Efficacy of SGLT2 inhibitors in glycemic control, weight loss and blood pressure reduction: a systematic review and meta-analysis
© Pinto et al. 2015
Published: 11 November 2015
Sodium–glucose cotransporter 2 inhibitors (SGLT2i) are a novel antidiabetic class that inhibits glucose reabsorption and produce glycosuria. These medications are being increasingly used as dual therapy with metformin for type 2 diabetes (T2D) treatment, due to their beneficial effect on weight and blood pressure. Three agents are approved for clinical use and they may differ on potency due to inhibition of only renal or both renal and bowel glucose transportation.
to evaluate the efficacy of SGLT2i, dapagliflozin (DAPA), canagliflozin (CANA) and empagliflozin (EMPA), on HbA1c, weight and blood pressure (BP) in comparison with placebo and other antidiabetic medications.
Materials and methods
MEDLINE, Cochrane central and EMBASE databases were searched for randomized clinical trials (RCTs) including patients with T2D allocated to SGLT2i for at least 12 weeks. A direct and network meta-analysis (NMA) were conducted.
In T2D patients, SGLT2i were superior to placebo for all outcomes analyzed, and CANA seems to be the most potent among then. SGLT2i are as effective as metformin and sulphonylurea and superior to DPP4 inhibitors for HbA1c, but more potent than these classes regarding weight and BP reduction.
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