Articles

Methylation quantitative trait loci within the TOMM20 gene are associated with metabolic syndrome-related lipid alterations in severely obese subjects

The TOMM20 gene was previously identified as differentially expressed and methylated between severely obese subjects with and without metabolic syndrome (MS). Since metabolic complications do not affect all obese...

Authors: Juan de Toro-Martín, Frédéric Guénard, André Tchernof, Yves Deshaies, Louis Pérusse, Frédéric-Simon Hould, Stéfane Lebel, Picard Marceau and Marie-Claude Vohl

Comparison between adherence assessments and blood glucose monitoring measures to predict glycemic control in adults with type 1 diabetes: a cross-sectional study

Adherence to treatment has been defined as the degree to which a patient’s behavior corresponds to medical or health advice; however, the most appropriate method to evaluate adherence to diabetes care has yet ...

Authors: Gabriela Heiden Telo, Martina Schaan de Souza, Thais Stürmer Andrade and Beatriz D’Agord Schaan

The relationship between HbA1c values and the occurrence of hypoglycemia as assessed by continuous glucose monitoring in patients with type 1 diabetes

We aimed to examine the relationship between the occurrence of hypo-/hyperglycemia and HbA1c values, as assessed by continuous glucose monitoring (CGM) in patients with type 1 diabetes.

Authors: Daisuke Tsujino, Rimei Nishimura, Yoshiko Onda, Chiaki Seo, Kiyotaka Ando, Aya Morimoto and Kazunori Utsunomiya

Association of cardiac NT pro-β-type natriuretic peptide with metabolic and endothelial risk factors in young obese hypertensive patients: a perspective on the hypothalamic pituitary adrenal axis activation

In practice, there is increasing recognition of the importance of hypothalamic pituitary adrenal axis in the cardiovascular disease progression. The association of brain natriuretic peptide with obesity and ch...

Authors: Mona Schaalan, Waleed Mohamed and Rania Rahmo

Screening for coeliac disease in adult patients with type 1 diabetes mellitus: myths, facts and controversy

This review aims at summarizing the present knowledge on the clinical consequences of concomitant coeliac disease (CD) in adult patients with type 1 diabetes mellitus (T1DM). The cause of the increased prevale...

Authors: Sjoerd F. Bakker, Maarten E. Tushuizen, Boudewina M. E. von Blomberg, Hetty J. Bontkes, Chris J. Mulder and Suat Simsek

Interactions between kidney disease and diabetes: dangerous liaisons

Type 2 diabetes mellitus (DM) globally affects 18–20 % of adults over the age of 65 years. Diabetic kidney disease (DKD) is one of the most frequent and dangerous complications of DM2, affecting about one-thir...

Authors: Roberto Pecoits-Filho, Hugo Abensur, Carolina C. R. Betônico, Alisson Diego Machado, Erika B. Parente, Márcia Queiroz, João Eduardo Nunes Salles, Silvia Titan and Sergio Vencio

Impact of metabolic syndrome on lipid target achievements in the Arabian Gulf: findings from the CEPHEUS study

The aim of this study was to determine the impact of metabolic syndrome (MetS) on lipid target achievements in the Arabian Gulf.

Authors: Ibrahim Al-Zakwani, Wael Al Mahmeed, Abdullah Shehab, Mohamed Arafah, Ali T. Al-Hinai, Omer Al Tamimi, Mahmoud Al Awadhi, Shorook Al Herz, Faisal Al Anazi, Khalid Al Nemer, Othman Metwally, Akram Alkhadra, Mohammed Fakhry, Hossam Elghetany, Abdel Razak Medani, Afzal Hussein Yusufali…

Use of a real time continuous glucose monitoring system as an educational tool for patients with gestational diabetes

Women with gestational diabetes mellitus (GDM) are required to control their blood glucose shortly after GDM diagnosis to minimize adverse pregnancy outcomes. A real time-continuous glucose monitoring system (...

Authors: Eman Alfadhli, Eman Osman and Taghreed Basri

Obesity, maternal smoking and SHBG in neonates

Sex hormone binding globulin (SHBG), a glycoprotein produced by hepatocytes that transports testosterone and other steroids in plasma, is a marker for developing metabolic syndrome and T2DM. SHBG is present in...

