Skip to main content
  • Meeting abstract
  • Open access
  • Published:

Type 1 diabetes induces biomechanical changes in skeletal muscle of Wistar rats?


Chronic hyperglycemia caused by diabetes mellitus type 1 is associated with damage, dysfunction and failure of several organs and systems, including the musculoskeletal system[1]. In the installed framework of diabetic insulin deficiency, there is an imbalance between the rates of protein synthesis and degradation, causing a condition called diabetic myopathy[2]. However, there are no reports about investigations of biomechanical characteristics of skeletal muscles in diabetic state.


To evaluate the biomechanical properties of the gastrocnemius muscles of rats induced to experimental type 1 diabetes.

Materials and methods

Male Wistar rats were used and were divided into two groups: a) control group, CG (n=11); b) Diabetic Group, GD (n=19). The GD group was induced to diabetes by intraperitoneal administration of Streptozotocin. After nine weeks, the gastrocnemius-plantar complex of all groups was collected and forwarded to the mechanical tests, which provided the biomechanical parameters. For statistical analysis Kolmolgorov-Smirnov normality test was used, with the Student t test for parametric data and Mann-Whitney test for nonparametric, p <0.05.


Biomechanical testing GD group exhibited lower values for the variables: maximum power (GC 51.5±9.21, 26.52±9.74 GD; p=0.0001), deformation (GC 17.85±5 75; GD 10.2±3.30; p=0.002), specific strain (GC 41.04±15.89, GD 26.59±8.23, p=0.019), force/width (CG 2 06±0.37, 1.05±0.39 GD; p <0.001) power/area (GC 45.58±2.71; GD 4.9±2.21; p=0.003), cross-sectional area (GC 67.49±16.37; 30.13±7.48 GD; p=0.0001). There was no difference in voltage values at full strength and elastic modulus. In clinical and metabolic parameters, experimental diabetes reduced body weight (GC 429.8±32,65g; GD 238.8±26,98g, p <0.001) and increased blood glucose values when compared to GC group from the first week post induction by the end of the experiment (GC 103.82±16.59/GD 471.30±71.55, p <0.001).


Most of the evaluated parameters showed a biomechanical disadvantage in the gastrocnemius-plantar complex of animals submitted to Diabetes type 1, making them weaker when subjected to traction.


  1. Arkkila , et al: 2003

  2. Krause , et al: 2011

Download references

Author information

Authors and Affiliations



Corresponding author

Correspondence to Camilla Rodrigues de Souza Silva.

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

de Souza Silva, C.R., Coutinho, M.P.G., Amaral, M.V.F. et al. Type 1 diabetes induces biomechanical changes in skeletal muscle of Wistar rats?. Diabetol Metab Syndr 7 (Suppl 1), A7 (2015).

Download citation

  • Published:

  • DOI: