Table 4 Summary of count data analysis with Random effects or fixed effects ORs (95% CI) estimate with a p-value for analysis of primary safety outcomes

All adverse events

1.04 (1.00, 1.09)

P ≥ 0.05

1.07 (1.03, 1.11)

P < 0.05

1.10 (1.07, 1.14)

P < 0.05

1.07 (1.05, 1.10)

P < 0.05

Serious adverse events

1.04 (0.97, 1.10)

P ≥ 0.05

1.02 (0.98, 1.05)

P ≥ 0.05

0.99 (0.95, 1.02)

P ≥ 0.05

1.01 (0.99, 1.03)

P ≥ 0.05

Hypoglycemic events

0.75 (0.69, 0.81)

P < 0.05

0.93 (0.89, 0.98)

P < 0.05

0.75 (0.69, 0.81)

P < 0.05

0.89 (0.87, 0.92)

P < 0.05

Gastrointestinal events

1.078 (0.965, 1.203)

P ≥ 0.05

1.262 (1.138, 1.400)

P < 0.05

1.296 (1.172, 1.432)

P < 0.05

1.213 (1.142, 1.289)

P < 0.05

Discontinuation of therapy

1.22 (1.12, 1.33)

P < 0.05

1.13 (1.07, 1.19)

P < 0.05

1.15 (1.09, 1.21)

P < 0.05

1.15 (1.12, 1.19)

P < 0.05

Fatal adverse events

1.04 (0.98, 1.09)

P ≥ 0.05

0.98 (0.96, 1.00)

P ≥ 0.05

1.00 (0.97, 1.02)

P ≥ 0.05

1.00 (0.98, 1.01)

P ≥ 0.05

Decreased appetite

3.213 (1.423, 7.256)

P < 0.05

2.963 (1.153, 7.612)

P < 0.05

1.12 (1.06, 1.19)

P < 0.05

3.021 (1.863, 4.901)

P < 0.05