Articles

Enhancement of the serum chloride concentration by administration of sodium–glucose cotransporter-2 inhibitor and its mechanisms and clinical significance in type 2 diabetic patients: a pilot study

Chloride is a key electrolyte that regulates the body fluid distribution. Accordingly, manipulating chloride kinetics by selecting a suitable diuretic could be an attractive strategy for correcting body fluid ...

Authors: Hajime Kataoka and Yuichi Yoshida

Impact of sodium–glucose cotransporter 2 inhibitors on renal function in participants with type 2 diabetes and chronic kidney disease with normoalbuminuria

We compared the effects of sodium–glucose cotransporter 2 (SGLT2) inhibitors on renal function in participants with type 2 diabetes and chronic kidney disease (CKD) classified by degree of albuminuria.

Authors: Akinobu Nakamura, Hideaki Miyoshi, Hiraku Kameda, Kumiko Yamashita and Yoshio Kurihara

Real-world flash glucose monitoring in Brazil: can sensors make a difference in diabetes management in developing countries?

New technologies are changing diabetes treatment and contributing better outcomes in developed countries. To our knowledge, no previous studies have investigated the comparative effect of sensor-based monitori...

Authors: Luis Eduardo P. Calliari, Marcio Krakauer, Andre Gustavo Daher Vianna, Yashesvini Ram, Douglas Eugenio Barbieri, Yongjin Xu and Timothy C. Dunn

The prevalence of metabolic syndrome and its association with body fat distribution in middle-aged individuals from Indonesia and the Netherlands: a cross-sectional analysis of two population-based studies

The prevalence of metabolic syndrome varies among populations with different ethnicities. Asian populations develop metabolic complications at lower amounts of adiposity than western populations. The role of a...

Authors: Fathimah S. Sigit, Dicky L. Tahapary, Stella Trompet, Erliyani Sartono, Ko Willems van Dijk, Frits R. Rosendaal and Renée de Mutsert

Curcumin analog A13 alleviates oxidative stress by activating Nrf2/ARE pathway and ameliorates fibrosis in the myocardium of high-fat-diet and streptozotocin-induced diabetic rats

Diabetes mellitus is an important risk factor for cardiomyopathy. Increasing oxidative stress may be one of the main factors of diabetic cardiomyopathy. A13, a newly synthesized curcumin analog, was proved to ...

Authors: Lanting Xiang, Qiongying Zhang, Chen Chi, Gu Wu, Zhongmin Lin, Jianmin Li, Qianru Gu and Guorong Chen

MMP-2 salivary activity in type 2 diabetes mellitus patients

Type 2 diabetes mellitus (T2DM) and periodontitis are chronic inflammatory diseases with a bidirectional relationship. The uncontrolled levels of glucose in T2DM patients change the pathophysiology and balance...

Authors: Juan Antonio Arreguin-Cano, Brenda Ayerdi-Nájera, Arvey Tacuba-Saavedra, Napoleón Navarro-Tito, Alfonso Dávalos-Martínez, Abel Emigdio-Vargas, Elia Barrera-Rodríguez, Nubia Blanco-García, Gloria Gutiérrez-Venegas, Elías Ventura-Molina and Gladys León-Dorantes

Age-specific diabetes risk by the number of metabolic syndrome components: a Korean nationwide cohort study

Metabolic syndrome is associated with an increased risk of diabetes. This study investigated the associations between the number of metabolic syndrome components and diabetes risk by age, sex and BMI.

Authors: Min-Kyung Lee, Kyungdo Han and Hyuk-Sang Kwon

The effect of genistein on lipid levels and LDLR, LXRα and ABCG1 expression in postmenopausal women with hyperlipidemia

This study investigates the effect of genistein (Gen) on the lipid profiles and expression of low-density lipoprotein receptor (LDLR), liver X receptor α (LXRα) and ATP-binding cassette transporter G1 (ABCG1) ...

