Variables | Total (n = 1028) | Q1 (n = 205) | Q2 (n = 204) | Q3 (n = 209) | Q4 (n = 204) | Q5 (n = 206) | p-value |  |
---|---|---|---|---|---|---|---|---|
Age, years | 71.09 (60.05, 81.97) | 72.1 (62.44, 82.39) | 72.96 (62.34, 82.28) | 72.69 (63.21, 84.18) | 67.81 (56.2, 79.31) | 68.73 (56.89, 77.79) | < 0.001 | |
Male, n% | 548 (53) | 108 (53) | 113 (55) | 120 (57) | 114 (56) | 93 (45) | 0.097 | |
GCS | 14 (12, 15) | 14 (13, 15) | 14 (12, 15) | 14 (11, 15) | 14 (12, 15) | 14 (11, 15) | 0.332 | |
Severe Score | Â | Â | Â | Â | Â | Â | Â | |
 APSIII | 34 (25, 44) | 32 (24, 43) | 30 (21.75, 40) | 34 (26, 44) | 34 (26, 45) | 40.5 (31, 51) | < 0.001 | |
 SAPSII | 31 (25, 39) | 31 (25, 40) | 30 (24, 37) | 30 (24, 36) | 31 (24, 38) | 35 (28, 41) | < 0.001 | |
 SOFA | 3 (1, 4) | 2 (1, 4) | 2 (1, 4) | 2 (1, 4) | 3 (1, 4) | 4 (2, 5) | < 0.001 | |
 OASIS | 30 (26, 36) | 29 (25, 35) | 29 (24, 34) | 30 (26, 35) | 30 (26, 35) | 33 (28, 38) | < 0.001 | |
Comorbidities, n(%) | Â | Â | Â | Â | Â | Â | Â | |
 MI | 95 (9) | 19 (9) | 22 (11) | 18 (9) | 10 (5) | 26 (13) | 0.089 | |
 CHF | 157 (15) | 36 (18) | 33 (16) | 30 (14) | 25 (12) | 33 (16) | 0.623 | |
 Diabetes | 304 (30) | 72 (35) | 48 (24) | 52 (25) | 44 (22) | 88 (43) | < 0.001 | |
 Renal disease | 128 (12) | 34 (17) | 22 (11) | 28 (13) | 19 (9) | 25 (12) | 0.217 | |
 RD | 16 (2) | 4 (2) | 2 (1) | 4 (2) | 0 (0) | 6 (3) | 0.108 | |
 PVD | 70 (7) | 17 (8) | 15 (7) | 17 (8) | 14 (7) | 7 (3) | 0.271 | |
 CPD | 120 (12) | 26 (13) | 19 (9) | 24 (11) | 20 (10) | 31 (15) | 0.37 | |
 Hypertension | 275 (27) | 60 (29) | 64 (31) | 58 (28) | 52 (25) | 41 (20) | 0.088 | |
Vital signs | Â | Â | Â | Â | Â | Â | Â | |
 Mean HR (min− 1) | 78.2 (70.06, 87.87) | 73.27 (66.88, 82.84) | 74.78 (68.95, 84.37) | 79.06 (70.29, 87.62) | 80.96 (72, 89.73) | 84 (74.14, 94.42) | < 0.001 | |
 Mean AP (mmHg) | 85.83 ± 10.03 | 85.96 ± 9.95 | 86.77 ± 9.19 | 86.64 ± 10.7 | 86.08 ± 10.29 | 83.72 ± 9.74 | 0.015 | |
 Mean RR (min− 1) | 18.35 (16.79, 20.21) | 18.1 (16.5, 19.68) | 18.12 (16.54, 20.21) | 18.42 (16.94, 19.88) | 18.44 (16.31, 20.72) | 18.72 (17.29, 20.64) | 0.033 | |
 Mean Temp (°C) | 36.94 (36.73, 37.24) | 36.87 (36.69, 37.1) | 36.92 (36.73, 37.22) | 36.95 (36.73, 37.24) | 37 (36.78, 37.28) | 36.99 (36.77, 37.36) | 0.001 | |
 Mean SpO2 (%) | 97.08 (95.92, 98.34) | 96.93 (96.05, 98) | 96.9 (95.8, 98.08) | 96.9 (95.72, 98.23) | 97.42 (96.16, 98.38) | 97.72 (95.89, 98.96) | 0.004 | |
Laboratory test | Â | Â | Â | Â | Â | Â | Â | |
 WBC (K/uL) | 9.95 (7.93, 12.78) | 9.75 (7.9, 12.43) | 10.22 (8.11, 13.04) | 10.05 (8.07, 12.61) | 10.2 (8.18, 12.93) | 9.78 (7.51, 12.49) | 0.233 | |
 Neutrophils (%) | 79.9 (70.35, 85.8) | 80 (69.42, 86.14) | 80.5 (70.47, 86.21) | 78.3 (70.25, 84.3) | 81.6 (72.75, 86.34) | 78.65 (69.54, 85.05) | 0.252 | |
 Lymphocytes (%) | 25 (15.8, 38.8) | 25.75 (16.38, 39.53) | 24.4 (15.2, 38.62) | 27.2 (17.8, 39.5) | 22.3 (14.05, 37.15) | 26.9 (17.8, 39.73) | 0.132 | |
 Hemoglobin (g/dL) | 12.7 (11.45, 13.8) | 12.7 (11.23, 13.78) | 12.4 (11.35, 13.57) | 12.95 (11.7, 14.16) | 12.5 (11.38, 13.8) | 12.75 (11.45, 13.8) | 0.05 | |
