Skip to main content

Diabetic yoga protocol improves glycemic, anthropometric and lipid levels in high risk individuals for diabetes: a randomized controlled trial from Northern India



To study the effectiveness of diabetic yoga protocol (DYP) against management of cardiovascular risk profile in a high-risk community for diabetes, from Chandigarh, India.


The study was a randomized controlled trial, conducted as a sub study of the Pan India trial Niyantrita Madhumeha Bharath (NMB). The cohort was identified through the Indian Diabetes Risk Scoring (IDRS) (≥ 60) and a total of 184 individuals were randomized into intervention (n = 91) and control groups (n = 93). The DYP group underwent the specific DYP training whereas the control group followed their daily regimen. The study outcomes included changes in glycemic and lipid profile. Analysis was done under intent-to-treat principle.


The 3 months DYP practice showed diverse results showing glycemic and lipid profile of the high risk individuals. Three months of DYP intervention was found to significantly reduce the levels of post-prandial glucose levels (p = 0.035) and LDL-c levels (p = 0.014) and waist circumference (P = 0.001).


The findings indicate that the DYP intervention could improve the metabolic status of the high-diabetes-risk individuals with respect to their glucose tolerance and lipid levels, partially explained by the reduction in abdominal obesity. The study highlights the potential role of yoga intervention in real time improvement of cardiovascular profile in a high diabetes risk cohort.

Trial registration: CTRI, CTRI/2018/03/012804. Registered 01 March 2018—Retrospectively registered,


The rise of diabetes in the developing world poses a threat to meager health budgets. Owing to the strong association between various morbidity and mortality outcomes as complications of this dreaded disease, early detection of diabetes risk through non-invasive parameters is a primary requisite. Observational studies show that the risk reduction for diabetes can be decreased by 58% or 63–65% if risk factors could be controlled [1, 2]. Many argue that such experimental strategies for the possible halting of conversion of prediabetes into diabetes must continue to include pharmacological interventions even though the rates have not been compared [3]. Identification of individuals at increased risk for the disease with invasive measurements of fasting and post challenge (postprandial) blood glucose are costly and time consuming. Hence, it has been advocated that the realistic prevention of diabetes should identify high-risk subjects with the use of the non-invasive risk scores [4]. Such studies should also target subjects with normoglycemia and prevent their progression to poor glycemic status [4].

Yoga plays a promising role in minimizing the risk of Diabetes for high-risk individuals with prediabetes [5, 6]. It reduces body weight, glucose, and lipid levels, though, most of these studies comply with the guidelines of randomized controlled trials adhered to the CONSORT statements [7,8,9,10,11] whereas majority of studies have not reported as per CONSORT statements [12,13,14,15]. Several review of published studies, in people with diabetes and prediabetes, have concluded that the practice of yoga may reduce insulin resistance and related cardiovascular disease (CVD) risk factors and improve clinical outcomes [16]. Specifically, reports suggest that a yoga-based lifestyle intervention reduces body weight, glucose and lipid levels that should reduce diabetes risk. Keeping in view the high transition rates of diabetes in India, we selected a high-risk cohort from Chandigarh, one of the most affluent Union Territories of India with highest reported prevalence of diabetes in order to establish the efficacy of yoga to alleviate the cardiovascular disease. Indian Diabetes Risk Score (IDRS), specific for Indian ethnicity a validated tool was used for identification of the high-risk population [17]. We developed a national consensus ‘Diabetes Yoga protocol’ based on published reports and classical literature with an aim to stimulate weight reduction by combination of postures and meditation techniques [18, 19]. Additionally, cardiometabolic risk reduction has also been recognized as one of the potential outcomes of yoga-based interventions [20]. Yoga has been shown to be regulating the risk parameters of diabetes, waist circumference (WC), body mass index (BMI), oxidative stress, fasting blood sugar (FBS) and systolic blood pressure (SBP) respectively [21]. Hence, in this study we tested the efficacy of diabetic yoga protocol (DYP) on alleviation of glycemic and lipid imbalances in individuals at high risk of diabetes.

Materials and methods

Study population

Under the multi-region survey of Niyantarita Maduhmeha Bharat (NMB-2017) a door-to-door screening was carried out for the identification of high risk individuals among the population of Chandigarh (U.T) and Panchkula (District in Haryana state) on the basis of Indian Diabetes Risk Score (IDRS). The data collection was carried out by well trained yoga volunteers for diabetes management (YVDMs). Written informed consents were taken from every subject during door to door screening as well as at the time of registration. All the experimental protocol, methods and procedures were approved by Ethics committee of Indian Yoga Association (IYA) (ID: RES/IEC-IYA/001). All experiments methods and procedures were carried out in accordance with relevant guidelines and regulations of ethics committee. The study was registered at clinical trial registry of India, CTRI/2018/03/012804 (dated: 01/03/2018).

