Articles

1α,25(OH)₂D₃ attenuates IL-6 and IL-1β-mediated inflammatory responses in macrophage conditioned medium-stimulated human white preadipocytes by modulating p44/42 MAPK and NF-κB signaling pathways

Metabolic syndrome is characterized by macrophage infiltration and inflammatory responses—metaflammation in adipose tissue. IL-6 and IL-1β could mediate the inflammatory responses in macrophage stimulated-prea...

Authors: Jingjing Zhu, Chen Bing and John P. H. Wilding

Leptin-deficient mice have altered three-dimensional growth plate histomorphometry

Leptin is an adipokine that regulates energy homeostasis and is also needed for normal bone growth and maintenance. Mutation in the lep gene, which characterizes the ob/ob mouse model, results in the development ...

Authors: Jun Hung, Layla Al-Nakkash, Tom L. Broderick, Monica Castro and Jeffrey H. Plochocki

Diabetic nephropathy: recent advances in pathophysiology and challenges in dietary management

Diabetic nephropathy (DN) or diabetic kidney disease refers to the deterioration of kidney function seen in chronic type 1 and type 2 diabetes mellitus patients. The progression of the disease is known to occu...

Authors: Mahaboob Khan Sulaiman

Low empowerment and diabetes regimen distress are related to HbA1c in low income type 1 diabetes patients in a Brazilian tertiary public hospital

Adults with type 1 diabetes (T1D) have a high risk of developing depressive symptoms and diabetes-related distress (DD). Low socioeconomic level is associated with increased risk of poor self-management, treat...

Authors: M. S. V. M. Silveira, A. Moura Neto, A. C. Sposito, L. Siminerio and E. J. Pavin

Probiotic assisted weight management as a main factor for glycemic control in patients with type 2 diabetes: a randomized controlled trial

To evaluate the effect of Lactobacillus casei 01 on dietary intake, body weight, and glycemic control in patients with T2DM.

Authors: Leila Khalili, Beitullah Alipour, Mohammad Asghari Jafarabadi, Tohid Hassanalilou, Mehran Mesgari Abbasi and Ismail Faraji

The MTHFR promoter hypermethylation pattern associated with the A1298C polymorphism influences lipid parameters and glycemic control in diabetic patients

Polymorphisms in the gene encoding methylenetetrahydrofolate reductase (MTHFR) have been investigated as risk factors for microvascular complications of diabetes; however, simultaneous analysis of these polymo...

Authors: Herlanny Santana Bezerra, Caroline Severo de Assis, Mayara Karla dos Santos Nunes, Isabella Wanderley de Queiroga Evangelista, João Modesto Filho, Cecília Neta Alves Pegado Gomes, Rayner Anderson Ferreira do Nascimento, Rafaella Cristhine Pordeus Luna, Maria José de Carvalho Costa, Naila Francis Paulo de Oliveira and Darlene Camati Persuhn

Metabolic syndrome is a risk factor for cancer mortality in the general Japanese population: the Jichi Medical School Cohort Study

Metabolic syndrome (MetS) and cancer are major public health problems worldwide. The relationship between MetS and cancer death is of great interest. We examined the predictive value of MetS for cancer mortali...

Authors: Jun Watanabe, Eiichi Kakehi, Kazuhiko Kotani, Kazunori Kayaba, Yosikazu Nakamura and Shizukiyo Ishikawa

Short-acting insulin analogues versus regular human insulin on postprandial glucose and hypoglycemia in type 1 diabetes mellitus: a systematic review and meta-analysis

Strict glucose control using multiple doses of insulin is the standard treatment for type 1 diabetes mellitus (T1DM), but increased risk of hypoglycemia is a frequent drawback. Regular insulin in multiple dose...

Authors: Karla F. S. Melo, Luciana R. Bahia, Bruna Pasinato, Gustavo J. M. Porfirio, Ana Luiza Martimbianco, Rachel Riera, Luis E. P. Calliari, Walter J. Minicucci, Luiz A. A. Turatti, Hermelinda C. Pedrosa and Beatriz D. Schaan

Evaluation of the hypothalamic–pituitary–adrenal axis in a case series of familial partial lipodystrophy

Familial partial lipodystrophy (FPL) is a rare genetic disease characterized by body fat abnormalities that lead to insulin resistance (IR). Clinical conditions linked to milder IR, such as type 2 diabetes (T2...

