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Table 2 Regression analysis of the association of 10% increased of myocardial microvascular function and myocardial extracellular volume with myocardial systolic global strain parameters

From: Early signs of myocardial systolic dysfunction in patients with type 2 diabetes are strongly associated with myocardial microvascular dysfunction independent of myocardial fibrosis: a prospective cohort study

 

GLS

GCS

GRS

Beta (95% CI)

p

Beta (95% CI)

p

Beta (95% CI)

p

Univariable

 10% MBF rest

0.2 (− 0.0001 to 0.4)

0.05

− 0.3 (− 0.5 to − 0.1)

**

0.6 (0.02 to 1.1)

0.047

 10% MBF stress

− 0.2 (− 0.4 to − 0.1)

**

− 0.04 (− 0.2 to 0.07)

0.5

0.1 (− 0.2 to 0.5)

0.5

 10% MPR

− 0.6 (− 0.8 to − 0.4)

**

0.1 (− 0.07 to 0.4)

0.2

− 0.2 (− 0.9 to 0.5)

0.6

 10% ECV

0.6 (0.2 to 1.1)

0.003

0.04 (− 0.40 to 0.48)

0.9

− 0.23 (− 1.58 to 1.11)

0.73

Multivariable, age, sex, hypertension and smoking

 10% MBF rest

0.2 (− 0.05 to 0.4)

0.1

− 0.2 (− 0.4 to − 0.02)

0.03

0.3 (− 0.3 to 0.9)

0.3

 10% MBF stress

− 0.2 (− 0.4 to − 0.1)

**

0.05 (− 0.07 to 0.2)

0.4

0.02 (− 0.4 to 0.4)

0.9

 10% MPR

− 0.5 (− 0.8 to − 0.3)

**

0.3 (0.02 to 0.5)

0.035

− 0.2 (− 0.9 to 0.6)

0.7

 10% ECV

0.5 (0.1 to 0.9)

0.03

0.20 (− 0.24 to 0.64)

0.4

− 0.79 (− 2.20 to 0.61)

0.3

Multivariable where both ECV and MPR are included in the same multivariable model

 10% MBF rest

0.2 (− 0.04 to 0.4)

0.1

− 0.2 (− 0.4 to 0.02)

0.08

0.3 (− 0.3 to 0.9)

0.4

 10% MBF stress

− 0.2 (− 0.3 to − 0.08)

**

0.08 (− 0.05 to 0.2)

0.2

− 0.01 (− 0.4 to 0.4)

1.0

 10% MPR

− 0.5 (− 0.8 to − 0.3)

**

0.3 (0.02 to 0.5)

0.03

− 0.2 (− 0.9 to 0.6)

0.7

 10% ECV

0.1 (− 0.3 to 0.6)

0.5

0.15 (− 0.31 to 0.63)

0.5

− 0.56 (− 2.08 to 0.96)

0.5

  1. MPR myocardial perfusion ratio, MBF myocardial blood flow, ECV extra cellular volume, GLS global longitudinal strain, GCS global circumferential strain, GRS global radial strain. Results with a p value < 0.05 were highlighted in bold
  2. **p value < 0.001