Study design

The present study is the two-armed randomized controlled trial conducted in the population of Chandigarh and Panchkula regions of northern India. Indian Diabetes Risk Score (IDRS) was used for detection of high risk (≥ 60 score) individuals from the study. Self-declared diabetics and low (< 30 score) and moderate [between 30–50 score] risk individuals were excluded from the study. As evident from the flow of patients presented in the flowchart, out of 1214 eligible subjects, there was approximately 50% loss of sample data due to error in the sampling. Further out of 564, we had to exclude as they were self-declared patients with diabetes and did not further participate in the study. However, this led to final participation of only 184 subjects in the study and allocation of these subjects diminishing the random selection of the study cohort. A cohort of high diabetes-risk cohort consisting of n = 184 participants was randomized into the interventional and control groups (n = 91:93). After excluding the dropouts from the study, based on CONSORT guidelines, the remaining subjects in the DYP and control group were further assessed for selected anthropometric, glycemic and lipid parameters. The intervention group was given the Diabetic Yoga Protocol for three months and control group continued with their daily routine activities. The detailed categorization of the samples is shown in Fig. 1. The control group was waitlisted for yoga.

Fig. 1
figure 1

Flowchart of study design. PCA  principal component analysis, MIPCA multiple imputations with PCA


Simple randomization technique was used to allocate participants into the intervention and the control groups. An independent statistician generated a computer-generated random number sequence and the sequence was given to an external staff who had no involvement in the study procedures. The participants were allocated their consecutive numbers, after baseline measurements. Blinding of the participants was not possible due to the nature of the intervention. However, the outcome assessors were blinded.

Risk assessment

To identify the individuals at high-risk of diabetes, Indian Diabetes Risk Score (IDRS) was administered as proposed by Mohan et al. [22]. It consisted of two unmodifiable (i.e. age, and family history) and two modifiable (physical activity and waist circumference) risk factors for diabetes, which can predict the level of risk for the development of diabetes in the community. The IDRS is one of the easily accessible and budget friendly questionnaire to be administered. The aggregate score of the unmodifiable and modifiable risk used to probe the level of risk among the population (i.e. High risk > 60, Moderate risk-30–50, Low risk < 30).

Sample size

Sample size estimation for the main Pan India study was focused for prediabetes subjects [23]. However, for the present pilot scale study we calculated sample size assuming a small effect size 0.3 [5] of DYP vs waitlist control 0.25, α = 0.80 as 180 (n = 90:90). Further, assuming an attrition rate of 20%, the final sample size was n = 220.

Study outcomes

Changes in the glycemic and other metabolic variables (anthropometric and lipid) over 3 months were documented. The fasting blood sample was withdrawn. For glucose analysis, fasting samples for 10–12 h were taken early in the morning for the estimation of FBS and afterwards 75 g glucose was given to the participants. The blood sampling was repeated after 2 h. for estimation of OGTT.

Biochemical analysis

For the estimation of biochemical parameters viz. FBS (Fasting Blood Sugar, Rxl-Max 500), OGTT (Oral Glucose Tolerance Test), HbA1c (Bio-Rad D-10), Triglycerides, Cholesterol, HDL, LDL, Chol/HDL ratio, HDL/LDL ratio (Rxl-Max 500) and VLDL about 9 ml of blood was drawn and analyzed by phlebotomist of Sisco Research Laboratories (SRL) of Chandigarh. Anthropometric measurements were also obtained (i.e. height, weight, waist circumference) by trained researcher. The waist circumference (WC) was reported in centimeters. The BMI was obtained by using the formula (weight in kg/height (meter)2).


The study protocol consisted of Diabetic Yoga Protocol (DYP) approved by the Ministry of AYUSH and Quality Council of India as shown in Table 1. This is the first protocol to be made specifically for the prediabetics and diabetics. The complete sequence of prayer, yogic postures, breathing and meditative techniques, along with specified time, was shown in previously published paper [24]. The Yogic practices were performed for 3 months for 60 min. Certified yoga instructors took the yoga classes and they recorded regular attendance. Randomization was done through a computer-generated list of random numbers and allocation was concealed to the participants until the completion of the baseline assessment.

