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Fig. 4 | Diabetology & Metabolic Syndrome

Fig. 4

From: Sacubitril/valsartan ameliorates tubulointerstitial fibrosis by restoring mitochondrial homeostasis in diabetic kidney disease

Fig. 4

In vitro sacubitril/ valsartan improved mitochondrial function and morphology in HG-treated HK-2 cells. (A, B) Typical fluorescence photomicrograph and quantitative analysis of mitochondrial superoxide. (C, D) Mitochondrial membrane potential assessed by JC-1 assay. (E) Representative images of mitochondria morphology with MitoTracker staining. (F) The percentage of cells with mitochondrial fragmentation in MitoTracker staining. Results represent means ± SEM, n = 4. *P < 0.05, **P < 0.01, ***P < 0.001. NC, normal control; HM, high mannitol; HG, high glucose; HG + Val, high glucose + Valsartan; HG + LBQ/Val, high glucose + LBQ657 + valsartan

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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