 1990, 2006, and 2016

The aims of this study were to estimate the mortality due to diabetes mellitus attributed to physical inactivity in Brazil, to analyze these estimate in three points in time (1990, 2006 and, 2016), and to anal...

Authors: Diego Augusto Santos Silva, Mohsen Naghavi, Bruce B. Duncan, Maria Inês Schmidt, Maria de Fatima Marinho de Souza and Deborah Carvalho Malta

Stem cells from human exfoliated deciduous teeth ameliorate type II diabetic mellitus in Goto-Kakizaki rats

By 2030, diabetes mellitus (DM) will be the 7th leading cause of death worldwide. Type 2 DM (T2DM) is the most common type of DM and is characterized by insulin resistance and defective β-cell secretory functi...

Authors: Nanquan Rao, Xiaotong Wang, Yue Zhai, Jingzhi Li, Jing Xie, Yuming Zhao and Lihong Ge

People with type 2 diabetes and screen-detected cognitive impairment use acute health care services more often: observations from the COG-ID study

Patients with type 2 diabetes have an increased risk of cognitive impairment which can lead to impaired diabetes self-management and an increased risk of diabetes-related complications. Routine screening for c...

Authors: Jolien Janssen, Paula S. Koekkoek, Geert Jan Biessels, L. Jaap Kappelle and Guy E. H. M. Rutten

Stem cells as a potential therapy for diabetes mellitus: a call-to-action in Latin America

Latin America is a fast-growing region that currently faces unique challenges in the treatment of all forms of diabetes mellitus. The burden of this disease will be even greater in the coming years due, in par...

Authors: Mairim Alexandra Solis, Ilais Moreno Velásquez, Ricardo Correa and Lynn L. H. Huang

Hormonal assessment of participants in a long distance walk

Exercise can disrupt homeostasis and trigger many adaptive responses in different hormonal axes. The study of hormonal interactions with physical activity is highly complex due to the number of variables, such...

Authors: Haroldo Silva de Souza, Thiago Veiga Jardim, Weimar Kunz Sebba Barroso, Priscila Valverde de Oliveira Vitorino, Ana Luiza Lima Souza and Paulo César Veiga Jardim

Hypoglycemia in blood glucose level in type 2 diabetic Japanese patients by continuous glucose monitoring

Hypoglycemia is associated with cardiovascular diseases, increased risk of death. Therefore, it is important to avoid hypoglycemia. The aim of this study was to characterize hypoglycemia according to glycated ...

Authors: Maiko Hajime, Yosuke Okada, Hiroko Mori, Fumi Uemura, Satomi Sonoda, Kenichi Tanaka, Akira Kurozumi, Manabu Narisawa, Keiichi Torimoto and Yoshiya Tanaka

Multiple poor sleep characteristics and metabolic abnormalities consistent with metabolic syndrome among white, black, and Hispanic/Latina women: modification by menopausal status

Poor sleep is a potential risk factor for metabolic syndrome (MetS), and its relationship with MetS may vary by race/ethnicity and menopausal status among women.

Authors: Symielle A. Gaston, Yong-Moon Park, Ketrell L. McWhorter, Dale P. Sandler and Chandra L. Jackson

Empirical dietary inflammatory pattern and risk of metabolic syndrome and its components: Tehran Lipid and Glucose Study

The rising incidence of metabolic syndrome (MetS) is a major public health problem. The inflammatory potential of diet contributes to the development of MetS. The aim of this study was to investigate the relat...

Authors: Zeinab Shakeri, Parvin Mirmiran, Sajjad Khalili-Moghadam, Firoozeh Hosseini-Esfahani, Asal Ataie-Jafari and Fereidoun Azizi

Beneficial effects of 6-shogaol on hyperglycemia, islet morphology and apoptosis in some tissues of streptozotocin-induced diabetic mice

Diabetes is characterized by hyperglycemia due to impaired insulin secretion and aberrant glucagon secretion resulting from changes in pancreatic islet cell function and/or mass. The aim of the present study w...

Authors: Jun-Koo Yi, Zae-Young Ryoo, Jae-Jung Ha, Dong-Yep Oh, Myoung-Ok Kim and Sung-Hyun Kim

Reduced plasma albumin predicts type 2 diabetes and is associated with greater adipose tissue macrophage content and activation

Plasma albumin is reduced during inflammation. Obesity, a strong risk factor for type 2 diabetes (T2D), is associated with adipose tissue inflammation. However, whether albumin is associated with adipose tissu...