Table 1 Diabetic yoga protocol (DYP)

Statistical analysis

For the analysis of data SPSS for Windows (version 22; IBM SPSS Inc., Chicago IL) 0 and R statistical package were used. The normality of data was analyzed using Kolmogorov–Smirnov test. The paired t-test was used to estimate the Baseline and posttest differences of DYP, and control group and the significant level was set at ≤ 0.05. The trial outcomes were analyzed according to the intention-to-treat principle; hence multiple imputation was carried for the missing variables accounting for the loss to follow up. We used absolute change (time and treatment interaction), to estimate intervention effects refers to the difference in the outcome of the intervention and control over different time-points of assessment. Absolute change was determined as follows: absolute change = [(intervention group follow-up) – (intervention group baseline)] – [(control group follow-up) – (control group baseline)]. The percentage change, also called the relative change was determined as relative change = (absolute change / intervention group baseline) × 100%. To evaluate the influence of missing data, we applied multiple imputations to the data using missMDA R package (v1.13) based on the principal component analysis method [25] from the package, using 5 components to reconstruct the data and over 1000 imputed datasets. One-way multivariate analysis of covariance (MANCOVA) was conducted to compare the effects of the DYP with control group glycemic and metabolic measures, while controlling for the age, gender and baseline values of the covariates.


Baseline characteristics

The data used in this study was collected in (NMB-2017) the northern region of India i.e. Chandigarh and Panchkula. The age range of participants was 3–70 years; [mean age 48.51 (SD 10.08) years]with baseline characteristics of the yoga and control groups as shown in Table 2. Mean HbA1c of the high-risk cohort was 5.64% (0.38), mean FBS was 97.13 mg/dl (SD 11.10), and mean PPBS were 108.40 mg/dl (SD 28.79). Distributions of age and gender was similar between the intervention and the control groups. The IDRS and anthropometric values were also similarly distributed between the groups. Overall, there was no significant difference in the distribution of demographic, anthropometric, or biochemical parameters between the DYP and the control groups at the baseline.

Table 2 Baseline characteristics of the participants in the intervention and control group

When analyzed by multivariate analysis of covariance (MANCOVA), adjusting for age, gender and status of diabetes/prediabetes/normoglycemia, and baseline values of the covariates, yoga intervention was found to have significant influence on few cardinal parameters related to glycemic control (PPBS), and lipid control (LDL-C) as shown in Table 3. We also observed a significant influence of DPP on waist circumference reduction [relative changes, − 1.94%. Compared to the control, DYP also resulted in significant reductions in LDL-C and, − 0.16% and − 2.81%, for LDL-Cholesterol and post-prandial blood glucose levels from baseline to 3 months [absolute changes, − 0.18% and − 3.08%, respectively and relative changes, − 0.16% and − 2.81%, respectively].

Table 3 Comparative assessment of influence of DYP on biochemical and weight related variables with the control group


We examined the effect of Diabetic Yoga Protocol on baseline and post (3 months) levels of HbA1c and other glycemic (OGTT and FBS), Lipid (Total cholesterol, triglycerides, HDL-c, LDL-c, and VLDL-c, CDL/HDL, LDL/HDL) and anthropometric parameters (BMI). In the present study, we show the efficacy of DYP in substantial improvement in the waist circumference in a high-risk diabetes population from Chandigarh (relative change of 1.94 cm). We could also demonstrate a significant decline in the worsening of post prandial glucose levels with yoga intervention as compared to the wait-list control group (relative change of 2.82 mg/ml). However, for LDL-c levels, there were clinically significant improvements by 0.16 units. Notably, over 3 months study duration there was an overall increase in the levels of total cholesterol, triglyceride and VLDL means in the study cohort, while HDL levels had decreased. In particular TG levels have gone from normal range to mildly high (> 150 mg/dl) [26] which draws our attention towards accelerated pace of metabolic dysfunction in the high risk population. These findings comply with Chandigarh being an affluent union territory of India with high per-capita GDP and has been documented to have highest prevalence of diabetes 13.6%, 12.8–15·2 as compared to other Indian states [27]. As mentioned above, there was a significant influence of DYP on the waist circumference, one of the two important modifiable parameters of Indian Diabetes Risk Score [17]. The relevance of WC reduction in context of reduced risk of CVD is well established; a 1 cm increase in WC has been associated with a 2% increase in the relative risk of future CVD [28]. The visceral adipose tissue is a primary source of cytokine production and insulin resistance (IR) [29]. Given the higher susceptibility towards visceral fat accumulation and insulin resistance in Asian populations as compared to their Caucasian counterparts, the observed influence of DYP on WC is of particular relevance to the metabolically obese phenotype of Asian Indians [30].

