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Table 3 The univariate and multivariate analysis of adverse perinatal outcomes with different ICP severity between ICP with GDM group and ICP group

From: Gestational diabetes mellitus aggravates adverse perinatal outcomes in women with intrahepatic cholestasis of pregnancy

Characteristics

severity of ICP

ICP with GDM

(n = 390)

ICP without GDM

(n = 1,788)

Univariate analysis

Multivariate analysis*

OR (95% CI)

p.value

OR (95% CI)

p.value

Preterm labour, n, (%)

Mild

71(22.6%)

180(12.1%)

2.12(1.56, 2.88)

< 0.001

1.80(1.30, 2.50)

< 0.001

Moderate

19(29.2%)

64(23.4%)

1.35(0.74, 2.47)

0.331

1.12(0.59, 2.15)

0.726

Severe

6(54.5%)

5(17.9%)

5.52(1.19, 25.52)

0.029

9.70(0.95, 99.00)

0.055

Meconium-stained amniotic fluid, n (%)

Mild

42(13.4%)

198(13.3%)

1.00(0.70, 1.44)

0.977

1.02(0.71, 1.48)

0.908

Moderate

12(18.5%)

47(17.2%)

1.09(0.54, 2.19)

0.812

1.01(0.48, 2.12)

0.987

Severe

5(45.5%)

8(28.6%)

2.08(0.49, 8.82)

0.319

1.83(0.20, 17.10)

0.595

Low birth weight, n (%)

Mild

76(24.2%)

257(17.3%)

1.53(1.14, 2.05)

0.004

1.25(0.91, 1.71)

0.173

Moderate

23(35.4%)

79(28.9%)

1.35(0.76, 2.38)

0.310

0.92(0.48, 1.76)

0.795

Severe

6(54.5%)

8(28.6%)

3.00(0.71, 12.69)

0.136

4.71(0.52, 42.36)

0.167

  1. *Excluded confounders: maternal age, pregestational weight, gestational weight gain, pre-pregnancy body mass index, bile acid concentration, use of ursodeoxycholic acid, ART, and total bile acid