Skip to main content

Table 4 Echocardiographic indexes of left ventricular diastolic function

From: The influence of dapagliflozin on cardiac remodeling, myocardial function and metabolomics in type 1 diabetes mellitus rats

 

C (n = 14)

DM (n = 15)

DM + DAPA (n = 13)

p value

Mitral E (cm/s)

74 ± 5.64

69 ± 7.28

64 ± 7.00 *

0.003

Mitral A (cm/s)

48 ± 6.29

50 ± 9.62

39 ± 5.67 *#

0.002

E/A

1.60 ± 0.18

1.37 ± 0.27 *

1.65 ± 0.23 #

0.005

IVRT (ms)

33 (33–37)

44 (37–44) *

37 (33–41)

< 0.001

EDT (ms)

52 ± 9.33

51 ± 9.21

49 ± 6.70

0.693

TDI E’ (average. cm/s)

3.93 ± 0.49

3.47 ± 0.56

3.52 ± 0.50

0.048

E/TDI E’ (average)

18.9 ± 2.53

20.1 ± 3.78

18.1 ± 3.23

0.227

  1. C: control; DM: diabetes mellitus; DM + DAPA: DM treated with dapagliflozin; n: number of rats; E/A: ratio between early (E)-to-late (A) diastolic mitral inflow; IVRT: isovolumetric relaxation time; EDT: E wave deceleration time; TDI E’: tissue Doppler imaging of early diastolic velocity of mitral annulus (average of lateral and septal walls). Data are means ± standard deviation or medians and percentiles. ANOVA and Tukey or Kruskal-Wallis and Dunn; * statistically different from C; # statistically different from DM