In relation to the glucose metabolism, we could also demonstrate a significant decline in the worsening of post prandial glucose levels with DYP as compared to the wait-list control group (relative change = − 2.81%, P < 0.05); however, no significant influence could be established for fasting blood glucose concentration. These findings could be justified by the phenotypic differences underlying fasting and post-challenge hyperglycemia that represent distinct natural histories in the evolution of type 2 diabetes [31]. Postprandial glucose disposal is the primary pathogenic manifestation in impaired glucose tolerance (IGT), and impaired fasting glucose (IFG) merely signifies an abnormal glucose set point [31, 32]. Our relevance of the study findings is further underlined by the previous results wherein PPG has been reported to contribute more than FBS to overall hyperglycemia and its control was found essential either to decrease or to obtain HbA1c goals of < 7 [33]. Several epidemiological studies have suggested that increased glycemic exposure, especially post challenge or postprandial hyperglycemia, is an independent risk factor for macrovascular disease with no apparent upper or lower threshold. Our results indicate a significant influence of yoga on glycemic control integrating postprandial glycemic alterations in the high diabetes risk group. Since in the present study the high-risk cohort was selected through A1c based diagnosis, and IGT was not a primary manifestation in the cohort, hence, the overall improvement in postprandial glucose should be specifically tested in an IGT cohort. The findings of the current study with a 3-month intervention of yoga on postprandial measures of glucose at-risk population deserves clinical attention. Increase in the glucose concentration even in the prediabetes stage, manifests as a chronic inflammatory condition and predisposes an individual to the risk of pathogenic infections [32, 34, 35].

The simultaneous reduction in waist circumference observed in the cohort, is also consistent with the observation of an association between abdominal obesity and the risk of IGT. Based on a significant association between IGT and CVD risk [32, 33, 36], we note a significant improvement in lipid concentrations [LDL-c] by the DYP protocol as compared to the control group. These results are consistent with the previously reported overall beneficial effect of yoga in the management of hyperlipidemia [36]. These results need validation at larger scale and to ascertain the mechanistic insights into the action of yoga, the indices of monocyte chemotaxis, endothelial inflammation, oxidation, nitric oxide production, and thrombosis should also be explored [37], including animal models, invitro systems and other approaches [38,39,40,41,42,43,44].

The findings of the present study indicate that identification of high-risk group through IDRS and consequent intervention of Yoga based lifestyle protocol could be an effective strategy to combat the metabolic perturbations associated with diabetes, whose co-morbidity is also being reported to be associated with increasing vulnerability to the emerging viral pandemic of COVID-19. Lifestyle interventions are reported to reduce the risk of Type 2 diabetes in high-risk individuals after mid and long-term follow-up. Information on determinants of intervention outcome, adherence and the mechanisms underlying diabetes progression are valuable for a more targeted implementation. Weight loss is a major contributor in the prevention and management of type 2 diabetes. In many of the earlier lifestyle intervention group of the DPP, weight loss was the dominant predictor of reduced diabetes risk, with a 16% reduction observed for every kilogram of weight loss during the 3.2-year follow-up [45]. Though we failed to observe a significant weight loss over 3 months of DYP intervention, the significant reductions in WC indicate the plausibility of significant weight loss on longer interventions and follow ups.

Whether Yoga alters the conversion of prediabetics into healthy status and if it helps in maintenance of glycemic index can be assessed by longitudinal studies. There was a significant improvement in the glycemic status of the high risk population at administration of DYP. The analysis shows the aptness of Diabetic protocol which is apparently superior to previous studies where no standardized protocols were used for intervention [46, 47]. The findings suggest that there is potential of DYP to manage glucose levels in diabetes patients if public intervention is planned through forthcoming wellness centers in India. There are additional studies showing beneficial effects of Yoga on FBS [48], PPBS [49,50,51], HbA1c [50, 51], total cholesterol, LDL [50, 51]. The analysis of the yoga protocols used in above said studies reveal the incorporation of some common and important postures in DYP, which seem to be important in managing the disease. It is also the possible that the beneficial effects of mind body techniques are sensitive to mental disposition of subjects and has been characterized by various measures like psychometric analysis [52, 53], namely, Tridosha and Triguna scoring [54, 55]. These were not analyzed in this study.

Briefly, DYP’s promising efficacy on glycemic and metabolic parameters requires mechanistic insights. This can be examined by further studies, and long term follow up which was not possible in this study. As DYP is a non-pharmacological, cost-effective method to halt the conversion of early diabetes into prediabetes and/or healthy individuals, the success of its integration into public health policy will depend on its wider acceptability and perception of benefits by both public as well as healthcare workers [56,57,58,59]. Yoga’s benefits in maintaining and regulation of the glycemic status are supported by several other studies [49, 50], which might enable its inclusion in the National Ayushman Bharat scheme or as part COVID pandemic management protocol in which a large number of individuals with diabetes and heart disease are falling prey [60, 61]. This will further encourage molecular and Ayurgenomic studies which presumably underlie the stated clinical outcome.


Moreover, there are some limitations of our study that we only studied in two regions of North India and thus the result of this study cannot be generalized on the remaining population. Further, in this study, the socio economic status and psychological assessments were not carried out. We were not able to control for the dietary habits and psychological status of the study participants. However, the small sample size and absence of long term evaluations limit the strength of the study.