Authors: Douglas C. Chang, Xiaoyuan Xu, Anthony W. Ferrante Jr. and Jonathan Krakoff

Oxidative stress and adipokine levels were significantly correlated in diabetic patients with hyperglycemic crises

To investigate the relationship between blood adipokine level and oxidative stress in diabetic patients with hyperglycemic crises before and after treatment.

Authors: Juan Li and Xingping Shen

Potential impact of the joint association of total bilirubin and gamma-glutamyltransferase with metabolic syndrome

Metabolic syndrome is characterized by the clustering of different metabolic abnormalities. Total bilirubin and gamma-glutamyltransferase (GGT) levels have been reported to be associated with this condition. H...

Authors: Makoto Shiraishi, Muhei Tanaka, Hiroshi Okada, Yoshitaka Hashimoto, Shinichi Nakagawa, Muneaki Kumagai, Teruyuki Yamamoto, Hiromi Nishimura, Yohei Oda and Michiaki Fukui

The impact of diagnostic criteria for gestational diabetes on its prevalence: a systematic review and meta-analysis

The absence of universal gold standards for screening of gestational diabetes (GDM) has led to heterogeneity in the identification of GDM, thereby impacting the accurate estimation of the prevalence of GDM. We...

Authors: Samira Behboudi-Gandevani, Mina Amiri, Razieh Bidhendi Yarandi and Fahimeh Ramezani Tehrani

Effect of TCF7L2 polymorphism on pancreatic hormones after exenatide in type 2 diabetes

Glucagon-like peptide 1 (GLP-1) stimulates insulin secretion and reduces blood glucose in type 2 diabetes mellitus (T2DM). TCF7L2 rs7903146 polymorphism has been associated with decreased insulin secretion, reduc...

Authors: Mari Cassol Ferreira, Maria Elizabeth Rossi da Silva, Rosa Tsuneshiro Fukui, Maria do Carmo Arruda-Marques, Salman Azhar and Rosa Ferreira dos Santos

1α,25(OH)₂D₃ attenuates IL-6 and IL-1β-mediated inflammatory responses in macrophage conditioned medium-stimulated human white preadipocytes by modulating p44/42 MAPK and NF-κB signaling pathways

Metabolic syndrome is characterized by macrophage infiltration and inflammatory responses—metaflammation in adipose tissue. IL-6 and IL-1β could mediate the inflammatory responses in macrophage stimulated-prea...

Authors: Jingjing Zhu, Chen Bing and John P. H. Wilding

Leptin-deficient mice have altered three-dimensional growth plate histomorphometry

Leptin is an adipokine that regulates energy homeostasis and is also needed for normal bone growth and maintenance. Mutation in the lep gene, which characterizes the ob/ob mouse model, results in the development ...

Authors: Jun Hung, Layla Al-Nakkash, Tom L. Broderick, Monica Castro and Jeffrey H. Plochocki

Diabetic nephropathy: recent advances in pathophysiology and challenges in dietary management

Diabetic nephropathy (DN) or diabetic kidney disease refers to the deterioration of kidney function seen in chronic type 1 and type 2 diabetes mellitus patients. The progression of the disease is known to occu...

Authors: Mahaboob Khan Sulaiman

Low empowerment and diabetes regimen distress are related to HbA1c in low income type 1 diabetes patients in a Brazilian tertiary public hospital

Adults with type 1 diabetes (T1D) have a high risk of developing depressive symptoms and diabetes-related distress (DD). Low socioeconomic level is associated with increased risk of poor self-management, treat...

Authors: M. S. V. M. Silveira, A. Moura Neto, A. C. Sposito, L. Siminerio and E. J. Pavin

Probiotic assisted weight management as a main factor for glycemic control in patients with type 2 diabetes: a randomized controlled trial

To evaluate the effect of Lactobacillus casei 01 on dietary intake, body weight, and glycemic control in patients with T2DM.

Authors: Leila Khalili, Beitullah Alipour, Mohammad Asghari Jafarabadi, Tohid Hassanalilou, Mehran Mesgari Abbasi and Ismail Faraji

The MTHFR promoter hypermethylation pattern associated with the A1298C polymorphism influences lipid parameters and glycemic control in diabetic patients

Polymorphisms in the gene encoding methylenetetrahydrofolate reductase (MTHFR) have been investigated as risk factors for microvascular complications of diabetes; however, simultaneous analysis of these polymo...

