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  1. The COVID-19 pandemic is a global public health emergency, which presents wide-ranging negative impacts on individuals with diabetes. To examine psychosocial well-being and diabetes outcomes in individuals wit...

    Authors: Samereh Abdoli, Monica S. V. M. Silveira, Mehri Doosti-Irani, Paulo Fanti, Katherine Miller-Bains, Elizabeth João Pavin, Edimariz Buin Cardoso, Leila Rafiee Vardanjani, Kobra Noorian and Danielle Hessler
    Citation: Diabetology & Metabolic Syndrome 2021 13:63
    Content type: Research Published on:

    The Correction to this article has been published in Diabetology & Metabolic Syndrome 2021 13:78

  2. Research elucidating the metabolic mechanisms that differentiate subtypes of obesity has been increasing. We aimed to investigate the effects of a 12-week dietary intervention on the metabolomic profiles of ob...

    Authors: Hye Yoon Jang, Youngmin Han, Hye Jin Yoo, Jong Ho Lee and Minjoo Kim
    Citation: Diabetology & Metabolic Syndrome 2021 13:62
    Content type: Research Published on:

  3. Prediabetes is characterized by a hemoglobin A1c of 5.7–6.4% and fasting blood glucose of 100–125 mg/dl. A high percentage of prediabetes subjects develop type 2 diabetes mellitus in the next years. The effect...

    Authors: Shatha Rouf Moustafa
    Citation: Diabetology & Metabolic Syndrome 2021 13:61
    Content type: Research Published on:

  4. Laminin, one of the largest glycoproteins of the basement membrane, is an important component of the extracellular matrix. Functions of the basement membrane include regulation of cell signaling behaviors and ...

    Authors: Özgür Altun, Yücel Arman, Şengül Aydın Yoldemir, Ayşe Selcen Pala, Perihan Özkan Gümüşkaya, Mustafa Özcan, Mustafa Karataş, Okan Dikker and Tufan Tükek
    Citation: Diabetology & Metabolic Syndrome 2021 13:60
    Content type: Research Published on:

  5. To identify genetic associations of quantitative metabolic syndrome (MetS) traits and characterize heterogeneity across ethnic groups.

    Authors: Jia Y. Wan, Deborah L. Goodman, Emileigh L. Willems, Alexis R. Freedland, Trina M. Norden-Krichmar, Stephanie A. Santorico and Karen L. Edwards
    Citation: Diabetology & Metabolic Syndrome 2021 13:59
    Content type: Research Published on:

  6. Gestational diabetes mellitus (GDM) is the most common medical complication of pregnancy. CircRNA polyribonucleotide nucleotidyltransferase 1 (circ-PNPT1) has been found to be abnormally expressed in GDM patie...

    Authors: Li Zhang, Ming Zeng, Fei Tang, Jun Chen, Dongmei Cao and Ze-nan Tang
    Citation: Diabetology & Metabolic Syndrome 2021 13:58
    Content type: Research Published on:

  7. Adipocytokines, which are secreted by the adipose tissue, contribute to the pathogenesis of obesity-related complications. To evaluate this assumption, we investigated the effects of aerobic exercise training ...

    Authors: Hamideh Dinari Ghozhdi, Ali Heidarianpour, Maryam Keshvari and Hassan Tavassoli
    Citation: Diabetology & Metabolic Syndrome 2021 13:57
    Content type: Research Published on:

  8. Roux-en-Y gastric bypass (RYGB) surgery is one of the most efficient procedures for the treatment of obesity, also improving metabolic and inflammatory status, in patients with mild obesity. The underlying mec...