The findings indicate that the DYP intervention could improve the metabolic status of the high-diabetes-risk individuals with respect to their glucose tolerance and lipid levels, partially explained by the reduction in abdominal obesity. The study highlights the potential role of yoga intervention in real time improvement of cardiovascular profile in a high diabetes risk cohort.

Availability of data and materials

The datasets used during the present study are available from the corresponding author on reasonable request.



American Diabetes Association


Body mass Index


Cardiovascular disease


Diabetic yoga protocol


Fasting blood sugar


Glycated hemoglobin


High density lipid-cholesterol


Indian Diabetes Risk Score


Impaired fasting glucose


Impaired glucose tolerance


Indian Yoga Association


Low density lipid-cholesterol


Niyantarita Maduhmeha Bharat


Oral glucose tolerance test


Postprandial blood glucose


Systolic blood pressure


Very low density lipid-cholesterol


Waist circumference


Yoga volunteers for diabetes management


  1. Laaksonen DE, Lindström J, Lakka TA, Eriksson JG, Niskanen L, Wikström K, Aunola S, Keinänen-Kiukaanniemi S, Laakso M, Valle TT, Ilanne-Parikka P. Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study. Diabetes. 2005;54(1):158–65.

    CAS  PubMed  Google Scholar 

  2. Lindström J, Ilanne-Parikka P, Peltonen M, Aunola S, Eriksson JG, Hemiö K, Hämäläinen H, Härkönen P, Keinänen-Kiukaanniemi S, Laakso M, Louheranta A. Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study. Lancet. 2006;368(9548):1673–9.

    PubMed  Google Scholar 

  3. DREAM (Diabetes REduction Assessment with ramipril and rosiglitazone Medication) Trial Investigators. Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet. 2006;368(9541):1096–105.

    Google Scholar 

  4. Lindström J, Tuomilehto J. The diabetes risk score: a practical tool to predict type 2 diabetes risk. Diabetes Care. 2003;26(3):725–31.

    PubMed  Google Scholar 

  5. McDermott KA, Rao MR, Nagarathna R, Murphy EJ, Burke A, Nagendra RH, Hecht FM. A yoga intervention for type 2 diabetes risk reduction: a pilot randomized controlled trial. BMC Complement Altern Med. 2014;14(1):1–4.

    Google Scholar 

  6. Jyotsna VP. Prediabetes and type 2 diabetes mellitus: evidence for effect of yoga. Indian J Endocrinol Metab. 2014;18(6):745.

    PubMed  PubMed Central  Google Scholar 

  7. Thind H, Lantini R, Balletto BL, Donahue ML, Salmoirago-Blotcher E, Bock BC, Scott-Sheldon LA. The effects of yoga among adults with type 2 diabetes: a systematic review and meta-analysis. Prev Med. 2017;1(105):116–26.

    Google Scholar 

  8. Singh VP, Khandelwal B. Effect of yoga and exercise on glycemic control and psychosocial parameters in type 2 diabetes mellitus: a randomized controlled study. Int J Yoga. 2020;13(2):144.

    PubMed  PubMed Central  Google Scholar 

  9. Chen N, Xia X, Qin L, Luo L, Han S, Wang G, Zhang R, Wan Z. Effects of 8-week Hatha yoga training on metabolic and inflammatory markers in healthy, female Chinese subjects: a randomized clinical trial. BioMed Res Int. 2016.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Ramamoorthi R, Gahreman D, Skinner T, Moss S. Development of Sham yoga poses to assess the benefits of yoga in future randomized controlled trial studies. Life. 2021;11(2):130.

    PubMed  PubMed Central  Google Scholar 

  11. Sreedevi A, Gopalakrishnan UA, Ramaiyer SK, Kamalamma L. A randomized controlled trial of the effect of yoga and peer support on glycaemic outcomes in women with type 2 diabetes mellitus: a feasibility study. BMC Complement Altern Med. 2017;17(1):1–8.

    Google Scholar 

  12. Ramamoorthi R, Gahreman D, Skinner T, Moss S. The effect of yoga practice on glycemic control and other health parameters in the prediabetic state: a systematic review and meta-analysis. PLoS ONE. 2019;14(10): e0221067.

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Chimkode SM, Kumaran SD, Kanhere VV, Shivanna R. Effect of yoga on blood glucose levels in patients with type 2 diabetes mellitus. J Clin Diagn Res JCDR. 2015;9(4):CC01.

    PubMed  Google Scholar 

  14. Kacker S, Saboo N, Sharma S, Sorout J. Quasi prospective comparative study on effect of yoga among prediabetics on progression of cardiovascular risk factors. Int J Yoga. 2019;12(2):114.

