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Table 2 Hypoglycemia inputs

From: Cost-effectiveness of continuous glucose monitoring with FreeStyle Libre® in Brazilian insulin-treated patients with types 1 and 2 diabetes mellitus

Parameter

Mean

Lower Bound

Upper Bound

Source

T1DM

    

 Non-severe hypoglycemia events per patient-years

99

94.8

103.3

Lamounier et al. [7]

 Events of glucose level < 3.9 mmol/L (70 mg/dL) within 24 h

− 25.8%

− 20.6%

− 31.0%

Bolinder et al. [24]

 Severe hypoglycemia events per patient-years

9.8

8.5

11.3

Lamounier et al. [7]

 Events of glucose level < 2.5 mmol/L (45 mg/dL) within 24 h per patient-years with FSL

5.05

4.38

5.82

Bolinder et al. [24]

 Proportion of nocturnal hypoglycemia events

54%

Lamounier et al. [7]

 Proportion of severe hypoglycemia events requiring hospitalization

5.2%

4.2%

6.2%

Lamounier et al. [7]

T2DM

    

 Non-severe hypoglycemia events per patient-years

25.5

23.7

27.9

Lamounier et al. [7]

 Events of glucose level < 3.9 mmol/L (70 mg/dL) within 24 h

− 27.7%

− 22.2%

− 33.2%

Haak et al. [25]

 Severe hypoglycemia events per patient-years

6.2

5.2

7.4

Lamounier et al. [7]

 Events of glucose level < 2.5 mmol/L (45 mg/dL) within 24 h per patient-years with FSL

3.17

2.66

3.79

Haak et al. [25]

 Proportion of nocturnal hypoglycemia events

27%

Lamounier et al. [7]

 Proportion of severe hypoglycemia events requiring hospitalization

3.3%

2.6%

4.0%

Lamounier et al. [7]

  1. Mean numbers were used in base-case analysis. Lower and upper bound values were used in sensitivity analysis
  2. T1DM, Type 1 diebetes mellitus; T2DM, type 2 diabetes mellitus