Authors: Cecília Pacheco Elias, Daniela Espíndola Antunes, Michella Soares Coelho, Caroline Lourenço de Lima, Nelson Rassi, Ana Paula Meireles de Melo and Angélica Amorim Amato

Anti-inflammatory effects of empagliflozin in patients with type 2 diabetes and insulin resistance

Inflammation might be a pathological mediator of cardiovascular events in patients with type 2 diabetes and high cardiovascular risk.

Authors: Sachiko Hattori

To the editor regarding article “Coadministration of DPP-4 inhibitor and insulin therapy does not further reduce the risk of cardiovascular events compared with DPP-4 inhibitor therapy in diabetic foot patients: a nationwide population-based study”

Authors: Florian J. Mayer, Gerfried Pesau and Gerit H. Schernthaner

Liraglutide ameliorates beta-cell function, alleviates oxidative stress and inhibits low grade inflammation in young patients with new-onset type 2 diabetes

The prevalence of type 2 diabetes in youth is escalating rapidly. We aimed to evaluate the effects of liraglutide on beta-cell function, metabolic productions of oxidative stress, low grade inflammation compar...

Authors: Wen-qiang Zhang, Yuan Tian, Xiao-min Chen, Li-fen Wang, Chan-chan Chen and Chuan-mei Qiu

Evaluating the Diabetes–Cardiology interface: a glimpse into the diabetes management of cardiology inpatients in western Sydney’s ‘diabetes hotspot’ and the establishment of a novel model of care

Approximately two-thirds of individuals presenting to emergency departments in Western Sydney have glucose dysregulation, accelerating their risk of cardiovascular disease (CVD). We evaluated the prevalence an...

Authors: Ramy H. Bishay, Gideon Meyerowitz-Katz, David Chandrakumar, Rajini Jayaballa, Tien-Ming Hng, Mark Mclean, Dilini Punchihewa, Maiyoori Jeyaprakash, David Burgess, John Riskallah and Glen F. Maberly

Antidiabetic efficacy of lactoferrin in type 2 diabetic pediatrics; controlling impact on PPAR-γ, SIRT-1, and TLR4 downstream signaling pathway

The current study aims to investigate the antidiabetic efficacy of camel milk-derived lactoferrin and potential involvement of PPAR-γ and SIRT-1 via TLR-4/NFκB signaling pathway in obese diabetic pediatric pop...

Authors: Waleed A. Mohamed and Mona F. Schaalan

Fasting plasma mannose levels are associated with insulin sensitivity independent of BMI in Japanese individuals with diabetes

Recently, an integrated network analysis has revealed dysregulation in the metabolism of mannose, a glucose epimer, in severely obese individuals without diabetes. In addition, fasting plasma mannose levels (M₀) ...

Authors: Eri Amano, Shogo Funakoshi, Kumiko Yoshimura, Seiki Hirano, Satoko Ohmi, Hiroshi Takata, Yoshio Terada and Shimpei Fujimoto

Exploring structural barriers to diabetes self-management in Alberta First Nations communities

Type 2 diabetes is highly prevalent in Canadian First Nations (FN) communities. FN individuals with diabetes are less likely to receive guideline recommended care and access specialist care. They are also less...

Authors: Stephanie Kulhawy-Wibe, Kathryn M. King-Shier, Cheryl Barnabe, Braden J. Manns, Brenda R. Hemmelgarn and David J. T. Campbell

The association between attitude, self-efficacy, and social support and adherence to diabetes self-care behavior

Diabetes is a chronic illness which requires lifelong self-care behaviors. The objective of the present research was to investigate the association of self-efficacy, attitude and social support with adherence ...

Authors: Mahmood Karimy, Hamid Reza Koohestani and Marzieh Araban

Insulin Injection Technique Questionnaire: results of an international study comparing Brazil, Latin America and World data

In 2014–2015, the largest international survey of insulin injection technique in patients with diabetes taking insulin was conducted in 42 countries, totaling 13,289 participants. In Brazil, patients from five...