Authors: Tao Zhang and Xiao-Xing Chi

Clinical outcome comparison of percutaneous coronary intervention and bypass surgery in diabetic patients with coronary artery disease: a meta-analysis of randomized controlled trials and observational studies

The optimal revascularization technique in diabetic patients with complex coronary artery disease (CAD), including left main CAD and multivessel coronary disease (MVD), remains controversial. The current study...

Authors: ChuanNan Zhai, HongLiang Cong, Kai Hou, YueCheng Hu, JingXia Zhang and YingYi Zhang

Effects of exercise training on markers of adipose tissue remodeling in patients with coronary artery disease and type 2 diabetes mellitus: sub study of the randomized controlled EXCADI trial

Investigate effects of long-term exercise on the remodeling markers MMP-9, TIMP-1, EMMPRIN and Galectin-3 in combined type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) patients. Any association...

Authors: Hani Zaidi, Rune Byrkjeland, Ida U. Njerve, Sissel Åkra, Svein Solheim, Harald Arnesen, Ingebjørg Seljeflot and Trine B. Opstad

The effect of cassia seed extract on the regulation of the LKB1–AMPK–GLUT4 signaling pathway in the skeletal muscle of diabetic rats to improve the insulin sensitivity of the skeletal muscle

This study aimed to observe the hypoglycemic effect of cassia seed extract in rats with type-2 diabetes mellitus and its effect on reducing insulin resistance in the skeletal muscle.

Authors: Qiu-Ying Wang, Ai-Hua Tong, Ying-Ying Pan, Xian-Dang Zhang, Wen-Yu Ding and Wen Xiong

Efficacy and safety of evogliptin in the treatment of type 2 diabetes mellitus in a Brazilian population: a randomized bridging study

Evogliptin (EVO) is a potent and selective dipeptidyl peptidase-4 inhibitor (DPP4i) developed for the treatment of type 2 diabetes mellitus (T2DM). DPP4is are known to exhibit a better glucose-lowering effect ...

Authors: Cintia Cercato, Joao Soares Felício, Luis Augusto Tavares Russo, Joao Lindolfo Cunha Borges, Joao Salles, Patricia Muskat, Teresa Bonansea, Antonio Roberto Chacra, Freddy Goldberg Eliaschewitz and Adriana Costa Forti

Cost effectiveness of different screening strategies for gestational diabetes mellitus screening: study protocol of a randomized community non-inferiority trial

There is lack of ideal and comprehensive economic evaluations of various GDM strategies. The aim of this study is to the compare efficacy and cost-effectiveness of five different methods of screening for gesta...

Authors: Fahimeh Ramezani Tehrani

Association of predicted 10 years cardiovascular mortality risk with duration of HIV infection and antiretroviral therapy among HIV-infected individuals in Durban, South Africa

South Africa has the largest population of human immunodeficiency virus (HIV) infected patients on antiretroviral therapy (ART) realising the benefits of increased life expectancy. However, this population may...

Authors: Olamide O. Todowede, Benn Sartorius, Nombulelo Magula and Aletta E. Schutte

Relatively young T1D adults using fixed doses of insulin have higher diabetes distress levels in a sample of patients from a Brazilian tertiary hospital

Elevated rates of anxiety and depressive symptoms in Type 1 Diabetes patients (T1D) and high rates of diabetes-specific distress (DD) have been shown. Several factors may be responsible for increase the DD lev...

Authors: M. S. V. M. Silveira, T. G. Bovi and E. J. Pavin

Effect of synbiotic bread containing lactic acid on glycemic indicators, biomarkers of antioxidant status and inflammation in patients with type 2 diabetes: a randomized controlled trial

The aim of this randomized, double-blinded, controlled trial was to investigate the effect of daily consumption of a synbiotic bread containing lactic acid on glycemic status, antioxidant biomarkers and inflam...