Authors: Herlanny Santana Bezerra, Caroline Severo de Assis, Mayara Karla dos Santos Nunes, Isabella Wanderley de Queiroga Evangelista, João Modesto Filho, Cecília Neta Alves Pegado Gomes, Rayner Anderson Ferreira do Nascimento, Rafaella Cristhine Pordeus Luna, Maria José de Carvalho Costa, Naila Francis Paulo de Oliveira and Darlene Camati Persuhn

Metabolic syndrome is a risk factor for cancer mortality in the general Japanese population: the Jichi Medical School Cohort Study

Metabolic syndrome (MetS) and cancer are major public health problems worldwide. The relationship between MetS and cancer death is of great interest. We examined the predictive value of MetS for cancer mortali...

Authors: Jun Watanabe, Eiichi Kakehi, Kazuhiko Kotani, Kazunori Kayaba, Yosikazu Nakamura and Shizukiyo Ishikawa

Short-acting insulin analogues versus regular human insulin on postprandial glucose and hypoglycemia in type 1 diabetes mellitus: a systematic review and meta-analysis

Strict glucose control using multiple doses of insulin is the standard treatment for type 1 diabetes mellitus (T1DM), but increased risk of hypoglycemia is a frequent drawback. Regular insulin in multiple dose...

Authors: Karla F. S. Melo, Luciana R. Bahia, Bruna Pasinato, Gustavo J. M. Porfirio, Ana Luiza Martimbianco, Rachel Riera, Luis E. P. Calliari, Walter J. Minicucci, Luiz A. A. Turatti, Hermelinda C. Pedrosa and Beatriz D. Schaan

Evaluation of the hypothalamic–pituitary–adrenal axis in a case series of familial partial lipodystrophy

Familial partial lipodystrophy (FPL) is a rare genetic disease characterized by body fat abnormalities that lead to insulin resistance (IR). Clinical conditions linked to milder IR, such as type 2 diabetes (T2...

Authors: Cecília Pacheco Elias, Daniela Espíndola Antunes, Michella Soares Coelho, Caroline Lourenço de Lima, Nelson Rassi, Ana Paula Meireles de Melo and Angélica Amorim Amato

Anti-inflammatory effects of empagliflozin in patients with type 2 diabetes and insulin resistance

Inflammation might be a pathological mediator of cardiovascular events in patients with type 2 diabetes and high cardiovascular risk.

Authors: Sachiko Hattori

To the editor regarding article “Coadministration of DPP-4 inhibitor and insulin therapy does not further reduce the risk of cardiovascular events compared with DPP-4 inhibitor therapy in diabetic foot patients: a nationwide population-based study”

Authors: Florian J. Mayer, Gerfried Pesau and Gerit H. Schernthaner

Liraglutide ameliorates beta-cell function, alleviates oxidative stress and inhibits low grade inflammation in young patients with new-onset type 2 diabetes

The prevalence of type 2 diabetes in youth is escalating rapidly. We aimed to evaluate the effects of liraglutide on beta-cell function, metabolic productions of oxidative stress, low grade inflammation compar...

Authors: Wen-qiang Zhang, Yuan Tian, Xiao-min Chen, Li-fen Wang, Chan-chan Chen and Chuan-mei Qiu

Evaluating the Diabetes–Cardiology interface: a glimpse into the diabetes management of cardiology inpatients in western Sydney’s ‘diabetes hotspot’ and the establishment of a novel model of care

Approximately two-thirds of individuals presenting to emergency departments in Western Sydney have glucose dysregulation, accelerating their risk of cardiovascular disease (CVD). We evaluated the prevalence an...

Authors: Ramy H. Bishay, Gideon Meyerowitz-Katz, David Chandrakumar, Rajini Jayaballa, Tien-Ming Hng, Mark Mclean, Dilini Punchihewa, Maiyoori Jeyaprakash, David Burgess, John Riskallah and Glen F. Maberly

Antidiabetic efficacy of lactoferrin in type 2 diabetic pediatrics; controlling impact on PPAR-γ, SIRT-1, and TLR4 downstream signaling pathway

The current study aims to investigate the antidiabetic efficacy of camel milk-derived lactoferrin and potential involvement of PPAR-γ and SIRT-1 via TLR-4/NFκB signaling pathway in obese diabetic pediatric pop...

Authors: Waleed A. Mohamed and Mona F. Schaalan

Fasting plasma mannose levels are associated with insulin sensitivity independent of BMI in Japanese individuals with diabetes

Recently, an integrated network analysis has revealed dysregulation in the metabolism of mannose, a glucose epimer, in severely obese individuals without diabetes. In addition, fasting plasma mannose levels (M₀) ...

