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Fig. 5 | Diabetology & Metabolic Syndrome

Fig. 5

From: Enhancing insulin sensitivity in type 2 diabetes mellitus using apelin-loaded small extracellular vesicles from Wharton’s jelly-derived mesenchymal stem cells: a novel therapeutic approach

Fig. 5

Effects of MSC-sEVs and Ap-MSC-sEVs on pancreatic β-cell function in T2DM mice. (a) Increased β-cell area in pancreatic tissues (P < 0.05). (b) Presence of more insulin-positive and Ki-67-positive β-cells, indicating cell replication in Ap-MSC-sEV treatment (P < 0.05). (c) Increased number of Ki67+Insulin+/Insulin+ cells in the Ap-MSC-sEV-treated group (P < 0.05). (d) Comparison of islet area and Ki-67 positive cell count between treatments (*P < 0.05, **P < 0.01, ***P < 0.001). Abbreviations: sEVs, small extracellular vesicles; AP-MSC-sEVs, apelin-MSC-sEVs, engineered sEVs loaded with overexpressed apelin; Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs)

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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