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Fig. 6 | Diabetology & Metabolic Syndrome

Fig. 6

From: Enhancing insulin sensitivity in type 2 diabetes mellitus using apelin-loaded small extracellular vesicles from Wharton’s jelly-derived mesenchymal stem cells: a novel therapeutic approach

Fig. 6

Analysis of adipose tissue in T2DM model mice treated with MSC-sEVs and AP-MSC-sEVs. (a–b) SDS-PAGE results showing the effects of sEV treatments on AMPK and Akt phosphorylation. MSC-sEV and AP-MSC-sEV treatments enhanced AMPK phosphorylation and the p-Akt/Akt ratio, indicating improved insulin sensitivity (P < 0.05); more pronounced phosphorylation effect was observed with AP-MSC-sEVs. GLUT4 protein expression also significantly increased following sEV treatments (*P < 0.05, **P < 0.01, ***P < 0.001). Abbreviations: sEVs, small extracellular vesicles; AP-MSC-sEVs, apelin-MSC-sEVs, engineered sEVs loaded with overexpressed apelin; Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs)

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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