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  1. Short report

    Metabolic profiling of type 1 diabetes mellitus in children and adolescents: a case–control study

    Type 1 diabetes mellitus (T1DM) is one of the most common pediatric diseases and its incidence is rising in many countries. Recently, it has been shown that metabolites other than glucose play an important rol...

    Liene Bervoets, Guy Massa, Wanda Guedens, Evelyne Louis, Jean-Paul Noben and Peter Adriaensens

    Diabetology & Metabolic Syndrome 2017 9:48

    Published on: 26 June 2017

  2. Research

    Introduction of the DiaGene study: clinical characteristics, pathophysiology and determinants of vascular complications of type 2 diabetes

    Type 2 diabetes is a major healthcare problem. Glucose-, lipid-, and blood pressure-lowering strategies decrease the risk of micro- and macrovascular complications. However, a substantial residual risk remains...

    Thijs T. W. van Herpt, Roosmarijn F. H. Lemmers, Mandy van Hoek, Janneke G. Langendonk, Ronald J. Erdtsieck, Bert Bravenboer, Annelies Lucas, Monique T. Mulder, Harm R. Haak, Aloysius G. Lieverse and Eric J. G. Sijbrands

    Diabetology & Metabolic Syndrome 2017 9:47

    Published on: 19 June 2017

  3. Research

    Understanding the barriers and improving care in type 2 diabetes: Brazilian perspective in time to do more in diabetes

    Type 2 diabetes mellitus (T2DM) is a complex disease, particularly in a continental country like Brazil. We attempted to understand and evaluate the perceptions and routines of Brazilians with T2DM and physici...

    Sérgio Vencio, Päivi M. Paldánius, Matthias Blüher, Daniel Giannella-Neto, Rafael Caiado-Vencio and W. David Strain

    Diabetology & Metabolic Syndrome 2017 9:46

    Published on: 15 June 2017

  4. Research

    Verification of B-lymphocyte activating factor’s involvement in the exacerbation of insulin resistance as well as an autoimmune response in patients with nonalcoholic steatohepatitis and patients with HCV-related chronic liver disease

    Ten to forty percent of nonalcoholic steatohepatitis (NASH) and HCV-related chronic liver disease (CLD-C) patients have antinuclear antibodies (ANAs). However, the relationship between autoimmune response and ...

    Takashi Himoto, Koji Fujita, Takako Nomura, Joji Tani, Asahiro Morishita, Hirohito Yoneyama, Reiji Haba and Tsutomu Masaki

    Diabetology & Metabolic Syndrome 2017 9:45

    Published on: 13 June 2017

  5. Research

    Unacylated ghrelin modulates circulating angiogenic cell number in insulin-resistant states

    Type 2 diabetes (T2D) is associated with reduced numbers and impaired function of circulating angiogenic cells (CAC) which contributes to the progression of atherosclerosis and microvascular disease. Previous ...

    Behiye Özcan, Pieter J. M. Leenen, Patric J. D. Delhanty, Lucy Y. Baldéon-Rojas, Sebastian J. Neggers and Aart Jan van der Lely

    Diabetology & Metabolic Syndrome 2017 9:43

    Published on: 31 May 2017

  6. Research

    Skin autofluorescence, a non-invasive biomarker for advanced glycation end products, is associated with the metabolic syndrome and its individual components

    The metabolic syndrome (MetS) comprises several cardiometabolic risk factors associated with increased risk for both type 2 diabetes and cardiovascular disease. Skin autofluorescence (SAF), a non-invasive biom...

    Robert P. van Waateringe, Sandra N. Slagter, Andre P. van Beek, Melanie M. van der Klauw, Jana V. van Vliet-Ostaptchouk, Reindert Graaff, Andrew D. Paterson, Helen L. Lutgers and Bruce H. R. Wolffenbuttel

    Diabetology & Metabolic Syndrome 2017 9:42

    Published on: 30 May 2017

  7. Research

    Soluble plasma proteins ST2 and CD163 as early biomarkers of nephropathy in Swedish patients with diabetes, 15–34 years of age: a prospective cohort study

    The aim of this study was to investigate plasma levels of sST2 and sCD163 to determine whether they at an early stage could predict development of diabetic nephropathy and/or diabetic retinopathy in patients a...