    PubMed  PubMed Central  Google Scholar 

  15. Ebrahimi M, Guilan-Nejad TN, Pordanjani AF. Effect of yoga and aerobics exercise on sleep quality in women with Type 2 diabetes: a randomized controlled trial. Sleep Sci. 2017;10(2):68.

    PubMed  PubMed Central  Google Scholar 

  16. Innes KE, Vincent HK. The influence of yoga-based programs on risk profiles in adults with type 2 diabetes mellitus: a systematic review. Evid-Based Complementary Altern Med. 2007;4(4):469–86.

    Google Scholar 

  17. Mohan V, Anbalagan VP. Expanding role of the Madras diabetes research foundation-Indian diabetes risk score in clinical practice. Indian J Endocrinol Metab. 2013;17(1):31.

    PubMed  PubMed Central  Google Scholar 

  18. Wilson PW, Meigs JB, Sullivan L, Fox CS, Nathan DM, D’Agostino RB. Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study. Arch Intern Med. 2007;167(10):1068–74.

    PubMed  Google Scholar 

  19. Chen L, Magliano DJ, Balkau B, Colagiuri S, Zimmet PZ, Tonkin AM, Mitchell P, Phillips PJ, Shaw JE. AUSDRISK: an Australian Type 2 Diabetes Risk Assessment Tool based on demographic, lifestyle and simple anthropometric measures. Med J Aust. 2010;192(4):197–202.

    PubMed  Google Scholar 

  20. Yang K, Bernardo LM, Sereika SM, Conroy MB, Balk J, Burke LE. Utilization of 3-month yoga program for adults at high risk for type 2 diabetes: a pilot study. Evid-Based Complementary Altern Med. 2011;1:2011.

    Google Scholar 

  21. Hegde SV, Adhikari P, Shetty S, Manjrekar P, D’Souza V. Effect of community-based yoga intervention on oxidative stress and glycemic parameters in prediabetes: a randomized controlled trial. Complement Ther Med. 2013;21(6):571–6.

    PubMed  Google Scholar 

  22. Mohan V, Deepa R, Deepa M, Somannavar S, Datta M. A simplified Indian Diabetes Risk Score for screening for undiagnosed diabetic subjects. J Assoc Phys India. 2005;53:759–63.

    CAS  Google Scholar 

  23. Nagarathna R, Rajesh SK, Amit S, Patil S, Anand A, Nagendra HR. Methodology of Niyantrita Madhumeha Bharata Abhiyaan-2017, a nationwide multicentric trial on the effect of a validated culturally acceptable lifestyle intervention for primary prevention of diabetes: Part 2. Int J Yoga. 2019;12(3):193.

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Nagarathna Raghuram VR, Vijaya Majumdar RS, Amit Singh SP, Akshay Anand IJ, Srikanta Bhaskara JR. Effectiveness of a yoga-based lifestyle protocol (YLP) in preventing diabetes in a high-risk Indian cohort: a multicenter cluster-randomized controlled trial (NMB-trial). Front Endocrinol. 2021.

    Article  Google Scholar 

  25. Josse J, Husson F. missMDA: a package for handling missing values in multivariate data analysis. J Stat Softw. 2016;70(1):31.

    Google Scholar 

  26. Anjana RM, Pradeepa R, Deepa M, Datta M, Sudha V, Unnikrishnan R, et al., ICMR–INDIAB Collaborative Study Group. Prevalence of diabetes and prediabetes (impaired fasting glucose and/or impaired glucose tolerance) in urban and rural India: phase I results of the Indian Council of Medical Research-INdia DIABetes (ICMR-INDIAB) study. Diabetologia. 2011;54(12):3022–7. Epub 2011 Sep 30. PMID: 21959957.

  27. Rygiel K. Hypertriglyceridemia—common causes, prevention and treatment strategies. Curr Cardiol Rev. 2018;14(1):67–76.

    CAS  PubMed  PubMed Central  Google Scholar 

  28. De Koning L, Merchant AT, Pogue J, Anand SS. Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies. Eur Heart J. 2007;28(7):850–6.

    PubMed  Google Scholar 

  29. McLaughlin T, Lamendola C, Liu A, Abbasi F. Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity. J Clin Endocrinol Metab. 2011;96(11):E1756–60.

    CAS  PubMed  PubMed Central  Google Scholar 

  30. Jeon J, Jung KJ, Jee SH. Waist circumference trajectories and risk of type 2 diabetes mellitus in Korean population: the Korean genome and epidemiology study (KoGES). BMC Public Health. 2019;19(1):1–1.

    Google Scholar 

  31. Roumen C, Corpeleijn E, Feskens EJ, Mensink M, Saris WH, Blaak EE. Impact of 3-year lifestyle intervention on postprandial glucose metabolism: the SLIM study. Diabet Med. 2008;25(5):597–605.

