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Table 1 Baseline characteristics of women with ICP.

From: Gestational diabetes mellitus aggravates adverse perinatal outcomes in women with intrahepatic cholestasis of pregnancy

Characteristic

ICP with GDM

(n = 390)

ICP without GDM

(n = 1,788)

p.value

Maternal age, y, mean ± SD

30.99 ± 3.93

29.99 ± 4.28

< 0.001*

Pregestational weight, kg, mean ± SD

53.61 ± 7.23

52.57 ± 7.19

0.010*

Pre-delivery weight, kg, mean ± SD

65.75 ± 7.86

66.46 ± 8.28

0.122

Gestational weight gain, kg, mean ± SD

12.14 ± 4.66

13.88 ± 4.77

< 0.001*

Pre-pregnancy BMI, kg/m2, mean ± SD

21.55 ± 2.82

20.91 ± 2.71

< 0.001*

pregnancy BMI, kg/m2, mean ± SD

26.42 ± 2.95

26.43 ± 3.10

0.924

History of ICP, n (%)

18(4.6%)

82(4.6%)

0.980

Smoking, n (%)

2(0.5%)

18(1.0%)

0.558

Drinking, n (%)

1(0.3%)

12(0.7%)

0.485

Use of ursodeoxycholic acid, n (%)

134(34.4%)

716(40.0%)

0.037*

Adverse pregnancy history, n (%)

37(9.5%)

133(7.4%)

0.172

ART, n (%)

82(21.0%)

219(12.2%)

< 0.001*

Total bile acid, µmol/L, median (interquartile range)

20.20(13.68, 35.48)

18.60(13.00, 31.70)

0.024*

  1. Abbreviations: SD: standard deviation; BMl: body mass index; ICP: intrahepatic cholestasis of pregnancy; ART: assisted reproductive technology
  2. *Significant difference between ICP with GDM group and ICP group