    Authors: Eva Lau, Eugeni Belda, Paul Picq, Davide Carvalho, Manuel Ferreira-Magalhães, Maria Manuel Silva, Isaac Barroso, Flora Correia, Cidália Pina Vaz, Isabel Miranda, Adelino Barbosa, Karine Clément, Joel Doré, Paula Freitas and Edi Prifti
    Citation: Diabetology & Metabolic Syndrome 2021 13:56
    Content type: Research Published on:

  9. This study aims to analyze the patient-reported outcome (PRO) of treatment satisfaction in a sample of children, adolescents and young adults with long-duration type 1 diabetes and to determine potential risk ...

    Authors: Anna Stahl-Pehe, Silvia Selinski, Christina Bächle and Joachim Rosenbauer
    Citation: Diabetology & Metabolic Syndrome 2021 13:55
    Content type: Short report Published on:

  10. Type 2 diabetes (T2D) is a chronic low-grade inflammatory disease, which characterized by islet beta cell dysfunction. Serum adenosine deaminase (ADA) is an important enzyme that regulates the biological activ...

    Authors: Jie Cao, Hong Wang, Jian-bin Su, Xue-qin Wang, Dong-mei Zhang, Xiao-hua Wang, Wang-shu Liu and Xiao-qin Ge
    Citation: Diabetology & Metabolic Syndrome 2021 13:54
    Content type: Research Published on:

  11. We aim to assess the association of empirical dietary (EDIH) and lifestyle (ELIH) index for hyperinsulinemia with the risk of insulin resistance, hyperinsulinemia, insulin sensitivity, and β-cell dysfunction i...

    Authors: Ebrahim Mokhtari, Hossein Farhadnejad, Farshad Teymoori, Parvin Mirmiran and Fereidoun Azizi
    Citation: Diabetology & Metabolic Syndrome 2021 13:53
    Content type: Research Published on:

  12. This study aimed to examine the effects of l-citrulline (l-CIT) on low-grade inflammation (meta-inflammation) and insulin sensitivity in type 2 diabetes (T2D) patients since it has exhibited hypoglycemic and anti...

    Authors: Fatemeh Abbaszadeh, Samaneh Azizi, Majid Mobasseri and Mehrangiz Ebrahimi-Mameghani
    Citation: Diabetology & Metabolic Syndrome 2021 13:52
    Content type: Research Published on:

  13. The adipokine asprosin, which was recently discovered, facilitates hepatic glucose production. The aim of this study is to see whether serum asprosin concentrations are linked to diabetic nephropathy (DN).

    Authors: Rui Wang, Peng Lin, Huibo Sun and Wenchao Hu
    Citation: Diabetology & Metabolic Syndrome 2021 13:51
    Content type: Research Published on:

  14. Hesperidin, a natural flavanone, has been proven to have multiple protective effects in diabetic rats, such as antioxidant, anti-inflammatory and anti-apoptotic effects. However, the molecular mechanisms under...

    Authors: Miao Tian, Yu-Bo Han, Cheng-Cheng Zhao, Li Liu and Fu-Li Zhang
    Citation: Diabetology & Metabolic Syndrome 2021 13:50
    Content type: Research Published on:

  15. As a subcomponent of low-density lipoprotein cholesterol (LDL-C), small dense LDL-C (sdLDL-C) has been suggested to be a better predictor of cardiovascular diseases (CVD). The aim of this research was to evalu...

    Authors: Li Xu, Xu Chen, Jingfen Lu, Yan Xu, Honglin Yang, Xuewen Zhou, Jun Zhou, Jianhong Xu and Hao Shen
    Citation: Diabetology & Metabolic Syndrome 2021 13:49
    Content type: Research Published on:

  16. Atherosclerosis cardiovascular disease (ASCVD) is the main cause of morbidity and mortality in type 2 diabetes mellitus (T2DM). As most diabetic patients with ASCVD are asymptomatic, it is most neglected in cl...

    Authors: Lu Gao, Wei Zhao, Jin-Kui Yang and Ming-Zhao Qin
    Citation: Diabetology & Metabolic Syndrome 2021 13:48
    Content type: Research Published on:

  17. This claims-based retrospective cohort study examined the prevalence and incremental impact of non-alcoholic steatohepatitis among children with type 2 diabetes mellitus in the United States. Although diagnose...

