Table 2 Main results of the MR analysis and sensitivity analysis
Outcome | N | MR analysis | Heterogeneity | MR-Egger pleiotropy | MR PRESSO | Directionality | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
SNVs | Test | Test | Test | Test | |||||||
Method | Estimate (95% CI) | P | Q value | P | Egger intercept | P | Global Test P | Correct directionaliy | P | ||
Type 1 diabetes (T1DM) | |||||||||||
PD risk* | 68 | IVW | 0.9708(0.9466, 0.9956) | 0.0214 | 69.3901 | 0.3968 | 0.0002 | 0.9704 | 0.3885 | TRUE | 0 |
PD AAO | 49 | IVW | -0.0432(-0.2235, 0.1369) | 0.6379 | 36.5035 | 0.8875 | -0.0132 | 0.6908 | 0.8941 | TRUE | 0 |
UPDRS3 | 29 | IVW | 0.0081(-0.0347, 0.0508) | 0.712 | 6.2855 | 1 | 0.0059 | 0.5376 | 1 | TRUE | 0.6823 |
MMSE | 31 | IVW | -0.0502(-0.1265, 0.0261) | 0.1969 | 8.1621 | 1 | 0.0018 | 0.9106 | 1 | TRUE | 0.0654 |
MOCA | 23 | IVW | -0.0983(-0.3123, 0.1157) | 0.3678 | 7.9993 | 0.9972 | 0.0037 | 0.9445 | 0.9951 | TRUE | 0.8692 |
Type 2 diabetes (T2DM) | |||||||||||
PD risk | 154 | IVW | 1.0292(0.9714, 1.0905) | 0.3284 | 194.3979 | 0.0132 | -0.0077 | 0.0921 | 0.0262 | TRUE | 0 |
PD AAO | 119 | IVW | 0.0780(-0.2895, 0.4455) | 0.6774 | 67.9223 | 0.9999 | 0.03 | 0.3063 | 1 | TRUE | 0 |
UPDRS3 | 49 | IVW | -0.0796(-0.1834, 0.0243) | 0.1331 | 7.9237 | 1 | 0.01 | 0.2797 | 1 | FALSE | 0.0017 |
MMSE | 46 | IVW | -0.0194(-0.2116, 0.1728) | 0.8431 | 4.1319 | 1 | 0.004 | 0.8081 | 1 | FALSE | 0 |
MOCA | 45 | IVW | -0.0532(-0.6078, 0.5014) | 0.8508 | 5.8716 | 1 | 0.0415 | 0.3616 | 1 | FALSE | 0.0003 |