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  • Open Access

Type 1 diabetes induces biomechanical changes in skeletal muscle of Wistar rats?

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Diabetology & Metabolic Syndrome20157 (Suppl 1) :A7

  • Published:


  • Diabetes Mellitus Type
  • Diabetes Type
  • Myopathy
  • Diabetic Group
  • Gastrocnemius Muscle


Chronic hyperglycemia caused by diabetes mellitus type 1 is associated with damage, dysfunction and failure of several organs and systems, including the musculoskeletal system[1]. In the installed framework of diabetic insulin deficiency, there is an imbalance between the rates of protein synthesis and degradation, causing a condition called diabetic myopathy[2]. However, there are no reports about investigations of biomechanical characteristics of skeletal muscles in diabetic state.


To evaluate the biomechanical properties of the gastrocnemius muscles of rats induced to experimental type 1 diabetes.

Materials and methods

Male Wistar rats were used and were divided into two groups: a) control group, CG (n=11); b) Diabetic Group, GD (n=19). The GD group was induced to diabetes by intraperitoneal administration of Streptozotocin. After nine weeks, the gastrocnemius-plantar complex of all groups was collected and forwarded to the mechanical tests, which provided the biomechanical parameters. For statistical analysis Kolmolgorov-Smirnov normality test was used, with the Student t test for parametric data and Mann-Whitney test for nonparametric, p <0.05.


Biomechanical testing GD group exhibited lower values for the variables: maximum power (GC 51.5±9.21, 26.52±9.74 GD; p=0.0001), deformation (GC 17.85±5 75; GD 10.2±3.30; p=0.002), specific strain (GC 41.04±15.89, GD 26.59±8.23, p=0.019), force/width (CG 2 06±0.37, 1.05±0.39 GD; p <0.001) power/area (GC 45.58±2.71; GD 4.9±2.21; p=0.003), cross-sectional area (GC 67.49±16.37; 30.13±7.48 GD; p=0.0001). There was no difference in voltage values at full strength and elastic modulus. In clinical and metabolic parameters, experimental diabetes reduced body weight (GC 429.8±32,65g; GD 238.8±26,98g, p <0.001) and increased blood glucose values when compared to GC group from the first week post induction by the end of the experiment (GC 103.82±16.59/GD 471.30±71.55, p <0.001).


Most of the evaluated parameters showed a biomechanical disadvantage in the gastrocnemius-plantar complex of animals submitted to Diabetes type 1, making them weaker when subjected to traction.

Authors’ Affiliations

Universidade Federal de Pernambuco, Recife, Brazil


  1. Arkkila , et al: 2003Google Scholar
  2. Krause , et al: 2011Google Scholar