Authors: Eri Amano, Shogo Funakoshi, Kumiko Yoshimura, Seiki Hirano, Satoko Ohmi, Hiroshi Takata, Yoshio Terada and Shimpei Fujimoto

Exploring structural barriers to diabetes self-management in Alberta First Nations communities

Type 2 diabetes is highly prevalent in Canadian First Nations (FN) communities. FN individuals with diabetes are less likely to receive guideline recommended care and access specialist care. They are also less...

Authors: Stephanie Kulhawy-Wibe, Kathryn M. King-Shier, Cheryl Barnabe, Braden J. Manns, Brenda R. Hemmelgarn and David J. T. Campbell

The association between attitude, self-efficacy, and social support and adherence to diabetes self-care behavior

Diabetes is a chronic illness which requires lifelong self-care behaviors. The objective of the present research was to investigate the association of self-efficacy, attitude and social support with adherence ...

Authors: Mahmood Karimy, Hamid Reza Koohestani and Marzieh Araban

Insulin Injection Technique Questionnaire: results of an international study comparing Brazil, Latin America and World data

In 2014–2015, the largest international survey of insulin injection technique in patients with diabetes taking insulin was conducted in 42 countries, totaling 13,289 participants. In Brazil, patients from five...

Authors: Luis Eduardo Calliari, Laura Cudizio, Balduino Tschiedel, Hermelinda C. Pedrosa, Rosangela Rea, Augusto Pimazoni-Netto, Laurence Hirsch and Kenneth Strauss

Population attributable fractions for Type 2 diabetes: an examination of multiple risk factors including symptoms of depression and anxiety

Population attributable fractions (PAFs) are frequently used to quantify the proportion of Type 2 diabetes cases due to single risk factors, an approach which may result in an overestimation of their individua...

Authors: Kiyuri Naicker, Douglas Manuel, Simon Øverland, Jens C. Skogen, Jeffrey A. Johnson, Børge Sivertsen and Ian Colman

Hypoglycemia incidence and awareness among insulin-treated patients with diabetes: the HAT study in Brazil

Hypoglycemia affects patient safety and glycemic control during insulin treatment of both type 1 (T1DM) and type 2 diabetes mellitus (T2DM). The Hypoglycemia Assessment Tool study in Brazil aimed to determine ...

Authors: Rodrigo Nunes Lamounier, Bruno Geloneze, Silmara Oliveira Leite, Renan Montenegro Jr., Lenita Zajdenverg, Milene Fernandes, Fabiano de Oliveira Griciunas, Mariana Narbot Ermetice and António Roberto Chacra

Neck circumference is associated with non-traditional cardiovascular risk factors in individuals at low-to-moderate cardiovascular risk: cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Neck circumference (NC) is associated with traditional cardiovascular risk factors (CVRF), but its usefulness to identify earlier atherogenic risk has been scarcely examined. Associations of NC with non-tradit...

Authors: B. Almeida-Pititto, I. T. Silva, A. C. Goulart, M. I. H. Fonseca, M. S. Bittencourt, R. D. Santos, M. Blaha, S. Jones, P. P. Toth, K. Kulakarni, P. A. Lotufo, I. M. Bensenor and S. R. G. Ferreira

Cochlear dysfunction and microvascular complications in patients with type 1 diabetes mellitus

Sensorineural hearing impairment has been associated with DM, and it is probably linked to the same pathophysiological mechanisms as well-established in microvascular diabetes complications. The study of otoac...

Authors: João Soares Felício, Lilian de Souza d’Albuquerque Silva, Carlliane Lima e Lins Pinto Martins, João Felício Abrahão Neto, Manuela Nascimento de Lemos, Fabrício de Souza Resende, Wanderson Maia da Silva, Angélica Leite de Alcântara, Maria Clara Neres Iunes de Oliveira, Norberto Jorge Kzan de Souza Neto, Isabela Imbelloni Farias de Franco, Nathalie Abdallah Zahalan, Luísa Correa Janaú, Ana Carolina Contente Braga de Souza, Flavia Marques Santos, Natércia Neves Marques de Queiroz…

Comparative effects of vitamin D and vitamin C supplementations with and without endurance physical activity on metabolic syndrome patients: a randomized controlled trial

Vitamin D and C levels have inverse relation with the metabolic syndrome components and they are used as antioxidant supplements during enduring metabolic activities. In the present study, we hypothesized that...

