Articles

Tissue-specific methylation profile in obese patients with type 2 diabetes before and after Roux-en-Y gastric bypass

Eating habits, lifestyles, and exposure to specific environmental factors can greatly impact the risk of developing type 2 diabetes (T2D), influence the genome epigenetically, and affect the expression of gene...

Authors: Priscila Sala, Raquel Susana Matos de Miranda Torrinhas, Danielle Cristina Fonseca, Graziela Rosa Ravacci, Dan Linetzky Waitzberg and Daniel Giannella-Neto

Erratum to: Diagnostic performance analysis for diabetic cardiovascular autonomic neuropathy based on short-term heart rate variability using Bayesian methods: preliminary analysis

Authors: Jun Chen, Shuang-Bin Yang, Juanmei Liu and Zi-Hui Tang

Brazilian dietary patterns and the dietary approaches to stop hypertension (DASH) diet-relationship with metabolic syndrome and newly diagnosed diabetes in the ELSA-Brasil study

Studies evaluating dietary patterns, including the DASH diet, and their relationship with the metabolic syndrome and diabetes may help to understand the role of dairy products (low fat or full fat) in these co...

Authors: Michele Drehmer, Andrew O. Odegaard, Maria Inês Schmidt, Bruce B. Duncan, Letícia de Oliveira Cardoso, Sheila M. Alvim Matos, Maria del Carmen B. Molina, Sandhi M. Barreto and Mark A. Pereira

C-peptide is independent associated with diabetic peripheral neuropathy: a community-based study

Because the relationship between C-peptide and diabetic peripheral neuropathy (DPN) is controversial, the aim of our study was to evaluate the relationship between C-peptide and DPN in community-based Chinese ...

Authors: Xiaona Qiao, Hangping Zheng, Shuo Zhang, Siying Liu, Qian Xiong, Fei Mao, Zhaoyun Zhang, Jie Wen, Hongying Ye, Yiming Li and Bin Lu

The waist circumference-adjusted associations between hyperuricemia and other lifestyle-related diseases

Few studies have assessed the associations between hyperuricemia and lifestyle-related diseases after adjusting for waist circumference (WC) and sex.

Authors: Taiju Miyagami, Hirohide Yokokawa, Kazutoshi Fujibayashi, Toshiaki Gunji, Noriko Sasabe, Mitsue Okumura, Kimiko Iijima and Toshio Naito

Post-challenge insulin concentration is useful for differentiating between coronary artery disease and cardiac syndrome X in subjects without known diabetes mellitus

Cardiac syndrome X (CSX) is characterized by angina pectoris but with patent coronary arteries. Our previous study demonstrated that subjects with CSX had a higher fasting insulin-resistance (IR) than the cont...

Authors: Kae-Woei Liang, Wayne H.-H. Sheu, Wen-Jane Lee, Wen-Lieng Lee, Hung-Chih Pan, I.-Te Lee and Jun-Sing Wang

Health-related quality of life and utility values associated to hypoglycemia in patients with type 1 diabetes mellitus treated in the Brazilian Public Health System: a multicenter study

Hypoglycemia is a critical and limiting factor of a good metabolic control and can adversely affect the quality of life of diabetic patients. The aim of the study was to evaluate the health-related quality of ...

Authors: Luciana Bahia, Rosane Kupfer, Denise Momesso, Debora A. P. Cabral, Balduino Tschiedel, Marcia Puñales, Suzana Lavigne, Cristina F. S. Façanha, Adriana C. Forti, Angela D. N. Mendes and Bernardo R. Tura

Prevalence and risk factors of diabetes in a large community-based study in North India: results from a STEPS survey in Punjab, India

India is the diabetes capital with home to 69.1 million people with DM, the second highest number of cases after China. Recent epidemiological evidence indicates a rising DM epidemic across all classes, both a...