Authors: Luis Eduardo Calliari, Laura Cudizio, Balduino Tschiedel, Hermelinda C. Pedrosa, Rosangela Rea, Augusto Pimazoni-Netto, Laurence Hirsch and Kenneth Strauss

Population attributable fractions for Type 2 diabetes: an examination of multiple risk factors including symptoms of depression and anxiety

Population attributable fractions (PAFs) are frequently used to quantify the proportion of Type 2 diabetes cases due to single risk factors, an approach which may result in an overestimation of their individua...

Authors: Kiyuri Naicker, Douglas Manuel, Simon Øverland, Jens C. Skogen, Jeffrey A. Johnson, Børge Sivertsen and Ian Colman

Hypoglycemia incidence and awareness among insulin-treated patients with diabetes: the HAT study in Brazil

Hypoglycemia affects patient safety and glycemic control during insulin treatment of both type 1 (T1DM) and type 2 diabetes mellitus (T2DM). The Hypoglycemia Assessment Tool study in Brazil aimed to determine ...

Authors: Rodrigo Nunes Lamounier, Bruno Geloneze, Silmara Oliveira Leite, Renan Montenegro Jr., Lenita Zajdenverg, Milene Fernandes, Fabiano de Oliveira Griciunas, Mariana Narbot Ermetice and António Roberto Chacra

Neck circumference is associated with non-traditional cardiovascular risk factors in individuals at low-to-moderate cardiovascular risk: cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Neck circumference (NC) is associated with traditional cardiovascular risk factors (CVRF), but its usefulness to identify earlier atherogenic risk has been scarcely examined. Associations of NC with non-tradit...

Authors: B. Almeida-Pititto, I. T. Silva, A. C. Goulart, M. I. H. Fonseca, M. S. Bittencourt, R. D. Santos, M. Blaha, S. Jones, P. P. Toth, K. Kulakarni, P. A. Lotufo, I. M. Bensenor and S. R. G. Ferreira

Cochlear dysfunction and microvascular complications in patients with type 1 diabetes mellitus

Sensorineural hearing impairment has been associated with DM, and it is probably linked to the same pathophysiological mechanisms as well-established in microvascular diabetes complications. The study of otoac...

Authors: João Soares Felício, Lilian de Souza d’Albuquerque Silva, Carlliane Lima e Lins Pinto Martins, João Felício Abrahão Neto, Manuela Nascimento de Lemos, Fabrício de Souza Resende, Wanderson Maia da Silva, Angélica Leite de Alcântara, Maria Clara Neres Iunes de Oliveira, Norberto Jorge Kzan de Souza Neto, Isabela Imbelloni Farias de Franco, Nathalie Abdallah Zahalan, Luísa Correa Janaú, Ana Carolina Contente Braga de Souza, Flavia Marques Santos, Natércia Neves Marques de Queiroz…

Comparative effects of vitamin D and vitamin C supplementations with and without endurance physical activity on metabolic syndrome patients: a randomized controlled trial

Vitamin D and C levels have inverse relation with the metabolic syndrome components and they are used as antioxidant supplements during enduring metabolic activities. In the present study, we hypothesized that...

Authors: Halgord Ali M. Farag, Mohammad Javad Hosseinzadeh-Attar, Belal A. Muhammad, Ahmad Esmaillzadeh and Abdel Hamid El Bilbeisi

LIPC variants as genetic determinants of adiposity status, visceral adiposity indicators, and triglyceride-glucose (TyG) index-related parameters mediated by serum triglyceride levels

Visceral adiposity indicators and the product of triglyceride and fasting plasma glucose (TyG) index-related parameters are effective surrogate markers for insulin resistance (IR) and are predictors of metabol...

Authors: Ming-Sheng Teng, Semon Wu, Leay-Kiaw Er, Lung-An Hsu, Hsin-Hua Chou and Yu-Lin Ko

Association of sleep duration with metabolic syndrome and its components in children and adolescents; a propensity score-matched analysis: the CASPIAN-V study

This study aims to evaluate the association of sleep duration with metabolic syndrome (MetS) and its components in a pediatric population.