Authors: Halgord Ali M. Farag, Mohammad Javad Hosseinzadeh-Attar, Belal A. Muhammad, Ahmad Esmaillzadeh and Abdel Hamid El Bilbeisi

LIPC variants as genetic determinants of adiposity status, visceral adiposity indicators, and triglyceride-glucose (TyG) index-related parameters mediated by serum triglyceride levels

Visceral adiposity indicators and the product of triglyceride and fasting plasma glucose (TyG) index-related parameters are effective surrogate markers for insulin resistance (IR) and are predictors of metabol...

Authors: Ming-Sheng Teng, Semon Wu, Leay-Kiaw Er, Lung-An Hsu, Hsin-Hua Chou and Yu-Lin Ko

Association of sleep duration with metabolic syndrome and its components in children and adolescents; a propensity score-matched analysis: the CASPIAN-V study

This study aims to evaluate the association of sleep duration with metabolic syndrome (MetS) and its components in a pediatric population.

Authors: Zeinab Hemati, Nafiseh Mozafarian, Ramin Heshmat, Zeinab Ahadi, Mohammad Esmaeil Motlagh, Hasan Ziaodini, Majzoubeh Taheri, Tahereh Aminaee, Mostafa Qorbani and Roya Kelishadi

Clinical inertia on insulin treatment intensification in type 2 diabetes mellitus patients of a tertiary public diabetes center with limited pharmacologic armamentarium from an upper-middle income country

Clinical inertia is related to the difficulty of achieving and maintaining optimal glycemic control. It has been extensively studied the delay of the period to insulin introduction in type 2 diabetes mellitus ...

Authors: Marcelo Alves Alvarenga, William Ricardo Komatsu, Joao Roberto de Sa, Antonio Roberto Chacra and Sergio Atala Dib

Interaction between a variant of chromosome 9p21.3 locus and diet antioxidant capacity on metabolic syndrome in Tehrani adults

Genome-wide association studies have shown that risk alleles on chromosome 9p21.3 locus, are associated with increasing the risk of cardiovascular diseases (CVDs). Several epidemiological studies have found th...

Authors: Atieh Mirzababaei, Mehdi Mollahosseini, Mohammad Hossein Rahimi, Mir Saeed Yekaninejad, Zhila Maghbooli, Reza Sobhani and Khadijeh Mirzaei

Coadministration of DPP-4 inhibitor and insulin therapy does not further reduce the risk of cardiovascular events compared with DPP-4 inhibitor therapy in diabetic foot patients: a nationwide population-based study

The effect of combined insulin and dipeptidyl peptidase-4 inhibitor (DPP4i) therapy on major adverse cardiovascular events (MACEs) in patients with diabetic foot is unclear.

Authors: Yi-Hsuan Lin, Yu-Yao Huang, Yi-Ling Wu, Cheng-Wei Lin, Pei-Chun Chen, Chee Jen Chang, Sheng-Hwu Hsieh, Jui-Hung Sun, Szu-Tah Chen and Chia-Hung Lin

Metabolic clustering of risk factors: evaluation of Triglyceride-glucose index (TyG index) for evaluation of insulin resistance

Metabolic syndrome over the years have structured definitions to classify an individual with the disease. Literature review suggests insulin résistance is hallmark of these metabolic clustering. While measurin...

Authors: Sikandar Hayat Khan, Farah Sobia, Najmusaqib Khan Niazi, Syed Mohsin Manzoor, Nadeem Fazal and Fowad Ahmad

Combined effect of glycemic and blood pressure control on diabetic retinopathy among Chinese with type-2 diabetes mellitus

To explore the associations of glycemic and blood pressure (BP) control with diabetic retinopathy (DR), with special focus on whether different combinations of categories of these two interventions are additive.

Authors: Chen-Wei Pan, Shan Wang, Cai-Lian Xu and E. Song

Neck circumference and its association with cardiometabolic risk factors: a systematic review and meta-analysis

Recently, neck circumference (NC) has been used to predict the risk of cardiometabolic factors. This study aimed to perform a systematic review and meta-analysis to examine: (i) the sensitivity (SE) and specif...

Authors: Asal Ataie-Jafari, Nazli Namazi, Shirin Djalalinia, Pouria Chaghamirzayi, Mohammad Esmaeili Abdar, Sara Sarrafi Zadehe, Hamid Asayesh, Maryam Zarei, Armita Mahdavi Gorabi, Morteza Mansourian and Mostafa Qorbani

Pancreatic fat deposition is increased and related to beta-cell function in women with familial partial lipodystrophy

To study pancreatic fat deposition and beta-cell function in familial partial lipodystrophy (FPLD) patients.

Authors: Amelio F. Godoy-Matos, Cynthia M. Valerio, Rodrigo O. Moreira, Denise P. Momesso and Leonardo K. Bittencourt