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Fig. 1 | Diabetology & Metabolic Syndrome

Fig. 1

From: Sacubitril/valsartan ameliorates tubulointerstitial fibrosis by restoring mitochondrial homeostasis in diabetic kidney disease

Fig. 1

Primary metabolic parameters and biochemistry of blood and 24-hour urine in diabetic mice. (A) Diagram illustrating the experimental design (by Figdraw). (B) Kidney weight/body weight. (C) The percentage of increase in body weight at the end of treatment. (D) Fasting blood glucose. (E) Urinary NAG. (F) Serum creatinine. (G) blood urea nitrogen. (H) Urinary albumin-to-creatinine. Results represent means ± SEM, n = 4. *P < 0.05, **P < 0.01, ***P < 0.001. STZ, streptozotocin; i.p., intraperitoneal injection; DKD, diabetic kidney disease; Val, DKD + Valsartan treated; Sac/Val, DKD + Sacubitril/Valsartan treated; KW, kidney weight; BW, body weight; NAG, N-acetyl-β-d-glucosamine-dase; Scr, serum creatinine; BUN, blood urea nitrogen; ACR, albumin-to-creatinine

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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