Authors: Zeinab Hemati, Nafiseh Mozafarian, Ramin Heshmat, Zeinab Ahadi, Mohammad Esmaeil Motlagh, Hasan Ziaodini, Majzoubeh Taheri, Tahereh Aminaee, Mostafa Qorbani and Roya Kelishadi

Clinical inertia on insulin treatment intensification in type 2 diabetes mellitus patients of a tertiary public diabetes center with limited pharmacologic armamentarium from an upper-middle income country

Clinical inertia is related to the difficulty of achieving and maintaining optimal glycemic control. It has been extensively studied the delay of the period to insulin introduction in type 2 diabetes mellitus ...

Authors: Marcelo Alves Alvarenga, William Ricardo Komatsu, Joao Roberto de Sa, Antonio Roberto Chacra and Sergio Atala Dib

Interaction between a variant of chromosome 9p21.3 locus and diet antioxidant capacity on metabolic syndrome in Tehrani adults

Genome-wide association studies have shown that risk alleles on chromosome 9p21.3 locus, are associated with increasing the risk of cardiovascular diseases (CVDs). Several epidemiological studies have found th...

Authors: Atieh Mirzababaei, Mehdi Mollahosseini, Mohammad Hossein Rahimi, Mir Saeed Yekaninejad, Zhila Maghbooli, Reza Sobhani and Khadijeh Mirzaei

Coadministration of DPP-4 inhibitor and insulin therapy does not further reduce the risk of cardiovascular events compared with DPP-4 inhibitor therapy in diabetic foot patients: a nationwide population-based study

The effect of combined insulin and dipeptidyl peptidase-4 inhibitor (DPP4i) therapy on major adverse cardiovascular events (MACEs) in patients with diabetic foot is unclear.

Authors: Yi-Hsuan Lin, Yu-Yao Huang, Yi-Ling Wu, Cheng-Wei Lin, Pei-Chun Chen, Chee Jen Chang, Sheng-Hwu Hsieh, Jui-Hung Sun, Szu-Tah Chen and Chia-Hung Lin

Metabolic clustering of risk factors: evaluation of Triglyceride-glucose index (TyG index) for evaluation of insulin resistance

Metabolic syndrome over the years have structured definitions to classify an individual with the disease. Literature review suggests insulin résistance is hallmark of these metabolic clustering. While measurin...

Authors: Sikandar Hayat Khan, Farah Sobia, Najmusaqib Khan Niazi, Syed Mohsin Manzoor, Nadeem Fazal and Fowad Ahmad

Combined effect of glycemic and blood pressure control on diabetic retinopathy among Chinese with type-2 diabetes mellitus

To explore the associations of glycemic and blood pressure (BP) control with diabetic retinopathy (DR), with special focus on whether different combinations of categories of these two interventions are additive.

Authors: Chen-Wei Pan, Shan Wang, Cai-Lian Xu and E. Song

Neck circumference and its association with cardiometabolic risk factors: a systematic review and meta-analysis

Recently, neck circumference (NC) has been used to predict the risk of cardiometabolic factors. This study aimed to perform a systematic review and meta-analysis to examine: (i) the sensitivity (SE) and specif...

Authors: Asal Ataie-Jafari, Nazli Namazi, Shirin Djalalinia, Pouria Chaghamirzayi, Mohammad Esmaeili Abdar, Sara Sarrafi Zadehe, Hamid Asayesh, Maryam Zarei, Armita Mahdavi Gorabi, Morteza Mansourian and Mostafa Qorbani

Pancreatic fat deposition is increased and related to beta-cell function in women with familial partial lipodystrophy

To study pancreatic fat deposition and beta-cell function in familial partial lipodystrophy (FPLD) patients.

Authors: Amelio F. Godoy-Matos, Cynthia M. Valerio, Rodrigo O. Moreira, Denise P. Momesso and Leonardo K. Bittencourt

Effects of moderate intensity endurance training vs. high intensity interval training on weight gain, cardiorespiratory capacity, and metabolic profile in postnatal overfed rats

Obesity is associated with several comorbidities, such as cardiovascular disease and type 2 diabetes mellitus, and may have its origin in early life stages, such as in the lactation period, through metabolic p...