Authors: Atie Ghafouri, Mitra Zarrati, Farzad Shidfar, Iraj Heydari, Raheleh Shokouhi Shoormasti and Omid Eslami

Survey of knowledge for diagnosing and managing prediabetes in Latin-America: cross-sectional study

Prediabetes has been proposed as a risk factor for the development of type 2 diabetes mellitus (DM2) and cardiovascular disease (CVD). Despite the clinical importance of prediabetes, little is known about the ...

Authors: Jennifer Garay, Paul A. Camacho, Jose Lopez-Lopez, Juliana Alvernia, Marcela Garcia, Daniel D. Cohen, Carlos Calderon and Patricio Lopez-Jaramillo

Zinc supplementation improves body weight management, inflammatory biomarkers and insulin resistance in individuals with obesity: a randomized, placebo-controlled, double-blind trial

The present study was designed to determine whether zinc supplementation would increase the effects of restricted calorie diet (RCD) on obesity.

Authors: Hoda Khorsandi, Omid Nikpayam, Reyhaneh Yousefi, Maryam Parandoosh, Nima Hosseinzadeh, Atoosa Saidpour and Arman Ghorbani

Physiological serum total bilirubin concentrations were inversely associated with diabetic peripheral neuropathy in Chinese patients with type 2 diabetes: a cross-sectional study

Although bilirubin has been generally regarded as a waste with potential neurotoxicity at high levels, a few clinical studies suggest a potential protective role of physiological serum total bilirubin (TBIL) c...

Authors: Pijun Yan, Zhihong Zhang, Ying Miao, Yong Xu, Jianhua Zhu and Qin Wan

Reducing effect of insulin resistance on alpha-synuclein gene expression in skeletal muscle

Alpha-synuclein (SNCA) as the presynaptic protein is expressed in different tissues and prevents insulin-resistance (IR) through increasing glucose-uptake by adipocytes and muscles. However, the effect of insu...

Authors: Amirhosein Khoshi, Golnaz Goodarzi, Rezvan Mohammadi, Roghaye Arezumand, Meysam Moghbeli and Mahnaz Najariyan

Comparison of visceral adipose tissue DNA methylation and gene expression profiles in female adolescents with obesity

Epigenetic changes in visceral adipose tissue (VAT) with obesity and their effects on gene expression are poorly understood, especially during emergent obesity in youth. The current study tested the hypothesis...

Authors: Matthew D. Barberio, Evan P. Nadler, Samantha Sevilla, Rosemary Lu, Brennan Harmon and Monica J. Hubal

Interaction between ELMO1 gene polymorphisms and environment factors on susceptibility to diabetic nephropathy in Chinese Han population

The association of diabetic nephropathy (DN) risk with single nucleotide polymorphisms (SNPs) within Engulfment and Cell Motility 1 (ELMO1) gene and gene–environment synergistic effect have not been extensively e...

Authors: Yi Hou, Yong Gao, Yan Zhang, Si-Tong Lin, Yue Yu and Liu Yang

Effects of metformin on metabolism of white and brown adipose tissue in obese C57BL/6J mice

To investigate effects of metformin on the regulation of proteins of white adipose tissue (WAT) and brown adipose tissue (BAT) in obesity and explore the underlying mechanisms on energy metabolism.

Authors: Tao Yuan, Juan Li, Wei-Gang Zhao, Wei Sun, Shuai-Nan Liu, Quan Liu, Yong Fu and Zhu-Fang Shen

Fasting triglycerides and glucose index: a useful screening test for assessing insulin resistance in patients diagnosed with rheumatoid arthritis and systemic lupus erythematosus

Insulin resistance (IR) is frequently observed in patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). In clinical practice, IR assessment is limited to a low proportion of patients d...

