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Table 5 Papillary muscle functional data at basal condition

From: The influence of dapagliflozin on cardiac remodeling, myocardial function and metabolomics in type 1 diabetes mellitus rats

 

C (n = 13)

DM (n = 13)

DM + DAPA (n = 13)

p value

DT (g/mm 2 )

5.94 ± 0.83

4.82 ± 1.24 *

6.27 ± 1.12 #

0.004

RT (g/mm 2 )

0.66 ± 0.09

0.69 ± 0.17

0.71 ± 0.15

0.696

+dT/dt (g/mm 2 /s)

60 ± 8.70

45 ± 11.4 *

61 ± 9.63 #

< 0.001

-dT/dt (g/mm 2 /s)

28 ± 2.02

20 ± 5.10 *

25 ± 3.31 #

< 0.001

TPT (ms)

180 (170 − 90)

210 (200–220) *

190 (185–210)

< 0.001

CSA (mm 2 )

0.95 ± 0.16

1.06 ± 0.19

0.96 ± 0.12

0.171

  1. C: control; DM: diabetes mellitus; DM + DAPA: DM treated with dapagliflozin; DT: developed tension; RT: resting tension; +dT/dt: maximum rate of tension development; -dT/dt: maximum rate of tension decline; TPT: time to peak tension; CSA: papillary muscle cross sectional area. Data are means ± standard deviation or medians and percentiles. ANOVA and Tukey or Kruskal-Wallis and Dunn; * statistically different from C; # statistically different from DM