    My Samuelsson, Jonatan Dereke, Maria K. Svensson, Mona Landin-Olsson and Magnus Hillman

    Diabetology & Metabolic Syndrome 2017 9:41

    Published on: 25 May 2017

  8. Research

    Association of metabolic syndrome and electrocardiographic markers of subclinical cardiovascular disease

    The metabolic syndrome (MetS) and its components are well-established risk factors for cardiovascular diseases (CVD). It is inconclusive whether MetS and MetS score are associated with electrocardiographic mar...

    Theodora W. Elffers, Renée de Mutsert, Hildo J. Lamb, Arie C. Maan, Peter W. Macfarlane, Ko Willems van Dijk, Frits R. Rosendaal, J. Wouter Jukema and Stella Trompet

    Diabetology & Metabolic Syndrome 2017 9:40

    Published on: 22 May 2017

  9. Research

    Basal hyperinsulinemia beyond a threshold predicts major adverse cardiac events at 1 year after coronary angiogram in type 2 diabetes mellitus: a retrospective cohort study

    There is a substantial reduction in cardiovascular related morbidity and mortality in the general population attributed to improved treatment of cardiac risk factors and disease, the same magnitude of benefit ...

    Mukund Srinivasan, Padmanabh Kamath, Narayan Bhat, Narasimha Pai, Rajesh Bhat, Tejas Shah, Poornima Manjrekar and Chakrapani Mahabala

    Diabetology & Metabolic Syndrome 2017 9:38

    Published on: 19 May 2017

  10. Research

    Disease management programs for patients with type 2 diabetes mellitus in Germany: a longitudinal population-based descriptive study

    The primary aim of the disease management program (DMP) for patients with diabetes mellitus type 2 is to improve the quality of health care and the treatment process. 12 years after its introduction in Germany...

    Michael Mehring, Ewan Donnachie, Florian Cornelius Bonke, Christoph Werner and Antonius Schneider

    Diabetology & Metabolic Syndrome 2017 9:37

    Published on: 18 May 2017

  11. Review

    Mesenchymal stem cell therapy in type 2 diabetes mellitus

    Type 2 diabetes mellitus (T2DM), which is characterized by the combination of relative insulin deficiency and insulin resistance, cannot be reversed with existing therapeutic strategies. Transplantation of ins...

    Li Zang, Haojie Hao, Jiejie Liu, Yijun Li, Weidong Han and Yiming Mu

    Diabetology & Metabolic Syndrome 2017 9:36

    Published on: 15 May 2017

  12. Research

    Vildagliptin has the same safety profile as a sulfonylurea on bone metabolism and bone mineral density in post-menopausal women with type 2 diabetes: a randomized controlled trial

    Several antidiabetic therapies affect bone metabolism. Sulfonylureas have the lowest impact on bone among oral antidiabetics. The objective of this study is to compare the effects of vildagliptin and gliclazid...

    Andre Gustavo Daher Vianna, Claudio Silva de Lacerda, Luciana Muniz Pechmann, Michelle Garcia Polesel, Emerson Cestari Marino, Victoria Zeghbi Cochenski Borba and Fellype de Carvalho Barreto

    Diabetology & Metabolic Syndrome 2017 9:35

    Published on: 15 May 2017

  13. Research

    Gene variants in the FTO gene are associated with adiponectin and TNF-alpha levels in gestational diabetes mellitus

    Obesity may have a role in the development of gestational diabetes mellitus (GDM). Single-nucleotide-polymorphisms (SNPs) of the FTO (fat mass and obesity associated) gene have been associated with obesity. Th...

