Skip to main content

Table 6 Papillary muscle functional data under positive inotropic stimulation

From: The influence of dapagliflozin on cardiac remodeling, myocardial function and metabolomics in type 1 diabetes mellitus rats

  

C

(n = 13)

DM

(n = 13)

DM + DAPA

(n = 13)

P value

PRC

DT (g/mm 2 )

9.13 ± 1.91

5.70 ± 1.70 *

7.56 ± 1.48 #

< 0.001

RT (g/mm 2 )

0.60 ± 0.17

0.68 ± 0.16

0.71 ± 0.15

0.224

+dT/dt (g/mm 2 /s)

94 ± 23

54 ± 16 *

74 ± 12 *#

< 0.001

-dT/dt (g/mm 2 /s)

37 ± 8.06

21 ± 5.31 *

26 ± 3.53 *

< 0.001

TPT (ms)

187 ± 15

217 ± 18 *

204 ± 24

0.002

2.5 mM [Ca + 2 ] 0

DT (g/mm 2 )

9.03 ± 1.44

4.88 ± 2.02 *

6.71 ± 1.25 #

< 0.001

RT (g/mm 2 )

0.63 ± 0.08

0.61 ± 0.15

0.66 ± 0.13

0.666

+dT/dt (g/mm 2 /s)

97 ± 19

50 ± 14 *

68 ± 12 *#

< 0.001

-dT/dt (g/mm 2 /s)

36 ± 6.34

21 ± 5.76 *

26 ± 3.53 *#

< 0.001

TPT (ms)

170 (165–180)

200 (190–205) *

185 (167–200)

0.003

10− 6 M ISO

DT (g/mm 2 )

7.49 ± 1.70

4.55 ± 1.24 *

6.14 ± 1.32 #

< 0.001

RT (g/mm 2 )

0.56 ± 0.15

0.56 ± 0.14

0.59 ± 0.13

0.786

+dT/dt (g/mm 2 /s)

89 ± 23

50 ± 14 *

65 ± 25 #

< 0.001

-dT/dt (g/mm 2 /s)

48 ± 11.3

27 ± 10.6 *

36 ± 9.40 #

< 0.001

TPT (ms)

150 (140–150)

170 (160–185) *

160 (140–170)

0.003

  1. C: control; DM: diabetes mellitus; DM + DAPA: DM treated with dapagliflozin; DT: developed tension; RT: resting tension; +dT/dt: maximum rate of tension development; -dT/dt: maximum rate of tension decline; TPT: time to peak tension; PRC: 60 s post-rest contraction; [Ca+ 2]0: extracellular calcium concentration; ISO: addition of isoproterenol. Data are means ± standard deviation or medians and percentiles. ANOVA and Tukey or Kruskal-Wallis and Dunn; * statistically different from C; # statistically different from DM