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Fig. 7 | Diabetology & Metabolic Syndrome

Fig. 7

From: Human umbilical cord mesenchymal stem cell-derived exosomes promote microcirculation in aged diabetic mice by TGF-β1 signaling pathway

Fig. 7

Therapeutic mechanism of hUCMSCs after increased microcirculation permability in diabetic mice. Exosomes obtained by overspeed centrifugation were injected through the caudel vein, binding to CD105/TβR-II receptor complexes on the surface of endothelial cell membrane in mice through TGF-β cytokines in exosomes, activating downstream signals, endothelial cell activation and proliferation, endothelial space narrowing, permability reduction, and angiogenesis

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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