|  |  |  | Model 1a |  | Model 2 b |  | Model 3 c |  |
---|---|---|---|---|---|---|---|---|---|
Outcomes | Adipo-IR groups | N | Events, n (%) | HR/OR (95%CI)d | P Value | HR/OR (95%CI)d | PValue | HR/OR (95%CI)d | P Value |
Stroke recurrence | Q1 (< 2.28) | 447 | 24 (5.4) | Ref. | Â | Ref. | Â | Ref. | Â |
 | Q2 (2.28-4.00) | 440 | 39 (8.9) | 1.84 (1.08–3.13) | 0.03 | 1.77 (1.04–3.03) | 0.04 | 1.68 (1.24–2.28) | < 0.001 |
 | Q3 (4.01–6.05) | 447 | 48 (10.7) | 2.32 (1.38–3.90) | 0.002 | 2.19 (1.30–3.68) | 0.003 | 2.08 (1.55–2.80) | < 0.001 |
 | Q4 (6.06–9.49) | 441 | 37 (8.4) | 1.93 (1.11–3.36) | 0.02 | 1.84 (1.06–3.21) | 0.03 | 1.82 (1.33–2.50) | < 0.001 |
 | Q5 (≥ 9.50) | 447 | 37 (8.3) | 2.22 (1.27–3.91) | 0.01 | 2.11 (1.20–3.71) | 0.01 | 2.12 (1.55–2.91) | < 0.001 |
 | Per SD |  |  | 1.19 (1.02–1.39) | 0.03 | 1.19 (1.01–1.39) | 0.03 | 1.22 (1.12–1.33) | < 0.001 |
 | P for trend |  |  |  | 0.04 |  | 0.055 |  | < 0.001 |
Combined vascular eventse | Q1 (< 2.28) | 447 | 28 (6.3) | Ref. | Â | Ref. | Â | Ref. | Â |
 | Q2 (2.28-4.00) | 440 | 41 (9.3) | 1.65 (0.99–2.72) | 0.052 | 1.60 (0.97–2.64) | 0.07 | 1.51 (1.13–2.01) | 0.01 |
 | Q3 (4.01–6.05) | 447 | 49 (11.0) | 2.02 (1.24–3.30) | 0.01 | 1.91 (1.17–3.13) | 0.01 | 1.82 (1.38–2.40) | < 0.001 |
 | Q4 (6.06–9.49) | 441 | 38 (8.6) | 1.69 (0.99–2.86) | 0.051 | 1.62 (0.96–2.75) | 0.07 | 1.61 (1.20–2.17) | 0.002 |
 | Q5 (≥ 9.50) | 447 | 37 (8.3) | 1.91 (1.11–3.26) | 0.02 | 1.80 (1.05–3.09) | 0.03 | 1.81 (1.34–2.45) | < 0.001 |
 | Per SD |  |  | 1.17 (1.02–1.37) | 0.045 | 1.17 (0.98–1.37) | 0.055 | 1.20 (1.10–1.31) | < 0.001 |
 | P for trend |  |  |  | 0.08 |  | 0.12 |  | 0.003 |
Death | Q1 (< 2.28) | 447 | 12 (2.7) | Ref. | Â | Ref. | Â | Ref. | Â |
 | Q2 (2.28-4.00) | 440 | 9 (2.0) | 0.92 (0.37–2.29) | 0.86 | 0.91 (0.36–2.32) | 0.84 | 0.91 (0.54–1.54) | 0.72 |
 | Q3 (4.01–6.05) | 447 | 16 (3.6) | 1.55 (0.68–3.52) | 0.30 | 1.72 (0.75–3.99) | 0.20 | 1.68 (1.04–2.71) | 0.03 |
 | Q4 (6.06–9.49) | 441 | 9 (2.0) | 1.07 (0.41–2.84) | 0.89 | 1.16 (0.43–3.14) | 0.76 | 1.23 (0.71–2.14) | 0.47 |
 | Q5 (≥ 9.50) | 447 | 12 (2.7) | 1.77 (0.72–4.36) | 0.21 | 1.55 (0.62–3.91) | 0.35 | 1.53 (0.91–2.57) | 0.11 |
 | Per SD |  |  | 1.07 (0.78–1.46) | 0.67 | 1.01 (0.74–1.38) | 0.95 | 0.99 (0.84–1.18) | 0.95 |
 | P for trend |  |  |  | 0.19 |  | 0.33 |  | 0.08 |
Poor outcomef | Q1 (< 2.28) | 439 | 43 (9.8) | Ref. | Â | Ref. | Â | Ref. | Â |
 | Q2 (2.28-4.00) | 427 | 47 (11.0) | 1.20 (0.76–1.91) | 0.44 | 1.19 (0.73–1.95) | 0.49 | 1.19 (0.90–1.58) | 0.21 |
 | Q3 (4.01–6.05) | 436 | 52 (11.9) | 1.45 (0.92–2.28) | 0.11 | 1.35 (0.83–2.19) | 0.22 | 1.30 (0.99–1.71) | 0.06 |
 | Q4 (6.06–9.49) | 435 | 53 (12.2) | 1.72 (1.07–2.75) | 0.02 | 1.62 (0.98–2.69) | 0.06 | 1.62 (1.22–2.15) | 0.001 |
 | Q5 (≥ 9.50) | 432 | 55 (12.7) | 2.00 (1.23–3.24) | < 0.001 | 1.53 (0.91–2.56) | 0.11 | 1.47 (1.10–1.96) | 0.01 |
 | Per SD |  |  | 1.25 (1.08–1.45) | < 0.001 | 1.15 (0.98–1.36) | 0.09 | 1.14 (1.04–1.25) | 0.004 |
 | P for trend |  |  |  | 0.003 |  | 0.09 |  | <0.001 |