    CAS  PubMed  Google Scholar 

  32. Bock G, Dalla Man C, Campioni M, Chittilapilly E, Basu R, Toffolo G, et al. Pathogenesis of pre-diabetes: mechanisms of fasting and postprandial hyperglycemia in people with impaired fasting glucose and/or impaired glucose tolerance. Diabetes. 2006;55:3536–49.

    CAS  PubMed  Google Scholar 

  33. Gerich JE. The importance of tight glycemic control. Am J Med. 2005;118(9):7–11.

    Google Scholar 

  34. Buysschaert M, Medina JL, Bergman M, Shah A, Lonier J. Prediabetes and associated disorders. Endocrine. 2015;48(2):371–93.

    CAS  PubMed  Google Scholar 

  35. Diabetes D. Learning about prediabetes. American Diabetes Association website 2014.

  36. Shantakumari N, Sequeira S. Effects of a yoga intervention on lipid profiles of diabetes patients with dyslipidemia. Indian Heart J. 2013;65(2):127–31.

    PubMed  PubMed Central  Google Scholar 

  37. DeGoma EM, Degoma RL, Rader DJ. Beyond high-density lipoprotein cholesterol levels: evaluating high-density lipoprotein function as influenced by novel therapeutic approaches. J Am Coll Cardiol. 2008;51(23):2199–211.

    CAS  PubMed  PubMed Central  Google Scholar 

  38. Anand A, Saraf MK, Prabhakar S. Sustained inhibition of brotizolam induced anterograde amnesia by norharmane and retrograde amnesia by l-glutamic acid in mice. Behav Brain Res. 2007;182(1):12–20.

    CAS  PubMed  Google Scholar 

  39. Anand A, Saraf MK, Prabhakar S. Antiamnesic effect of B. monniera on L-NNA induced amnesia involves calmodulin. Neurochem Res. 2010;35(8):1172–81.

    CAS  PubMed  Google Scholar 

  40. Goyal K, Koul V, Singh Y, Anand A. Targeted drug delivery to central nervous system (CNS) for the treatment of neurodegenerative disorders: trends and advances. Cent Nerv Syst Agents Med Chem (Formerly Current Medicinal Chemistry-Central Nervous System Agents). 2014;14(1):43–59.

    CAS  Google Scholar 

  41. Gupta PK, Prabhakar S, Abburi C, Sharma NK, Anand A. Vascular endothelial growth factor-A and chemokine ligand (CCL2) genes are upregulated in peripheral blood mononuclear cells in Indian amyotrophic lateral sclerosis patients. J Neuroinflammation. 2011;8(1):1–6.

    Google Scholar 

  42. Kumar S, Modgil S, Bammidi S, Minhas G, Shri R, Kaushik S, Singh V, Anand A. Allium cepa exerts neuroprotective effect on retinal ganglion cells of pterygopalatine artery (PPA) ligated mice. J Ayurveda Integr Med. 2020;11(4):489–94.

    PubMed  PubMed Central  Google Scholar 

  43. Saraf MK, Prabhakar S, Anand A. Neuroprotective effect of Bacopa monniera on ischemia induced brain injury. Pharmacol Biochem Behav. 2010;97(2):192–7.

    CAS  PubMed  Google Scholar 

  44. Singh T, Prabhakar S, Gupta A, Anand A. Recruitment of stem cells into the injured retina after laser injury. Stem Cells Dev. 2012;21(3):448–54.

    CAS  PubMed  Google Scholar 

  45. Diabetes Prevention Program Research Group. 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet. 2009;374(9702):1677–86.

    Google Scholar 

  46. Hegde SV, Adhikari P, Kotian S, Pinto VJ, D’Souza S, D’Souza V. Effect of 3-month yoga on oxidative stress in type 2 diabetes with or without complications: a controlled clinical trial. Diabetes Care. 2011;34(10):2208–10.

    PubMed  PubMed Central  Google Scholar 

  47. Sharma M, Knowlden AP. Role of yoga in preventing and controlling type 2 diabetes mellitus. J Evid-Based Complementary Altern Med. 2012;17(2):88–95.

    Google Scholar 

  48. Keerthi GS, Pal P, Pal GK, Sahoo JP, Sridhar MG, Balachander J. Effect of 12 Weeks of yoga therapy on quality of life and Indian diabetes risk score in normotensive Indian young adult prediabetics and diabetics: randomized control trial. J Clin Diagn Res. 2017;11(9):CC10.

    PubMed  PubMed Central  Google Scholar 

  49. Sahay BK. Role of yoga in diabetes. JAPI. 2007;55:121–6.

    CAS  PubMed  Google Scholar 

  50. Balaji PA. Effects of yoga-pranayama practices on metabolic parameters and anthropometry in type 2 diabetes. Int Multidiscipl Res J. 2011;1(10).