    Renata Saucedo, Jorge Valencia, Claudia Gutierrez, Lourdes Basurto, Marcelino Hernandez, Edgardo Puello, Guadalupe Rico, Gloria Vega and Arturo Zarate

    Diabetology & Metabolic Syndrome 2017 9:32

    Published on: 12 May 2017

  14. Research

    Roles of fasting and postprandial blood glucose in the effect of type 2 diabetes on central arterial stiffness: a 5-year prospective community-based analysis

    Cardiovascular disease constitutes a major challenge for the health of community-dwelling population, it is essential to delay the development of atherosclerosis. However, long-term prospective studies analyzi...

    Shihui Fu, Wenji Chen, Leiming Luo and Ping Ye

    Diabetology & Metabolic Syndrome 2017 9:33

    Published on: 12 May 2017

  15. Research

    Urinary podocyte-associated mRNA levels correlate with proximal tubule dysfunction in early diabetic nephropathy of type 2 diabetes mellitus

    The study assessed mRNA expression of podocyte-associated molecules in urinary sediments of patients with type 2 diabetes mellitus (DM) in relation to urinary podocytes, biomarkers of podocyte injury and of pr...

    Ligia Petrica, Sorin Ursoniu, Florica Gadalean, Adrian Vlad, Gheorghe Gluhovschi, Victor Dumitrascu, Daliborca Vlad, Cristina Gluhovschi, Silvia Velciov, Flaviu Bob, Petru Matusz, Oana Milas, Alina Secara, Anca Simulescu and Roxana Popescu

    Diabetology & Metabolic Syndrome 2017 9:31

    Published on: 6 May 2017

  16. Research

    Inpatient screening for albuminuria and retinopathy to predict long-term mortality in type 2 diabetic patients: a retrospective cohort study

    There is a high hospitalization rate for diabetic patients. Since retinopathy and albuminuria are both important manifestations of microvascular disease in diabetes, our aim was to investigate the effect of re...

    Ya-Mei Hsieh, Wen-Jane Lee, Wayne H.-H. Sheu, Yu-Hsuan Li, Shih-Yi Lin and I.-Te Lee

    Diabetology & Metabolic Syndrome 2017 9:29

    Published on: 3 May 2017

  17. Research

    Dipeptidyl peptidase-4 levels are increased and partially related to body fat distribution in patients with familial partial lipodystrophy type 2

    Dipeptidyl peptidase-4 (DDP4) is an enzyme responsible for glucagon-like peptide-1 inactivation and plays an important role in glucose metabolism.

    Cynthia Melissa Valerio, Juliana Severo de Almeida, Rodrigo Oliveira Moreira, Luiza Barreto. S. Aguiar, Priscila O. Siciliano, Denise P. Carvalho and Amelio F. Godoy-Matos

    Diabetology & Metabolic Syndrome 2017 9:26

    Published on: 24 April 2017

  18. Review

    Cardiovascular risk assessment in patients with diabetes

    Although patients with diabetes have 2 to 4 times increased risk of cardiovascular morbidity and mortality than individuals without diabetes, recent studies indicate that a significant part of patients are in ...

    Marcello Casaccia Bertoluci and Viviane Zorzanelli Rocha

    Diabetology & Metabolic Syndrome 2017 9:25

    Published on: 20 April 2017

    The Erratum to this article has been published in Diabetology & Metabolic Syndrome 2017 9:70

  19. Research

    Cardiometabolic risk factors, metabolic syndrome and pre-diabetes in adolescents in the Sierra region of Ecuador

    Excess weight (overweight and obesity) is the major modifiable risk factor for type 2 diabetes mellitus (T2DM) and other non-communicable diseases. However, excess weight may not be as predictive of diabetes r...

    Sharon L. Casapulla, Cheryl A. Howe, Gabriela Rosero Mora, Darlene Berryman, Mario J. Grijalva, Edgar W. Rojas, Masato Nakazawa and Jay H. Shubrook

    Diabetology & Metabolic Syndrome 2017 9:24

    Published on: 19 April 2017

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