- Meeting abstract
- Open Access
Insulin lispro low mixture twice daily vs basal insulin glargine once daily and prandial insulin lispro once daily as insulin intensification strategies in patients with type 2 diabetes: A Latin American subpopulation analysis of a randomized trial
© Barbieri et al. 2015
- Published: 11 November 2015
- Insulin Glargine
- Insulin Lispro
- Glycemic Variability
This post-hoc analysis examined the efficacy and safety of twice-daily insulin lispro low mixture (LM25) and once-daily basal insulin glargine plus once-daily prandial insulin lispro (IGL) in a Latin American subpopulation (Argentina, Brazil, and Mexico) of participants with type 2 diabetes mellitus (T2D).
This phase 4, randomized, open-label, parallel-arm trial included participants aged 18–75 yrs. with T2D who were taking once-daily insulin glargine and stable doses of metformin and/or pioglitazone and had glycosylated hemoglobin (HbA1c) between ≥7.5% and ≤10.5% and fasting plasma glucose ≤6.7 mmol/L (121 mg/dL). Participants were randomized 1: 1 to receive twice-daily LM25 (before breakfast and dinner) or basal insulin glargine (at bedtime) and IGL (before the largest daily meal) in addition to their existing dose of metformin and/or pioglitazone for 24 weeks. The primary efficacy outcome was the change in HbA1c from baseline to Week 24.
The results of this post-hoc analysis in a Latin American population are consistent with the results reported in the trial-level population and suggest that both LM25 and IGL are viable treatment options for insulin intensification in patients with T2D who do not achieve glycemic control on basal insulin glargine. ClinicalTrials.gov Number: NCT01175824.
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