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Table 2 Perinatal outcomes of women with ICP.

From: Gestational diabetes mellitus aggravates adverse perinatal outcomes in women with intrahepatic cholestasis of pregnancy

Variables

ICP with GDM

(n = 390)

ICP without GDM

(n = 1,788)

Univariate analysis

Multivariate analysis*

OR (95% CI)

p.value

OR(95% CI)

p.value

Preeclampsia, n (%)

21(5.4%)

110(6.2%)

0.87(0.54, 1.40)

0.564

0.80(0.48, 1.31)

0.369

Anemia during pregnancy, n (%)

36(9.2%)

205(11.5%)

0.79(0.54, 1.14)

0.203

0.77(0.53, 1.13)

0.186

Nuchal cord, n (%)

111(28.5%)

502(28.1%)

1.02(0.80, 1.30)

0.878

1.07(0.83, 1.37)

0.620

PPROM, n (%)

64(16.4%)

277(15.5%)

1.07(0.80, 1.44)

0.651

1.13(0.83, 1.54)

0.439

Placenta accreta, n (%)

38(9.7%)

130(7.3%)

1.38(0.94, 2.01)

0.098

1.25(0.85, 1.85)

0.257

Abnormal placental shape, n (%)

13(3.3%)

49(13.9%)

1.22(0.66, 2.28)

0.524

1.10(0.58, 2.09)

0.772

Preterm labour, n (%)

96(24.6%)

249(13.9%)

2.02(1.55, 2.63)

< 0.001

1.67(1.26, 2.22)

< 0.001

Fetal respiratory distress syndrome, n (%)

33(8.5%)

140(7.8%)

1.09(0.73, 1.62)

0.676

0.98(0.65, 1.48)

0.940

Fetal macrosomia, n (%)

9(2.3%)

48(2.7%)

0.86(0.42, 1.76)

0.673

1.04(0.50, 2.18)

0.922

Fetal growth restriction, n (%)

8(2.1%)

32(1.8%)

1.15(0.53, 2.51)

0.728

0.94(0.42, 2.11)

0.880

NICU admission, n (%)

66(16.9%)

210(11.7%)

1.53(1.13, 2.07)

0.006

1.28(0.93, 1.76)

0.135

Meconium-stained amniotic fluid, n (%)

59(15.1%)

253(14.1%)

1.08(0.80, 1.47)

0.617

1.01(0.74, 1.39)

0.928

polyhydramnios, n (%)

18(4.6%)

36(2.0%)

2.36(1.32, 4.19)

0.004

2.66(1.46, 4.86)

0.001

Oligohydramnios, n (%)

21(5.4%)

180(10.1%)

0.51(0.32, 0.81)

0.004

0.52(0.32, 0.83)

0.006

Fetal anomaly, n (%)

5(1.3%)

31(1.7%)

0.74(0.28, 1.91)

0.528

0.64(0.24, 1.70)

0.370

Fetal chromosomal abnormalities, n (%)

1(0.3%)

12(0.7%)

0.38(0.05, 2.94)

0.354

0.32(0.40, 2.53)

0.280

Low birth weight, n (%)

105(26.9%)

344(19.2%)

1.55(1.20, 1.99)

0.001

1.21(0.92, 1.60)

0.169

  1. Abbreviations: CI: confidence interval; PPROM: preterm prelabor rupture of membranes; NICU: neonatal intensive care unit
  2. * excluded confounders: maternal age, pregestational weight, gestational weight gain, pre-pregnancy body mass index, bile acid concentration, use of ursodeoxycholic acid, ART, and total bile acid