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Fig. 1 | Diabetology & Metabolic Syndrome

Fig. 1

From: Dapagliflozin improves podocytes injury in diabetic nephropathy via regulating cholesterol balance through KLF5 targeting the ABCA1 signalling pathway

Fig. 1

Dapagliflozin could effectively alleviate cell injury induced by high glucose. (A) The chemical structure of dapagliflozin. (B) WST assay shows that there was no significant difference in cell viability when concentration of dapagliflozin was less than 10µM. (C) WB revealed that dapagliflozin could inhibit apoptosis which was induced by high glucose. (D) FCM showed dapagliflozin could relieve the apoptosis ratio. (E) The cytoskeleton of HPCs stained by FITC-phalloidin showed that the rearrangement induced by HG can be efficiently restored by dapagliflozin. (F) WB showed dapagliflozin could relieve cell injury induced by high glucose. (Data presented are the mean ± S.D.; *P < 0.05 vs. LG, # P < 0.05 vs. HG, n = 3)

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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