Authors: Swapna Dharashivkar, Lawrence Wasser, Richard N. Baumgartner, Jeffrey C. King and Stephen J. Winters

Is vaspin related to cardio-metabolic status and autonomic function in early stages of glucose intolerance and in metabolic syndrome?

This study aims to assess serum vaspin in early stages of glucose intolerance and in the presence of metabolic syndrome (MetS); and to evaluate vaspin correlation to different cardio-metabolic parameters and a...

Authors: Rumyana Dimova, Tsvetalina Tankova, Georgi Kirilov, Nevena Chakarova, Lilia Dakovska and Greta Grozeva

Empagliflozin (an SGLT2 inhibitor), alone or in combination with linagliptin (a DPP-4 inhibitor), prevents steatohepatitis in a novel mouse model of non-alcoholic steatohepatitis and diabetes

Sodium-glucose co-transporter-2 (SGLT2) inhibitors are new oral antidiabetic drugs that reduce hyperglycemia by promoting urinary glucose excretion. Glycosuria produced by SGLT2 inhibitors is associated with w...

Authors: Teruo Jojima, Takanori Tomotsune, Toshie Iijima, Kazumi Akimoto, Kunihiro Suzuki and Yoshimasa Aso

Increased depression and metabolic risk in postmenopausal breast cancer survivors

Breast cancer survivors (BCS) are at high risk for the development of obesity, type 2 diabetes mellitus, and metabolic syndrome. There is increasing interest in the association between depression and metabolic...

Authors: Monica C. Serra, Andrew P. Goldberg and Alice S. Ryan

Hemoglobin A1c as screening for gestational diabetes mellitus in Nordic Caucasian women

Gestational diabetes mellitus (GDM) increases the risk for preeclampsia and macrosomia. GDM is conventionally diagnosed by an oral glucose tolerance test (OGTT). Hemoglobin A1c (HbA1c) is a marker for the aver...

Authors: Ingrid Hov Odsæter, Arne Åsberg, Eszter Vanky, Siv Mørkved, Signe Nilssen Stafne, Kjell Åsmund Salvesen and Sven Magnus Carlsen

A study for association and interaction analysis to metabolic syndrome and the ESR1 gene on cardiovascular autonomic neuropathy in a Chinese Han population

The aim of this study was to investigate the association and interaction of metabolic syndrome (MetS) and estrogen receptor alpha 1 (ESR1) gene polymorphisms on cardiovascular autonomic neuropathy (CAN).

Authors: Fangfang Zeng, Linuo Zhou and Zihui Tang

Challenges associated with insulin therapy progression among patients with type 2 diabetes: Latin American MOSAIc study baseline data

Poor glycemic control in patients with type 2 diabetes is commonly recorded worldwide; Latin America (LA) is not an exception. Barriers to intensifying insulin therapy and which barriers are most likely to neg...

Authors: Bruno Linetzky, Brad Curtis, Gustavo Frechtel, Renan Montenegro Jr., Miguel Escalante Pulido, Oded Stempa, Janaina Martins de Lana and Juan José Gagliardino

Visceral adiposity syndrome

The association of anthropometric (waist circumference) and hemodynamic (blood pressure) changes with abnormalities in glucose and lipid metabolism has been motivation for a lot of discussions in the last 30 y...

Authors: Heno F. Lopes, Maria Lúcia Corrêa-Giannella, Fernanda M. Consolim-Colombo and Brent M. Egan

Overweight among children and adolescent with type I diabetes mellitus: prevalence and associated factors

Describe the overweight frequency (overweight and obesity) and identify the factors associated with this in children and adolescents with type 1 diabetes mellitus (T1DM) treated at a University Children’s Hosp...

Authors: Verônica Medeiros da Costa, Patricia de Carvalho Padilha, Géssica Castor Fontes de Lima, Aline Alves Ferreira, Jorge Luiz Luescher, Luciana Porto and Wilza Arantes Ferreira Peres

NK cell count and glucotransporter 4 (GLUT4) expression in subjects with type 2 diabetes and colon cancer

Type 2 diabetes (T2D) and colon cancer (CC) are numbered among the most common diseases in the world. The decreased activity of natural killer (NK) cells previously revealed in both mentioned pathological sta...

Authors: Paweł Piątkiewicz, Małgorzata Bernat-Karpińska, Tomasz Miłek, Michał Rabijewski and Elżbieta Rosiak

LEADER 7: cardiovascular risk profiles of US and European participants in the LEADER diabetes trial differ

To determine whether US and European participants in the Liraglutide Effect and Action in Diabetes: Evaluation of cardiovascular outcome Results (LEADER) trial differ regarding risk factors for cardiovascular ...

Authors: Guy E. H. M. Rutten, Cees J. Tack, Thomas R. Pieber, Abdurrahman Comlekci, David Dynnes Ørsted, Florian M. M. Baeres, Steven P. Marso and John B. Buse

Lixisenatide improves glycemic outcomes of Japanese patients with type 2 diabetes: a meta-analysis

The GetGoal-L-Asia and -S trials were multi-center trials conducted in 4 and 16 countries, respectively including Japan that evaluated the efficacy and safety of lixisenatide add-on treatment vs. placebo among...

Authors: Hiroaki Seino, Yukiko Onishi, Yusuke Naito and Mitsuhisa Komatsu

Access to medicines for diabetes treatment in Brazil: evaluation of “health has no price” program

In 2011, private pharmacies associated to the Brazilian Ministry of Health provided patients with two types of insulin (regular human insulin and isophane insulin or NPH) and three oral antidiabetic medication...

Authors: João Leopoldo Oliveira Araujo, Mariana Donato Pereira, Cristiane de Cássia Bergamaschi, Fernando de Sá Del Fiol, Luciane Cruz Lopes, Maria Inês de Toledo and Silvio Barberato-Filho

Oxidative DNA damage and oxidized low density lipoprotein in Type II diabetes mellitus among patients with Helicobacter pylori infection

Helicobacter pylori (H. pylori) infection is reported to be associated with various extragastrointestinal conditions such as insulin resistance, diabetes mellitus and metabolic syndrom...

Authors: Wesam Ahmed Nasif, Mohammed Hasan Mukhtar, Mohammed Mahmoud Nour Eldein and Sami Sadagah Ashgar

Seborrheic keratoses and severe hypoinsulinemic hypoglycemia associated with insulin grow factor 2 secretion by a malignant solitary fibrous tumor

A rare sign of some malignant tumors is a sudden eruption of multiple seborrheic keratoses called Leser-Trélat sign. Overproduction of insulin-like growth factor-2 (IGF2) or its precursor is the main mechanism...

Authors: Andreia Latanza Gomes Mathez, Debora Moroto, Sergio Atala Dib and Joao Roberto de Sa

Inadequacies in the habitual nutrient intakes of patients with metabolic syndrome: a cross-sectional study

Dietary factors are important environmental factors associated with the prevalence of metabolic syndrome (MS). The objective of this study was to assess the habitual nutrient intakes of patients with MS.

Authors: Aline Tuane Oliveira da Cunha, Hermilla Torres Pereira, Sephora Louyse Silva de Aquino, Cristiane Hermes Sales, Karine Cavalcanti Maurício Sena-Evangelista, Josivan Gomes Lima, Severina Carla Vieira Cunha Lima and Lucia Fatima Campos Pedrosa

The usefulness of quantifying intraepidermal nerve fibers density in the diagnostic of diabetic peripheral neuropathy: a cross-sectional study

Distal symmetric polyneuropathy (DSPN) is the most common complication of type 2 diabetes mellitus (T2DM) and the most common form of peripheral neuropathy. DSPN increases the risk of foot ulceration up to sev...

Authors: Bogdan Timar, Simona Popescu, Romulus Timar, Flavia Baderca, Bogdan Duica, Mihaela Vlad, Codrina Levai, Bogdan Balinisteanu and Mihaela Simu

Association between health literacy and metabolic syndrome or healthy lifestyle characteristics among community-dwelling Japanese people

Few studies have assessed the association between health literacy (HL) and healthy lifestyle characteristics among Japanese people, and reports on the association between HL and prevalence of metabolic syndrom...