Authors: Betsabe Contreras-Haro, Sandra Ofelia Hernandez-Gonzalez, Laura Gonzalez-Lopez, Maria Claudia Espinel-Bermudez, Leonel Garcia-Benavides, Edsaul Perez-Guerrero, Maria Luisa Vazquez-Villegas, Jose Antonio Robles-Cervantes, Mario Salazar-Paramo, Diana Mercedes Hernandez-Corona, Arnulfo Hernan Nava-Zavala and Jorge I. Gamez-Nava

Long-term treatment with metformin in the prevention of fatty liver in Zucker diabetic fatty rats

Treatment with metformin, the biguanide of hepatic insulin sensitizer, in patients with non-alcoholic fatty liver disease (NAFLD) has been reported with contradictory findings regarding the effectiveness on bl...

Authors: Yi Sui, Xianhe Kong, Rongrong Fan, Yanbin Ye, Haiyan Mai, Shuyu Zhuo, Wei Lu, Peishan Ruan, Shi Fang and Tao Yang

The discriminatory power of visceral adipose tissue area vs anthropometric measures as a diagnostic marker for metabolic syndrome in South African women

A number of studies have shown central adiposity, in particular visceral adipose tissue (VAT) accumulation to be a hallmark of metabolic syndrome (MetS). In clinical practice, waist circumference (WC) is used ...

Authors: Florence E. Davidson, Tandi E. Matsha, Rajiv T. Erasmus, Andre Pascal Kengne and Julia H. Goedecke

Statins and/or fibrates for diabetic retinopathy: a systematic review and meta-analysis

Evidence from observational studies have found a relationship between serum cholesterol and diabetic retinopathy (DR). Apart of the assumption that cholesterolemic control has benefits for patients with diabet...

Authors: Vânia Mozetic, Rafael Leite Pacheco, Carolina de Oliveira Cruz Latorraca and Rachel Riera

Effects of green coffee extract on fasting blood glucose, insulin concentration and homeostatic model assessment of insulin resistance (HOMA-IR): a systematic review and meta-analysis of interventional studies

Many studies have investigated the relationship between coffee and diabetes. Evaluation of the current evidence on the effect of coffee intake on diabetes is critical. Therefore, we aimed to investigate the po...

Authors: Omid Nikpayam, Marziyeh Najafi, Samad Ghaffari, Mohammad Asghari Jafarabadi, Golbon Sohrab and Neda Roshanravan

Treatment patterns of drug-naive patients with type 2 diabetes mellitus: a retrospective cohort study using a Japanese hospital database

Guidelines for Type 2 diabetes mellitus (T2DM) management in Japan provide physicians the discretion to select treatment options based on patient pathophysiology of the disease. There exists a wide variation o...

Authors: Yohei Morita, Hiroki Murayama, Masato Odawara and Melissa Bauer

Foot function and strength of patients with diabetes grouped by ulcer risk classification (IWGDF)

The stratification system from the International Working Group on the Diabetic Foot (IWGDF) was used to classify the participants as to the ulcer risk. However, it is not yet known what the classification grou...

Authors: Jane S. S. P. Ferreira, João P. Panighel, Érica Q. Silva, Renan L. Monteiro, Ronaldo H. Cruvinel Júnior and Isabel C. N. Sacco

Midnight salivary cortisol secretion and the use of antidepressants were associated with abdominal obesity in women with type 1 diabetes: a cross sectional study

Abdominal obesity is a risk factor for cardiovascular disease. The aim was to explore the influence of midnight salivary cortisol (MSC), antidepressants and sex on abdominal obesity in type 1 diabetes (T1D). W...

Authors: Eva Olga Melin, Magnus Hillman, Maria Thunander and Mona Landin-Olsson

Hyperhomocysteinemia is an independent risk factor of atherosclerosis in patients with metabolic syndrome

Metabolic syndrome (MetS) is a clinical condition potentially promoting the development of atherosclerotic disease. To date, the clinical impact of elevated serum homocysteine (Hcy) levels in MetS is still und...