Authors: Jaya Prasad Tripathy, J. S. Thakur, Gursimer Jeet, Sohan Chawla, Sanjay Jain, Arnab Pal, Rajendra Prasad and Rajiv Saran

Interaction between peroxisome proliferator-activated receptor gamma polymorphism and obesity on type 2 diabetes in a Chinese Han population

The aim of this study was to investigate the association of four single nucleotide polymorphisms (SNPs) of peroxisome proliferator-activated receptor gamma (PPARG) with type 2 diabetes mellitus (T2DM) risk and...

Authors: Xiaohui Lv, Li Zhang, Jiayu Sun, Zhigang Cai, Qing Gu, Ruipeng Zhang and Aiyun Shan

Is there a justification for classifying GLP-1 receptor agonists as basal and prandial?

Several GLP-1 receptor agonists are currently available for treatment of type 2 diabetic patients. Based on their pharmacokinetic/pharmacodynamic profile, these drugs are classified as short-acting GLP-1 recep...

Authors: Inka Miñambres and Antonio Pérez

Genetic diagnosis and treatment of a Chinese ketosis-prone MODY 3 family with depression

To analyze the gene mutation and mental disorder of a Chinese ketosis-prone diabetes (KPD) family, and to make a precise diagnosis and give a treatment for them.

Authors: Jun Tang, Chen-Yi Tang, Fang Wang, Yue Guo, Hao-Neng Tang, Ci-La Zhou, Shu-Wen Tan, Shi-Ping Liu, Zhi-Guang Zhou and Hou-De Zhou

Clinical aspects of pancreatogenic diabetes secondary to hereditary pancreatitis

Hereditary pancreatitis is a rare inherited form of pancreatitis, characterized by recurrent episodes of acute pancreatitis with early onset and/or chronic pancreatitis, and presenting brittle diabetes, compos...

Authors: Marcio Garrison Dytz, Pedro Arthur Hamamoto Marcelino, Olga de Castro Santos, Lenita Zajdenverg, Flavia Lucia Conceição, Tânia Maria Ortiga-Carvalho and Melanie Rodacki

Improvement of quality of life through glycemic control by liraglutide, a GLP-1 analog, in insulin-naive patients with type 2 diabetes mellitus: the PAGE1 study

In addition to achieving good glycemic control, diabetes care management aims to improve the quality of life (QOL) in patients. Treatment-associated difficulties and side effects frequently cause deterioration...

Authors: Hitoshi Ishii, Tetsuji Niiya, Yasuhiro Ono, Naoyuki Inaba, Hideaki Jinnouchi and Hirotaka Watada

Diagnostic protocol for gestational diabetes mellitus (GDM) (IADPSG/ADA, 2011): influence on the occurrence of GDM and mild gestational hyperglycemia (MGH) and on the perinatal outcomes

In August 2011, the Specialized Center for Diabetes and Pregnancy of the Botucatu Medical School/Unesp adopted a new diagnostic protocol for gestational diabetes mellitus, recommended by the American Diabetes ...

Authors: Mariana Pinto Sirimarco, Helena Maciel Guerra, Eduardo Guimarães Lisboa, Joice Monalisa Vernini, Bianca Nicolosi Cassetari, Roberto Antonio de Araujo Costa, Marilza Vieira Cunha Rudge and Iracema de Mattos Paranhos Calderon

Serotonin improves glucose metabolism by Serotonylation of the small GTPase Rab4 in L6 skeletal muscle cells

Serotonin (5-HT) improves insulin sensitivity and glucose metabolism, however, the underlying molecular mechanism has remained elusive. Previous studies suggest that 5-HT can activate intracellular small GTPas...

Authors: Ramona Al-Zoairy, Michael T. Pedrini, Mohammad Imran Khan, Julia Engl, Alexander Tschoner, Christoph Ebenbichler, Gerhard Gstraunthaler, Karin Salzmann, Rania Bakry and Andreas Niederwanger

CML/RAGE signal induces calcification cascade in diabetes

Vascular calcification is a significant predictor of coronary heart disease events, stroke, and lower-limb amputation. Advanced glycation end-products (AGEs) play a key role in the development of vascular calc...

