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Table 1 Anatomical variables

From: The influence of dapagliflozin on cardiac remodeling, myocardial function and metabolomics in type 1 diabetes mellitus rats

 

C

(n = 14)

DM

(n = 15)

DM + DAPA (n = 13)

p value

BW (g)

574 ± 43

339 ± 31 *

413 ± 30 *#

< 0.001

RV weight (g)

0.29 (0.26–0.31)

0.19(0.18–0.21) *

0.21 (0.19–0.23) *

< 0.001

RV weight/BW (mg/g)

0.52 ± 0.07

0.57 ± 0.05

0.51 ± 0.04 #

0.026

RV weight (wet/dry)

4.31 (4.18–4.51)

4.15 (3.97–4.23) *

4.13 (3.99–4.37)

0.023

Atria weight (g)

0.11 (0.10–0.12)

0.08 (0.07–0.08) *

0.08 (0.07–0.10) *

< 0.001

Atria weight/BW (mg/g)

0.20 ± 0.02

0.24 ± 0.02 *

0.21 ± 0.04

0.005

Atria weight (wet/dry)

4.79 ± 0.45

4.45 ± 0.77

4.66 ± 0.92

0.481

Lung weight (g)

2.33 ± 0.29

1.82 ± 0.29 *

2.11 ± 0.32 #

< 0.001

Lung weight/BW (mg/g)

3.99 ± 0.62

5.34 ± 0.96 *

5.07 ± 0.94 *

< 0.001

Lung weight (wet/dry)

4.70 (4.45–4.91)

4.69 (4.43–4.81)

4.68 (4.40–5.76)

0.804

Liver weight (wet/dry)

3.20 (3.13–3.24)

3.21 (3.16–3.23)

3.10 (2.93–3.40)

0.614

  1. C: control; DM: diabetes mellitus; DM + DAPA: DM treated with dapagliflozin; n: number of rats; BW: body weight; RV: right ventricle. Data are means ± standard deviation or medians and percentiles. ANOVA and Tukey or Kruskal-Wallis and Dunn; * statistically different from C; # statistically different from DM