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Fig. 5 | Diabetology & Metabolic Syndrome

Fig. 5

From: High glucose-induced injury in human umbilical vein endothelial cells is alleviated by vitamin D supplementation through downregulation of TIPE1

Fig. 5

?Overexpression of TIPE1 reverses the effects of Vitamin D in apoptosis, migration and viability in human umbilical vein endothelial cells treated by high glucose. (A) Cell migration was tested by Transwell assay. (B) Cell apoptosis level was detected by flowcytometry. (C) Cell viability was analysed by CCK-8 assay. (D) ELISA was used to determine the level of inflammatory cytokines, (E) ELISA was used to test the level of ET-1 and NO. Ctrl, a normal concentration of glucose (5.6 mM); G, high glucose treatment; G+VD, high glucose plus vitamin D treatment; G+VD+pc-NC, high glucose plus vitamin D treatment as well as pc-NC transfection; G+VD+pc-TIPE1, high glucose plus vitamin D treatment as well as pc-TIPE1 transfection. *P<0.05, **P<0.01

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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