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Evaluation of restless legs syndrome symptoms in patients with and without the diagnosis of type 2 diabetes mellitus


Restless legs syndrome (RLS) is a neurological sleep disorder. Literature suggests association between RLS and diabetes, but few studies have been done evaluating the association between these conditions[1].


Evaluate the prevalence of RLS symptoms in patients with and without the diagnosis of Type 2 Diabetes Mellitus (DM2).

Materials and methods

Case control study. 112 individuals were studied, 28 with DM2 (cases) and 84 without DM2 (controls), in a medical clinic specialities at Tubarão, Brazil. They answered a questionnaire with socio demographic questions, information about diabetes and to the four minimum criteria, defined by The International Restless Legs Syndrome Study Group (IRLSSG), for RLS diagnosis[2]. Furthermore, they were subjected to the Epworth Sleepiness scale and the IRLSSG rating scale, both translated and validated to Portuguese[3, 4].


Among the cases, 21.4% presented RLS, compared to 14.3% in controls (p=0.269). The group with DM2 showed higher prevalence of Excessive daytime Sleepiness (EDS) (21.4% vs. 13.1%; p=0.219), and had higher scores in the IRLSSG rating scale (23,3±11,3 vs. 15,7±6,5; p=0.086). Correlating severity of RLS with glycemia, we obtained a Pearson correlation of 0.698 (p=0.003).


DM2 patients have a higher, but non-significant prevalence of RLS symptoms and EDS than the non-diabetics. It has been found a correlation between RLS severity and glycemia.


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Correspondence to Arthur Onofre Beltran Filho.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Filho, A.O.B., Jung, G.A., Zoehler, L.V. et al. Evaluation of restless legs syndrome symptoms in patients with and without the diagnosis of type 2 diabetes mellitus. Diabetol Metab Syndr 7 (Suppl 1), A89 (2015).

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