    Authors: Lauren Parlett, Qinli Ma, Qian Shi, Geoffrey Crawford, Laura Herrera Scott, Vincent Willey and Abiy Agiro
    Citation: Diabetology & Metabolic Syndrome 2021 13:47
    Content type: Letter to the Editor Published on:

  18. Bariatric surgery can alleviate cardiovascular risk via effects on cardiovascular disease (CVD) risk factors such as diabetes mellitus, hypertension, and dyslipidemia. Our study aimed to assess the cholesterol...

    Authors: Himani Thakkar, Vinnyfred Vincent, Sakshi Shukla, Manraj Sra, Uma Kanga, Sandeep Aggarwal and Archna Singh
    Citation: Diabetology & Metabolic Syndrome 2021 13:46
    Content type: Research Published on:

    The Correction to this article has been published in Diabetology & Metabolic Syndrome 2021 13:67

  19. HbA1c variability is independent of mean HbA1c, and associated with mortality due to vascular complications. However, the significance of HbA1c variability is unknown at present. In this study, we used flash g...

    Authors: Akemi Tokutsu, Yosuke Okada, Keiichi Torimoto and Yoshiya Tanaka
    Citation: Diabetology & Metabolic Syndrome 2021 13:45
    Content type: Research Published on:

  20. The impact of subcutaneous fat accumulation remains controversial. This study assessed the association between visceral or subcutaneous fat area (VFA and SFA, respectively) and diabetes mellitus (DM) among Jap...

    Authors: Hirohide Yokokawa, Hiroshi Fukuda, Mizue Saita, Kento Goto, Tengen Kaku, Taiju Miyagami, Yuichi Takahashi, Chieko Hamada, Teruhiko Hisaoka and Toshio Naito
    Citation: Diabetology & Metabolic Syndrome 2021 13:44
    Content type: Research Published on:

  21. Metformin plays a consolidated role in the management of polycystic ovary syndrome (PCOS). However, there is no clear answer on how long we should treat and on how long its beneficial impact sustain after we s...

    Authors: Nika Aleksandra Kravos, Andrej Janež, Katja Goričar, Vita Dolžan and Mojca Jensterle
    Citation: Diabetology & Metabolic Syndrome 2021 13:43
    Content type: Research Published on:

  22. Continuous glucose monitoring systems are increasingly being adopted as an alternative to self-monitoring of blood glucose (SMBG) by persons with diabetes mellitus receiving insulin therapy.

    Authors: Marcio Krakauer, Jose Fernando Botero, Fernando J. Lavalle-González, Adrian Proietti and Douglas Eugenio Barbieri
    Citation: Diabetology & Metabolic Syndrome 2021 13:42
    Content type: Review Published on:

  23. Obesity is considered a major health concern and mounting evidence suggests that the exposure to environmental endocrine disruptors, including Bisphenol-A (BPA), may enhance the risk to develop the disease. Mo...

    Authors: Amin Salehpour, Farzad Shidfar, Mehdi Hedayati, Ali Asghar Farshad, Asal Neshatbini Tehrani and Saeed Mohammadi
    Citation: Diabetology & Metabolic Syndrome 2021 13:41
    Content type: Research Published on:

  24. The aim of the present study was to assess diabetes-related distress in inpatients and its association with metabolic control in people with diabetes type 1 (DM1) and type 2 (DM2).

    Authors: Nadine Kuniss, Guido Kramer, Ulrich A. Müller, Gunter Wolf and Christof Kloos
    Citation: Diabetology & Metabolic Syndrome 2021 13:40
    Content type: Research Published on:

  25. To investigate the effects of intermittently scanned continuous glucose monitoring (isCGM) on blood glucose control, clinical value of blood glucose monitoring and production of urinary ketone bodies in preges...

