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Table 4 Association between GLP-1R polymorphisms and risk of GDM after stratification by age and BMI

From: Genetic variants of the GLP-1R gene affect the susceptibility and glucose metabolism of gestational diabetes mellitus: a two-center nested case‒control study

SNP

Genotype

Age < 35 years (n = 354)

Age ≥ 35 years (n = 46)

BMI < 24 (n = 280)

BMI ≥ 24 (n = 120)

NGT (n = 182)

GDM (n = 172)

OR (95%CI)

p

NGT (n = 18)

GDM (n = 28)

OR (95%CI)

p

NGT (n = 142)

GDM (n = 138)

OR (95%CI)

p

NGT (n = 58)

GDM (n = 62)

OR (95%CI)

p

rs3765468

GG

121

105

1.00

 

12

16

1.00

 

92

78

1.00

 

41

43

1.00

 
 

GA

54

56

1.19 (0.76, 1.89)

0.444

5

10

1.50 (0.41, 5.55)

0.544

44

49

1.31 (0.79, 2.18)

0.291

15

17

1.08 (0.48, 2.44)

0.852

 

AA

7

11

1.81 (0.68, 4.84)

0.236

1

2

1.50 (0.12, 18.54)

0.751

6

11

2.16 (0.77, 6.12)

0.146

2

2

0.95 (0.13, 7.09)

0.963

 

GA + AA

61

67

1.27 (0.82, 1.95)

0.288

6

12

1.50 (0.44, 5.15)

0.519

50

60

1.42 (0.87, 2.29)

0.157

17

19

1.07 (0.49, 2.33)

0.873

rs3765467

GG

116

100

1.00

 

8

20

1.00

 

87

83

1.00

 

37

37

1.00

 
 

GA

60

65

1.26 (0.81, 1.95)

0.310

9

4

0.18 (0.04, 0.75)

0.018

50

52

1.09 (0.67, 1.78)

0.731

19

17

0.90 (0.40, 1.99)

0.79

0.20 (0.04, 0.91)a

0.037a

 

AA

6

7

1.35 (0.44, 4.16)

0.597

1

4

1.60 (0.15, 16.61)

0.694

5

3

0.63 (0.15, 2.72)

0.534

2

8

4.00 (0.80, 20.11)

0.093

 

GA + AA

66

72

1.27 (0.83, 1.94)

0.281

10

8

0.32 (0.09, 1.11)

0.072

55

55

1.05 (0.65, 1.69)

0.848

21

25

1.19 (0.57, 2.49)

0.643

rs1042044

AA

46

32

1.00

 

3

7

1.00

 

32

28

1.00

 

17

11

1.00

 
 

AC

86

90

1.50 (0.88, 2.58)

0.138

7

10

0.61 (0.12, 3.23)

0.563

69

68

1.13 (0.61, 2.07)

0.701

24

32

2.06 (0.82, 5.20)

0.125

 

CC

50

50

1.44 (0.79, 2.61)

0.234

8

11

0.59 (0.12, 3.01)

0.525

41

42

1.17 (0.60, 2.28)

0.642

17

19

1.73 (0.63, 4.70)

0.285

 

AC + CC

136

140

1.48 (0.89, 2.46)

0.131

15

21

0.60 (0.13, 2.71)

0.506

110

110

1.14 (0.65, 2.03)

0.647

41

51

1.92 (0.81, 4.56)

0.138

rs10305478

CC

144

143

1.00

 

13

22

1.00

 

113

114

1.00

 

44

51

1.00

 
 

CT

34

28

0.83 (0.48, 1.44)

0.506

5

6

0.71 (0.18, 2.80)

0.623

26

23

0.88 (0.47, 1.63)

0.677

13

11

0.73 (0.30, 1.79)

0.492

 

TT

4

1

0.25 (0.03, 2.28)

0.220

0

0

–

–

3

1

0.33 (0.03, 3.22)

0.341

1

0

0.00

1.00

 

CT + TT

38

29

0.77 (0.45, 1.31)

0.335

5

6

0.71 (0.18, 2.80)

0.623

29

24

0.82 (0.45, 1.50)

0.52

14

11

0.68 (0.28, 1.65)

0.39

rs6458093

AA

72

48

1.00

 

4

9

1.00

 

51

41

1.00

 

25

16

1.00

 
 

AG

77

88

1.71 (1.07, 2.77)

0.027

10

12

0.533 (0.13, 2.27)

0.394

64

67

1.30 (0.76, 2.22)

0.333

23

33

2.24 (0.99, 5.11)

0.055

1.71 (1.06, 2.75)a

0.029a

 

GG

33

36

1.64 (0.90, 2.98)

0.106

4

7

0.78 (0.14, 4.27)

0.772

27

30

1.38 (0.71, 2.68)

0.339

10

13

2.03 (0.72, 5.72)

0.180

 

AG + GG

110

124

1.69 (1.08, 2.64)

0.021

14

19

0.60 (0.15, 2.36)

0.603

91

97

1.33 (0.80, 2.19)

0.270

33

46

2.18 (1.01, 4.71)

0.048

1.68 (1.07, 2.63)a

0.024a

2.32 (1.04, 5.18)a

0.041a

  1. GDM gestational diabetes mellitus, NGT normal glucose tolerance, BMI body mass index, GLP-1R glucagon-like peptide-1 receptor
  2. aAdjusted for age, first-trimester BMI and systolic blood pressure. The unmarked p and OR values were crude. The p and OR values were calculated using unconditional binary logistic regression. Variables with statistical significance are shown in boldface
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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