Fig. 2

Effect of RYGB on islet function in db/db mice. A and B, Intraperitoneal glucose tolerance and oral glucose tolerance in db/m and db/db mice after RYGB and sham surgery (n = 4–5). The areas under the curve of each group are shown on their right. C, Insulin tolerance test in db/db mice after sham and RYGB surgery (n = 4). The inversed areas under the curve of each group are shown on their right. D, The fasting and stimulated insulin in sham- and RYGB-treated db/db mice (n = 4–6). The data are presented as the mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001