    Authors: Shu-ying Li, Hang Guo, Yi Zhang, Pei Li, Pei Zhou, Li-rong Sun, Jing Li and Li-ming Chen
    Citation: Diabetology & Metabolic Syndrome 2021 13:39
    Content type: Research Published on:

  26. The exact incidence, clinical features and uniform diagnostic criteria of exogenous insulin autoimmune syndrome (EIAS) are still unclear. The purpose of this study is to explore the clinical characteristics of...

    Authors: Zuojun Li, Dan Yi, Lijuan Zheng, Shiran Li, Weijin Fang and Chunjiang Wang
    Citation: Diabetology & Metabolic Syndrome 2021 13:38
    Content type: Research Published on:

  27. This study aimed to explore predictive factors of time below target glucose range (TBR) ≥ 1% among patients’ characteristics and glycemic variability (GV) indices using continuous glucose monitoring data in el...

    Authors: Takahisa Handa, Akinobu Nakamura, Aika Miya, Hiroshi Nomoto, Hiraku Kameda, Kyu Yong Cho, So Nagai, Narihito Yoshioka, Hideaki Miyoshi and Tatsuya Atsumi
    Citation: Diabetology & Metabolic Syndrome 2021 13:37
    Content type: Research Published on:

  28. Gut leakage has been shown to associate with low-grade inflammation and lower cardiorespiratory fitness in diabetic subjects. We aimed to investigate whether gut leakage markers related to cardiorespiratory fi...

    Authors: Susanne Kristine Aune, Rune Byrkjeland, Svein Solheim, Harald Arnesen, Marius Trøseid, Ayodeji Awoyemi, Ingebjørg Seljeflot and Ragnhild Helseth
    Citation: Diabetology & Metabolic Syndrome 2021 13:36
    Content type: Research Published on:

  29. Traditional anthropometric indices are used in diagnosing metabolic syndrome (MetS). This study aimed to propose a novel index, a product of waist and neck circumferences (PWNC), and compared its value with tr...

    Authors: Yunhong Huang, Liping Gu, Na Li, Fang Fang, Xiaoying Ding, Yufan Wang and Yongde Peng
    Citation: Diabetology & Metabolic Syndrome 2021 13:35
    Content type: Research Published on:

  30. Asprosin, a novel adipokine that raises glucose levels and stimulates appetite, has been proved to be pathologically increased in populations predisposed to type 2 diabetes mellitus (T2DM), obesity, and cardio...

    Authors: Aijun Jiang, Zhanrong Feng, Lu Yuan, Ying Zhang, Qian Li and Yuqing She
    Citation: Diabetology & Metabolic Syndrome 2021 13:34
    Content type: Research Published on:

  31. Data on non-alcoholic fatty liver disease (NAFLD) in individuals with type 1 diabetes (T1D) is controversial and so far, there are no published data on the Brazilian population. We investigated the prevalence ...

    Authors: Bianca Senger Vasconcelos Barros, Fernanda Cruz Monteiro, Carlos Terra and Marilia Brito Gomes
    Citation: Diabetology & Metabolic Syndrome 2021 13:33
    Content type: Research Published on:

  32. Overweight and obesity are a worldwide public health problem. Obesity prevalence has increased considerably, which indicates the need for more studies to better understand these diseases and related complicati...

    Authors: Mariana de Moura e Dias, Sandra Aparecida dos Reis, Lisiane Lopes da Conceição, Catarina Maria Nogueira de Oliveira Sediyama, Solange Silveira Pereira, Leandro Licursi de Oliveira, Maria do Carmo Gouveia Peluzio, J. Alfredo Martinez and Fermín Ignacio Milagro
    Citation: Diabetology & Metabolic Syndrome 2021 13:32
    Content type: Review Published on:

  33. Due to diverging international recommendations, the unclear role of HbA1c and the lack of longitudinal data, we investigated the accuracy of diagnostic tests in the early and late postpartum in women with gest...

