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Fig. 5 | Diabetology & Metabolic Syndrome

Fig. 5

From: Up-regulated autophagy: as a protective factor in adipose tissue of WOKW rats with metabolic syndrome

Fig. 5

Detection of adiponectin immunoreactivity after autophagy inhibition in visceral adipocytes of WOKW and LEW.1W rats. a–d″ Adionectin (red) with perilipin A (green) were detected in visceral adipocytes (higher autophagic activity) of WOKW and LEW.1W rats using double immunofluorescence staining Note the adiponectin immunoreactivity was lower in visceral adipocytes of WOKW rats than in LEW.1W rats (a–a″, c–c″). In accordance with Western blot data, the inhibition of PI3K signaling pathway and autophagic activity resulted in strikingly increase of adiponectin immunoreactivity (positive adipocytes) of both strains, with prevalence to WOKW rats (b–b″, d–d″). Nuclei are counterstained with DAPI (blue)

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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