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Table 2 Association between HOMA-IR and cognitive functions in patients with T2DM

From: Impact of insulin resistance on mild cognitive impairment in type 2 diabetes mellitus patients with non-alcoholic fatty liver disease

 

Model 1

Model 2

Model 3

 

R

P

R

P

R

P

MoCA

-0.116

0.168

-0.131

0.124

-0.120

0.161

DST

-0.111

0.187

-0.096

0.262

-0.093

0.276

VFT

-0.226

0.007**

-0.221

0.009**

-0.214

0.012*

CDT

-0.037

0.664

-0.013

0.876

-0.024

0.780

TMTA

0.086

0.306

0.078

0.364

0.056

0.511

TMTB

0.261

0.002**

0.253

0.003**

0.241

0.004**

AVLT-IR

-0.111

0.185

-0.122

0.152

-0.115

0.178

AVLT-DR

-0.139

0.098

-0.154

0.070

-0.150

0.079

LMT

-0.028

0.741

-0.041

0.630

-0.041

0.631

  1. Notes: Model 1 showed the Pearson association between HOMA-IR and cognitive function in patients with T2DM; Model 2 showed the partial correlation between HOMA-IR and cognitive function adjusting for age, gender, duration of DM and hypertension; Model 3 showed the partial correlation between HOMA-IR and cognitive function adjusting for age, gender, duration of DM and hypertension as well as HbA1c. * P < 0.05; ** P < 0.01. Abbreviations: T2DM, type 2 diabetes mellitus; MoCA, Montreal cognitive assessment; DST, digit span test; VFT, verbal fluency test; CDT, clock drawing test; TMTA, trail making test-A; TMTB, trail making test-B; AVLT-IR, auditory verbal learning test-immediate recall; AVLT-DR, auditory verbal learning test-delayed recall; LMT, logical memory test; DM, diabetes mellitus; HbA1c, glycosylated hemoglobin