Authors: Giuseppina Piazzolla, Mafalda Candigliota, Margherita Fanelli, Anna Castrovilli, Elsa Berardi, Gianfranco Antonica, Stefano Battaglia, Vincenzo Solfrizzi, Carlo Sabbà and Cosimo Tortorella

Effects of vitamin D supplementation on advanced glycation end products signaling pathway in T2DM patients: a randomized, placebo-controlled, double blind clinical trial

Several researches have recommended vitamin D possible health benefits on diabetic complications development, but a few number of studies have been accomplished on the molecular and cellular mechanisms. Certai...

Authors: Mahsa Omidian, Mahmoud Djalali, Mohammad Hassan Javanbakht, Mohammad Reza Eshraghian, Maryam Abshirini, Parisa Omidian, Ehsan Alvandi and Maryam Mahmoudi

Smoking and diabetes: dangerous liaisons and confusing relationships

The combined harmful effects of cigarette smoking and hyperglycemia can accelerate vascular damage in patients with diabetes who smoke, as is well known. Can smoking cause diabetes? What are the effects of smo...

Authors: D. Campagna, A. Alamo, A. Di Pino, C. Russo, A. E. Calogero, F. Purrello and R. Polosa

Mobile phone applications and their use in the self-management of Type 2 Diabetes Mellitus: a qualitative study among app users and non-app users

Mobile phone applications (apps) have been shown to successfully facilitate the self-management of chronic disease. This study aims to evaluate firstly the experiences, barriers and facilitators to app usage a...

Authors: Bronte Jeffrey, Melina Bagala, Ashley Creighton, Tayla Leavey, Sarah Nicholls, Crystal Wood, Jo Longman, Jane Barker and Sabrina Pit

22nd Brazilian Diabetes Society Congress

Authors:

Association between metabolic syndrome and the incidence of gastric cancer: a meta-analysis of cohort studies

Previous studies investigating the association between metabolic syndrome (MetS) and incidence of gastric cancer (GC) showed inconsistent results. The aim of the study was to evaluate the influence of MetS on ...

Authors: Zhibin Li, Hongfeng Han and Yuan Chang

Metformin paradoxically worsens insulin resistance in SHORT syndrome

SHORT syndrome is an autosomal dominant condition associated severe insulin resistance (IR) and lipoatrophy due to post-receptor defect in insulin signaling involving phosphoinositide-3-kinase regulatory subun...

Authors: Krzysztof C. Lewandowski, Katarzyna Dąbrowska, Maria Brzozowska, Joanna Kawalec and Andrzej Lewiński

Consensus recommendations for management of patients with type 2 diabetes mellitus and cardiovascular diseases

The recent American Diabetes Association and the European Association for the Study of Diabetes guideline mentioned glycaemia management in type 2 diabetes mellitus (T2DM) patients with cardiovascular diseases...

Authors: Alaaeldin Bashier, Azza Bin Hussain, Elamin Abdelgadir, Fatheya Alawadi, Hani Sabbour and Robert Chilton

Serum fibroblast growth factor 19 and endogenous islet beta cell function in type 2 diabetic patients

Fibroblast growth factor 19 (FGF19) takes part in maintaining the balance of glycolipids and may be involved in regulating the secretory activity of islet beta cells in patients with type 2 diabetes. This stud...

Authors: Meng-jie Tang, Jian‑bin Su, Tian-li Xu, Xue‑qin Wang, Dong-mei Zhang and Xiao-hua Wang

Interaction of HSD11B1 and H6PD polymorphisms in subjects with type 2 diabetes are protective factors against obesity: a cross-sectional study

The enzyme 11-beta hydroxysteroid dehydrogenase type 1 (HSD11B1) converts inactive cortisone to active cortisol in a process mediated by the enzyme hexose-6-phosphate dehydrogenase (H6PD). The generation of co...

Authors: Marcio F. Chedid, Filipe V. do Nascimento, Fernanda S. de Oliveira, Bianca M. de Souza, Cleber R. P. Kruel, Richard R. Gurski, Luis H. Canani, Daisy Crispim and Fernando Gerchman

Association of dietary pattern with carotid intima media thickness among children with overweight or obesity

Since there is no evidence demonstrating the relationship between dietary patterns and subclinical atherosclerosis in children and adolescents, we aimed to examine the association between dietary patterns and ...

