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Fig. 3 | Diabetology & Metabolic Syndrome

Fig. 3

From: Didymin protects pancreatic beta cells by enhancing mitochondrial function in high-fat diet-induced impaired glucose tolerance

Fig. 3

Didymin improves mitochondrial function in PBCs. (A) MitoTracker Green staining for mitochondrial content in INS-1 cells. Scale bar = 30 μm. (n = 4) (B) Western blot analysis of NRF1, TFAM, NDUFB8, SDHB and MTCO2 in INS-1 cells (n = 3). (C) Mitochondrial oxygen consumption ratio (OCR) of INS-1 cells (n = 4). (D) ROS concentration in INS-1 cells (n = 4). (E) Analysis of mitochondrial structure of PBCs in mice by electron microscopy. Scale bar = 0.6 μm. (F) Immunofluorescence staining of COX-IV (green) and insulin (red) in pancreas. Scale bar = 20 μm. Data are expressed as mean ± SD. *P < 0.05, **P < 0.01, ****P < 0.0001 PA vs. PA + Didymin. # P < 0.05, ## P < 0.01, ### P < 0.001, #### P < 0.0001 control vs. PA.

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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