Fig. 3

mmu_circ_0001100 (circ-Snhg11) has indispensable roles in BMSC-Exo-mediated wound repair. (A) NGS identified several downregulated and upregulated circRNAs in the ulcer site between the Exo and PBS treatment groups. (B) RT-qPCR showing upregulated circRNA expression levels in the ulcer site betwen the Exo and PBS treatment groups. (C) RT-qPCR data showing differences in mmu_circ_0001100 expression between normal and DM mouse serum. (D-E) Representative images showing wound healing processes at distinct time points in different groups. Quantification of the wound healing rate. N = 6. (F-G) Immunofluorescence data showing ROS levels in the ulcer site. (H and I) Immunofluorescence data showed GPX4 expression levels. (J-K) Immunofluorescence data showing CD31 expression in the ulcer site. Data are expressed as mean ± SD. ^*p < 0.05, ^***p < 0.001 vs. Exo group