Authors: Hirohide Yokokawa, Hiroshi Fukuda, Motoyuki Yuasa, Hironobu Sanada, Teruhiko Hisaoka and Toshio Naito

High frequency of vitamin D receptor gene polymorphism FokI in Brazilian Type 1 diabetes mellitus patients with clinical autoimmune thyroid disease

Polymorphisms of vitamin D receptor (VDR) gene have been studied as genetic markers of type 1 diabetes mellitus (T1DM) and some studies have reported associations with autoimmune thyroid disease. The aim of th...

Authors: Denise Barreto Mory, Monica Andrade Lima Gabbay, Eloá R. Rocco, Teresa Kasamatsu, Felipe Crispim, Walquíria Lopes Miranda and Sérgio Atala Dib

Double-diabetes in a real-world sample of 2711 individuals: associated with insulin treatment or part of the heterogeneity of type 1 diabetes?

Double diabetes (DD) describes both individuals with obesity upon diagnosis of type 1 diabetes and those who have gained weight during follow-up, although cardiovascular risk factors (CVRF) are not well unders...

Authors: Fernando M. A. Giuffrida, Caroline Bulcão, Roberta A. Cobas, Carlos Antonio Negrato, Marilia B. Gomes and Sergio Atala Dib

Prevalence of metabolic syndrome in non-diabetic, pregnant Angolan women according to four diagnostic criteria and its effects on adverse perinatal outcomes

Metabolic syndrome (MetS) is a cluster of risk factors for type 2 diabetes (Type2 DM) and cardiovascular diseases (CVD), and its prevalence varies based on region, population, and sex. Newborns of women with M...

Authors: Hamilton dos Prazeres Tavares, Débora Cristina Damasceno Meirelles dos Santos, Joelcio Francisco Abbade, Carlos Antonio Negrato, Paulo Adão de Campos, Iracema Mattos Paranhos Calderon and Marilza Vieira Cunha Rudge

Dipeptidyl peptidase-4 inhibitors improve arterial stiffness, blood pressure, lipid profile and inflammation parameters in patients with type 2 diabetes mellitus

This uncontrolled open label study evaluated the effect of dipeptidyl peptidase-4 inhibitors (DPP-4i): sitagliptin and vildagliptin on augmentation index standardized for 75 beats per minute (cAiX@75), blood p...

Authors: Lea Duvnjak and Kristina Blaslov

Baseline characteristics and risk factors for ulcer, amputation and severe neuropathy in diabetic foot at risk: the BRAZUPA study

Studies on diabetic foot and its complications involving a significant and representative sample of patients in South American countries are scarce. The main objective of this study was to acquire clinical and...

Authors: Maria Candida R. Parisi, Arnaldo Moura Neto, Fabio H. Menezes, Marilia Brito Gomes, Rodrigo Martins Teixeira, José Egídio Paulo de Oliveira, Joana Rodrigues Dantas Pereira, Reine Marie Chaves Fonseca, Lorena Barreto Arruda Guedes, Adriana Costa e Forti, Ana Mayra Andrade de Oliveira, Marta Barreto de Medeiros Nóbrega, Víctor Nóbrega Quintas Colares, Helena Schmid, Otto Henrique Nienov, Marcia Nery…

The role of adipose tissue and adipokines in the manifestation of type 2 diabetes in the long-term period following myocardial infarction

This study aimed to evaluate the markers of insulin resistance and adipokine status in patients with visceral obesity during hospitalization following myocardial infarction (MI) and assess the disturbances of ...

Authors: Olga Barbarash, Olga Gruzdeva, Evgenya Uchasova, Yulia Dyleva, Ekaterina Belik, Olga Akbasheva, Victoria Karetnikova and Alexander Kokov

Clinical and laboratory data of a large series of patients with congenital generalized lipodystrophy

Berardinelli-Seip congenital lipodystrophy (BSCL) was initially described by Berardinelli in Brazil in 1954 and 5 years later by Seip in Norway. It is an autosomal recessive disease that leads to a generalized...