Authors: Zhongqun Wang, Lihua Li, Rui Du, Jinchuan Yan, Naifeng Liu, Wei Yuan, Yicheng Jiang, Suining Xu, Fei Ye, Guoyue Yuan, Baohai Zhang and Peijing Liu

Diabetes self-management education after pre-selection of patients: design of a randomised controlled trial

Many self-management programs have been developed so far. Their effectiveness varies. The program ‘Beyond Good Intentions’ (BGI) is based on proactive coping and has proven to be (cost-) effective in achieving...

Authors: Rimke C. Vos, Nathalie W. D. Eikelenboom, Maarten Klomp, Rebecca K. Stellato and Guy E. H. M. Rutten

Impact of a 6-month treatment with intragastric balloon on body composition and psychopathological profile in obese individuals with metabolic syndrome

The aim of this study was to investigate the effects of a 6-month treatment with intragastric balloon (IGB) on body composition and depressive/anxiety symptoms in obese individuals with metabolic syndrome (MS).

Authors: Erika P. Guedes, Eduardo Madeira, Thiago T. Mafort, Miguel Madeira, Rodrigo O. Moreira, Laura Maria C. Mendonça, Amélio F. Godoy-Matos, Agnaldo J. Lopes and Maria Lucia F. Farias

Association of diabetic vascular complications with poor sleep complaints

Literatures reported that poor sleep complaints were associated with a great deal of health outcomes. However, there are few studies on the association of poor sleep complaints with diabetic vascular complicat...

Authors: Ling-Ling Meng, Ying Liu, Rui-Na Geng, Yun-Zhao Tang and Dai-Qing Li

Obesity and hypertensive heart disease: focus on body composition and sex differences

There is evidence that hypertension is frequently associated with overweight/obesity even in kids and adolescents. Either conditions influence development of left ventricular (LV) hypertrophy (LVH), through di...

Authors: Giovanni de Simone, Costantino Mancusi, Raffaele Izzo, Maria Angela Losi and L. Aldo Ferrara

Accumulation of intestinal tissue 3-deoxyglucosone attenuated GLP-1 secretion and its insulinotropic effect in rats

Our recent findings support the idea that 3-deoxyglucosone (3DG), a dietary composition, has been suggested as an independent factor for the development of prediabetes. Secretion of glucagon-like peptide-1 (GL...

Authors: Lurong Zhang, Xiudao Song, Liang Zhou, Guoqiang Liang, Heng Xu, Fei Wang, Fei Huang and Guorong Jiang

Relationship between vitamin D status, glycemic control and cardiovascular risk factors in Brazilians with type 2 diabetes mellitus

Determine the prevalence and identify predictors of hypovitaminosis D in patients with type 2 diabetes mellitus (T2DM); 2) correlate vitamin D levels with variables indicative of glycemic control and cardiovas...

Authors: Maria Creusa Rolim, Bárbara Mendes Santos, Gildasio Conceição and Paulo Novis Rocha

Spermatozoal cell death-inducing DNA fragmentation factor-α-like effector A (CIDEA) gene expression and DNA fragmentation in infertile men with metabolic syndrome and normal seminogram

This is the first study to investigate spermatozoal cell death-inducing DNA fragmentation factor-α-like effector A (CIDEA) gene expression and DNA fragmentations in the spermatozoa of men diagnosed with metabo...

Authors: Ayman Z. Elsamanoudy, Hussein Abdelaziz Abdalla, Mohammed Hassanien and Mohammad A. Gaballah

Hypoadiponectinemia and the presence of metabolic syndrome in patients with chronic kidney disease: results from the KNOW-CKD study

In patients with chronic kidney disease, metabolic syndrome has been demonstrated to be the culprit behind diverse complications. Adiponectin is known to have anti-atherogenic and cardio-protective effects. Me...

Authors: Chang-Yun Yoon, Yung Ly Kim, Seung Hyeok Han, Tae-Hyun Yoo, Su-Ah Sung, Woo-kyung Chung, Dong-Wan Chae, Yong-Soo Kim, Curie Ahn and Kyu Hun Choi

Increased carotid intima-media thickness in Brazilian adolescents with type 1 diabetes mellitus

Increased carotid intima-media thickness (CIMT), a marker of subclinical atherosclerosis, is an independent predictor of future cardiovascular events, and has been reported in children with various chronic dis...

