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Table 3 The additional predictive value of uACR for CVD events

From: An elevated urinary albumin-to-creatinine ratio increases the risk of incident cardia-cerebrovascular disease in individuals with type 2 diabetes

  

AUC

NRI

P-value

IDI

P-value

Myocardial infarction

Model 2

0.641(0.594, 0.689)

ref

-

ref

-

Model 2 + ln(uACR)

0.679(0.628, 0.730)

0.213(0.121, 0.304)

< 0.001

0.006(0.002, 0.013)

< 0.001

Model 2 + uACR categories

0.668(0.618, 0.718)

0.226(0.131, 0.315)

< 0.001

0.004(0.001, 0.009)

< 0.001

Model 4*

0.684(0.635, 0.733)

ref

-

ref

-

Model 4 + ln(uACR)

0.701(0.653,0.749)

0.139(0.041, 0.240)

< 0.001

0.005(0.002, 0.013)

< 0.001

Model 4 + uACR categories

0.693(0.645, 0.741)

0.211(0.095, 0.301)

< 0.001

0.003(0.001, 0.009)

< 0.001

Ischemic stroke

Model 2

0.599(0.574, 0.625)

ref

-

ref

-

Model 2 + ln(uACR)

0.645(0.619, 0.671)

0.161(0.101, 0.216)

< 0.001

0.012(0.006, 0.019)

< 0.001

Model 2 + uACR categories

0.638(0.612, 0.664)

0.176(0.125, 0.218)

< 0.001

0.008(0.004, 0.015)

< 0.001

Model 4*

0.665(0.639, 0.689)

ref

-

ref

-

Model 4 + ln(uACR)

0.676(0.651, 0.701)

0.121(0.067, 0.172)

< 0.001

0.007(0.003, 0.014)

< 0.001

Model 4 + uACR categories

0.672(0.647, 0.698)

0.167(0.116, 0.211)

< 0.001

0.005(0.002, 0.010)

< 0.001

Hemorrhagic stroke

Model 2

0.588(0.485, 0.692)

ref

-

ref

-

Model 2 + ln(uACR)

0.644(0.538, 0.750)

0.178(-0.112, 0.397)

0.229

0.001(0.000, 0.007)

0.05

Model 2 + uACR categories

0.649(0.550, 0.749)

0.165(-0.044, 0.365)

0.09

0.001(0.000, 0.008)

0.030

Model 4*

0.666(0.569, 0.762)

ref

-

ref

-

Model 4 + ln(uACR)

0.703(0.600, 0.806)

0.164(-0.102, 0.365)

0.269

0.001(0.000, 0.017)

0.109

Model 4 + uACR categories

0.712(0.610, 0.813)

0.163(-0.058, 0.379)

0.119

0.001(0.000, 0.016)

0.139

Total CVD events

Model 2

0.604(0.582, 0.627)

ref

-

ref

-

Model 2 + ln(uACR)

0.653(0.630, 0.676)

0.191(0.111, 0.256)

< 0.001

0.011(0.006, 0.018)

< 0.001

Model 2 + uACR categories

0.644(0.621, 0.666)

0.221(0.152, 0.285)

< 0.001

0.008(0.004, 0.013)

< 0.001

Model 4*

0.660(0.638, 0.682)

ref

-

ref

-

Model 4 + ln(uACR)

0.678(0.656, 0.700)

0.121(0.053, 0.193)

< 0.001

0.008(0.004, 0.014)

< 0.001

Model 4 + uACR categories

0.674(0.652, 0.695)

0.199(0.116, 0.261)

< 0.001

0.005(0.002, 0.011)

< 0.001

  1. Model 2: age, sex; Model 4 (HKU-SG risk score): age, gender, SBP, DBP, HbA1c, LDL cholesterol, BMI, CKD(eGFR), atrial fibrillation and smoking
  2. Abbreviation: uACR, urine albumin-to-creatinine ratio; CVD: cardiovascular and cerebrovascular disease; AUC: the area under the receiver operating characteristic curve; NRI: net reclassification improvement; IDI: integrated discrimination improvement
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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