Table 1 Sensitivity analysis of the UVMR
Exposure | Number of IVs | Heterogeneity test | MR-Egger pleiotropy test | MR-PRESSO global and distorted outlier test | R2xz | F statistics | Statistics power | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Q value | P-value | Intercept | P-value | RSSobs | P-value | Number of outliers | Power | NCP | Minimum number of participants at 80% power | ||||
Metabolic syndrome | 77 | 656.4696 | 5.13E-08 | 0.0021 | 2.16E-01 | 659.3605 | 3.00E-04 | 2 | 11.96% | 75.6922 | 97% | 14.53 | NA |
Body mass index | 475 | 486.6747 | 5.04E-07 | 0.0000 | 9.83E-01 | 512.8289 | 2.00E-04 | 7 | 4.91% | 73.9818 | 100% | 46.67 | NA |
Waist circumference | 344 | 466.5209 | 1.08E-08 | −0.0029 | 3.28E-02 | 479.2033 | 2.00E-04 | 6 | 4.49% | 63.0433 | 100% | 84.94 | NA |
HDL cholesterol | 308 | 336.4586 | 2.20E-03 | 0.0024 | 7.07E-02 | 363.4878 | 1.00E-04 | 7 | 11.76% | 174.6032 | 6% | 0.07 | 32,989,842 |
Triglycerides | 267 | 44.7670 | 1.78E-01 | −0.0033 | 3.88E-01 | 57.3322 | 1.04E-01 | 5 | 9.63% | 175.9911 | 83% | 8.46 | NA |
Type 1 diabetes | 38 | 148.4480 | 1.20E-02 | 0.0072 | 1.85E-02 | 164.9014 | 5.00E-03 | 0 | 17.93% | 142.5518 | 7% | 0.16 | NA |
Type 2 diabetes | 113 | 96.4514 | 1.51E-03 | −0.0030 | 3.99E-01 | 108.7939 | 3.00E-04 | 2 | 13.95% | 940.3147 | 51% | 3.96 | 544,383 |
Fasting glucose | 60 | 50.3129 | 5.70E-02 | −0.0014 | 8.53E-01 | 52.8547 | 5.90E-02 | 3 | 4.40% | 153.7989 | 43% | 3.17 | 678,174 |
Fasting insulin | 37 | 556.1044 | 1.85E-05 | −0.0017 | 3.15E-01 | 603.9387 | 1.00E-04 | 0 | 1.75% | 51.6940 | 84% | 8.81 | NA |
Systolic blood pressure | 426 | 614.9849 | 8.85E-09 | −0.0014 | 3.99E-01 | 629.4504 | 1.00E-04 | 4 | 4.63% | 86.3792 | 5% | 0.02 | 113,387,310 |
Diastolic blood pressure | 430 | 99.0027 | 3.94E-02 | 0.0053 | 1.25E-01 | 104.7258 | 4.87E-02 | 8 | 4.80% | 88.7655 | 5% | 0.02 | 1,599,783,962 |