Authors: Carlos Gabriel de Lade, Ana Eliza Andreazzi, Mariana Bolotari, Vinícius Moreira Gonçalves Costa, Vera Maria Peters and Martha de Oliveira Guerra

Nerve conduction study of the association between glycemic variability and diabetes neuropathy

It remains unclear whether glycemic variability is related to diabetes microvascular disease, especially diabetes peripheral neuropathy (DPN). We investigated the association between glycemic variability and D...

Authors: Miho Akaza, Itaru Akaza, Tadashi Kanouchi, Tetsuo Sasano, Yuki Sumi and Takanori Yokota

Characterization of spontaneously-developed non-alcoholic fatty liver disease in aged rhesus monkeys

Non-alcoholic fatty liver disease (NAFLD) is a global epidemic afflicting 20–30% in the general population. The animal model of NAFLD available at the present are less clinically relevant. In this study. We ai...

Authors: Wen Zheng, Yuli Liu, Haibao Shang, Yan Zhang, Dongwei Ma, Ning Hou, Jue Wang, Xueting Sun, Ying Peng, Lin Pan, Zhilong Wang, Xinran Tang, Rui-Ping Xiao and Xiuqin Zhang

Effectiveness of educational intervention based on psychological factors on achieving health outcomes in patients with type 2 diabetes

Managing type 2 diabetes (T2D) is assumed to be heavily dependent on patients’ active participation in their own self-care behaviors including prescribed diets.

Authors: Arash Salahshouri, Fereshteh Zamani Alavijeh, Behzad Mahaki and Firoozeh Mostafavi

Associations among inflammation, mental health, and quality of life in adults with metabolic syndrome

Metabolic syndrome (MetS), a pro-inflammatory state, has become increasingly common worldwide and is a major risk factor for type 2 diabetes mellitus and cardiovascular disease. Recently, studies on the relati...

Authors: Ji-Ryang Kim, Ha-Na Kim and Sang-Wook Song

Accuracy of insulin resistance indices for metabolic syndrome: a cross-sectional study in adults

This study aimed to determine the ability of commonly used insulin resistance indices to identify the metabolic syndrome.

Authors: Luciana Pavan Antoniolli, Bárbara Limberger Nedel, Tassia Cividanes Pazinato, Leonardo de Andrade Mesquita and Fernando Gerchman

Twice-daily insulin degludec/insulin aspart effectively improved morning and evening glucose levels and quality of life in patients previously treated with premixed insulin: an observational study

Previous studies comparing insulin degludec/insulin aspart (IDegAsp) with premixed insulin twice daily among insulin users with type 2 diabetes have not thoroughly investigated differences in the glucose varia...

Authors: Kanta Fujimoto, Toshio Iwakura, Megumi Aburaya and Naoki Matsuoka

Practical guidance for treatment of patients with diabetes using flash glucose monitoring: a pilot study

Flash glucose monitoring (FGM) is a factory-calibrated, blood glucose measuring sensor system for patients with diabetes. We aimed to investigate the correlation between the sensor glucose (SG) value obtained ...

Authors: Keiko Koide, Koichiro Azuma, Jun Nojima, Kenichiro Kodama and Yoshihito Atsumi

Association between the expression of vascular endothelial growth factors and metabolic syndrome or its components: a systematic review and meta-analysis

Several studies have linked vascular endothelial growth factors (VEGFs) with metabolic syndrome or its components. However, there has been no systematic appraisal of the findings of these studies to date. The ...

Authors: Mohammad Ishraq Zafar, Kerry Mills, Xiaofeng Ye, Brette Blakely, Jie Min, Wen Kong, Nan Zhang, Luoning Gou, Anita Regmi, Sheng Qing Hu, Juan Zheng and Lu-Lu Chen

Association between homocysteine level and the risk of diabetic retinopathy: a systematic review and meta-analysis

Previous studies have demonstrated that elevated homocysteine (Hcy) level represents an independent risk factor for macrovascular disease. However, the relationship between hyperhomocysteinemia and the progres...

