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Fig. 2 | Diabetology & Metabolic Syndrome

Fig. 2

From: Enhancing insulin sensitivity in type 2 diabetes mellitus using apelin-loaded small extracellular vesicles from Wharton’s jelly-derived mesenchymal stem cells: a novel therapeutic approach

Fig. 2

Characterization of sEVs derived from WJ-MSCs and apelin-modified WJ-MSCs. (a) TEM image showing the typical cup-shaped morphology of the extracted sEVs. (b) Nanoparticle tracking analysis (NTA) displaying an average sEV diameter of 100–120 nm. (c) Western blot results indicating positive expression of sEV markers CD63, CD81, and TSG101 and negative expression of the non-sEVs marker calnexin blot as well as the presence of apelin protein in Ap-MSC-sEVs. Abbreviations: sEVs, small extracellular vesicles; AP-MSC-sEVs, apelin-MSC-sEVs, engineered sEVs loaded with overexpressed apelin; Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs); TEM, transmission electron microscopy

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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