Authors: Assa Akbari-Sedigh, Golaleh Asghari, Emad Yuzbashian, Pooneh Dehghan, Hossein Imani and Parvin Mirmiran

Body adiposity index in assessing the risk of type 2 diabetes mellitus development: the Baependi Heart Study

The association between diabetes and obesity is very well established. Faced with this, several anthropometric indices of adiposity are often involved in studies on diabetes. Our main goal in this paper is to ...

Authors: Camila Maciel de Oliveira, Jessica Pavani, José Eduardo Krieger, Rafael de Oliveira Alvim, Carlos Alberto Mourão-Junior and Alexandre da Costa Pereira

Effect of L. acidophilus and B. lactis on blood glucose in women with gestational diabetes mellitus: a randomized placebo-controlled trial

Gestational diabetes mellitus (GDM) is a complication of pregnancy that can be associated with neonatal complications and adverse pregnancy outcomes. Recently, probiotic use has been proposed for better contro...

Authors: Farnaz Sahhaf Ebrahimi, Aziz Homayouni Rad, Metanat Mosen, Fatemeh Abbasalizadeh, Aydin Tabrizi and Leila Khalili

Cardiovascular risk and obesity

This is an overview of the mechanisms of obesity and its relation to cardiovascular risks, describing the available treatment options to manage this condition.

Authors: C. Cercato and F. A. Fonseca

Evaluation of sexual dysfunction and female sexual dysfunction indicators in women with type 2 diabetes: a systematic review and meta-analysis

Type 2 diabetes is one of the most common chronic diseases worldwide, and one of the long-term complications of this disease is sexual dysfunction in women with type 2 diabetes, which has been studied in fewer...

Authors: Elham Rahmanian, Nader Salari, Masoud Mohammadi and Rostam Jalali

The effect of exercise on the prevention of gestational diabetes in obese and overweight pregnant women: a systematic review and meta-analysis

Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and its prevalence worldwide is increasing along with enhancing type two of diabetes. Contrary results have been found i...

Authors: Fatemeh Nasiri-Amiri, Mahdi Sepidarkish, Marjan Ahmad Shirvani, Payam Habibipour and Narges Sadat Motahari Tabari

Early pregnancy metabolic factors associated with gestational diabetes mellitus in normal-weight women with polycystic ovary syndrome: a two-phase cohort study

Polycystic ovary syndrome (PCOS) has been consistently associated with subsequent gestational diabetes mellitus (GDM). Women with PCOS showed a high prevalence of obesity, which raises the question regarding t...

Authors: Wei Zheng, Wenyu Huang, Li Zhang, Zhihong Tian, Qi Yan, Teng Wang, Lirui Zhang and Guanghui Li

30-days effects of vildagliptin on vascular function, plasma viscosity, inflammation, oxidative stress, and intestinal peptides on drug-naïve women with diabetes and obesity: a randomized head-to-head metformin-controlled study

Obesity is the main risk factor for diabetes and excessive visceral fat triggers low-grade inflammatory process, mediated by activation and release of cytokines and high flow of free fatty acids that contribut...

Authors: Alessandra Schiapaccassa, Priscila A. Maranhão, Maria das Graças Coelho de Souza, Diogo G. Panazzolo, José Firmino Nogueira Neto, Eliete Bouskela and Luiz Guilherme Kraemer-Aguiar

Comparison between newly diagnosed hypertension in diabetes and newly diagnosed diabetes in hypertension

Hypertension and diabetes mellitus are often jointly present, especially in early onset cases of either disease. We investigated clinical characteristics of hypertensive patients with newly diagnosed diabetes ...

Authors: Chang-Yuan Liu, Wei Zhang, Li-Nong Ji and Ji-Guang Wang