Prevalence and profile of diabetes kidney disease according to different diagnostic criteria in type 2 diabetes mellitus patients

Background

Diabetes kidney disease (DKD) is the worldwide leading cause of end-stage renal disease. Diagnostic criteria have been recently revised.

Objective

The aim of this study was to evaluate the prevalence and clinical profile of type 2 DM patients according to the employed definition of DKD: previous diagnostic criteria as compared to the present one.

Materials and methods

566 type 2 DM outpatients from the Endocrine Unit ambulatory were included. DKD was defined by the presence of elevated urinary albumin excretion alone (UAE; >14 mg/l) -previous definition- or by the presence of elevated UAE and/or reduced (<60 ml/min/1.73 m2) glomerular filtration rate (GFR) -present definition.

Results

Mean age was 63±11 yrs., 37% men, 86% white, 10% smokers, DM duration 16 yrs. When evaluated by elevated UAE only, 50% of the patients presented DKD. Table 1 shows the profile of these patients (Fig 1). When defined by both UAE and GFR, 57% presented DKD, and Table 2 shows the profile of these patients (Fig 2).

Figure 1

Clinical and laboratory characteristics of DKD patients according to the presence of elevated UAE only.

Figure 2

Clinical and laboratory characteristics of DKD patients according to the presence of elevated UAE and/or reduced GFR.

Conclusion

DKD cases would be missed if only UAE is taken into account.