Authors: Josivan G. Lima, Lucia Helena C. Nobrega, Natalia Nobrega de Lima, Maria Goretti do Nascimento Santos, Maria F. P. Baracho and Selma Maria Bezerra Jeronimo

Gender-specific associations of serum sex hormone-binding globulin with features of metabolic syndrome in children

Sex hormone-binding globulin (SHBG) has been proposed as a biomarker of MetS in children and adults. We aim to determine the associations of SHBG with components of MetS in children from the Middle-East where ...

Authors: Nasser M. Al-Daghri, Nasiruddin Khan, Shaun Sabico, Omar S. Al-Attas, Majed S. Alokail and Sudhesh Kumar

Factors associated with glucose tolerance, pre-diabetes, and type 2 diabetes in a rural community of south India: a cross-sectional study

India’s national rural prevalence of type 2 diabetes has quadrupled in the past 25 years. Despite the growing rural burden, few studies have examined putative risk factors and their relationship with glucose i...

Authors: Matthew Little, Sally Humphries, Kirit Patel, Warren Dodd and Cate Dewey

Erratum to: Expression of REG Iα gene in type 2 diabetics in Pakistan

Authors: Sadaf Saleem Uppal, Abdul Khaliq Naveed, Saeeda Baig and Bushra Chaudhry

Usefulness of circulating E-selectin to early detection of the atherosclerotic process in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

This cross-sectional analysis evaluated whether determination of E-selectin concentrations could identify deterioration of cardiometabolic risk profile or subclinical atherosclerosis in individuals at low-to-m...

Authors: Bianca de Almeida-Pititto, Fernando Flexa Ribeiro-Filho, Marcio Sommer Bittencourt, Paulo A. Lotufo, Isabela Bensenor and Sandra R. G. Ferreira

Associations between fish consumption and metabolic syndrome. A large cross-sectional study from the Norwegian Tromsø Study: Tromsø 4

Fish consumption may prevent or improve metabolic health. The aim of this study was to identify associations between fish consumption, both fatty and lean, and metabolic syndrome and its components.

Authors: C. Tørris, M. Molin and M. Cvancarova Småstuen

Reviewer acknowledgement 2015

Authors: Daniel Giannella-Neto

DPP-4 inhibition improves early mortality, β cell function, and adipose tissue inflammation in db/db mice fed a diet containing sucrose and linoleic acid

Diabetes therapy that not only lowers glucose levels but also lengthens life spans is required. We previously demonstrated that DPP-4 inhibition ameliorated β cell apoptosis and adipose tissue inflammation in ...

Authors: Jun Shirakawa, Tomoko Okuyama, Mayu Kyohara, Eiko Yoshida, Yu Togashi, Kazuki Tajima, Shunsuke Yamazaki, Mitsuyo Kaji, Megumi Koganei, Hajime Sasaki and Yasuo Terauchi

Sitagliptin monotherapy has better effect on insulinogenic index than glimepiride monotherapy in Japanese patients with type 2 diabetes mellitus: a 52-week, multicenter, parallel-group randomized controlled trial

The 52-week monotherapy with the dipeptidyl peptidase-4 inhibitor sitagliptin and the sulphonylurea glimepiride on early-phase insulin secretion in Japanese patients with type 2 diabetes mellitus (T2DM) is not...

Authors: Yaeko Kondo, Norio Harada, Akihiro Hamasaki, Shizuka Kaneko, Koichiro Yasuda, Eiichi Ogawa, Shin-ichi Harashima, Hiroko Yoneda, Yoshihito Fujita, Norikazu Kitano, Yoshio Nakamura, Fujio Matsuo, Megumi Shinji, Shiro Hinotsu, Takeo Nakayama and Nobuya Inagaki

Effect of birthplace on cardiometabolic risk among blacks in the Metabolic Syndrome Outcome Study (MetSO)

Metabolic syndrome poses an increased global burden of disease and causes immense financial burden, warranting heightened public health attention. The present study assessed the prevalence and severity of card...