Authors: Maria Fernanda Gontijo Sepulveda Fusaro, Jovita Lane Soares Santos Zanini and Ivani Novato Silva

Adipose tissue dysfunction increases fatty liver association with pre diabetes and newly diagnosed type 2 diabetes mellitus

To evaluate the role of adipose tissue function on the association of fatty liver (FL) with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes mellitus (nT2D).

Authors: Esteban Jorge-Galarza, Aida Medina-Urrutia, Rosalinda Posadas-Sánchez, Carlos Posadas-Romero, Guillermo Cardoso-Saldaña, Gilberto Vargas-Alarcón, Nacú Caracas-Portilla, Carmen González-Salazar, Margarita Torres-Tamayo and Juan Gabriel Juárez-Rojas

Changes in antidiabetic prescription patterns and indicators of diabetic control among 200,000 patients over 13 years at a single institution in Japan

We examined the long-term changes in the management of diabetes at a single institution in Japan.

Authors: Kazutoshi Fujibayashi, Michio Hayashi, Hirohide Yokokawa and Toshio Naito

Factors that could explain the increasing prevalence of type 2 diabetes among adults in a Canadian province: a critical review and analysis

The prevalence of diabetes has increased since the last decade in New Brunswick. Identifying factors contributing to the increase in diabetes prevalence will help inform an action plan to manage the condition....

Authors: Véronique Thibault, Mathieu Bélanger, Emilie LeBlanc, Lise Babin, Stuart Halpine, Beverly Greene and Michelina Mancuso

Trends in the prevalence of self-reported diabetes in Brazilian capital cities and the Federal District, 2006–2014

Diabetes is increasing globally, particularly in low and middle income countries, posing a great challenge to health systems. Brazil is currently ranked 4th in the world in terms of the absolute number of pers...

Authors: Betine Pinto Moehlecke Iser, Álvaro Vigo, Bruce Bartholow Duncan and Maria Inês Schmidt

Insulin lispro low mixture twice daily vs basal insulin glargine once daily and prandial insulin lispro once daily as insulin intensification strategies in patients with type 2 diabetes: Latin American subpopulation analysis of a randomized trial

This post hoc analysis examined the efficacy and safety of twice-daily insulin lispro low mixture (LM25) and once-daily basal insulin glargine plus once-daily prandial insulin lispro (IGL) in a Latin American ...

Authors: Arturo Rojas, Georgina Sposetti, Jorge L. Gross, Douglas Eugenio Barbieri, Ran Duan, Bruno Linetzky, Janaina Martins De Lana, Oded Stempa and Angel Rodriguez

Maternal adipokines and insulin as biomarkers of pregnancies complicated by overweight and obesity

Maternal obesity is associated with several adverse pregnancy outcomes. This study was conducted aiming to evaluate maternal levels of adipokines and insulin in pregnancies complicated by overweight and obesit...

Authors: Joice Monaliza Vernini, Jusciéle Brogin Moreli, Roberto Antônio Araújo Costa, Carlos Antonio Negrato, Marilza Vieira Cunha Rudge and Iracema Mattos Paranhos Calderon

The C1431T polymorphism of peroxisome proliferator activated receptor γ (PPARγ) is associated with low risk of diabetes in a Pakistani cohort

Diabetes is a socioeconomic burden in Pakistan. International diabetes federation reported 6.9 million cases of diabetes and 87,548 deaths due to diabetes in Pakistan in 2014. Peroxisome proliferators-activate...

Authors: Huma Butt, Shabana and Shahida Hasnain

Brazilian multicenter study for the evaluation of patients’ satisfaction of blood glucose self-monitoring with BGStar^® blood glucose meter in insulinized patients with diabetes mellitus type 1 and 2

Diabetes mellitus (DM) is considered a global epidemic, and patient self-management education and support are critical in preventing and reducing the risk of complications. Self-monitoring of blood glucose (SM...