 Platelets (K/uL) | 209 (171, 257.88) | 197.5 (165.75, 260.25) | 219.75 (169.88, 276.75) | 210 (170.88, 256.25) | 209.25 (176.5, 253.38) | 205 (172.75, 246.38) | 0.274 | |
 RDW (%) | 13.6 (13, 14.49) | 13.65 (13.1, 14.35) | 13.65 (13.1, 14.7) | 13.55 (12.9, 14.31) | 13.5 (12.9, 14.5) | 13.68 (13, 14.49) | 0.299 | |
 Calcium (mg/dL) | 8.8 (8.4, 9.2) | 8.8 (8.35, 9.2) | 8.78 (8.4, 9.15) | 8.9 (8.51, 9.3) | 8.85 (8.33, 9.24) | 8.85 (8.55, 9.15) | 0.358 | |
 Sodium (mEq/L) | 139.5 (137.5, 142) | 140 (137.75, 142) | 139.5 (137, 141.5) | 140 (137.5, 142) | 139.5 (137.5, 142) | 139.5 (137.88, 142) | 0.858 | |
 Potassium (mEq/L) | 4 (3.7, 4.3) | 3.95 (3.7, 4.3) | 4.05 (3.75, 4.34) | 4 (3.7, 4.31) | 4 (3.75, 4.3) | 3.92 (3.7, 4.3) | 0.701 | |
 Creatinine (mg/dL) | 0.9 (0.75, 1.1) | 0.95 (0.75, 1.1) | 0.9 (0.75, 1.15) | 0.9 (0.7, 1.1) | 0.9 (0.74, 1.1) | 0.9 (0.75, 1.1) | 0.123 | |
 BUN (mg/dL) | 16.5 (13, 21.5) | 17 (13, 21.5) | 16.5 (13, 21.5) | 16 (12, 20.5) | 17 (12.5, 22.12) | 16.5 (13, 21) | 0.679 | |
 Bilirubin (mg/dL) | 0.6 (0.4, 0.9) | 0.6 (0.4, 0.9) | 0.6 (0.4, 0.8) | 0.6 (0.5, 0.9) | 0.6 (0.4, 0.9) | 0.7 (0.5, 0.9) | 0.685 | |
 ALT c | 1.28 (1.18, 1.45) | 1.3 (1.15, 1.48) | 1.3 (1.18, 1.45) | 1.28 (1.15, 1.45) | 1.28 (1.18, 1.45) | 1.28 (1.17, 1.4) | 0.929 | |
 AST d | 1.41 (1.3, 1.58) | 1.42 (1.32, 1.6) | 1.41 (1.28, 1.57) | 1.41 (1.28, 1.58) | 1.41 (1.3, 1.59) | 1.41 (1.32, 1.56) | 0.711 | |
 PT (s) | 12.4 (11.5, 13.8) | 12.5 (11.6, 13.75) | 12.4 (11.62, 14.07) | 12.32 (11.5, 14) | 12.3 (11.51, 13.65) | 12.4 (11.36, 13.69) | 0.685 | |
 APTT (s) | 27.95 (25.45, 30.85) | 28.2 (25.32, 30.9) | 28.1 (25.7, 30.65) | 27.7 (25.59, 31.97) | 27.95 (25, 30.35) | 27.92 (25.98, 30.63) | 0.537 | |
 TG (mg/dL) | 94 (71, 138) | 100 (74, 147.25) | 99 (72, 140) | 93 (67.5, 139.25) | 98 (70.75, 133.75) | 91 (69.25, 120.38) | 0.438 | |
 ABG (mg/dL) | 124 (103, 155) | 96 (89, 109) | 108 (98, 119) | 121 (111, 137) | 136.5 (125.75, 153.25) | 181 (156, 239.5) | < 0.001 | |
 HbA1C (%) | 5.7 (5.4, 6.3) | 6 (5.6, 6.7) | 5.7 (5.38, 6.1) | 5.7 (5.4, 6.3) | 5.6 (5.3, 6) | 5.7 (5.2, 6.68) | < 0.001 | |
Events | Â | Â | Â | Â | Â | Â | Â | |
 Los ICU (days) | 3.32 (1.73, 7.59) | 2.07 (1.14, 4.95) | 3.22 (1.66, 6.65) | 3.31 (1.78, 6.84) | 4.24 (1.92, 8.09) | 4.76 (2.04, 9.61) | < 0.001 | |
 Los hospital (days) | 7.63 (4.05, 14.82) | 5.78 (3.65, 12) | 7.66 (3.92, 13.15) | 7.02 (4.46, 13.64) | 8.72 (4.92, 16.27) | 9.75 (4.76, 16.8) | 0.002 | |
 30-day mortaility (%) | 195 (19) | 23 (11) | 22 (11) | 36 (17) | 39 (19) | 75 (36) | < 0.001 | |
 1-year mortality (%) | 323 (31) | 52 (25) | 48 (24) | 65 (31) | 58 (28) | 100 (49) | < 0.001 | |
 Lung infection (%) | 168 (16) | 26 (13) | 25 (12) | 30 (14) | 36 (18) | 51 (25) | 168 (16) | |
Medications | Â | Â | Â | Â | Â | Â | Â | |
 Vasoactive drugs | 148 (14) | 29 (14) | 30 (15) | 27 (13) | 35 (17) | 27 (13) | 0.748 | |
 RRT | 20 (2) | 3 (1) | 5 (2) | 5 (2) | 6 (3) | 1 (0) | 0.334 | |
 Invasive ventilation | 384 (37) | 70 (34) | 80 (39) | 70 (33) | 88 (43) | 76 (37) | 0.242 | |
 Vent time (hours) | 40.34 (22.5, 108.87) | 34.6 (18.87, 139.9) | 37.7 (22, 92) | 43.51 (27.15, 112.75) | 41.9 (25.5, 97.09) | 43.23 (22.45, 123.53) | 0.921 |