Fig. 2

Receiver operating curve (ROC) analysis for diagnostic accuracy of glycated hemoglobin (HbA1c) at 8 to 14 weeks’ gestation to predict plasma glucose concentrations > 90 percentile at one or more timepoints (0 h, 1 h and/or 2 h) during an oral glucose tolerance test performed at 12 to 16 weeks’ gestation. The true positive fraction (TPF) is presented in the y-axis and the false negative fraction (FNF) in the x-axis. The black dot depicts the optimal cut-off point. Dotted line represents 45-degree reference line