Authors: Miguel Nasser Hissa

Prevalence of diabetes in Brazil over time: a systematic review with meta-analysis

Diabetes is one of the most important epidemic diseases of this century and the number of people with diabetes has more than doubled over the past three decades. Our aim was to estimate the prevalence of diabe...

Authors: Gabriela H. Telo, Felipe Vogt Cureau, Martina S. de Souza, Thais S. Andrade, Fabiana Copês and Beatriz D. Schaan

Impact of longitudinal status change in metabolic syndrome defined by two different criteria on new onset of type 2 diabetes in a general Japanese population: the Tanno–Sobetsu Study

We investigated the effect of longitudinal status change in metabolic syndrome (MetS) assessed by two different criteria on new onset of type 2 diabetes (NODM) in a Japanese population.

Authors: Hirofumi Ohnishi, Shigeyuki Saitoh, Hiroshi Akasaka, Tetsuaki Furukawa, Mitsuru Mori and Tetsuji Miura

Skin disorders in diabetes mellitus: an epidemiology and physiopathology review

Skin disorders, usually neglected and frequently underdiagnosed among diabetic patients, are common complications and encounter a broad spectrum of disorders in both type 1 and type 2 diabetes mellitus (DM)—e....

Authors: Geisa Maria Campos de Macedo, Samanta Nunes and Tania Barreto

Fasting plasma glucose concentrations for specified HbA1c goals in Korean populations: data from the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-2, 2011)

To examine the correlation between the fasting plasma glucose and HbA1c levels using regression equation and to assess the average fasting plasma glucose levels for the specific HbA1c (A1C) goals in the patien...

Authors: Sangmo Hong, Jun Goo Kang, Chul Sik Kim, Seong Jin Lee, Chang Beom Lee and Sung-Hee Ihm

Early diabetes screening in women with previous gestational diabetes: a new insight

Gestational diabetes mellitus (GDM) is a risk factor for the development of diabetes mellitus (DM). However, there is a low return rate for this screening, so it is important to search for earlier methods for ...

Authors: Aline Nabuco, Samara Pimentel, Carolina A. Cabizuca, Melanie Rodacki, Denise Finamore, Marcus M. Oliveira and Lenita Zajdenverg

β-Cell death is decreased in women with gestational diabetes mellitus

Gestational diabetes mellitus (GDM) affects approximately 7–17 % of all pregnancies and has been recognized as a significant risk factor to neonatal and maternal health. Postpartum, GDM significantly increases...

Authors: Lauren A. Kenna, John A. Olsen, Michael G. Spelios, Michael S. Radin and Eitan M. Akirav

The impact of the metabolic phenotype on thyroid function in obesity

Obesity is known to promote mild hyperthyrotropinaemia by unknown metabolic mechanisms. This investigation aimed to explore the association between thyroid function and metabolic phenotype in euthyroid obese i...

Authors: Paolo Marzullo, Chiara Mele, Stefania Mai, Gabriele Guzzaloni, Davide Soranna, Maria Antonella Tagliaferri, Maria Elisa Berselli, Flavia Prodam, Daniela Surico, Gianluca Aimaretti and Massimo Scacchi

Dietary factors associated with metabolic syndrome and its components in overweight and obese Brazilian schoolchildren: a cross-sectional study

The metabolic syndrome (MS) has been assessed since childhood mainly because of the nutritional and epidemiological transition that has occurred worldwide. Our objectives were to explore the MS and its compone...

Authors: Ana Elisa Madalena Rinaldi, Gleice Fernanda Costa Pinto Gabriel, Fernando Moreto, José Eduardo Corrente, Kátia Cristina Portero McLellan and Roberto Carlos Burini

Occupation and metabolic syndrome: is there correlation? A cross sectional study in different work activity occupations of German firefighters and office workers

The treatment and prevention of the metabolic syndrome (MetS) is currently one of the major challenges in medicine. The impact of working conditions on metabolic risk has not been adequately studied. Our objec...

