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Table 5 Association between SUA and TIR and other indices of glycemic fluctuation after SUA quartile stratification

From: Correlation between time in range and serum uric acid in Chinese patients with type-2 diabetes: an observational cross-sectional study

Exposure

Non-adjusted

Model I

Model II

β

(95%CI)

P value

β

(95%CI)

P value

β

(95%CI)

P value

TIR

 SUAQ1

−

−

−

 SUAQ2

− 0.71

(− 6.98, 5.57)

0.826

− 2.32

(− 8.67, 4.02)

0.474

− 1.10

(− 7.47, 5.27)

0.735

 SUAQ3

1.44

(− 4.91, 7.78)

0.657

− 1.41

(− 8.13, 5.31)

0.682

1.49

(− 5.13, 8.12)

0.659

 SUAQ4

11.71

(5.39, 18.03)

0.001

9.99

(3.16, 16.81)

0.004

11.84

(4.50, 19.19)

0.002

TBR

 SUAQ1

−

−

−

 SUAQ2

− 0.05

(− 0.64, 0.54)

0.871

0.11

(− 0.51, 0.73)

0.736

− 0.01

(− 0.61, 0.60)

0.981

 SUAQ3

− 0.51

(− 1.10, 0.08)

0.092

− 0.22

(− 0.87, 0.44)

0.521

− 0.36

(− 0.99, 0.27)

0.261

 SUAQ4

− 0.53

(− 1.12, 0.06)

0.082

− 0.21

(− 0.87, 0.46)

0.545

− 0.29

(− 0.99,0.41)

0.419

TAR

 SUAQ1

−

−

−

 SUAQ2

1.00

(− 5.35, 7.34)

0.758

2.48

(− 3.95, 8.92)

0.450

1.32

(− 5.11, 7.74)

0.688

 SUAQ3

− 0.93

(− 7.35, 5.49)

0.777

1.89

(− 4.93, 8.70)

0.588

− 1.19

(− 7.87, 5.49)

0.727

 SUAQ4

− 10.94

(− 17.33, − 4.56)

0.001

− 9.50

(− 16.42,− 2.58)

0.007

− 11.41

(− 18.82,− 4.00)

0.003

SD

 SUAQ1

−

−

−

 SUAQ2

− 0.13

(− 0.39, 0.13)

0.334

− 0.06

(− 0.33, 0.22)

0.691

− 0.14

(− 0.41, 0.13)

0.298

 SUAQ3

− 0.53

(− 0.80, − 0.27)

 < 0.001

− 0.42

(− 0.71, − 0.13)

0.004

− 0.48

(− 0.76, − 0.20)

0.001

 SUAQ4

− 0.77

(− 1.04, − 0.50)

 < 0.001

− 0.70

(− 0.99, − 0.41)

 < 0.001

− 0.73

(− 1.04, − 0.42)

 < 0.001

MODD

 SUAQ1

−

−

−

 SUAQ2

− 0.17

(− 0.47, 0.13)

0.257

− 0.11

(− 0.41, 0.20)

0.497

− 0.18

(− 0.48, 0.13)

0.252

 SUAQ3

− 0.51

(− 0.81, − 0.22)

0.001

− 0.42

(− 0.74, − 0.11)

0.010

− 0.47

(− 0.78, − 0.16)

0.003

 SUAQ4

− 0.72

(− 1.02, − 0.42)

 < 0.001

− 0.65

(− 0.98, − 0.32)

0.001

− 0.65

(− 1.01, − 0.29)

0.004

ADRR

 SUAQ1

−

−

−

 SUAQ2

0.71

(− 2.70, 4.12)

0.684

1.93

(− 1.55, 5.41)

0.278

0.96

(− 2.52, 4.44)

0.590

 SUAQ3

− 3.18

(− 6.59, 0.23)

0.069

− 1.18

(− 4.82, 2.47)

0.527

− 2.31

(− 5.89, 1.27)

0.207

 SUAQ4

− 7.39

(− 10.82, − 3.95)

 < 0.001

− 5.91

(− 9.66, − 2.16)

0.002

− 5.98

(− 10.05,− 1.91)

0.004

MAGE

 SUAQ1

–

–

–

 SUAQ2

− 0.03

(− 0.49, 0.43)

0.908

0.07

(− 0.40, 0.54)

0.763

− 0.10

(− 0.56, 0.37)

0.687

 SUAQ3

− 0.96

(− 1.42, −0.49)

 < 0.001

− 0.84

(− 1.34, − 0.34)

0.001

− 0.90

(− 1.38, − 0.41)

 < 0.001

 SUAQ4

− 1.22

(− 1.69, − 0.76)

 < 0.001

− 1.15

(− 1.66, − 0.63)

 < 0.001

− 1.18

(− 1.72, − 0.64)

 < 0.001

M value

   

 SUAQ1

−

−

−

 SUAQ2

− 2.75

(− 8.06, 2.57)

0.312

− 1.60

(− 7.19, 3.98)

0.574

− 2.46

(− 7.97, 3.06)

0.383

 SUAQ3

− 5.97

(− 11.34, − 0.61)

0.030

− 4.31

(− 10.21, 1.59)

0.153

− 4.97

(− 10.69, 0.75)

0.089

SUAQ4

− 7.91

(− 13.25, − 2.58)

0.004

− 6.67

(− 12.66, − 0.68)

0.030

− 6.75

(− 13.09, -0.41)

0.038

  1. Model I: Adjusted age, sex, Diabetes duration, smoking, DBP, SBP, Weight and BMI
  2. Model II: Adjusted Model I, FBG, SUN, SCr, TC, TG, HDL, LDL, HbA1c
  3. β Regression coefficient, CI Confidence interval,TBR time below range, TIR time in range, TAR time above range, SD standard deviation, ADRR average daily risk range, MODD mean of daily differences, MAGE mean amplitude of glycemic excursions
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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