Genetic variants of the GLP-1R gene affect the susceptibility and glucose metabolism of gestational diabetes mellitus: a two-center nested case‒control study

Table 3 Association between GLP-1R gene polymorphisms and gestational diabetes mellitus susceptibility

SNPs	Genotypes	NGT (n = 200)	GDM (n = 200)	Codominant		Dominant		Recessive		Overdominant		Log-additive		Allele
SNPs	Genotypes	NGT (n = 200)	GDM (n = 200)	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p
rs3765468	GG	133	121	1.00		1.30 (0.86–1.95)	0.213	1.67 (0.68–4.12)	0.267	1.18 (0.77–1.80)	0.450	1.28 (0.91–1.79)	0.150	1.29 (0.92–1.82)	0.140
G > A	GA	59	66	1.23 (0.80–1.89)	0.345
	AA	8	13	1.79 (0.72–4.46)	0.214
rs3765467	GG	124	120	1.00		1.09 (0.73–1.63)	0.682	1.60 (0.61–4.23)	0.339	1.00 (0.66–1.51)	1.00	1.13 (0.80–1.58)	0.490	1.12 (0.80–1.57)	0.493
G > A	GA	69	69	1.03 (0.68–1.57)	0.878
	AA	7	11	1.62 (0.61–4.33)	0.332
rs1042044	AA	49	39	1.00		1.34 (0.83–2.16)	0.228	1.07 (0.70–1.65)	0.743	1.15 (0.78–1.70)	0.484	0.88 (0.67–1.16)	0.360	1.14 (0.86–1.51)	0.357
A > C	AC	93	100	1.35 (0.81–2.24)	0.244
	CC	58	61	1.32 (0.76–2.30)	0.324
rs10305478	CC	157	165	1.00		0.77 (0.47–1.27)	0.313	0.25 (0.03–2.22)	0.212	0.85 (0.51–1.41)	0.518	0.75 (0.47–1.18)	0.210	0.74 (0.47–1.17)	0.203
C > T	CT	39	34	0.83 (0.50–1.38)	0.472
	TT	4	1	0.24 (0.03–2.15)	0.201
rs6458093	AA	76	57	1.00		1.54 (1.01–2.34)	0.044	1.21 (0.74–1.97)	0.454	1.30 (0.88–1.93)	0.193	1.28 (0.97–1.68)	0.080	1.29 (0.98–1.71)	0.075
A > G	AG	87	100	1.53 (0.98–2.40)	0.062	1.53 (1.00–2.34)^a	0.049^a
	GG	37	43	1.55 (0.89–2.71)	0.124

GDM gestational diabetes mellitus, NGT normal glucose tolerance, GLP-1R glucagon-like peptide-1 receptor
^aAdjusted for age, first-trimester BMI and systolic blood pressure. The unmarked p and OR values were crude. The p and OR values were calculated using unconditional binary logistic regression. Variables with statistical significance are shown in boldface. Codominant: mutant homozygous genotype vs heterozygous genotype vs wild homozygous genotype; Dominant: heterozygous genotype + mutant homozygous genotype vs wild homozygous genotype; Recessive: mutant homozygous genotype vs wild homozygous genotype + heterozygous genotype; Overdominant: heterozygous genotype vs wild homozygous genotype + mutant homozygous genotype; Log-additive: additive effects of risk allele

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