Authors: Markus Strauß, Peter Foshag, Bianca Przybylek, Marc Horlitz, Alejandro Lucia, Fabian Sanchis-Gomar and Roman Leischik

Evaluation, intervention, and follow-up of patients with diabetes in a primary health care setting in Brazil: the importance of a specialized mobile consultancy

Studies show that educational interventions improve glycemic control in patients with diabetes mellitus (DM), reducing the occurrence of complications associated with the disease.

Authors: Wilson Eik Filho, Letícia Pastorelli Bonjorno, Ana Julia Mendes Franco, Márcia Lorena Alves dos Santos, Eniuce Menezes de Souza and Sonia Silva Marcon

Methylation quantitative trait loci within the TOMM20 gene are associated with metabolic syndrome-related lipid alterations in severely obese subjects

The TOMM20 gene was previously identified as differentially expressed and methylated between severely obese subjects with and without metabolic syndrome (MS). Since metabolic complications do not affect all obese...

Authors: Juan de Toro-Martín, Frédéric Guénard, André Tchernof, Yves Deshaies, Louis Pérusse, Frédéric-Simon Hould, Stéfane Lebel, Picard Marceau and Marie-Claude Vohl

Comparison between adherence assessments and blood glucose monitoring measures to predict glycemic control in adults with type 1 diabetes: a cross-sectional study

Adherence to treatment has been defined as the degree to which a patient’s behavior corresponds to medical or health advice; however, the most appropriate method to evaluate adherence to diabetes care has yet ...

Authors: Gabriela Heiden Telo, Martina Schaan de Souza, Thais Stürmer Andrade and Beatriz D’Agord Schaan

The relationship between HbA1c values and the occurrence of hypoglycemia as assessed by continuous glucose monitoring in patients with type 1 diabetes

We aimed to examine the relationship between the occurrence of hypo-/hyperglycemia and HbA1c values, as assessed by continuous glucose monitoring (CGM) in patients with type 1 diabetes.

Authors: Daisuke Tsujino, Rimei Nishimura, Yoshiko Onda, Chiaki Seo, Kiyotaka Ando, Aya Morimoto and Kazunori Utsunomiya

Association of cardiac NT pro-β-type natriuretic peptide with metabolic and endothelial risk factors in young obese hypertensive patients: a perspective on the hypothalamic pituitary adrenal axis activation

In practice, there is increasing recognition of the importance of hypothalamic pituitary adrenal axis in the cardiovascular disease progression. The association of brain natriuretic peptide with obesity and ch...

Authors: Mona Schaalan, Waleed Mohamed and Rania Rahmo

Screening for coeliac disease in adult patients with type 1 diabetes mellitus: myths, facts and controversy

This review aims at summarizing the present knowledge on the clinical consequences of concomitant coeliac disease (CD) in adult patients with type 1 diabetes mellitus (T1DM). The cause of the increased prevale...

Authors: Sjoerd F. Bakker, Maarten E. Tushuizen, Boudewina M. E. von Blomberg, Hetty J. Bontkes, Chris J. Mulder and Suat Simsek

Interactions between kidney disease and diabetes: dangerous liaisons

Type 2 diabetes mellitus (DM) globally affects 18–20 % of adults over the age of 65 years. Diabetic kidney disease (DKD) is one of the most frequent and dangerous complications of DM2, affecting about one-thir...

Authors: Roberto Pecoits-Filho, Hugo Abensur, Carolina C. R. Betônico, Alisson Diego Machado, Erika B. Parente, Márcia Queiroz, João Eduardo Nunes Salles, Silvia Titan and Sergio Vencio

Use of a real time continuous glucose monitoring system as an educational tool for patients with gestational diabetes

Women with gestational diabetes mellitus (GDM) are required to control their blood glucose shortly after GDM diagnosis to minimize adverse pregnancy outcomes. A real time-continuous glucose monitoring system (...

Authors: Eman Alfadhli, Eman Osman and Taghreed Basri