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Table 5 The best threshold, sensitivities, specificities, and area under the curve of four IR surrogates for predicting diabetes in different subgroups

From: Predictive value of insulin resistance surrogates for the development of diabetes in individuals with baseline normoglycemia: findings from two independent cohort studies in China and Japan

 

Chinese cohort

Japanese cohort

AUC

Best threshold

Specificity

Sensitivity

AUC

Best threshold

Specificity

Sensitivity

Sex (male)

 TyG index

0.7221*

8.7791

0.6470

0.6859

0.6966*

8.7670

0.8002

0.5105

 TyG-BMI

0.7356

220.2488

0.6465

0.7145

0.7251

206.1369

0.7113

0.6573

 TG/HDL-C ratio

0.6454*

1.1398

0.5567

0.6679

0.6936*

0.8178

0.5687

0.7448

 MetS-IR

0.7186*

36.7735

0.5754

0.7532

0.7346*

37.6406

0.7627

0.6154

Sex (female)

 TyG index

0.7996

8.4446

0.7030

0.7831

0.7934

8.0568

0.7346

0.7816

 TyG-BMI

0.8000

197.4111

0.7221

0.7604

0.8016

180.6269

0.7858

0.7241

 TG/HDL-C ratio

0.7396*

0.9309

0.7469

0.6204

0.7796

0.4560

0.6764

0.7931

 MetS-IR

0.7842*

33.8494

0.7369

0.7352

0.8001

29.8919

0.7256

0.7471

Non-obese

 TyG index

0.7622

8.5659

0.6598

0.7457

0.7269

8.2027

0.6830

0.6667

 TyG-BMI

0.7653

202.0524

0.6430

0.7603

0.7238

179.9124

0.6782

0.6617

 TG/HDL-C ratio

0.6938*

1.0237

0.6601

0.6341

0.7150

0.7524

0.7477

0.5871

 MetS-IR

0.7457*

34.6257

0.6482

0.7392

0.7314

31.2083

0.6762

0.6667

Obese

 TyG index

0.6497

8.8756

0.5268

0.7057

0.6531*

8.7738

0.6926

0.5523

 TyG-BMI

0.6440

272.1837

0.6726

0.5476

0.6898

8.7738

0.6926

0.5523

 TG/HDL-C ratio

0.5712*

1.8093

0.6730

0.4348

0.6494*

1.2743

0.6543

0.5698

 MetS-IR

0.6131*

44.9568

0.5091

0.6603

0.7049

41.7010

0.6330

0.6860

Age (≥ 50 years)

 TyG index

0.6780*

8.7798

0.6351

0.6276

0.6747

8.5186

0.7224

0.5396

 TyG-BMI

0.6927

219.2980

0.6528

0.6406

0.6889

198.2597

0.7009

0.6043

 TG/HDL-C ratio

0.6146*

0.9931

0.5048

0.6680

0.6741

1.1047

0.7813

0.4748

 MetS-IR

0.6835*

36.1923

0.5831

0.7070

0.7012

35.5029

0.7451

0.5468

Age (< 50 years)

 TyG index

0.8099*

8.6016

0.7122

0.7835

0.7776*

8.1960

0.6600

0.7991

 TyG-BMI

0.8272

214.0949

0.7489

0.7795

0.8094

192.9588

0.7241

0.7692

 TG/HDL-C ratio

0.7607*

1.1092

0.7142

0.7025

0.7716*

0.7505

0.7132

0.7350

 MetS-IR

0.8175*

36.0175

0.7099

0.7942

0.8143

33.7494

0.7235

0.7650

Hypertension (No)

 TyG index

0.7719*

8.5426

0.6524

0.7698

0.7544*

8.1960

0.6376

0.7695

 TyG-BMI

0.7811

213.7032

0.7413

0.6888

0.7752

197.2987

0.7625

0.6667

 TG/HDL-C ratio

0.7076*

1.0091

0.6544

0.6683

0.7465*

0.7747

0.7145

0.6791

 MetS-IR

0.7673*

35.4151

0.6774

0.7468

0.7795

34.7236

0.7680

0.6542

Hypertension (Yes)

 TyG index

0.6694

8.7874

0.5699

0.6784

0.6476

8.7327

0.6996

0.5577

 TyG-BMI

0.6595

219.6879

0.5193

0.7144

0.6708

230.2559

0.7401

0.5385

 TG/HDL-C ratio

0.6023*

1.1509

0.5223

0.6257

0.6501

0.9933

0.5813

0.6731

 MetS-IR

0.6474*

36.7532

0.4840

0.7359

0.6900

38.3738

0.6352

0.6538

  1. AUC area under the curve; other abbreviations as in Table 1
  2. *: Delong test P < 0.05 compared with TyG-BMI
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Diabetology & Metabolic Syndrome

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