    Authors: Dan Yedu Quansah, Justine Gross, Richard Mbundu-Ilunga and Jardena J. Puder
    Citation: Diabetology & Metabolic Syndrome 2021 13:31
    Content type: Research Published on:

  34. In the current study, we aimed to investigate the association of dietary inflammation scores (DIS) and lifestyle inflammation scores (LIS) with the risk of metabolic syndrome (MetS) in a prospective population...

    Authors: Hossein Farhadnejad, Karim Parastouei, Hosein Rostami, Parvin Mirmiran and Fereidoun Azizi
    Citation: Diabetology & Metabolic Syndrome 2021 13:30
    Content type: Research Published on:

  35. Chronic inflammation is associated with the development, progression and long-term complications of type 2 diabetes. Hyperglycemia is associated with chronic low-grade inflammation, and thus has become the foc...

    Authors: Amanda L. Missel, Laura R. Saslow, Dina H. Griauzde, Donna Marvicsin, Ananda Sen, Caroline R. Richardson and Xuefeng Liu
    Citation: Diabetology & Metabolic Syndrome 2021 13:29
    Content type: Research Published on:

  36. Dipeptidyl peptidase 4 (DPP4) is a serine exopeptidase able to inactivate various oligopeptides, and also a hepatokine. Hepatocyte-specific overexpression of DPP4 is associated with hepatic insulin resistance ...

    Authors: Sachiko Hattori, Kazuomi Nomoto, Tomohiko Suzuki and Seishu Hayashi
    Citation: Diabetology & Metabolic Syndrome 2021 13:28
    Content type: Short report Published on:

  37. Protein phosphatase 4 regulatory subunit 1 (PP4R1) is one of the regulatory subunits of PP4. It has been determined to be involved in the regulation of TNF-α-induced hepatic insulin resistance and gluconeogene...

    Authors: Wenjing Li, Lanbo Peng, Chao Yang and Guangmin Chen
    Citation: Diabetology & Metabolic Syndrome 2021 13:27
    Content type: Research Published on:

  39. The presence of metabolic syndrome among diabetes patients is frequent and is associated with an increased incidence of chronic complications and mortality. Despite several studies have been conducted, there i...

    Authors: Rebuma Belete, Zerihun Ataro, Ahmedmenewer Abdu and Merga Sheleme
    Citation: Diabetology & Metabolic Syndrome 2021 13:25
    Content type: Review Published on:

  40. We conducted a systematic review and meta-analysis of clinical trials evaluating the role of vitamin C supplementation on lipid profiles among diabetic patients to summarize the available findings.

    Authors: Amare Abera Tareke and Addis Alem Hadgu
    Citation: Diabetology & Metabolic Syndrome 2021 13:24
    Content type: Review Published on:

  41. Our understanding of the pathophysiology of the COVID-19 manifestations and evolution has improved over the past 10 months, but the reasons why evolution is more severe in obese and diabetic patients are not y...

    Authors: Andrey Santos, Daniéla Oliveira Magro, Rosana Evangelista-Poderoso and Mario José Abdalla Saad
    Citation: Diabetology & Metabolic Syndrome 2021 13:23
    Content type: Review Published on:

  42. The aim of the study was to evaluate the ultrasound-derived measurements of the fetal soft-tissue, heart, liver and umbilical cord in pregnancies complicated by gestational (GDM) and type 1 diabetes mellitus (...

    Authors: Paweł Jan Stanirowski, Agata Majewska, Michał Lipa, Dorota Bomba-Opoń and Mirosław Wielgoś
    Citation: Diabetology & Metabolic Syndrome 2021 13:22
    Content type: Research Published on:

  43. Diabetic encephalopathy is a severe diabetes complication with cognitive dysfunction and neuropsychiatric disability. The mechanisms underlying diabetic encephalopathy is believed to be relevant with oxidative...