Authors: Xunwen Lei, Guifeng Zeng, Yuemei Zhang, Qiang Li, Jinzhi Zhang, Zhenggang Bai and Kehu Yang

Normoalbuminuric kidney impairment in patients with T1DM: insights from annals initiative

We described, in a large sample of patients with type 1 diabetes mellitus (T1DM) and GFR ≤ 60 mL/min/1.73 m² (with or without albuminuria), the differences in the clinical features associated with the two differe...

Authors: Olga Lamacchia, Francesca Viazzi, Paola Fioretto, Antonio Mirijello, Carlo Giorda, Antonio Ceriello, Giuseppina Russo, Pietro Guida, Roberto Pontremoli and Salvatore De Cosmo

Markers of metabolic endotoxemia as related to metabolic syndrome in an elderly male population at high cardiovascular risk: a cross-sectional study

Metabolic syndrome (MetS) is a cluster of conditions that conjoined represents a 1.5–2.5 fold increased risk of developing cardiovascular disease (CVD). Recent studies have reported that gut dysbiosis and leak...

Authors: Ayodeji Awoyemi, Marius Trøseid, Harald Arnesen, Svein Solheim and Ingebjørg Seljeflot

The metabolic syndrome modifies the mRNA expression profile of extracellular vesicles derived from porcine mesenchymal stem cells

Mesenchymal stem cells (MSCs) perform paracrine functions by releasing extracellular vesicles (EVs) containing microRNA, mRNA, and proteins. We investigated the mRNA content of EVs in metabolic syndrome (MetS)...

Authors: Yu Meng, Alfonso Eirin, Xiang-Yang Zhu, Daniel R. O’Brien, Amir Lerman, Andre J. van Wijnen and Lilach O. Lerman

Impact of acute diabetes decompensation on outcomes of diabetic patients admitted with ST-elevation myocardial infarction

Acute hyperglycemia is associated with worse outcomes in diabetic patients admitted with ST-elevation myocardial infarction (STEMI). However, the impact of full-scale decompensated diabetes on STEMI outcomes h...

Authors: Mayada Issa, Fahad Alqahtani, Chalak Berzingi, Mohammad Al-Hajji, Tatiana Busu and Mohamad Alkhouli

A comparison of different definitions of metabolic syndrome for the risks of atherosclerosis and diabetes

The reported outcomes of the metabolic syndrome (MetS), containing atherosclerotic cardiovascular disease and diabetes, vary according to the definitions used. This study was designed to compare the performanc...

Authors: Sung-Sheng Tsai, Yun-Yi Chu, Szu-Tah Chen and Pao-Hsien Chu

Baseline and changes in serum uric acid independently predict glucose control among community-dwelling women

Elevated serum uric acid (SUA) levels are associated with glucose control. However, whether baseline and changes in SUA predict long-term follow-up glucose control [e.g., glycated hemoglobin (HbA1c)] remains u...

Authors: Ryuichi Kawamoto, Daisuke Ninomiya, Asuka Kikuchi, Taichi Akase and Teru Kumagi

Association of adiponectin with cognitive function precedes overt diabetes in the Brazilian Longitudinal Study of Adult Health: ELSA

Adiponectin is an insulin-sensitizer adipocytokine endowed with neuroprotective actions. Whether adiponectin regulates neuronal functioning toward delaying cognitive decline independently of the glucose metabo...

Authors: Adriana Cezaretto, Claudia Kimie Suemoto, Isabela Bensenor, Paulo A. Lotufo, Bianca de Almeida-Pititto and Sandra R. G. Ferreira

Smoke exposure and cardio-metabolic profile in youth with type 1 diabetes

To evaluate the relationship between smoking and metabolic parameters in patients affected by type 1 diabetes (T1D).

Authors: Valeria Calcaterra, Jonathan P. Winickoff, Catherine Klersy, Luca Maria Schiano, Rossella Bazzano, Chiara Montalbano, Valeria Musella, Corrado Regalbuto, Daniela Larizza and Hellas Cena