Metabolic syndrome and transaminases: systematic review and meta-analysis

Table 2 Evidence profile with GRADE pro for the meta-analyses

Certainty assessment							No. of subjects		Size of the effect	Quality of evidence
No. of studies	Study design	Risk of bias	Inconsistency	Indirect evidence	Imprecision	Other considerations	MetS+	MetS-	Mean difference (95% CI)	Quality of evidence
ALT Meta-analysis
n = 17	Observational studies	serious	Very serious	It is not serious	It is not serious	dose-response gradient	76.686	201.855	7.13 (5.73–8.54)	⨁◯◯◯ Very low
AST Meta-analysis
n = 15	Observational studies	serious	Very serious	It is not serious	It is not serious	dose-response gradient	74.526	196.212	2.68 (1.82–3.54)	⨁◯◯◯ Very low
GGT Meta-analysis
n = 5	Observational studies	serious	Very serious	It is not serious	It is not serious	dose-response gradient	13.302	42.431	11.2 (7.11–15.29)	⨁◯◯◯ Very low

Abbreviations; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma-glutamyltransferase; MetS, metabolic syndrome; CI, confidence interval

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