Authors: Joseph Ravenell, Azizi Seixas, Diana Margot Rosenthal, Olajide Williams, Chinwe Ogedegbe, Mary Ann Sevick, Valerie Newsome and Girardin Jean-Louis

Effects of different exercise programs and minimal detectable changes in hemoglobin A1c in patients with type 2 diabetes

The incidence of diabetes mellitus is increasing worldwide, resulting in a global epidemic. The most common type, the type 2 diabetes mellitus, constitutes of 90–95 % of the cases and is characterized by the acti...

Authors: Carlos Gabriel de Lade, João Carlos Bouzas Marins, Luciana Moreira Lima, Cristiane Junqueira de Carvalho, Robson Bonoto Teixeira, Maicon Rodrigues Albuquerque, Janice Sepúlveda Reis and Paulo Roberto dos Santos Amorim

Neck circumference as a risk factor of screen-detected diabetes mellitus: community-based study

Whereas an increase of neck circumference (NC) had been recently identified as a new independent cardiovascular disease (CVD) and metabolic syndrome risk factor, similar assessments concerning screen-detected ...

Authors: Mykolay Khalangot, Vitaliy Gurianov, Nadia Okhrimenko, Igor Luzanchuk and Victor Kravchenko

Effect of Cichorium intybus L. on the expression of hepatic NF-κB and IKKβ and serum TNF-α in STZ− and STZ+ niacinamide-induced diabetes in rats

Inflammation is an early event in the development of diabetes type 2 (T2D). Cichorium intybus L. (chicory) possesses anti-inflammatory action. We compared the anti-inflammatory aspect of aqueous chicory seed extr...

Authors: Lotfollah Rezagholizadeh, Yasin Pourfarjam, Azin Nowrouzi, Manuchehr Nakhjavani, Alipasha Meysamie, Nasrin Ziamajidi and Peyman S. Nowrouzi

Relationship between deep subcutaneous abdominal adipose tissue and metabolic syndrome: a case control study

The deep subcutaneous adipose tissue (dSAT) is closely related to the obesity-associated complications similarly to the characteristics of visceral adipose tissue (VAT). However, the association between dSAT a...

Authors: Se-Hong Kim, Ju-hye Chung, Sang-Wook Song, Won Sang Jung, Yun-Ah Lee and Ha-Na Kim

Comparison of adipokines in a cross-sectional study with healthy overweight, insulin-sensitive and healthy lean, insulin-resistant subjects, assisted by a family doctor primary care program

In most individuals, obesity and insulin resistance coexist. However, some individuals have excessive adipose tissue mass but remain insulin sensitive. Moreover, lean individuals can develop acute inflammation...

Authors: Samuel D. Moscavitch, Hye C. Kang, Rubens A. C. Filho, Evandro T. Mesquita, Hugo C. C. F. Neto and Maria L. G. Rosa

Juçara pulp supplementation improves glucose tolerance in mice

The consumption of hyperlipidic and hypercaloric diet is considered a major factor to promote obesity and the consumption of food with antioxidant properties, like Juçara (Euterpe edulis Mart), could be a tool to...

Authors: L. M. Oyama, F. P. Silva, J. Carnier, D. A. de Miranda, A. B. Santamarina, E. B. Ribeiro, C. M. Oller do Nascimento and V. V. de Rosso

The chronic care model for type 2 diabetes: a systematic review

The chronic care model (CCM) uses a systematic approach to restructure health care systems. The aim of this systematic review was to examine studies that evaluated different elements of the CCM in patients wi...

Authors: Deise Regina Baptista, Astrid Wiens, Roberto Pontarolo, Lara Regis, Walleri Christine Torelli Reis and Cassiano Januário Correr

Study on inflammation-related genes and microRNAs, with special emphasis on the vascular repair factor HGF and miR-574-3p, in monocytes and serum of patients with T2D

Recently, we reported signs of inflammation (raised IL-8, reduced miR-146a) and signs of vascular repair (raised HGF) in the serum of Ecuadorian patients with type 2 diabetes (T2D). In contrast, we found that ...

Authors: Lucy Baldeón Rojas, Karin Weigelt, Harm de Wit, Behiye Ozcan, Adri van Oudenaren, Fernando Sempértegui, Eric Sijbrands, Laura Grosse, Anton-Jan van Zonneveld, Hemmo A. Drexhage and Pieter J. M. Leenen