    Authors: Chengfeng Miao, Hanbin Chen, Yulian Li, Ying Guo, Feifei Xu, Qi Chen, Yanyan Zhang, Mengjun Hu and Guorong Chen
    Citation: Diabetology & Metabolic Syndrome 2021 13:21
    Content type: Research Published on:

  44. Previous studies reported that common functional variants (rs780093, rs780094, and rs1260326) in the glucokinase regulator gene (GCKR) were associated with metabolic syndrome despite the simultaneous association ...

    Authors: Asiyeh Sadat Zahedi, Mahdi Akbarzadeh, Bahareh Sedaghati-Khayat, Atefeh Seyedhamzehzadeh and Maryam S. Daneshpour
    Citation: Diabetology & Metabolic Syndrome 2021 13:20
    Content type: Research Published on:

  45. Bariatric surgery, especially Roux-en-Y gastric bypass (RYGB), is the most effective and durable treatment option for severe obesity. The mechanisms involving adipose tissue may be important to explain the eff...

    Authors: Rafael Ferraz-Bannitz, Caroline Rossi Welendorf, Priscila Oliveira Coelho, Wilson Salgado Jr, Carla Barbosa Nonino, Rebeca A. Beraldo and Maria Cristina Foss-Freitas
    Citation: Diabetology & Metabolic Syndrome 2021 13:19
    Content type: Research Published on:

  46. Polycystic ovary syndrome (PCOS) is a common endocrine disease affecting women of reproductive age and associated with reproductive and metabolic dysfunction. Few studies are available regarding metabolic trai...

    Authors: Poli Mara Spritzer, Ramon Bossardi Ramos, Lucas Bandeira Marchesan, Monica de Oliveira and Enrico Carmina
    Citation: Diabetology & Metabolic Syndrome 2021 13:18
    Content type: Research Published on:

  47. Glucagon-like peptide-1 receptor (GLP-1R) activation may improve myocardial performance in the context of ischaemia, independent of glycaemic control, in individuals with and without type 2 diabetes mellitus.

    Authors: Aung Myat, Simon R. Redwood, Satpal Arri, Bernard J. Gersh, Deepak L. Bhatt and Michael S. Marber
    Citation: Diabetology & Metabolic Syndrome 2021 13:17
    Content type: Research Published on:

  48. The beneficial effects of polyphenols have been reported. This study aimed to investigate the effect of oral Ellagic acid (EA) supplement on insulin resistance (IR) and Fetuin-A and serum sirtuin1 (SIRT1) in t...

    Authors: Mahnaz Ghadimi, Farshad Foroughi, Sima Hashemipour, Mohammadreza Rashidi Nooshabadi, Mohammad Hossein Ahmadi, Mojtaba Ghadimi Yari, Maria Kavianpour and Hossein Khadem Haghighian
    Citation: Diabetology & Metabolic Syndrome 2021 13:16
    Content type: Research Published on:

  49. Hypertriglyceridemia (HTG) is considered an independent risk factor for major adverse cardiovascular events (MACE).

    Authors: Yan-yan Qi, Li Yan, Zhong-min Wang, Xi Wang, Hua Meng, Wen-bo Li, Dong-chang Chen, Meng Li, Jun Liu and Song-tao An
    Citation: Diabetology & Metabolic Syndrome 2021 13:15
    Content type: Research Published on:

  50. Type 2 diabetes is a common non-communicable disease that is responsible for about 9% of all deaths and a 25% reduction in life expectancy. However, nearly half of the diabetic patients are not aware of their ...

    Authors: Fateme Kianpour, Mohammad Fararouei, Jafar Hassanzadeh, Mohammadnabi Mohammadi and Mostafa Dianatinasab
    Citation: Diabetology & Metabolic Syndrome 2021 13:13
    Content type: Research Published on:

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