Causal effects of glycemic traits and endometriosis: a bidirectional and multivariate mendelian randomization study

Table 3 Heterogeneity, pleiotropy, and MR-PRESSO global tests for the univariable mendelian randomization

Exposure	Outcome	Heterogeneity test		Pleiotropy test		MRPRESSO
Exposure	Outcome	Q value	p-value	Intercept	p-value	oulier	p-value
T1DM	Endometriosis	33.68	0.43	0.01	0.07	0	0.29
T2DM	Endometriosis	6.70	0.57	0.02	0.40	0	0.86
GDM	Endometriosis	1502.68	0.00	-0.20	0.00	6	0.01
GDM^a	Endometriosis	56.18	0.04	0.02	0.46	0	0.05
FI	Endometriosis	55.24	0.00	0.01	0.72	2	< 2E-04
FI^a	Endometriosis	26.52	0.01	0.00	0.96	0	0.02
FG	Endometriosis	21.38	0.38	-0.01	0.61	0	0.50
HbA1c	Endometriosis	22.84	0.64	0.01	0.12	0	0.72
Endometriosis	T1DM	8.74	0.19	0.00	0.97	0	0.26
Endometriosis	T2DM	8.31	0.14	0.01	0.70	0	0.21
Endometriosis	GDM	0.88	0.83	-0.69	0.55	0	0.75
Endometriosis	FI	15.10	0.13	0.00	0.30	0	0.17
Endometriosis	HbA1c	11.27	0.19	0.00	0.79	0	0.72

^aAfter removing outliers from MR-PRESSO outlier test. T1DM, Type 1 diabetes mellitus; T2DM, Type 2 diabetes mellitus; GDM, Gestational diabetes mellitus; FI, Fasting insulin; FG, Fasting glucose; HbA1c, Hemoglobin A1c; MR-PRESSO, Mendelian randomization pleiotropy residual sum and outlier; Q value, the statistics of Cochran’s Q test.

ISSN: 1758-5996