  51. Cui J, Yan JH, Yan LM, Pan L, Le JJ, Guo YZ. Effects of yoga in adults with type 2 diabetes mellitus: a meta-analysis. J Diabet Investig. 2017;8(2):201–9.

    CAS  Google Scholar 

  52. Sedlmeier P, Eberth J, Schwarz M, Zimmermann D, Haarig F, Jaeger S, Kunze S. The psychological effects of meditation: a meta-analysis. Psychol Bull. 2012;138(6):1139.

    PubMed  Google Scholar 

  53. Bonura KB, Tenenbaum G. Effects of yoga on psychological health in older adults. J Phys Act Health. 2014;11(7):1334–41.

    PubMed  Google Scholar 

  54. Rastogi S. Development and validation of a Prototype Prakriti Analysis Tool (PPAT): Inferences from a pilot study. AYU. 2012;33(2):209.

    PubMed  PubMed Central  Google Scholar 

  55. Govindaraj P, Nizamuddin S, Sharath A, Jyothi V, Rotti H, Raval R, Nayak J, Bhat BK, Prasanna BV, Shintre P, Sule M. Genome-wide analysis correlates Ayurveda Prakriti. Sci Rep. 2015;5(1):1–2.

    Google Scholar 

  56. Singh AK, Kaur N, Kaushal S, Tyagi R, Mathur D, Sivapuram MS, Metri K, Bammidi S, Podder V, Modgil S, Khosla R. Partitioning of radiological, stress and biochemical changes in pre-diabetic women subjected to Diabetic Yoga Protocol. Diabetes Metab Syndr. 2019;13(4):2705–13.

    PubMed  Google Scholar 

  57. Pal DK, Bhalla A, Bammidi S, Telles S, Kohli A, Kumar S, Devi P, Kaur N, Sharma K, Kumar R, Malik N. Can yoga-based diabetes management studies facilitate integrative medicine in India current status and future directions. Integr Med Int. 2017;4(3–4):125–41.

    Google Scholar 

  58. Bali P, Kaur N, Tiwari A, Bammidi S, Podder V, Devi C, Kumar S, Sivapuram MS, Ghani A, Modgil S, Malik N. Effectiveness of yoga as the public health intervention module in the management of diabetes and diabetes associated dementia in South East Asia: a narrative review. Neuroepidemiology. 2020;54(4):287–303.

    PubMed  Google Scholar 

  59. Anand A. Narendra Modi’s citizen centered Yoga-Diabetes Management Program: will Indian state install integrative medicine in premier institutes? Ann Neurosci. 2019;26(2):47–8.

    PubMed  PubMed Central  Google Scholar 

  60. Bansal M. Cardiovascular disease and COVID-19. Diabetes Metab Syndr. 2020;14(3):247–50.

    PubMed  PubMed Central  Google Scholar 

  61. Peric S, Stulnig TM. Diabetes and COVID-19. Wien Klin Wochenschr. 2020;132(13):356–61.

    CAS  PubMed  Google Scholar 

Download references


The authors would like to thank Central Council for Research in Yoga & Naturopathy (CCRYN) for their support for man power, Ministry of Health and Family Welfare (MOHFW) for support the cost of investigations and Indian Yoga Association (IYA) for the overall project implementation. The authors also like to thank to thank Yoga Volunteer for Diabetes Management (YVDMs) for helping in collection of data and also for training participants for yoga.


The Project was funded by Ministry of AYUSH, Government of India (grant number 16-63/2016-17/CCRYN/RES/Y&D/ MCT/).

Author information




NK: writing of manuscript, collection of data. VM: writing of manuscript, analysis. RN: conceptualization of manuscript, supervision and study design. NM: co-conceptualization of manuscript. AA: conceptualization of manuscript. HRN: supervision. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Raghuram Nagarathna or Akshay Anand.

Ethics declarations

Ethics approval and consent to participate

Written informed consents were taken from every subject during door to door screening as well as at the time of registration. All the experimental protocol, methods and procedures were approved by Ethics committee of Indian Yoga Association (IYA) (ID: RES/IEC-IYA/001). All experiments methods and procedures were carried out in accordance with relevant guidelines and regulations of ethics committee.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Kaur, N., Majumdar, V., Nagarathna, R. et al. Diabetic yoga protocol improves glycemic, anthropometric and lipid levels in high risk individuals for diabetes: a randomized controlled trial from Northern India. Diabetol Metab Syndr 13, 149 (2021).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI:


  • Diabetic yoga protocol
  • Indian diabetes risk score
  • Glycated hemoglobin
  • Diabetes
  • Prediabetes